Dean J Burkin

Summary

Affiliation: University of Nevada
Country: USA

Publications

  1. pmc Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression
    Jianming Liu
    Department of Cell and Developmental Biology, University of Illinois, 601 S Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    Am J Physiol Cell Physiol 294:C627-40. 2008
  2. pmc Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin
    Jennifer V Welser
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Am J Pathol 175:1545-54. 2009
  3. ncbi request reprint Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada, Reno, 89557, USA
    J Cell Sci 119:2185-95. 2006
  4. pmc Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 106:7991-6. 2009
  5. pmc Transgenic overexpression of the α7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A
    Jinger A Doe
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Cell Sci 124:2287-97. 2011
  6. pmc Cardiac-specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice
    Dazhi Xiong
    Center of Biomedical Research Excellence, Department of Pharmacology, MS 318, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Mol Cell Cardiol 48:211-9. 2010
  7. pmc Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathy
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Am J Pathol 174:256-64. 2009
  8. ncbi request reprint Loss of the alpha7 integrin promotes extracellular signal-regulated kinase activation and altered vascular remodeling
    Jennifer V Welser
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Circ Res 101:672-81. 2007
  9. pmc Laminin-111 protein therapy reduces muscle pathology and improves viability of a mouse model of merosin-deficient congenital muscular dystrophy
    Jachinta E Rooney
    Department of Pharmacology, Center for Molecular Medicine, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Am J Pathol 180:1593-602. 2012
  10. ncbi request reprint Role for the alpha7beta1 integrin in vascular development and integrity
    Nichole L Flintoff-Dye
    Department of Pharmacology, University of Nevada, Manville Health Science Building, Reno, 89557, USA
    Dev Dyn 234:11-21. 2005

Collaborators

  • Dayue Duan
  • Bradley L Hodges
  • William T Gerthoffer
  • Kathleen D Keef
  • Zipora Yablonka-Reuveni
  • Jachinta E Rooney
  • Jennifer V Welser
  • Dazhi Xiong
  • Cherie A Singer
  • Praveen B Gurpur
  • Paul Scowen
  • Stephen J Kaufman
  • Nichole L Flintoff-Dye
  • Ryan D Wuebbles
  • Nathan D Bozeat
  • Jinger A Doe
  • Diana T McCloskey
  • Honglin Tian
  • Joseph R Hume
  • Linda Ye
  • Shanti Rawat
  • Rebecca Evans
  • Margaret Elorza
  • Jianming Liu
  • Marni D Boppart
  • Jolie R Knapp
  • Erika T Allred
  • Linda L Ye
  • Sunny Yang Xiang
  • Fred S Lamb
  • Tammy Y Yao
  • Marie L Duan
  • Maria Valencik
  • Fiona C Britton
  • Nathanael S Heyman
  • Mi Zhang
  • Judith Airey
  • Ge Xin Wang
  • Rebecca A Evans
  • Nicolette C Cohen
  • William J Hatton
  • Ilia A Yamboliev
  • Bryan A Haines
  • Phillip S Keller
  • Naomi Lange
  • Melissa A Dechert
  • William Hatton
  • Jachinta Rooney
  • Susan Tamowski
  • Jennifer Welser

