Jane Burns

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Kawasaki disease: the mystery continues
    J C Burns
    UCSD School of Medicine, La Jolla, CA, USA
    Minerva Pediatr 54:287-94. 2002
  2. pmc A diagnostic algorithm combining clinical and molecular data distinguishes Kawasaki disease from other febrile illnesses
    Xuefeng B Ling
    Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    BMC Med 9:130. 2011
  3. ncbi request reprint Intravenous gamma-globulin treatment and retreatment in Kawasaki disease. US/Canadian Kawasaki Syndrome Study Group
    J C Burns
    Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla 92093 0830, USA
    Pediatr Infect Dis J 17:1144-8. 1998
  4. ncbi request reprint Kawasaki syndrome
    Jane C Burns
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, USA
    Lancet 364:533-44. 2004
  5. doi request reprint Kawasaki Disease update
    Jane C Burns
    Department of Pediatrics, UCSD School of Medicine, Rady Children s Hospital, La Jolla, CA 92093, USA
    Indian J Pediatr 76:71-6. 2009
  6. pmc Seasonality and temporal clustering of Kawasaki syndrome
    Jane C Burns
    Department of Pediatrics, UCSD School of Medicine, La Jolla, California 92093 0830, USA
    Epidemiology 16:220-5. 2005
  7. pmc Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease
    J C Burns
    Department of Pediatrics 0830, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA
    Genes Immun 6:438-44. 2005
  8. ncbi request reprint Commentary: translation of Dr. Tomisaku Kawasaki's original report of fifty patients in 1967
    Jane C Burns
    Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, USA
    Pediatr Infect Dis J 21:993-5. 2002
  9. ncbi request reprint Kawasaki disease: A brief history
    J C Burns
    Department of Pediatrics, University of California San Diego, La Jolla, California 92093 0830, USA
    Pediatrics 106:E27. 2000
  10. ncbi request reprint Adenovirus, adeno-associated virus and Kawasaki disease
    Hiroko Shike
    Department of Pediatrics, University of California San Diego School of Medicine, San Diego, CA, USA
    Pediatr Infect Dis J 24:1011-4. 2005

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Kawasaki disease: the mystery continues
    J C Burns
    UCSD School of Medicine, La Jolla, CA, USA
    Minerva Pediatr 54:287-94. 2002
    ..This review will highlight some of the many unanswered questions about KD...
  2. pmc A diagnostic algorithm combining clinical and molecular data distinguishes Kawasaki disease from other febrile illnesses
    Xuefeng B Ling
    Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    BMC Med 9:130. 2011
    ..We sought to develop a diagnostic algorithm to help clinicians distinguish Kawasaki disease patients from febrile controls to allow timely initiation of treatment...
  3. ncbi request reprint Intravenous gamma-globulin treatment and retreatment in Kawasaki disease. US/Canadian Kawasaki Syndrome Study Group
    J C Burns
    Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla 92093 0830, USA
    Pediatr Infect Dis J 17:1144-8. 1998
    ..To determine the prevalence and outcome of intravenous gamma-globulin (IVIG) retreatment in patients with Kawasaki disease (KD)...
  4. ncbi request reprint Kawasaki syndrome
    Jane C Burns
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, USA
    Lancet 364:533-44. 2004
    ..This review includes discussion of the history of the syndrome, the diagnostic challenges, epidemiology, aetiology, pathology, immunopathogenesis, therapy, genetic influences, and the long-term cardiovascular sequelae...
  5. doi request reprint Kawasaki Disease update
    Jane C Burns
    Department of Pediatrics, UCSD School of Medicine, Rady Children s Hospital, La Jolla, CA 92093, USA
    Indian J Pediatr 76:71-6. 2009
    ..New treatments aimed at modifying the host immune response are currently under study. The genetic influence on susceptibility and disease outcome is an area of active research...
  6. pmc Seasonality and temporal clustering of Kawasaki syndrome
    Jane C Burns
    Department of Pediatrics, UCSD School of Medicine, La Jolla, California 92093 0830, USA
    Epidemiology 16:220-5. 2005
    ..The distribution of a syndrome in space and time may suggest clues to its etiology. The cause of Kawasaki syndrome, a systemic vasculitis of infants and children, is unknown, but an infectious etiology is suspected...
