Ellen L Burnham

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Alveolar macrophage gene expression is altered in the setting of alcohol use disorders
    Ellen L Burnham
    Department of Medicine, University of Colorado School of Medicine, Denver, USA
    Alcohol Clin Exp Res 35:284-94. 2011
  2. pmc Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking
    Ellen L Burnham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 304:L873-82. 2013
  3. pmc Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders
    Ellen L Burnham
    Division of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 302:L688-99. 2012
  4. pmc Alcohol use disorders affect antimicrobial proteins and anti-pneumococcal activity in epithelial lining fluid obtained via bronchoalveolar lavage
    Ellen L Burnham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO, USA
    Alcohol Alcohol 45:414-21. 2010
  5. pmc Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells
    Ellen L Burnham
    Department of Medicine, University of Colorado Denver School of Medicine, Aurora, 80045, USA
    Am J Respir Cell Mol Biol 43:326-33. 2010
  6. pmc Mentoring K scholars: strategies to support research mentors
    Ellen L Burnham
    Colorado CTSI KL2 Program, University of Colorado Denver School of Medicine, Denver, CO, USA
    Clin Transl Sci 4:199-203. 2011
  7. ncbi request reprint Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal
    Brendan J Clark
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, Colorado
    Alcohol Clin Exp Res 37:1536-43. 2013
  8. pmc Diagnosis and treatment of post-extubation dysphagia: results from a national survey
    Madison Macht
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Crit Care 27:578-86. 2012
  9. ncbi request reprint Elevated plasma and lung endothelial selectin levels in patients with acute respiratory distress syndrome and a history of chronic alcohol abuse
    Ellen L Burnham
    Department of Medicine, Division of Pulmonary and Critical Care, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 32:675-9. 2004
  10. ncbi request reprint Alcohol screening scores and 90-day outcomes in patients with acute lung injury
    Brendan J Clark
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, CO, USA
    Crit Care Med 41:1518-25. 2013

Detail Information

Publications28

  1. pmc Alveolar macrophage gene expression is altered in the setting of alcohol use disorders
    Ellen L Burnham
    Department of Medicine, University of Colorado School of Medicine, Denver, USA
    Alcohol Clin Exp Res 35:284-94. 2011
    ..Therefore, we sought to determine the effects of AUDs on human alveolar macrophage gene expression...
  2. pmc Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking
    Ellen L Burnham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 304:L873-82. 2013
    ..Furthermore, cigarette smoking additionally influences BAL IL-12 and VEGF that may be relevant to the pulmonary immune response...
  3. pmc Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders
    Ellen L Burnham
    Division of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado School of Medicine, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 302:L688-99. 2012
    ..However, our work demonstrates the feasibility of safely conducting clinical trials that include serial bronchoscopies in a vulnerable population at risk for acute lung injury...
  4. pmc Alcohol use disorders affect antimicrobial proteins and anti-pneumococcal activity in epithelial lining fluid obtained via bronchoalveolar lavage
    Ellen L Burnham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO, USA
    Alcohol Alcohol 45:414-21. 2010
    ..Further, differences in BAL lysozyme activity and lactoferrin concentrations between these two groups were examined to determine the effect of AUDs on these antimicrobial proteins...
  5. pmc Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells
    Ellen L Burnham
    Department of Medicine, University of Colorado Denver School of Medicine, Aurora, 80045, USA
    Am J Respir Cell Mol Biol 43:326-33. 2010
    ..Factors contributing to colony formation by PBMCs in ALI, and the role PBMCs play in its pathogenesis remain to be fully established...
  6. pmc Mentoring K scholars: strategies to support research mentors
    Ellen L Burnham
    Colorado CTSI KL2 Program, University of Colorado Denver School of Medicine, Denver, CO, USA
    Clin Transl Sci 4:199-203. 2011
    ....
  7. ncbi request reprint Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal
    Brendan J Clark
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, Colorado
    Alcohol Clin Exp Res 37:1536-43. 2013
    ....
