- The final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinasesRobert F Lera
Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
Molecules 17:12172-86. 2012..We believe a complete "chemical genetic toolbox" will ultimately allow a comprehensive understanding of how protein kinases regulate mitosis...
- Validating cancer drug targets through chemical geneticsMark E Burkard
University of Wisconsin Carbone Cancer Center and Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
Biochim Biophys Acta 1806:251-7. 2010..One approach, referred to as chemical genetics, accomplishes this by genetic control of chemical susceptibility. Chemical genetics is a crucial tool for the rational development of cancer drugs...