Affiliation: University of Arizona
Burt J, Nelson T, Simon A, Fang J. Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells. Am J Physiol Cell Physiol. 2008;295:C1103-12 pubmed publisher
..Our results indicate that Cx37 expression suppresses cell proliferation by significantly increasing cell cycle time by extending all phases of the cell cycle and accumulating cells at the G(1)/S checkpoint. ..
Burt J, Fletcher A, Steele T, Wu Y, Cottrell G, Kurjiaka D. Alteration of Cx43:Cx40 expression ratio in A7r5 cells. Am J Physiol Cell Physiol. 2001;280:C500-8 pubmed
Good M, Ek VitorÃn J, Burt J. Structural determinants and proliferative consequences of connexin 37 hemichannel function in insulinoma cells. J Biol Chem. 2014;289:30379-86 pubmed publisher
Jacobsen N, Pontifex T, Li H, Solan J, Lampe P, Sorgen P, et al
. Regulation of Cx37 channel and growth-suppressive properties by phosphorylation. J Cell Sci. 2017;130:3308-3321 pubmed publisher
..These data suggest that differential phosphorylation of the C-terminus regulates channel conformation and, thereby, cell cycle progression and cell survival. ..