  8. pmc Diagnosis and treatment of post-extubation dysphagia: results from a national survey
    Madison Macht
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Crit Care 27:578-86. 2012
    ..This study sought to determine the utilization of speech-language pathologist (SLPs) for the diagnosis and treatment of post-extubation dysphagia in survivors of mechanical ventilation...
  9. ncbi request reprint Elevated plasma and lung endothelial selectin levels in patients with acute respiratory distress syndrome and a history of chronic alcohol abuse
    Ellen L Burnham
    Department of Medicine, Division of Pulmonary and Critical Care, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 32:675-9. 2004
    ..Based on the effects of alcohol on endothelial cell and alveolar-capillary barrier function, we hypothesized that chronic alcohol exposure may be associated with increased sE-selectin in ARDS patients...
  10. ncbi request reprint Alcohol screening scores and 90-day outcomes in patients with acute lung injury
    Brendan J Clark
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, CO, USA
    Crit Care Med 41:1518-25. 2013
    ....
  11. pmc Chest CT features are associated with poorer quality of life in acute lung injury survivors
    Ellen L Burnham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA
    Crit Care Med 41:445-56. 2013
    ..We sought to determine if pulmonary dysfunction is independently associated with functional impairment among acute lung injury survivors and to determine if high-resolution computed tomography could be used to predict its development...
  12. ncbi request reprint Increased fibronectin expression in lung in the setting of chronic alcohol abuse
    Ellen L Burnham
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 31:675-83. 2007
    ..Our objective was to determine whether alcohol abuse, independent of other comorbidities, alters fibronectin and metalloproteinase gene expression in alveolar macrophages and in epithelial lining fluid (ELF) of the lung...
  13. pmc Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response
    Darren M Boé
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Anschutz Medical Campus, Research 2, Box C272, 9th Floor, 12700 East 19th Avenue, Aurora, CO 80045, USA
    Alcohol Clin Exp Res 34:1723-32. 2010
    ..The effects of alcohol on pulmonary Rho pathway activation and efferocytosis have not been determined. We hypothesize that acute and chronic alcohol exposure impair pulmonary efferocytosis, leading to heightened inflammation during ARDS...
  14. ncbi request reprint Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione homeostasis
    Ellen L Burnham
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Alcohol Clin Exp Res 27:1167-72. 2003
    ..We postulated that humans who chronically abuse alcohol will have similar alterations in alveolar-capillary barrier function...
  15. ncbi request reprint Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction
    Marc Moss
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 31:S207-12. 2003
    ..To review the effects of chronic alcohol abuse on the incidence, severity, and pathogenesis of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction...
  16. pmc Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia
    Abigail R Lara
    Division of Pulmonary Science and Critical Care Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Chest 142:1569-76. 2012
    ....
  17. doi request reprint Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation
    James H Finigan
    Dept of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Eur Respir J 41:396-401. 2013
    ..7±354.2 versus 25.17±19.33 pg·mL(-1), p<0.001) and inversely correlated with VFDs (r= -0.51, p=0.04). These results confirm shedding of NRG-1 in ALI and suggest that the NRG-1-HER2 pathway is active in patients with ALI...
  18. pmc Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illness
    Madison Macht
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, 12700 East 19th Avenue, Aurora, CO 80045, USA
    Crit Care 15:R231. 2011
    ..The risk factors associated with the development of postextubation dysphagia, and the effects of dysphagia on patient outcomes, have been relatively unexplored...
  19. pmc The effects of alcohol abuse on pulmonary alveolar-capillary barrier function in humans
    Ellen L Burnham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver and Health Sciences Center, Denver, CO, USA
    Alcohol Alcohol 44:8-12. 2009
    ..This could contribute to their propensity for the development of this disorder...