  7. pmc Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease
    J C Burns
    Department of Pediatrics 0830, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA
    Genes Immun 6:438-44. 2005
    ..Thus, the largest family-based genotyping study of KD patients to date suggests that genetic variation in the IL-4 gene, or regions linked to IL-4, plays an important role in KD pathogenesis and disease susceptibility...
  8. ncbi request reprint Commentary: translation of Dr. Tomisaku Kawasaki's original report of fifty patients in 1967
    Jane C Burns
    Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, USA
    Pediatr Infect Dis J 21:993-5. 2002
  9. ncbi request reprint Kawasaki disease: A brief history
    J C Burns
    Department of Pediatrics, University of California San Diego, La Jolla, California 92093 0830, USA
    Pediatrics 106:E27. 2000
    ..Regional investigations and national surveys suggest an annual incidence of 4 to 15 cases per 100 000 children <5 years o..
  10. ncbi request reprint Adenovirus, adeno-associated virus and Kawasaki disease
    Hiroko Shike
    Department of Pediatrics, University of California San Diego School of Medicine, San Diego, CA, USA
    Pediatr Infect Dis J 24:1011-4. 2005
    ..No evidence was found to suggest a link between either virus and Kawasaki disease...
  11. pmc Memory T-cells and characterization of peripheral T-cell clones in acute Kawasaki disease
    Alessandra Franco
    Department of Pediatrics, University of California San Diego School of Medicine and Rady Children s Hospital, La Jolla, CA 92093 0641, USA
    Autoimmunity 43:317-24. 2010
    ..The large majority of these T-cells displayed the functional phenotype of peripherally induced regulatory T-cells (T(reg)). These findings provide insight into the nature and kinetics of the adaptive immune response in KD...
  12. doi request reprint Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones
    Alessandra Franco
    Department of Pediatrics, Rady s Children s Hospital, University of California, San Diego, La Jolla, 92093 0641, United States
    Cell Immunol 266:1-6. 2010
    ..Il-10 transcription is also enhanced by exogenous TNF╬▒. These results disclose a role for ER stress in driving T cell plasticity...
  13. pmc Recurrent fever syndromes in patients after recovery from Kawasaki syndrome
    Lori Broderick
    Department of Pediatrics, University of California San Diego and Rady Children s Hospital, San Diego, California, USA
    Pediatrics 127:e489-93. 2011
    ..We propose that these 2 syndromes exist within a family of febrile disorders related to innate immune dysregulation...
  14. ncbi request reprint Recurrent Kawasaki disease-like syndrome in a patient with acquired immunodeficiency syndrome
    Jennifer N Blanchard
    Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA
    Clin Infect Dis 36:105-11. 2003
    ..Analysis of a conjunctival tissue sample revealed endothelial cell damage with fibrin deposition and infiltration of immunoglobulin A-secreting plasma cells...
  15. pmc Spatial and temporal clustering of Kawasaki syndrome cases
    Annie S Kao
    Division of Epidemiology, Graduate School of Public Health, San Diego State University, San Diego, CA, USA
    Pediatr Infect Dis J 27:981-5. 2008
    ....
  16. pmc Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease
    Jane C Burns
    Department of Pediatrics, University of California San Diego School of Medicine and Rady Children s Hospital San Diego, La Jolla, CA, USA
    J Pediatr 153:833-8. 2008
    ..To investigate the safety, tolerability, and pharmacokinetics of the anti-tumor necrosis factor-alpha monoclonal antibody infliximab in subjects with intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD)...
  17. ncbi request reprint Infliximab treatment for refractory Kawasaki syndrome
    Jane C Burns
    Children s Hospital of San Diego, and Department of Pediatrics, UCSD School of Medicine, San Diego, CA, USA
    J Pediatr 146:662-7. 2005
    ....
  18. ncbi request reprint The riddle of Kawasaki disease
    Jane C Burns
    Division of Pediatric Allergy, Immunology, and Rheumatology at the University of California, San Diego, School of Medicine, La Jolla, USA
    N Engl J Med 356:659-61. 2007
  19. pmc Delayed diagnosis by physicians contributes to the development of coronary artery aneurysms in children with Kawasaki syndrome
    Matthew S Wilder
    Department of Pediatrics 0830, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0830, USA
    Pediatr Infect Dis J 26:256-60. 2007
    ..In this study, we examined the contributions of sociodemographic factors and parent and physician behavior to the development of coronary artery aneurysms in children with Kawasaki syndrome...
