Research Topics
| SUMNER HOWARD BURSTEINSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Detail Information
Publications
Regulation of anandamide tissue levels by N-arachidonylglycineSumner H Burstein
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Room 803, New Research Building, 264 Plantation Street, Worcester, MA 01605, USA
Biochem Pharmacol 64:1147-50. 2002..Moreover, the findings presented here suggest that NAGly can serve as a model for the design of agents to provide pharmacological control of tissue anandamide concentrations...
N-Amino acid linoleoyl conjugates: anti-inflammatory activitiesSumner Burstein
Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
Bioorg Med Chem Lett 22:872-5. 2012..It was concluded that linoleic acid conjugates could provide suitable templates in a drug discovery program leading to novel agents for promoting the resolution of chronic inflammation...- Resolution of inflammation by N-arachidonoylglycineSumner H Burstein
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, Massachusetts 01605, USA
J Cell Biochem 112:3227-33. 2011..Thus, we hypothesize that NAgly induces the death of inflammatory cells, a process that is considered to be important for the resolution of inflammation... - Cannabinoids, endocannabinoids, and related analogs in inflammationSumner H Burstein
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, Massachusetts 01605, USA
AAPS J 11:109-19. 2009..This differentiates these cannabinoids from cyclooxygenase-2 inhibitors that suppress the synthesis of eicosanoids that promote the induction of the inflammatory process... 
Acylamido analogs of endocannabinoids selectively inhibit cancer cell proliferationSumner Burstein
Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, Worcester, MA 01605, USA
Bioorg Med Chem 16:9644-51. 2008..No clear structure-activity pattern could be derived from these studies since the intensity of the inhibitory action seemed to depend on three factors, namely, the fatty acid, the amine group and the cell type...- The elmiric acids: biologically active anandamide analogsSumner Burstein
Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School Worcester, MA 01605, USA
Neuropharmacology 55:1259-64. 2008..Future studies should be aimed at elucidating the actions of all of the members of this interesting family of molecules... - Potential anti-inflammatory actions of the elmiric (lipoamino) acidsSumner H Burstein
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Bioorg Med Chem 15:3345-55. 2007..The ear edema assay results were generally in agreement with the prostaglandin assay findings indicating a connection between them... - Oxidative metabolism of anandamideS H Burstein
Department of Biochemistry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, USA
Prostaglandins Other Lipid Mediat 61:29-41. 2000..This molecule displays activities in experimental models that suggest that it may play a role in some of the activities attributed to its precursor, anandamide... - Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trialsSummer Burstein
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
AAPS J 7:E143-8. 2005..Studies to date indicate a unique mechanism of action for AJA that may explain its lack of adverse side effects... - PPAR-gamma: a nuclear receptor with affinity for cannabinoidsSumner Burstein
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605 2324, USA
Life Sci 77:1674-84. 2005..It is suggested that PPAR-gamma may serve a receptor function for certain actions of some cannabinoids... - Ajulemic acid: A novel cannabinoid produces analgesia without a "high"Sumner H Burstein
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
Life Sci 75:1513-22. 2004..Data on its mechanism of action are not yet complete; however, the activation of PPAR-gamma, and regulation of eicosanoid and cytokine production, appear to be important for its potential therapeutic effects... - Ajulemic acid (CT3): a potent analog of the acid metabolites of THCS H Burstein
Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Curr Pharm Des 6:1339-45. 2000..There is also circumstantial evidence for a putative endogenous ajulemic acid, namely, arachidonylglycine... - Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gammaAndre L B Ambrosio
Centro de Biotecnologia Molecular Estrutural, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, São Carlos SP CEP 13560 970, Brazil
J Biol Chem 282:18625-33. 2007..The structure also provides clues to the understanding of partial agonism itself, suggesting a rational approach to the design of molecules capable of activating the receptor at levels that avoid undesirable side effects... - Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acidJilin Liu
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Mol Pharmacol 63:983-92. 2003..These studies also implicate other potential therapeutic actions of AJA through PPARgamma activation in multiple signaling pathways... - Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoidRobert B Zurier
Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Biochem Pharmacol 65:649-55. 2003..Development of nonpsychoactive therapeutically useful synthetic analogs of Cannabis constituents, such as AjA, may help resolve the ongoing debate about the use of marijuana as medicine... - Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acidDavid R Johnson
Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Biochem 100:184-90. 2007..These results suggest that AjA may be useful for treatment of patients with rheumatoid arthritis and osteoarthritis...
Research Grants
- NON PSYCHOACTIVE CANNABINOIDS WITH THERAPEUTIC POTENTIALSumner Burstein; Fiscal Year: 2002..abstract_text> ..
- Endocannabinoid Analogs as Anti-inflammatory AgentsSumner Burstein; Fiscal Year: 2006..Thus, agents such as NAGly that can regulate in vivo anandamide levels could be effective modulators of many of these health related processes. ..
- The elmiric acids: biologically active anandamide analogs.SUMNER HOWARD BURSTEIN; Fiscal Year: 2010..A promising use for these compounds would be as narcotic replacement agents. ..