  20. ncbi request reprint Alcohol abuse and pulmonary disease
    Darren M Boé
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, 12700 E 19th Ave, C272, Aurora, CO 80045, USA
    J Leukoc Biol 86:1097-104. 2009
    ..These pathways represent potential therapeutic targets for patients at risk for ARDS as a result of alcohol abuse...
  21. pmc Severity of acute illness is associated with baseline readiness to change in medical intensive care unit patients with unhealthy alcohol use
    Brendan J Clark
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Alcohol Clin Exp Res 36:544-51. 2012
    ..We further sought to determine whether this effect is modified by the severity of unhealthy alcohol use...
  22. ncbi request reprint Myopathies in critical illness: characterization and nutritional aspects
    Ellen L Burnham
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, and the Division of Endocrinology and Metabolism, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 135:1818S-1823S. 2005
    ..However, additional studies must be performed in order to develop appropriate therapies for this potentially devastating disorder...
  23. pmc The prevalence and impact of post traumatic stress disorder and burnout syndrome in nurses
    Meredith Mealer
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80045, USA
    Depress Anxiety 26:1118-26. 2009
    ..To determine whether post traumatic stress disorder (PTSD) and burnout syndrome (BOS) are common in nurses, and whether the co-existence of PTSD and BOS is associated with altered perceptions of work and nonwork-related activities...
  24. ncbi request reprint Increased circulating endothelial progenitor cells are associated with survival in acute lung injury
    Ellen L Burnham
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, and the Atlanta Venterans Affairs Medical Center, Atlanta, GA 30335, USA
    Am J Respir Crit Care Med 172:854-60. 2005
    ..Repair of damaged endothelium is important in recovery from acute lung injury. In animal models, bone marrow-derived endothelial progenitor cells differentiate into mature endothelium and assist in repairing damaged vasculature...
  25. ncbi request reprint The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance
    Ellen L Burnham
    Dept of Medicine, University of Colorado Health Sciences Center, Aurora, CO
    Eur Respir J 43:276-85. 2014
    ....
  26. pmc Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome
    Kenneth C Malcolm
    Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 6:e21958. 2011
    ..aeruginosa. Therefore, the ISG expression signature is associated with an altered circulating neutrophil response phenotype in ARDS that may predispose a large subgroup of patients to increased risk of specific bacterial infections...
  27. ncbi request reprint Training mentors of clinical and translational research scholars: a randomized controlled trial
    Christine Pfund
    Dr Pfund is researcher, Institute for Clinical and Translational Research and Wisconsin Center for Education Research, University of Wisconsin Madison, Madison, Wisconsin Ms House is research project director, Research Education and Career Development, Institute for Clinical and Translational Research, University of Wisconsin Madison, Madison, Wisconsin Dr Asquith is administrative director, Research Education and Career Development, Institute for Clinical and Translational Research, University of Wisconsin Madison, Madison, Wisconsin Dr Fleming is interim chair, Department of Family and Community Medicine, and Professor, Family and Community Medicine and Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois Dr Buhr is associate scientist, Department of Biostatistics and Medical Informatics, University of Wisconsin Madison, Madison, Wisconsin Dr Burnham is associate professor, Department of Medicine, University of Colorado Denver, Denver, Colorado Dr Gilmore is associate administrator, Education, Preventive and Community Dentistry, Institute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa Dr Huskins is professor, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota Dr McGee is professor of medical education and faculty development and associate dean for faculty recruitment and professional development, Feinberg School of Medicine, Northwestern University, Chicago, West Bengal
    Acad Med 89:774-82. 2014
    ..To determine whether a structured mentoring curriculum improves research mentoring skills...
  28. ncbi request reprint Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock
    Marc Moss
    Department of Medicine, Division of Pulmonary and Critical Care, Emory University School of Medicine, Atlanta, GA 30335, USA
    Crit Care Med 31:869-77. 2003
    ..The goal of this study was to determine the effects of chronic alcohol abuse on the incidence and severity of the acute respiratory distress syndrome and multiple organ dysfunction syndrome in patients with septic shock...