Paul R Burghardt
Affiliation: University of Michigan
- Effect of amygdalar opioids on the anxiolytic properties of ethanolMarlene A Wilson
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
Ann N Y Acad Sci 985:472-5. 2003
- Anxiolytic effects of diazepam and ethanol in two behavioral models: comparison of males and femalesMarlene A Wilson
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Building 1, D26 Columbia, SC 29208, USA
Pharmacol Biochem Behav 78:445-58. 2004..These results suggest a dissociation between the anxiety-reducing influences of these compounds and the changes in stress-related endocrine responses...
- The effects of chronic treadmill and wheel running on behavior in ratsPaul R Burghardt
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Building 1 Room D26, Columbia, SC 29208, USA
Brain Res 1019:84-96. 2004..The behavioral adaptations found after 4 and 8 weeks of wheel running were not due solely to enriched environment and appear to be indicative of enhanced defensive behavior...
- Microinjection of naltrexone into the central, but not the basolateral, amygdala blocks the anxiolytic effects of diazepam in the plus mazePaul R Burghardt
Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, USA
Neuropsychopharmacology 31:1227-40. 2006..Further, opioid receptor systems in the CeA and BLA do not regulate the anxiolytic properties of ethanol in this test...
- Alterations in fear conditioning and amygdalar activation following chronic wheel running in ratsPaul R Burghardt
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208, USA
Pharmacol Biochem Behav 84:306-12. 2006..These data demonstrate the ability of chronic physical activity to alter contextual fear conditioning and implicate the amygdala as a potential site of plasticity underlying this phenomenon...
- Leptin regulates dopamine responses to sustained stress in humansPaul R Burghardt
Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 32:15369-76. 2012..The capacity for leptin to influence stress-induced dopaminergic function is of importance for pathological states where dopamine is thought to play an integral role, such as mood, substance-use disorders, eating disorders, and obesity...
- Risk-assessment and coping strategies segregate with divergent intrinsic aerobic capacity in ratsPaul R Burghardt
Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, MI 48109, USA
Neuropsychopharmacology 36:390-401. 2011..Within this context, we propose that intrinsic aerobic capacity is a central feature mechanistically linking complex metabolic disease and behavior...
- Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndromeBradley J Buck
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
Neurosci Lett 419:178-83. 2007..These data are consistent with the notion of altered GABAergic neurotransmission in the NTS and VLM in metabolic syndrome, and point to the importance of these regions in cardiovascular regulation...
- Dietary n-3:n-6 fatty acid ratios differentially influence hormonal signature in a rodent model of metabolic syndrome relative to healthy controlsPaul R Burghardt
Molecular and Behavioral Neuroscience Institute, The University of Michigan, MBNI 2028, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Nutr Metab (Lond) 7:53. 2010..Further research is necessary to establish these responses in human populations...
- Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced ObesityMike J F Robinson
1 Department of Psychology, University of Michigan, Ann Arbor, MI, USA 2 Department of Psychology, Wesleyan University, Middletown, CT, USA
Neuropsychopharmacology 40:2113-23. 2015....
- Endogenous Opioid Mechanisms Are Implicated in Obesity and Weight Loss in HumansPaul R Burghardt
Departments of Psychiatry P R B, J K Z, Radiology J K Z, and Internal Medicine A E R, C F B, and Molecular and Behavioral Neuroscience Institute K E D, J K Z, University of Michigan, Ann Arbor, Michigan 48109 and Department of Nutrition and Food Science P R B, Wayne State University, Detroit, Michigan 48202
J Clin Endocrinol Metab 100:3193-201. 2015..Successful long-term weight loss is challenging. Brain endogenous opioid systems regulate associated processes; however, their role in the maintenance of weight loss has not been adequately explored in humans...