Research Topics
| Wylie BurkeSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
Personalized medicine in the era of genomicsWylie Burke
Center for Genomics and Healthcare Equality and Department of Medical History and Ethics, University of Washington, Seattle, WA 98195, USA
JAMA 298:1682-4. 2007
Translational genomics: seeking a shared vision of benefitWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, WA 98195, USA
Am J Bioeth 8:54-6; discussion W1-3. 2008- Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic reviewNoralane M Lindor
Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, Minn, USA
JAMA 296:1507-17. 2006..Current recommendations regarding cancer screening and prevention require careful consultation between clinicians, clinical cancer genetic services, and well-informed patients... - The path from genome-based research to population health: development of an international public health genomics networkWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, WA 98195-7120, USA
Genet Med 8:451-8. 2006 - Ethical issues arising from the participation of children in genetic researchWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle 98195 7120, USA
J Pediatr 149:S34-8. 2006..Because genetic information is often accorded special power in our society, careful attention should be paid to how genetic information is collected and used in research involving pediatric participants... - Genetics as a tool to improve cancer outcomes: ethics and policyWylie Burke
Department of Medical History and Ethics, University of Washington, Box 357120, 1959 North East Pacific, Room A204, Seattle, Washington 98195 7120, USA
Nat Rev Cancer 6:476-82. 2006..When the benefits of testing are well established, efforts must also be made to ensure access to genetic services for all who can benefit... - Deliberate deceit of family members: a challenge to providers of clinical genetics servicesJennifer T Loud
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services; Food and Drug Administration, Rockville, MD 20853-7231, USA
J Clin Oncol 24:1643-6. 2006 - Practicing moral medicine: patient care to public healthDenise M Dudzinski
University of Washington, USA
Am J Bioeth 6:75-6. 2006 - Ethical obligations and counseling challenges in cancer geneticsWylie Burke
Department of Medical History and Ethics, University of Washington, Box 356120, 1959 NE Pacific, Room A204, Seattle, WA 98195 7120, USA
J Natl Compr Canc Netw 4:185-91. 2006..Clinicians must also provide emotional support and accurate information about cancer risks and cancer risk reduction measures, including uncertainties. Teamwork among different specialties is important in addressing these challenges... - Family history assessment to detect increased risk for colorectal cancer: conceptual considerations and a preliminary economic analysisScott D Ramsey
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M2 B230, P O Box 19024, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 14:2494-500. 2005..Although the rationale for earlier screening of persons with a family history of colorectal cancer is plausible, there is no direct evidence that earlier assessment is either effective or cost-effective... - Contributions of public health to genetics education for health care professionalsWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, WA 98195 7120, USA
Health Educ Behav 32:668-75. 2005.... - Potential for genetics to promote public health: genetics research on smoking suggests caution about expectationsChris Carlsten
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Occupational and Environmental Medicine Program, University of Washington, Seattle, USA
JAMA 296:2480-2. 2006 - Pharmacogenomic testing to prevent aminoglycoside-induced hearing loss in cystic fibrosis patients: potential impact on clinical, patient, and economic outcomesDavid L Veenstra
Institute for Public Health Genetics, Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Genet Med 9:695-704. 2007..Although the A1555G variant is very rare, it seems to confer a high risk of severe hearing loss in patients exposed to aminoglycosides... - Differential use of available genetic tests among primary care physicians in the United States: results of a national surveyAlexandra E Shields
Harvard MGH Center on Genomics, Vulnerable Populations, and Health Disparities, Massachusetts General Hospital Partners HealthCare, Boston, Massachusetts, USA
Genet Med 10:404-14. 2008..This study assesses primary care physicians' experience ordering and referring patients for genetic testing, and whether minority-serving physicians are less likely than those serving fewer minorities to offer such services... 
