WILLIAM BURLINGHAM

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Mouse strain and injection site are crucial for detecting linked suppression in transplant recipients by trans-vivo DTH assay
    W J Burlingham
    Division of Transplantation, Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Am J Transplant 7:466-70. 2007
  2. pmc Bidirectional alloreactivity: A proposed microchimerism-based solution to the NIMA paradox
    William J Burlingham
    Department of Surgery, University of Wisconsin, Madison, WI, USA
    Chimerism 3:29-36. 2012
  3. pmc IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants
    William J Burlingham
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Clin Invest 117:3498-506. 2007
  4. pmc Human CD8+ T-regulatory cells with low-avidity T-cell receptor specific for minor histocompatibility antigens
    William J Burlingham
    Department of Surgery, University of Wisconsin, Madison, WI, USA
    Hum Immunol 69:728-31. 2008
  5. ncbi request reprint Loss of tolerance to a maternal kidney transplant is selective for HLA class II: evidence from trans-vivo DTH and alloantibody analysis
    W J Burlingham
    Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 7375, USA
    Hum Immunol 61:1395-402. 2000
  6. pmc HLA-A, -B, and -DR zero-mismatched kidneys shipped to the University of Wisconsin, Madison, 1993-2006: superior graft survival despite longer preservation time
    William J Burlingham
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
    Transplantation 90:312-8. 2010
  7. ncbi request reprint HLA (A*0201) mimicry by anti-idiotypic monoclonal antibodies
    W J Burlingham
    Department of Surgery, University of Wisconsin, Madison 53792, USA
    J Immunol 161:6705-14. 1998
  8. ncbi request reprint Soluble donor HLA class I and beta 2m-free heavy chain in serum of lung transplant recipients: steady-state levels and increases in patients with recurrent CMV infection, acute rejection episodes, and poor outcome
    L D DeVito-Haynes
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    Hum Immunol 61:1370-82. 2000
  9. pmc Human allograft acceptance is associated with immune regulation
    A M VanBuskirk
    Department of Surgery, Ohio State University, Columbus, Ohio, USA
    J Clin Invest 106:145-55. 2000
  10. doi request reprint Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring
    S J Knechtle
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Transplant 9:1087-98. 2009

Research Grants

  1. Maternal Microchimerism and Neonatal Tolerance
    William J Burlingham; Fiscal Year: 2010
  2. Maternal Microchimerism and Neonatal Tolerance
    WILLIAM BURLINGHAM; Fiscal Year: 2009
  3. Minor H Antigen Regulatory Networks as an Alternative to Calcineurin Inhibitors i
    WILLIAM BURLINGHAM; Fiscal Year: 2007
  4. Maternal Microchimerism and Neonatal Tolerance
    WILLIAM BURLINGHAM; Fiscal Year: 2007
  5. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
  6. DONOR-DRIVEN REGULATION IN HUMAN ALLOGRAFT ACCEPTANCE
    WILLIAM BURLINGHAM; Fiscal Year: 2003
  7. KIDNEY TRANSPLANTATION & NON-INHERITED MATERNAL ANTIGENS
    WILLIAM BURLINGHAM; Fiscal Year: 2003
  8. Maternal Microchimerism and Neonatal Tolerance
    William J Burlingham; Fiscal Year: 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Mouse strain and injection site are crucial for detecting linked suppression in transplant recipients by trans-vivo DTH assay
    W J Burlingham
    Division of Transplantation, Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Am J Transplant 7:466-70. 2007
    ....
  2. pmc Bidirectional alloreactivity: A proposed microchimerism-based solution to the NIMA paradox
    William J Burlingham
    Department of Surgery, University of Wisconsin, Madison, WI, USA
    Chimerism 3:29-36. 2012
    ..If correct, the proposed solution points the way to clinical applications of microchimerism in solid organ and hematopoetic transplants...
  3. pmc IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants
    William J Burlingham
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Clin Invest 117:3498-506. 2007
    ..These data suggest that while alloimmunity initiates lung transplant rejection, de novo autoimmunity mediated by col(V)-specific Th17 cells and monocyte/macrophage accessory cells ultimately causes progressive airway obliteration...