Detail Information

Publications15

  1. pmc Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression
    Jianming Liu
    Department of Cell and Developmental Biology, University of Illinois, 601 S Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    Am J Physiol Cell Physiol 294:C627-40. 2008
    ..These results support the use of integrin enhancement as a therapy for muscular dystrophy...
  2. pmc Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin
    Jennifer V Welser
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Am J Pathol 175:1545-54. 2009
    ..Together, these results indicate that the alpha7beta1 integrin, dystrophin, and utrophin complexes act in a concerted manner to maintain the structural and functional integrity of skeletal muscle...
  3. ncbi request reprint Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada, Reno, 89557, USA
    J Cell Sci 119:2185-95. 2006
    ..These results point to complementary roles for dystrophin and alpha7beta1 integrin in maintaining the functional integrity of skeletal muscle...
  4. pmc Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 106:7991-6. 2009
    ..These findings demonstrate that laminin-111 is a highly potent therapeutic agent for the mdx mouse model of DMD and represents a paradigm for the systemic delivery of extracellular matrix proteins as therapies for genetic diseases...
  5. pmc Transgenic overexpression of the α7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A
    Jinger A Doe
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Cell Sci 124:2287-97. 2011
    ....
  6. pmc Cardiac-specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice
    Dazhi Xiong
    Center of Biomedical Research Excellence, Department of Pharmacology, MS 318, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Mol Cell Cardiol 48:211-9. 2010
    ..These results indicate that ClC-3 is a key component of native VSOACs in mammalian heart and plays a significant cardioprotective role against cardiac hypertrophy and failure...
  7. pmc Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathy
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Am J Pathol 174:256-64. 2009
    ..Our data demonstrate a critical role for a laminin-rich microenvironment in muscle repair and suggest laminin- 111 protein may serve as an unexpected and novel therapeutic agent for patients with congenital myopathies...
  8. ncbi request reprint Loss of the alpha7 integrin promotes extracellular signal-regulated kinase activation and altered vascular remodeling
    Jennifer V Welser
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Circ Res 101:672-81. 2007
    ....
  9. pmc Laminin-111 protein therapy reduces muscle pathology and improves viability of a mouse model of merosin-deficient congenital muscular dystrophy
    Jachinta E Rooney
    Department of Pharmacology, Center for Molecular Medicine, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Am J Pathol 180:1593-602. 2012
    ..Our results demonstrate that laminin-111 can serve as an effective protein substitution therapy for the treatment of muscular dystrophy in the dy(W-/-) mouse model and establish the potential for its use in the treatment of MDC1A...
  10. ncbi request reprint Role for the alpha7beta1 integrin in vascular development and integrity
    Nichole L Flintoff-Dye
    Department of Pharmacology, University of Nevada, Manville Health Science Building, Reno, 89557, USA
    Dev Dyn 234:11-21. 2005
    ....
  11. pmc Activation of volume regulated chloride channels protects myocardium from ischemia/reperfusion damage in second-window ischemic preconditioning
    Nathan D Bozeat
    Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557 0318, USA
    Cell Physiol Biochem 28:1265-78. 2011
    ..These results strongly support that activation of VRCCs may play an important cardioprotective role in second-window IPC...
  12. doi request reprint Cardiac-specific overexpression of the human short CLC-3 chloride channel isoform in mice
    Dazhi Xiong
    Center of Biomedical Research Excellence, Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Clin Exp Pharmacol Physiol 36:386-93. 2009
    ..6. In conclusion, enhanced VSOAC currents and acceleration of the time-course of RVD in atrial myocytes of OE mice is strong evidence supporting an essential role of sClC-3 in native VSOAC function in mouse atrial myocytes...
  13. doi request reprint A molecular bandage for diseased muscle
    Dean J Burkin
    Department of Pharmacology, Center for Molecular Medicine, University of Nevada School of Medicine, Reno, NV 89557, USA
    Sci Transl Med 4:139fs19. 2012
    ..MG53 promotes sarcolemmal repair in the mdx mouse model of Duchenne muscular dystrophy (Weisleder et al., this issue) and identifies a new protein therapeutic for muscle disease...
  14. pmc Transgenic expression of {alpha}7{beta}1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice
    Dean J Burkin
    Department of Cell and Structural Biology, University of Illinois, B107 Chemical and Life Sciences Laboratory, 601 South Goodwin Ave, Urbana, IL 61801, USA
    Am J Pathol 166:253-63. 2005
    ..We believe this multiplicity of responses to increased alpha7beta1 integrin collectively inhibits the development of muscle disease and increases longevity in these mice...
  15. ncbi request reprint Alpha7beta1-integrin regulates mechanotransduction and prevents skeletal muscle injury
    Marni D Boppart
    Dept of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA
    Am J Physiol Cell Physiol 290:C1660-5. 2006
    ..These experiments provide the first evidence that alpha7beta1-integrin is a negative regulator of mechanotransduction in vivo and provides resistance to exercise-induced muscle damage...

Research Grants1

  1. A drug-based approach for integrin-mediated alleviation of muscular dystrophy
    Dean Burkin; Fiscal Year: 2007
    ..This study aims to identify drugs that increase 17 integrin gene expression which may prove to be of therapeutic value to patients that suffer from DMD. ..