Pharmacogenetic testing: not as simple as it seemsSusanne B Haga
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina27708, USA
Genet Med 10:391-5. 2008..These issues have implications for informed consent and genetic counseling requirements, and for the role of health professionals...- Clinical validity and clinical utility of genetic testsWylie Burke
University of Washington, Seattle, Washington, USA
Curr Protoc Hum Genet . 2004..This unit defines clinical validity and clinical utility, provides examples, and considers the implications of these test properties for clinical practice... - Educational needs in genetic medicine: primary care perspectivesSusan B Trinidad
Department of Medical History and Ethics, University of Washington, Seattle, Wash 98195 7120, USA
Community Genet 11:160-5. 2008..This study was performed to identify primary care physicians' (PCPs) attitudes toward genetic medicine and their perceived needs for education in this area... - Waiving informed consent in newborn screening research: balancing social value and respectBeth A Tarini
Division of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
Am J Med Genet C Semin Med Genet 148:23-30. 2008.... - Defining purpose: a key step in genetic test evaluationWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195-7120, USA
Genet Med 9:675-81. 2007 - Hereditary diffuse gastric cancer: association with lobular breast cancerKasmintan A Schrader
Department of Pathology and Laboratory Medicine, University of British Columbia, British Columbia Cancer Agency, Vancouver, BC, Canada
Fam Cancer 7:73-82. 2008.... - Anticipating dissemination of cancer genomics in public health: a theoretical approach to psychosocial and behavioral challengesJennifer L Hay
Memorial Sloan Kettering Cancer Center, Department of Psychiatry and Behavioral Sciences, New York, NY 10022, USA
Ann Behav Med 34:275-86. 2007..Given the recent sequencing of the human genome, genetic susceptibility information will probably be increasingly useful in the prevention and control of many common diseases, including cancer... - Will genomics widen or help heal the schism between medicine and public health?Muin J Khoury
National Office of Public Health Genomics, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
Am J Prev Med 33:310-7. 2007..A strong medicine-public health partnership in the genomics era is needed for the translation of all scientific discoveries for the benefit of population health... - Gene expression profiling and breast cancer care: what are the potential benefits and policy implications?Nina Oestreicher
University of Washington, Seattle, Washington, USA
Genet Med 7:380-9. 2005..However, the outcomes associated with gene expression profiling are not clear, and guidelines for the appropriate use of genomic technologies have not been established... - The asthma consultative process: a collaborative approach to integrating genomics into public health practiceTabitha A Harrison
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98105, USA
Prev Chronic Dis 2:A27. 2005..This paper describes the methods used to conduct these professional and community consultations, referred to as the asthma consultative process, and discusses the lessons learned from this activity... - Family history as a predictor of asthma riskWylie Burke
Department of Medical History and Ethics, University of Washington, Box 357120, 1959 NE Pacific, Seattle, WA 98195, USA
Am J Prev Med 24:160-9. 2003..Positive family history may have utility in targeting some individual prevention efforts, but the low positive predictive value limits its value as a means to direct environmental remediation efforts... - Achieving utility with family history: colorectal cancer riskDeborah J Bowen
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, MP900, Seattle, WA 98109, USA
Am J Prev Med 24:177-82. 2003..Where available, we cite data to support the issues that could arise. Where there are no studies, we invite further research. The potential of family history as a health improvement tool is still under review... - Hereditary hemochromatosis: perspectives of public health, medical genetics, and primary careGiuseppina Imperatore
National Canter for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Genet Med 5:1-8. 2003..The authors review these data and consider their implications for public health, medical genetics, and primary care... - Re: On the use of familial aggregation in population-based case probands for calculating penetranceWylie Burke
J Natl Cancer Inst 95:78-9. 2003 - Genetic testingWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, WA 98195, USA
N Engl J Med 347:1867-75. 2002 - Genomics as a probe for disease biologyWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle 98195, USA
N Engl J Med 349:969-74. 2003 - Hereditary haemochromatosis: a realistic approach to prevention of iron overload disease in the populationWylie Burke
Department of Medical History and Ethics, Box 357120, University of Washington, 1959 NE Pacific, Room A204, Seattle, WA 98195, USA
Best Pract Res Clin Haematol 15:315-28. 2002.... - Reconsidering the family history in primary careEugene C Rich
Department of Medicine, Creighton University, 601 N 30th Street, Suite 8850, Omaha, NE 68131, USA
J Gen Intern Med 19:273-80. 2004.... - Breast cancer risk counseling improves women's functioningDeborah J Bowen
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 900, Seattle, WA 98109, USA
Patient Educ Couns 53:79-86. 2004..Cancer worry decreased in both counseling groups by one scale point (P < 0.05). These results indicate that counseling can relieve women's negative reactions to breast cancer risk... - Effects of risk counseling on interest in breast cancer genetic testing for lower risk womenDeborah J Bowen
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genet Med 4:359-65. 2002..CONCLUSION: These results indicate that counseling can change interest in genetic testing only slightly and that changing women's beliefs about the properties of testing might be one mechanism of doing so... - Ensuring the appropriate use of genetic testsWylie Burke
Department of Medical History and Ethics, Box 357120, University of Washington, 1959 NE Pacific, Room A204, Seattle, Washington 98195, USA
Nat Rev Genet 5:955-9. 2004..Other strategies, including resource allocation and matters related to clinical governance - such as practice-guideline development and health-provider education - are also important... - Diabetes and HFE mutations: cause or coincidence?Linda E Pinsky