  4. pmc Human CD8+ T-regulatory cells with low-avidity T-cell receptor specific for minor histocompatibility antigens
    William J Burlingham
    Department of Surgery, University of Wisconsin, Madison, WI, USA
    Hum Immunol 69:728-31. 2008
    ..We discuss the implications of our findings for chronic/persisting viral infections, residual tumor burden after cancer treatment and immunotherapy, and renal allograft tolerance...
  5. ncbi request reprint Loss of tolerance to a maternal kidney transplant is selective for HLA class II: evidence from trans-vivo DTH and alloantibody analysis
    W J Burlingham
    Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 7375, USA
    Hum Immunol 61:1395-402. 2000
    ....
  6. pmc HLA-A, -B, and -DR zero-mismatched kidneys shipped to the University of Wisconsin, Madison, 1993-2006: superior graft survival despite longer preservation time
    William J Burlingham
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
    Transplantation 90:312-8. 2010
    ..We compared these results with that of concurrent kidneys transplanted from HLA more than 0MM local donors and with shipped more than 0MM kidneys from "payback" donors...
  7. ncbi request reprint HLA (A*0201) mimicry by anti-idiotypic monoclonal antibodies
    W J Burlingham
    Department of Surgery, University of Wisconsin, Madison 53792, USA
    J Immunol 161:6705-14. 1998
    ..In the case of T10-505 and T10-938 mimicry was not based on exact replication of the epitope by the hypervariable loops of the anti-Id mAb...
  8. ncbi request reprint Soluble donor HLA class I and beta 2m-free heavy chain in serum of lung transplant recipients: steady-state levels and increases in patients with recurrent CMV infection, acute rejection episodes, and poor outcome
    L D DeVito-Haynes
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    Hum Immunol 61:1370-82. 2000
    ..However, recall responses to CMV and controlled immune responses to donor may result in little or no activation of sHLA class I release...
  9. pmc Human allograft acceptance is associated with immune regulation
    A M VanBuskirk
    Department of Surgery, Ohio State University, Columbus, Ohio, USA
    J Clin Invest 106:145-55. 2000
    ..This demonstrates that allograft acceptance in humans is associated with an immune regulation pattern, which may be useful in the diagnosis and/or monitoring of transplant patients for allograft acceptance...
  10. doi request reprint Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring
    S J Knechtle
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Transplant 9:1087-98. 2009
    ..Nevertheless, alloantibody was present in serum and/or C4d present on 1-year biopsy in half the patients. The combination of CKA and DSA monitoring or the performance of transvivo DTH correlated with immune status of the patients...
  11. ncbi request reprint The metalloproteinase-mediated pathway is essential for generation of soluble HLA class I proteins by activated cells in vitro: proposed mechanism for soluble HLA release in transplant rejection
    L D DeVito-Haynes
    University of Wisconsin, Madison 53792, USA
    Hum Immunol 59:426-34. 1998
    ..These data suggest an important role for the HLA class I-specific metalloproteinase in vivo in healthy individuals and during allograft rejection in the generation of soluble beta2m-free and beta2m-associated HLA proteins...
  12. ncbi request reprint What is known about blocking factors in renal allograft recipients
    W J Burlingham
    Department of Surgery, University of Wisconsin Hospital and Clinics, Madison 53792
    Am J Reprod Immunol Microbiol 16:15-20. 1988
    ..Alternatively, it may be possible to identify polymorphic structures on T cells other than the alpha, beta receptor complex as ligands for blocking antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. ncbi request reprint Human liver allograft acceptance and the "tolerance assay": in vitro anti-donor T cell assays show hyporeactivity to donor cells, but unlike DTH, fail to detect linked suppression
    F Geissler
    University of Wisconsin, Department of Surgery, Madison 53792, USA
    Transplantation 72:571-80. 2001
    ..CTL and MLC tests failed to do so. These findings may be relevant to the development of a tolerance assay suitable for use in clinical trials...
  14. ncbi request reprint Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients
    A W Thomson
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh and Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    Transplantation 72:S13-22. 2001
    ..It is anticipated that the results obtained may provide physicians with a tolerance assay "profile" that may determine those patients from whom immunosuppressive therapy may be safely withdrawn...