  20. pmc When children with kawasaki disease grow up myocardial and vascular complications in adulthood
    John B Gordon
    San Diego Cardiac Center, San Diego, California, USA
    J Am Coll Cardiol 54:1911-20. 2009
    ..We review here the current literature that may be helpful to clinicians who care for adults who experienced KD in childhood...
  21. pmc Quantitation of adenovirus genome during acute infection in normal children
    Hiroko Shike
    Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Pediatr Infect Dis J 24:29-33. 2005
    ..Adenovirus infection causes a wide range of clinical illness in normal children. New molecular techniques allow quantitation of viral genome to study the natural history of adenovirus infection and viral load in normal children...
  22. pmc Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease
    Jane C Burns
    Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla 92093 0830, USA
    J Infect Dis 192:344-9. 2005
    ..These findings, derived from the largest genetic study of any systemic vasculitis, suggest a central role of CCR5-CCL3L1 gene-gene interactions in KD susceptibility and the importance of gene modifiers in infectious diseases...
  23. pmc Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease
    Chisato Shimizu
    Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, 92093, USA
    J Infect Dis 192:1767-71. 2005
    ..Only 1 (2%) of 48 patients with acute KD was positive by RT-PCR for HCoV-NL63/NH in a nasopharyngeal swab. These data do not support an association between these HCoVs and KD...
  24. ncbi request reprint Failure to diagnose Kawasaki disease at the extremes of the pediatric age range
    Pia S Pannaraj
    Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    Pediatr Infect Dis J 23:789-91. 2004
    ..Failure to consider the diagnosis at the extremes of the pediatric age range puts children at risk because coronary artery abnormalities occur more often in young infants and adolescents with Kawasaki disease...
  25. pmc Recognition of a Kawasaki disease shock syndrome
    John T Kanegaye
    Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Pediatrics 123:e783-9. 2009
    ..We sought to define the characteristics that distinguish Kawasaki disease shock syndrome from hemodynamically normal Kawasaki disease...
  26. pmc Pyuria associated with acute Kawasaki disease and fever from other causes
    Hiroko Shike
    Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, CA 92093 0641, USA
    Pediatr Infect Dis J 28:440-3. 2009
    ..Overall, the presence of pyuria was neither specific nor sensitive as a marker for KD, but the magnitude of pyuria was significantly higher in KD patients compared with the FC group...
  27. pmc Resistance to intravenous immunoglobulin in children with Kawasaki disease
    Adriana H Tremoulet
    Department of Pediatrics, University of California San Diego School of Medicine and Rady Children s Hospital San Diego, San Diego, CA, USA
    J Pediatr 153:117-21. 2008
    ..To explore the increased incidence of intravenous immunoglobulin- (IVIG) resistance among San Diego County patients with Kawasaki disease (KD) in 2006 and to evaluate a scoring system to predict IVIG-resistant patients with KD...
  28. pmc Noninvasive determination of endothelial cell function in the microcirculation in Kawasaki syndrome
    Gregory H Kurio
    Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Pediatr Cardiol 29:121-5. 2008
    ..This suggests that the EC injury in KS is confined to the endothelium of medium-sized arteries and that microvascular EC function is normal after acute KS...
  29. pmc Periungual desquamation in patients with Kawasaki disease
    Susan Wang
    Department of Pediatrics, University of California, La Jolla, CA, USA
    Pediatr Infect Dis J 28:538-9. 2009
    ..This clinical sign is sometimes used to diagnose cases that were initially missed. We conducted a retrospective review to determine the frequency with which periungual desquamation is associated with KD...
  30. pmc Familial occurrence of Kawasaki syndrome in North America
    Marina Dergun
    Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arch Pediatr Adolesc Med 159:876-81. 2005
    ..To describe families with multiple members affected with Kawasaki syndrome (KS) to increase awareness of the familial occurrence of KS among practitioners who care for these patients...
  31. pmc ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, Yokohama, Kanagawa, 230 0045, Japan
    Nat Genet 40:35-42. 2008
    ..This finding provides new insights into the mechanisms of immune activation in Kawasaki disease and emphasizes the importance of activated T cells in the pathogenesis of this vasculitis...
  32. doi request reprint The two emergencies of Kawasaki syndrome and the implications for the developing world
    Howard I Kushner
    Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Pediatr Infect Dis J 27:377-83. 2008
    ....