Department of Medicine, Division of General Internal Medicine, University of Washington Medical Center, 4245 Roosevelt Way, NE Seattle, WA 98105 6920, USA
West J Med 176:114-5. 2002 - Genetic testing in primary careWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195 7120, USA
Annu Rev Genomics Hum Genet 5:1-14. 2004..A partnership between medical genetics and primary care will help to ensure the development of effective policies, educational tools, and practice guidelines for the coming era of genomic health care... - Genetics education for primary-care providersWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195, USA
Nat Rev Genet 3:561-6. 2002..Although most have little knowledge of genetics, their expertise in the prudent use of technology is relevant to the task. Successful educational programmes will need to forge partnerships between primary care and genetics... - Ethical issues in identifying and recruiting participants for familial genetic researchLaura M Beskow
Department of Health Policy and Administration, University of North Carolina at Chapel Hill School of Public Health, Chapel Hill, NC 27599 7411, USA
Am J Med Genet A 130:424-31. 2004..They suggest a framework for considering alternative recruitment strategies and their implications, as well as highlight areas in need of further empirical research... - Genetic test evaluation: information needs of clinicians, policy makers, and the publicWylie Burke
University of Washington, Seattle, WA, USA
Am J Epidemiol 156:311-8. 2002.... - American Cancer Society guidelines for breast screening with MRI as an adjunct to mammographyDebbie Saslow
Cancer Control Science Department, American Cancer Society, Atlanta, GA, USA
CA Cancer J Clin 57:75-89. 2007..Diagnostic uses of MRI were not considered to be within the scope of this review... - ASHG Statement* on direct-to-consumer genetic testing in the United StatesKathy Hudson
Department of Pediatrics, Johns Hopkins University, Washington, D.C, USA
Obstet Gynecol 110:1392-5. 2007 - Genetic risk in context: calculating the penetrance of BRCA1 and BRCA2 mutationsWylie Burke
J Natl Cancer Inst 94:1185-7. 2002 - 'That's like chopping off a finger because you're afraid it might get broken': disease and illness in women's views of prophylactic mastectomyNancy Press
Schools of Nursing and Medicine, Oregon Health and Science University, 3455 SW US Veterans Hospital Road, SN 5S, Portland, OR 97239 2941, USA
Soc Sci Med 61:1106-17. 2005..We suggest that while prophylactic mastectomy may prevent the "disease" of breast cancer, it may be of little interest to women who see this surgery as itself mimicking the "illness" of breast cancer... - Jewish identity and intentions to obtain breast cancer screeningDeborah J Bowen
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP900, Seattle, Washington 98109, USA
Cultur Divers Ethnic Minor Psychol 9:79-87. 2003..Religious identity was a significant predictor of intention to adhere to mammography recommendations. Findings show that culture and religion, although correlated, may have different associations with health attitudes... - Taking family history seriouslyWylie Burke
Ann Intern Med 143:388-9. 2005 - Effects of individual and family functioning on interest in genetic testingDeborah J Bowen
Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
Community Genet 7:25-32. 2004..The present study reports on the important issue of how family communication and support regarding breast cancer risk affects interest in genetic testing and mental health... - Using pharmacogenetics to improve drug safety and efficacySusanne B Haga
The Center for the Advancement of Genomics, Rockville, MD, USA
JAMA 291:2869-71. 2004 - Changing the clinical management of hereditary hemochromatosis: translating screening and early case detection strategies into clinical practiceAlexander R Hover
St John s Regional Health Center, St John s Health System, Springfield, MO 65804, USA
Arch Intern Med 164:957-61. 2004..This article describes the effect of an extensive physician educational program on detection and management of hereditary hemochromatosis (HH) before and after a hemochromatosis population screening study... - Effects of counseling Ashkenazi Jewish women about breast cancer riskDeborah J Bowen
Department of Health Services, University of Washington, Seattle, WA 98109, USA
Cultur Divers Ethnic Minor Psychol 12:45-56. 2006..Counseling can help women gain a more accurate perception of their risk, expose them to the benefits and limitations of genetic testing, and reduce their worry about cancer... - An economic viewpoint on alternative strategies for identifying persons with hereditary nonpolyposis colorectal cancerScott D Ramsey
Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle, Washington, USA
Genet Med 5:353-63. 2003..CONCLUSIONS: The Bethesda guidelines are the most cost-effectiveness approach to screen persons for HNPCC... - Adding pharmacogenetics information to drug labels: lessons learnedSusanne B Haga
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
Pharmacogenet Genomics 16:847-54. 2006..We review the reasons behind the cautious label changes and discuss some of the lessons that can be learned from these experiences... - Genomic profiling to promote a healthy lifestyle: not ready for prime timeSusanne B Haga
Center for the Advancement of Genomics, 1901 Research Blvd, Sixth Floor, Rockville, Maryland 20850, USA
Nat Genet 34:347-50. 2003 - Incorporating principles and practical wisdom in research ethics education: a preliminary studyNicole Deming
Department of Medical History and Ethics, University of Washington School of Medicine, Seattle, WA 98195 7120, USA
Acad Med 82:18-23. 2007..This study characterized researchers' responses to ethical dilemmas with the goal of aligning research ethics education programs with the demands of practice... - Genetic information: Special or not? Responses from focus groups with members of a health maintenance organizationBrenda Diergaarde
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Am J Med Genet A 143:564-9. 2007..These data may guide future research and policy concerning the use and protection of medical information, including genetic information... - Genetic exceptionalism. Too much of a good thing?James P Evans
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
Genet Med 10:500-1. 2008