  15. pmc Tolerance induction or sensitization in mice exposed to noninherited maternal antigens (NIMA)
    M L Molitor-Dart
    Department of Surgery, University of Wisconsin, Madison, WI, USA
    Am J Transplant 8:2307-15. 2008
    ..Our findings imply that transplants are predisposed to tolerance or rejection due to recipient developmental history and immunogenetic background...
  16. ncbi request reprint Donor dendritic cell persistence in organ allograft recipients in the absence of immunosuppression
    P J O'Connell
    Department of Surgery, University of Wisconsin, Madison, USA
    J Leukoc Biol 66:301-5. 1999
    ..The results have important implications for the planned withdrawal of immunosuppression in tolerance protocols as DC may play a role either in the maintenance of tolerance or immune activation...
  17. ncbi request reprint Human liver allograft acceptance and the "tolerance assay". II. Donor HLA-A, -B but not DR antigens are able to trigger regulation of DTH
    Ewa Jankowska-Gan
    Department of Surgery, H4 781 CSC, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    Hum Immunol 63:862-70. 2002
    ..On a practical level, they indicate that soluble HLA-A and B antigens are the proper choice for detection of DTH regulation as part of a "tolerance assay" in human liver transplant recipients...
  18. ncbi request reprint Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance
    Melanie L Molitor-Dart
    Department of Pathology and Laboratory Medicine, Cellular and Molecular Pathology, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 179:6749-61. 2007
    ..Their persistence in the adult, and the ability of the host to mobilize them to the graft, may determine whether NIMA-specific tolerance is achieved...
  19. pmc Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation
    Joseph L Bobadilla
    Microbiology and Immunology, Director, Center for Immunobiology, Indiana University School of Medicine, Van Nuys Medical Sciences Building MS224, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    Am J Respir Crit Care Med 177:660-8. 2008
    ..Human studies and rodent models have shown that collagen type V (col[V]), stimulates IL-17-dependent cellular immunity after lung transplantation...
  20. doi request reprint Lung transplant patients' T cell responses to influenza vaccine viruses between seasons
    Mary S Hayney
    School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
    Vaccine 26:2596-600. 2008
    ..The magnitude of the T cell responses in lung transplant patients is similar to those of healthy control individuals. These responses may be important in T cell memory...
  21. ncbi request reprint Immune regulation and graft survival in kidney transplant recipients are both enhanced by human leukocyte antigen matching
    Daniel S Rodriguez
    Department of Surgery, University of Wisconsin, Madison, WI, USA
    Am J Transplant 4:537-43. 2004
    ..0001). HLA matching, and HLA-DR matching in particular, correlates with the incidence of immune regulation after kidney transplantation...
  22. pmc Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction
    Takekazu Iwata
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 181:5738-47. 2008
    ..This study demonstrates a major role for anti-col(V) humoral immunity in PGD, and identifies the airway epithelium as a target in PGD...
  23. ncbi request reprint Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1
    Richard A Derks
    Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 179:3443-51. 2007
    ..These results shed light upon the mechanism of bystander suppression by donor Ag-specific TR in patients with organ transplant tolerance and underscores the distinct and critical roles of mDC and pDCs in this phenomenon...
  24. ncbi request reprint T-cell responses to hepatitis B surface antigen in lung transplant recipients
    Mary S Hayney
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    Pharmacotherapy 27:1248-52. 2007
    ....
  25. ncbi request reprint CMV-infected allogeneic endothelial cells initiate responder and bystander donor HLA class I release via the metalloproteinase cleavage pathway
    Lynn D Haynes
    University of Wisconsin, Madison, WI 53792, USA
    Hum Immunol 66:211-21. 2005
    ....
  26. ncbi request reprint Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance
    Qingyong Xu
    Department of Surgery, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    J Immunol 178:3983-95. 2007
    ..Thus, adaptive T(R) cells suppressing T(E) cell responses to donor allopeptides in two tolerant patients appear to be functionally and phenotypically distinct from CD4(+)CD25(high)FoxP3(+) T cells...
  27. ncbi request reprint Interferon-gamma drives the metalloproteinase-dependent cleavage of HLA class I soluble forms from primary human bronchial epithelial cells
    Lynn D Haynes
    Department of Surgery, University of Madison, H4 751 CSC, 600 Highland Avenue, Madison, WI 53792, USA
    Hum Immunol 63:893-901. 2002
    ..This adds to the growing understanding of the extracellular processing pathways of major histocompatibility complex class I that may be critical for both chronic rejection as well as immune regulation...