  33. ncbi request reprint The narratives of Kawasaki disease
    Howard I Kushner
    Bull Hist Med 78:410-39. 2004
    ..Equally important, it demonstrates how historians can make unique contributions as collaborators in clinical care and medical research...
  34. ncbi request reprint Rethinking the boundaries of Kawasaki disease: toward a revised case definition
    Howard I Kushner
    Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Perspect Biol Med 46:216-33. 2003
    ..We urge the construction of a more sensitive KD case definition that includes signs and laboratory findings associated with CAA...
  35. ncbi request reprint Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Circulation 110:2747-71. 2004
    ..Coronary artery aneurysms or ectasia develop in approximately 15% to 25% of untreated children and may lead to ischemic heart disease or sudden death...
  36. ncbi request reprint Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Pediatrics 114:1708-33. 2004
    ..Coronary artery aneurysms or ectasia develop in approximately 15% to 25% of untreated children and may lead to ischemic heart disease or sudden death...
  37. ncbi request reprint S100 proteins in the pathogenesis of Kawasaki disease
    Jane C Burns
    J Am Coll Cardiol 48:1265-7. 2006
  38. ncbi request reprint Impressions of Kawasaki syndrome in India
    Howard I Kushner
    Indian Pediatr 43:939-42. 2006
  39. ncbi request reprint Kawasaki disease and human coronavirus
    Ermias D Belay
    J Infect Dis 192:352-3; author reply 353. 2005
  40. ncbi request reprint Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young,
    Larry M Baddour
    Circulation 111:e394-434. 2005
    ..The continuing evolution of antimicrobial resistance among common pathogens that cause infective endocarditis creates additional therapeutic issues for physicians to manage in this potentially life-threatening illness...
  41. ncbi request reprint Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Co
    Walter Wilson
    Mayo Clinic, USA
    Circulation 116:1736-54. 2007
    ..The purpose of this statement is to update the recommendations by the American Heart Association (AHA) for the prevention of infective endocarditis that were last published in 1997...
  42. ncbi request reprint Revisiting steroids in the primary treatment of acute Kawasaki disease
    Jane C Burns
    J Pediatr 149:291-2. 2006
  43. pmc Gene-expression patterns reveal underlying biological processes in Kawasaki disease
    Stephen J Popper
    Departments of Microbiology and Immunology, and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genome Biol 8:R261. 2007
    ..No etiologic agent(s) has been identified, and the processes that mediate formation of coronary artery aneurysms and abatement of fever following treatment with intravenous immunoglobulin (IVIG) remain poorly understood...

Research Grants15

  1. Phase III infliximab for primary treatment of Kawasaki disease IND 11046 6/27/200
    Jane C Burns; Fiscal Year: 2010
    ..FDA funding is essential to carry out this study as too few patients in the U.S. would benefit from this therapy to make this new indication economically attractive to the manufacturer (Centocor). ..
  2. Genetic Markers and gene expression in Kawasaki Disease
    Jane Burns; Fiscal Year: 2007
    ..This project will build on previous work to understand the genetic basis for susceptibility to KD and its complications, which will lead to new insights into therapeutics and disease prevention. ..
  3. Matrix Metalloproteinases in Kawasaki Disease
    Jane Burns; Fiscal Year: 2007
    ..This K24 award will allow the PI to relinquish administrative responsibilities and to share clinical responsibilities with the fellows to allow more time for mentoring activities. ..
  4. Genetic Markers and gene expression in Kawasaki Disease
    Jane Burns; Fiscal Year: 2007
    ..This project will build on previous work to understand the genetic basis for susceptibility to KD and its complications, which will lead to new insights into therapeutics and disease prevention. ..
  5. 8th International Kawasaki Disease Symposium
    Jane Burns; Fiscal Year: 2005
    ....
  6. Genetic Influences & Gene Expression in Kawasaki Disease
    Jane Burns; Fiscal Year: 2004
    ..The role that genetic polymorphisms play in these gene expression patterns and their influence on disease susceptibility, response to therapy, and outcome will also be examined. ..
  7. Genetic Markers and gene expression in Kawasaki Disease
    Jane C Burns; Fiscal Year: 2010
    ..This project will build on previous work to understand the genetic basis for susceptibility to KD and its complications, which will lead to new insights into therapeutics and disease prevention. ..