Margit Burmeister

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain
    Xiaoxi Qiao
    Department of Cellular Biology and Anatomy, LSU Health Sciences Center, 1501 Kings Highway, P O Box 33932, Shreveport, LA 71130 3932, USA
    Vision Res 43:859-65. 2003
  2. ncbi Psychiatric genetics: progress amid controversy
    Margit Burmeister
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 5061 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
    Nat Rev Genet 9:527-40. 2008
  3. pmc Untangling genetic networks of panic, phobia, fear and anxiety
    Sandra Villafuerte
    Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan MI 48109 0720, USA
    Genome Biol 4:224. 2003
  4. pmc Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2,500 genotyped SNPs and 15,000 imputed SNPs
    Peng Zhang
    Center for Computational Medicine and Bioinformatics Center for Statistical Genetics, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Bipolar Disord 12:786-92. 2010
  5. ncbi Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism
    Srijan Sen
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Biol Psychiatry 55:244-9. 2004
  6. pmc PER3 polymorphism and insomnia severity in alcohol dependence
    Kirk J Brower
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    Sleep 35:571-7. 2012
  7. pmc Expression of Caytaxin protein in Cayman Ataxia mouse models correlates with phenotype severity
    Kristine M Sikora
    Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e50570. 2012
  8. doi Bayesian EM algorithm for scoring polymorphic deletions from SNP data and application to a common CNV on 8q24
    Sebastian Zollner
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Genet Epidemiol 33:357-68. 2009
  9. pmc Hardy-Weinberg analysis of a large set of published association studies reveals genotyping error and a deficit of heterozygotes across multiple loci
    Srijan Sen
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Genomics 3:36-52. 2008
  10. ncbi Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits
    Srijan Sen
    Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Med Genet B Neuropsychiatr Genet 127:85-9. 2004

Research Grants

  1. SNPs in Neurotransmitter Systems & Personality Traits
    Margit Burmeister; Fiscal Year: 2006
  2. Molecular Characterization of Cayman Ataxia, ATCAY
    Margit Burmeister; Fiscal Year: 2006
  3. Molecular Characterization of Cayman Ataxia, ATCAY
    Margit Burmeister; Fiscal Year: 2005
  4. Molecular Characterization of Cayman Ataxia, ATCAY
    Margit Burmeister; Fiscal Year: 2004
  5. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 2002
  6. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 2001
  7. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 2000
  8. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 1999
  9. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 1999
  10. Molecular Characterization of Cayman Ataxia, ATCAY
    Margit Burmeister; Fiscal Year: 2007

