SUMNER HOWARD BURSTEIN

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Regulation of anandamide tissue levels by N-arachidonylglycine
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Room 803, New Research Building, 264 Plantation Street, Worcester, MA 01605, USA
    Biochem Pharmacol 64:1147-50. 2002
  2. pmc N-Amino acid linoleoyl conjugates: anti-inflammatory activities
    Sumner Burstein
    Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Bioorg Med Chem Lett 22:872-5. 2012
  3. pmc Resolution of inflammation by N-arachidonoylglycine
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, Massachusetts 01605, USA
    J Cell Biochem 112:3227-33. 2011
  4. pmc Cannabinoids, endocannabinoids, and related analogs in inflammation
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, Massachusetts 01605, USA
    AAPS J 11:109-19. 2009
  5. doi request reprint Acylamido analogs of endocannabinoids selectively inhibit cancer cell proliferation
    Sumner Burstein
    Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, Worcester, MA 01605, USA
    Bioorg Med Chem 16:9644-51. 2008
  6. pmc The elmiric acids: biologically active anandamide analogs
    Sumner Burstein
    Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School Worcester, MA 01605, USA
    Neuropharmacology 55:1259-64. 2008
  7. pmc Potential anti-inflammatory actions of the elmiric (lipoamino) acids
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Bioorg Med Chem 15:3345-55. 2007
  8. ncbi request reprint Oxidative metabolism of anandamide
    S H Burstein
    Department of Biochemistry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, USA
    Prostaglandins Other Lipid Mediat 61:29-41. 2000
  9. pmc Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials
    Summer Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    AAPS J 7:E143-8. 2005
  10. ncbi request reprint PPAR-gamma: a nuclear receptor with affinity for cannabinoids
    Sumner Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605 2324, USA
    Life Sci 77:1674-84. 2005

Research Grants

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Regulation of anandamide tissue levels by N-arachidonylglycine
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Room 803, New Research Building, 264 Plantation Street, Worcester, MA 01605, USA
    Biochem Pharmacol 64:1147-50. 2002
    ..Moreover, the findings presented here suggest that NAGly can serve as a model for the design of agents to provide pharmacological control of tissue anandamide concentrations...
  2. pmc N-Amino acid linoleoyl conjugates: anti-inflammatory activities
    Sumner Burstein
    Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Bioorg Med Chem Lett 22:872-5. 2012
    ..It was concluded that linoleic acid conjugates could provide suitable templates in a drug discovery program leading to novel agents for promoting the resolution of chronic inflammation...
  3. pmc Resolution of inflammation by N-arachidonoylglycine
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, Massachusetts 01605, USA
    J Cell Biochem 112:3227-33. 2011
    ..Thus, we hypothesize that NAgly induces the death of inflammatory cells, a process that is considered to be important for the resolution of inflammation...
  4. pmc Cannabinoids, endocannabinoids, and related analogs in inflammation
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, Massachusetts 01605, USA
    AAPS J 11:109-19. 2009
    ..This differentiates these cannabinoids from cyclooxygenase-2 inhibitors that suppress the synthesis of eicosanoids that promote the induction of the inflammatory process...
  5. doi request reprint Acylamido analogs of endocannabinoids selectively inhibit cancer cell proliferation
    Sumner Burstein
    Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, Worcester, MA 01605, USA
    Bioorg Med Chem 16:9644-51. 2008
    ..No clear structure-activity pattern could be derived from these studies since the intensity of the inhibitory action seemed to depend on three factors, namely, the fatty acid, the amine group and the cell type...
  6. pmc The elmiric acids: biologically active anandamide analogs
    Sumner Burstein
    Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School Worcester, MA 01605, USA
    Neuropharmacology 55:1259-64. 2008
    ..Future studies should be aimed at elucidating the actions of all of the members of this interesting family of molecules...
  7. pmc Potential anti-inflammatory actions of the elmiric (lipoamino) acids
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Bioorg Med Chem 15:3345-55. 2007
    ..The ear edema assay results were generally in agreement with the prostaglandin assay findings indicating a connection between them...
  8. ncbi request reprint Oxidative metabolism of anandamide
    S H Burstein
    Department of Biochemistry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, USA
    Prostaglandins Other Lipid Mediat 61:29-41. 2000
    ..This molecule displays activities in experimental models that suggest that it may play a role in some of the activities attributed to its precursor, anandamide...
  9. pmc Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials
    Summer Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    AAPS J 7:E143-8. 2005
    ..Studies to date indicate a unique mechanism of action for AJA that may explain its lack of adverse side effects...
  10. ncbi request reprint PPAR-gamma: a nuclear receptor with affinity for cannabinoids
    Sumner Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605 2324, USA
    Life Sci 77:1674-84. 2005
    ..It is suggested that PPAR-gamma may serve a receptor function for certain actions of some cannabinoids...
  11. ncbi request reprint Ajulemic acid: A novel cannabinoid produces analgesia without a "high"
    Sumner H Burstein
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
    Life Sci 75:1513-22. 2004
    ..Data on its mechanism of action are not yet complete; however, the activation of PPAR-gamma, and regulation of eicosanoid and cytokine production, appear to be important for its potential therapeutic effects...
  12. ncbi request reprint Ajulemic acid (CT3): a potent analog of the acid metabolites of THC
    S H Burstein
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Curr Pharm Des 6:1339-45. 2000
    ..There is also circumstantial evidence for a putative endogenous ajulemic acid, namely, arachidonylglycine...
  13. ncbi request reprint Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma
    Andre L B Ambrosio
    Centro de Biotecnologia Molecular Estrutural, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, São Carlos SP CEP 13560 970, Brazil
    J Biol Chem 282:18625-33. 2007
    ..The structure also provides clues to the understanding of partial agonism itself, suggesting a rational approach to the design of molecules capable of activating the receptor at levels that avoid undesirable side effects...
  14. ncbi request reprint Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid
    Jilin Liu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Mol Pharmacol 63:983-92. 2003
    ..These studies also implicate other potential therapeutic actions of AJA through PPARgamma activation in multiple signaling pathways...
  15. ncbi request reprint Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid
    Robert B Zurier
    Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Biochem Pharmacol 65:649-55. 2003
    ..Development of nonpsychoactive therapeutically useful synthetic analogs of Cannabis constituents, such as AjA, may help resolve the ongoing debate about the use of marijuana as medicine...
  16. ncbi request reprint Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid
    David R Johnson
    Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 100:184-90. 2007
    ..These results suggest that AjA may be useful for treatment of patients with rheumatoid arthritis and osteoarthritis...

Research Grants8

  1. NON PSYCHOACTIVE CANNABINOIDS WITH THERAPEUTIC POTENTIAL
    Sumner Burstein; Fiscal Year: 2002
    ..abstract_text> ..
  2. Endocannabinoid Analogs as Anti-inflammatory Agents
    Sumner Burstein; Fiscal Year: 2006
    ..Thus, agents such as NAGly that can regulate in vivo anandamide levels could be effective modulators of many of these health related processes. ..
  3. The elmiric acids: biologically active anandamide analogs.
    SUMNER HOWARD BURSTEIN; Fiscal Year: 2010
    ..A promising use for these compounds would be as narcotic replacement agents. ..