  28. pmc Minor H antigen HA-1-specific regulator and effector CD8+ T cells, and HA-1 microchimerism, in allograft tolerance
    Junchao Cai
    Department of Surgery, University of Wisconsin Madison, 53792, USA
    J Exp Med 199:1017-23. 2004
    ..This is the first demonstration of coexisting CD8+ memory TR and TE cells, both specific for the same HA-1 antigen, in the context of renal allograft tolerance...
  29. ncbi request reprint In vitro parameters of donor-antigen-specific tolerance
    Richard A Derks
    Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    Curr Opin Immunol 17:560-4. 2005
    ....
  30. ncbi request reprint Metastable tolerance in nonhuman primates and humans
    Stuart J Knechtle
    Division of Transplantation, Department of Surgery, University of Wisconsin Medical School, Madison, WI 53792 7375, USA
    Transplantation 77:936-9. 2004
    ..Some of the reasons that tolerance remains such a challenging goal in clinical transplantation are discussed herein...
  31. ncbi request reprint Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates
    Jose R Torrealba
    Department of Pathology, University of Wisconsin and Veterans Affairs Hospital, Madison, WI 53792, USA
    J Immunol 172:5753-64. 2004
    ..Our data support the hypothesis that the recruitment of CD4(+) T regulatory cells to the allograft interstitium is a final common pathway for metastable renal transplant tolerance in a non-human primate model...
  32. ncbi request reprint The end of an era: Wayne Streilein and his impact on transplantation immunology
    William J Burlingham
    University of Wisconsin, Madison, WI, USA
    Transplantation 78:307-9. 2004
  33. ncbi request reprint Immunobiology of exposure to non-inherited maternal antigens
    Melanie L Molitor
    University of Wisconsin Madison, Madison, WI 53792, USA
    Front Biosci 12:3302-11. 2007
    ....
  34. ncbi request reprint Tolerance to noninherited maternal MHC antigens in mice
    Joachim Andrassy
    Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 171:5554-61. 2003
    ..These results suggest that the natural exposure of the fetus and newborn to maternal cells and/or soluble MHC Ags suppresses NIMA-allospecific T cells of the offspring, predisposing to organ transplant tolerance in adult mice...
  35. ncbi request reprint Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients
    Jean Kwun
    Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, WI 53792 7375, USA
    J Immunol 179:8016-25. 2007
    ..This role is most eminent in a transplant model when a less complex inflammatory milieu is involved such as a well-matched graft and chronic rejection...
  36. ncbi request reprint Detection of microchimerism by minor histocompatibility antigen HA-1 allele-specific nested polymerase chain reaction
    Brigitte Wieles
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Biol Blood Marrow Transplant 11:345-8. 2005
    ....

Research Grants19

  1. Maternal Microchimerism and Neonatal Tolerance
    William J Burlingham; Fiscal Year: 2010
    ..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
  2. Maternal Microchimerism and Neonatal Tolerance
    WILLIAM BURLINGHAM; Fiscal Year: 2009
    ..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
  3. Minor H Antigen Regulatory Networks as an Alternative to Calcineurin Inhibitors i
    WILLIAM BURLINGHAM; Fiscal Year: 2007
    ....
  4. Maternal Microchimerism and Neonatal Tolerance
    WILLIAM BURLINGHAM; Fiscal Year: 2007
    ..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
  5. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..
  6. DONOR-DRIVEN REGULATION IN HUMAN ALLOGRAFT ACCEPTANCE
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to develop a working model of how donor-derived leukocytes and the antigens they release contribute to a tonic equilibrium between host T regulator and effector cells in human allograft acceptance. ..
  7. KIDNEY TRANSPLANTATION & NON-INHERITED MATERNAL ANTIGENS
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to establish the basis for a rational approach to HLA-matching and selective NIMA mismatching to achieve the goal of clinical kidney transplantation tolerance. ..
  8. Maternal Microchimerism and Neonatal Tolerance
    William J Burlingham; Fiscal Year: 2010
    ..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..