Detail Information

Publications34

  1. ncbi Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain
    Xiaoxi Qiao
    Department of Cellular Biology and Anatomy, LSU Health Sciences Center, 1501 Kings Highway, P O Box 33932, Shreveport, LA 71130 3932, USA
    Vision Res 43:859-65. 2003
    ..We conclude that rd1 allele contamination is primarily responsible for photoreceptor degeneration, and caution against behavioral tests with visual cues in the present stocks...
  2. ncbi Psychiatric genetics: progress amid controversy
    Margit Burmeister
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 5061 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
    Nat Rev Genet 9:527-40. 2008
    ..More attention on unique families, rare variants, and on incorporating environment and the emerging knowledge of biological function and pathways into genetic analysis is warranted...
  3. pmc Untangling genetic networks of panic, phobia, fear and anxiety
    Sandra Villafuerte
    Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan MI 48109 0720, USA
    Genome Biol 4:224. 2003
    ..Recent reports have started to untangle the genetic relationships between predispositions to anxiety and anxiety disorders...
  4. pmc Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2,500 genotyped SNPs and 15,000 imputed SNPs
    Peng Zhang
    Center for Computational Medicine and Bioinformatics Center for Statistical Genetics, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Bipolar Disord 12:786-92. 2010
    ..We performed a detailed association analysis assessing the contribution of common genetic variation in this region to the risk of BP...
  5. ncbi Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism
    Srijan Sen
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Biol Psychiatry 55:244-9. 2004
    ..A GABA(A) receptor alpha6 subunit variant (Pro385Ser) has been associated with alcohol-related traits but has not been studied in neuroticism or depression...
  6. pmc PER3 polymorphism and insomnia severity in alcohol dependence
    Kirk J Brower
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    Sleep 35:571-7. 2012
    ..We hypothesized that the PER3 polymorphism would be an independent predictor of insomnia severity with greatest severity observed in those with the PER3(4/4)genotype...
  7. pmc Expression of Caytaxin protein in Cayman Ataxia mouse models correlates with phenotype severity
    Kristine M Sikora
    Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e50570. 2012
    ..Utilizing these animal models of human Cayman Ataxia will now allow an in-depth analysis to elucidate Caytaxin's role in maintaining normal neuronal function...
  8. doi Bayesian EM algorithm for scoring polymorphic deletions from SNP data and application to a common CNV on 8q24
    Sebastian Zollner
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Genet Epidemiol 33:357-68. 2009
    ..Finally, we assessed the power of this algorithm to detect shorter CNVs by sub-sampling from the SNPs covered by this deletion, demonstrating that our EM algorithm produces precise estimates of carrier status...
  9. pmc Hardy-Weinberg analysis of a large set of published association studies reveals genotyping error and a deficit of heterozygotes across multiple loci
    Srijan Sen
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Genomics 3:36-52. 2008
    ..For SNPs, HWD tends to be due to a deficit of heterozygotes, indicating that allelic dropout may be the most prevalent genotyping error...
  10. ncbi Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits
    Srijan Sen
    Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Med Genet B Neuropsychiatr Genet 127:85-9. 2004
    ....
  11. ncbi BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects
    Joshua A Bueller
    Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan, USA
    Biol Psychiatry 59:812-5. 2006
    ....
  12. pmc The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation
    Katja Karg
    Department of Human Genetics, University of Wuerzburg, Wuerzburg, Germany
    Arch Gen Psychiatry 68:444-54. 2011
    ..However, even the larger of the meta-analyses included only 14 of the 56 studies that have assessed the relationship between 5-HTTLPR, stress, and depression...
  13. ncbi Indirect effect of corticotropin-releasing hormone receptor 1 gene variation on negative emotionality and alcohol use via right ventrolateral prefrontal cortex
    Yi G Glaser
    Department of Psychiatry, Addiction Research Center, and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109
    J Neurosci 34:4099-107. 2014
    ..This work provides support for a model in which CRHR1 gene variation modulates the risk of problem drinking via an internalizing/negative affect pathway involving rVLPFC and reappraisal of negative emotion. ..
  14. pmc MicroRNA expression changes in lymphoblastoid cell lines in response to lithium treatment
    Haiming Chen
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Int J Neuropsychopharmacol 12:975-81. 2009
    ..Our results suggest that miRNAs are excellent candidates for the study of the molecular basis of Li's treatment action in cell systems such as lymphocytes given limited access to the human brain...
  15. pmc SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A
    Sandra M Villafuerte
    Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Psychiatr Genet 19:281-91. 2009
    ..Variations in gene expression in these genes may thus affect SSRI response...
  16. pmc Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 106:7501-6. 2009
    ..37, P = 0.042). Although these results are promising, analysis of additional samples will be required to confirm that variant(s) in these regions influence BP risk...
  17. ncbi A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression
    Srijan Sen
    Neuroscience Program, University of Michigan, Ann Arbor, MI, USA
    Neuropsychopharmacology 28:397-401. 2003
  18. doi Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression
    Agnes J Jasinska
    Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA
    Trends Neurosci 35:395-402. 2012
    ..In particular, the recently characterized stressor-responsive serotonergic interneurons originating from the dorsolateral DR may hold a key to unlocking the GxE mechanism of depression...
  19. ncbi Genetic research on complex behaviors: an examination of attempts to identify genes for smoking
    Ovide F Pomerleau
    Nicotine Research Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48105, USA
    Nicotine Tob Res 9:883-901. 2007
    ..These proceedings are excerpts based on the presentations at the conference...
  20. pmc Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence
    Marcin Wojnar
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Alcohol Clin Exp Res 33:693-702. 2009
    ..The purpose of this study was to examine relationships between genetic markers of central serotonin (5-HT) and dopamine function, and risk for post-treatment relapse, in a sample of alcohol-dependent patients...
  21. ncbi Association between a dopamine-4 receptor polymorphism and blood pressure
    Srijan Sen
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48106, USA
    Am J Hypertens 18:1206-10. 2005
    ..The long allele (defined as at least one 7 to 10 repeat) has been associated with the personality trait Novelty Seeking and with substance abuse, but associations between dopamine-4 receptor polymorphisms and BP have not been reported...
  22. ncbi Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcay(ji-hes) mice
    Katiuska Luna-Cancalon
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neurobiol Dis 67:140-8. 2014
    ..These results suggest that a combination of reduced Purkinje neuron activity and increased DCN intrinsic excitability can result in a combination of ataxia and a dystonia-like gait in mice. ..
  23. pmc BDNF Val(66)Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study
    Mark K Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    Addict Biol 18:836-45. 2013
    ..Whether this genotype is relevant to other abused substances besides opioids or nicotine, or treatment response, remains to be determined...
  24. pmc Tissue-specific functional networks for prioritizing phenotype and disease genes
    Yuanfang Guan
    Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Comput Biol 8:e1002694. 2012
    ..Our systems-level, tissue-specific scheme advances over traditional global integration and analyses and establishes a prototype to address the tissue-specific effects of genetic perturbations, diseases and drugs...
  25. pmc Dominant mutation of CCDC78 in a unique congenital myopathy with prominent internal nuclei and atypical cores
    Karen Majczenko
    Molecular and Behavioral Neuroscience Institute, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
    Am J Hum Genet 91:365-71. 2012
    ..Using a combination of linkage analysis, next-generation sequencing, and modeling in the zebrafish, we have identified a CCDC78 mutation associated with a unique myopathy with prominent internal nuclei and atypical cores...
  26. ncbi Familiality and diagnostic patterns of subphenotypes in the National Institutes of Mental Health bipolar sample
    Erika H Saunders
    University of Michigan Depression Center, Ann Arbor, Michigan 48109, USA
    Am J Med Genet B Neuropsychiatr Genet 147:18-26. 2008
    ..We have found evidence of familiality for subphenotypes of BP. In multicenter samples, familiality may be overestimated if variability in diagnosis of subphenotypes between site/wave of ascertainment is not considered...
  27. pmc Increased activity of Diaphanous homolog 3 (DIAPH3)/diaphanous causes hearing defects in humans with auditory neuropathy and in Drosophila
    Cynthia J Schoen
    Neuroscience Graduate Program, Molecular and Behavioral Neuroscience Institute, Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:13396-401. 2010
    ..Genetic testing for DIAPH3 may be useful for individuals with recessive as well as dominant inheritance of nonsyndromic auditory neuropathy...
  28. ncbi Mapping of genetic modifiers affecting the eye phenotype of ocular retardation (Chx10or-J) mice
    Gilbert Wong
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Mamm Genome 17:518-25. 2006
    ..Our scan revealed significant loci on Chromosomes 6 and 14 where the CASA/Rk alleles are maintained selectively. Markers were developed near candidate genes, but no candidate gene could be identified unequivocally...
  29. ncbi SNPs on chips: the hidden genetic code in expression arrays
    Elzbieta Sliwerska
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 2220, USA
    Biol Psychiatry 61:13-6. 2007
    ..Many Affymetrix chips contain thousands of SNPs that are both common and in the central probe region affecting hybridization, and thus have the potential to confound expression analysis...
  30. ncbi Mouse models for psychiatric disorders
    Eunju Seong
    Mental Health Research Institute, Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Genet 18:643-50. 2002
    ..Once a gene or pathway has been identified, mice are also used to study the interplay of different genes in that system...
  31. ncbi Genetical genomics: combining genetics with gene expression analysis
    Jun Li
    Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
    Hum Mol Genet 14:R163-9. 2005
    ....
  32. pmc Family-based SNP association study on 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 147:612-8. 2008
    ..These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility...
  33. ncbi [Influence of impulsivity, suicidality and serotonin genes on treatment outcomes in alcohol dependence]
    Marcin Wojnar
    Katedra i Klinika Psychiatryczna AM w Warszawie
    Psychiatr Pol 40:985-94. 2006
    ..The aim of the study was to identify risk factors of relapse by investigating relationships among suicidality, impulsivity, genetic markers of serotonin activity, and relapse in alcohol-dependent patients...
  34. ncbi Future of genetics of mood disorders research
    Kathleen R Merikangas
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 52:457-77. 2002
    ..To prepare for shifts to more complex genetic models, the committee recommended that the NIMH develop new interdisciplinary training strategies to prepare for the next generation of genetics research...

