Research Topics
| Ellen L BurnhamSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Detail Information
Publications
Alveolar macrophage gene expression is altered in the setting of alcohol use disordersEllen L Burnham
Department of Medicine, University of Colorado School of Medicine, Denver, USA
Alcohol Clin Exp Res 35:284-94. 2011..Therefore, we sought to determine the effects of AUDs on human alveolar macrophage gene expression...- Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disordersEllen L Burnham
Division of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado School of Medicine, Aurora, CO 80045, USA
Am J Physiol Lung Cell Mol Physiol 302:L688-99. 2012..However, our work demonstrates the feasibility of safely conducting clinical trials that include serial bronchoscopies in a vulnerable population at risk for acute lung injury... - Alcohol use disorders affect antimicrobial proteins and anti-pneumococcal activity in epithelial lining fluid obtained via bronchoalveolar lavageEllen L Burnham
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO, USA
Alcohol Alcohol 45:414-21. 2010..Further, differences in BAL lysozyme activity and lactoferrin concentrations between these two groups were examined to determine the effect of AUDs on these antimicrobial proteins... - Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cellsEllen L Burnham
Department of Medicine, University of Colorado Denver School of Medicine, Aurora, 80045, USA
Am J Respir Cell Mol Biol 43:326-33. 2010..Factors contributing to colony formation by PBMCs in ALI, and the role PBMCs play in its pathogenesis remain to be fully established... - Mentoring K scholars: strategies to support research mentorsEllen L Burnham
Colorado CTSI KL2 Program, University of Colorado Denver School of Medicine, Denver, CO, USA
Clin Transl Sci 4:199-203. 2011.... 
Elevated plasma and lung endothelial selectin levels in patients with acute respiratory distress syndrome and a history of chronic alcohol abuseEllen L Burnham
Department of Medicine, Division of Pulmonary and Critical Care, Emory University School of Medicine, Atlanta, GA, USA
Crit Care Med 32:675-9. 2004..15). CONCLUSIONS: ARDS patients who chronically abuse alcohol have elevated concentrations of sE-selectin in both the plasma and epithelial lining fluid consistent with altered endothelial cell and alveolar-capillary barrier function...
Chest CT features are associated with poorer quality of life in acute lung injury survivorsEllen L Burnham
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA
Crit Care Med 41:445-56. 2013..We sought to determine if pulmonary dysfunction is independently associated with functional impairment among acute lung injury survivors and to determine if high-resolution computed tomography could be used to predict its development...- Diagnosis and treatment of post-extubation dysphagia: results from a national surveyMadison Macht
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
J Crit Care 27:578-86. 2012..This study sought to determine the utilization of speech-language pathologist (SLPs) for the diagnosis and treatment of post-extubation dysphagia in survivors of mechanical ventilation... - Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione homeostasisEllen L Burnham
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Alcohol Clin Exp Res 27:1167-72. 2003..We postulated that humans who chronically abuse alcohol will have similar alterations in alveolar-capillary barrier function... - Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunctionMarc Moss
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Crit Care Med 31:S207-12. 2003..It also may lead to the development of novel therapies for those patients at greatest risk of acute lung injury as a consequence of chronic alcohol abuse... - Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illnessMadison Macht
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, 12700 East 19th Avenue, Aurora, CO 80045, USA
Crit Care 15:R231. 2011..The risk factors associated with the development of postextubation dysphagia, and the effects of dysphagia on patient outcomes, have been relatively unexplored... - The effects of alcohol abuse on pulmonary alveolar-capillary barrier function in humansEllen L Burnham
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver and Health Sciences Center, Denver, CO, USA
Alcohol Alcohol 44:8-12. 2009..This could contribute to their propensity for the development of this disorder... - Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory responseDarren M Boé
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Anschutz Medical Campus, Research 2, Box C272, 9th Floor, 12700 East 19th Avenue, Aurora, CO 80045, USA
Alcohol Clin Exp Res 34:1723-32. 2010..The effects of alcohol on pulmonary Rho pathway activation and efferocytosis have not been determined. We hypothesize that acute and chronic alcohol exposure impair pulmonary efferocytosis, leading to heightened inflammation during ARDS... - Increased fibronectin expression in lung in the setting of chronic alcohol abuseEllen L Burnham
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Alcohol Clin Exp Res 31:675-83. 2007..Our objective was to determine whether alcohol abuse, independent of other comorbidities, alters fibronectin and metalloproteinase gene expression in alveolar macrophages and in epithelial lining fluid (ELF) of the lung... - Alcohol abuse and pulmonary diseaseDarren M Boé
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, 12700 E 19th Ave, C272, Aurora, CO 80045, USA
J Leukoc Biol 86:1097-104. 2009..These pathways represent potential therapeutic targets for patients at risk for ARDS as a result of alcohol abuse... - Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumoniaAbigail R Lara
Division of Pulmonary Science and Critical Care Medicine, University of Colorado Denver, Aurora, CO 80045, USA
Chest 142:1569-76. 2012.... - Severity of acute illness is associated with baseline readiness to change in medical intensive care unit patients with unhealthy alcohol useBrendan J Clark
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
Alcohol Clin Exp Res 36:544-51. 2012..We further sought to determine whether this effect is modified by the severity of unhealthy alcohol use... - The prevalence and impact of post traumatic stress disorder and burnout syndrome in nursesMeredith Mealer
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80045, USA
Depress Anxiety 26:1118-26. 2009..To determine whether post traumatic stress disorder (PTSD) and burnout syndrome (BOS) are common in nurses, and whether the co-existence of PTSD and BOS is associated with altered perceptions of work and nonwork-related activities... - Myopathies in critical illness: characterization and nutritional aspectsEllen L Burnham
Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, and the Division of Endocrinology and Metabolism, Emory University School of Medicine, Atlanta, GA 30322, USA
J Nutr 135:1818S-1823S. 2005..However, additional studies must be performed in order to develop appropriate therapies for this potentially devastating disorder... - Increased circulating endothelial progenitor cells are associated with survival in acute lung injuryEllen L Burnham
Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, and the Atlanta Venterans Affairs Medical Center, Atlanta, GA 30335, USA
Am J Respir Crit Care Med 172:854-60. 2005..Repair of damaged endothelium is important in recovery from acute lung injury. In animal models, bone marrow-derived endothelial progenitor cells differentiate into mature endothelium and assist in repairing damaged vasculature... - Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammationJames H Finigan
Dept of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
Eur Respir J 41:396-401. 2013..7±354.2 versus 25.17±19.33 pg·mL(-1), p<0.001) and inversely correlated with VFDs (r= -0.51, p=0.04). These results confirm shedding of NRG-1 in ALI and suggest that the NRG-1-HER2 pathway is active in patients with ALI... - Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndromeKenneth C Malcolm
Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
PLoS ONE 6:e21958. 2011..aeruginosa. Therefore, the ISG expression signature is associated with an altered circulating neutrophil response phenotype in ARDS that may predispose a large subgroup of patients to increased risk of specific bacterial infections... - Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shockMarc Moss
Department of Medicine, Division of Pulmonary and Critical Care, Emory University School of Medicine, Atlanta, GA 30335, USA
Crit Care Med 31:869-77. 2003..The goal of this study was to determine the effects of chronic alcohol abuse on the incidence and severity of the acute respiratory distress syndrome and multiple organ dysfunction syndrome in patients with septic shock...