Research Grants15

  1. SNPs in Neurotransmitter Systems & Personality Traits
    Margit Burmeister; Fiscal Year: 2006
    ..It is anticipated that this R21 will lead to a more thorough, genome-wide genetic study of Neuroticism in this valuable sample. ..
  2. Molecular Characterization of Cayman Ataxia, ATCAY
    Margit Burmeister; Fiscal Year: 2006
    ..Our studies may reveal a novel pathway to the etiology of ataxia. ..
  3. Molecular Characterization of Cayman Ataxia, ATCAY
    Margit Burmeister; Fiscal Year: 2005
    ..Our studies may reveal a novel pathway to the etiology of ataxia. ..
  4. Molecular Characterization of Cayman Ataxia, ATCAY
    Margit Burmeister; Fiscal Year: 2004
    ..Our studies may reveal a novel pathway to the etiology of ataxia. ..
  5. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 2002
    ..g. autism, OCD, ADHD and epilepsy). Such polymorphisms will be made available for the scientific community to test as a candidate gene for other neurological or psychiatric disorders if justified by the results of the behavior tests. ..
  6. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 2001
    ..g. autism, OCD, ADHD and epilepsy). Such polymorphisms will be made available for the scientific community to test as a candidate gene for other neurological or psychiatric disorders if justified by the results of the behavior tests. ..
  7. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 2000
    ..g. autism, OCD, ADHD and epilepsy). Such polymorphisms will be made available for the scientific community to test as a candidate gene for other neurological or psychiatric disorders if justified by the results of the behavior tests. ..
  8. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 1999
    ....
  9. AP3 IN NEUROLOGICAL DISORDERS
    Margit Burmeister; Fiscal Year: 1999
    ..g. autism, OCD, ADHD and epilepsy). Such polymorphisms will be made available for the scientific community to test as a candidate gene for other neurological or psychiatric disorders if justified by the results of the behavior tests. ..
  10. Molecular Characterization of Cayman Ataxia, ATCAY
    Margit Burmeister; Fiscal Year: 2007
    ..Our studies may reveal a novel pathway to the etiology of ataxia. ..