Research Topics
Species | Andrew J BurghardtSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomographyAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
J Bone Miner Res 28:524-36. 2013..The data generated from this study will contribute to the future design and validation of standardized procedures that are broadly translatable to multicenter study designs...- A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnoverAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
J Bone Miner Res 25:2558-71. 2010..48, p < .05). These findings suggest a more pronounced response to ALN in the tibia than in the radius, driven by trabecular and endocortical changes... - High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitusAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3 Building, Suite 203, San Francisco, California 94158, USA
J Clin Endocrinol Metab 95:5045-55. 2010..Cross-sectional epidemiological studies have found that patients with type 2 diabetes mellitus (T2DM) have a higher incidence of certain fragility fractures despite normal or elevated bone mineral density (BMD)... 
The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomographyKevin A Davis
Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA, USA
Calcif Tissue Int 81:364-71. 2007..Furthermore, while the direct 3D Ct.Th method is less sensitive to threshold effects, both methods are moderate predictors of mechanical strength, with the annular method being the stronger correlate...- Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibiaAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
J Bone Miner Res 25:983-93. 2010..The biomechanical significance of these structural differences increases with age for men and women and provides discriminatory information for menopause-related bone quality effects... - Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMDGalateia J Kazakia
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, USA
J Biomech 44:257-66. 2011..Overlap of these indices among osteoporotic status groups reflects the reported incidence of osteoporotic fracture in subjects classified as osteopenic or normal... 
Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic womenJenny Folkesson
Musculoskeletal Quantitative Imaging Research Group MQIR, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
Bone 48:611-21. 2011..Treatment effects were observed in the distal tibia after 24 months. The BE-FCM method increased correlations to HR-pQCT-based parameters...- Contribution of the intra-specimen variations in tissue mineralization to PTH- and raloxifene-induced changes in stiffness of rat vertebraeSarah K Easley
Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA CA 94720 1740, USA
Bone 46:1162-9. 2010.... - In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imagingGalateia J Kazakia
Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, California 94158, USA
J Bone Miner Res 23:463-74. 2008..Significant but moderate correlations and 2- to 4-fold discrepancies in parameter values were detected, suggesting that differences in acquisition and analysis must be considered when interpreting data from these imaging modalities... - Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility studyRoland Krug
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
J Magn Reson Imaging 34:691-5. 2011..To implement and examine the feasibility of a three-dimensional (3D) ultrashort TE (UTE) sequence on a 7 Tesla (T) clinical MR scanner in comparison with 3T MRI at high isotropic resolution... - Morphology of the human vertebral endplateAzucena G Rodriguez
Department of Orthopaedic Surgery, University of California, San Francisco, California 94143, USA
J Orthop Res 30:280-7. 2012..Since ischemic disc cell behavior is commonly associated with degenerative change, this may be related to other factors such as the quality of vertebral capillaries, as opposed to decreased permeability of intervening tissues... - In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 TRoland Krug
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
J Magn Reson Imaging 27:854-9. 2008.... - Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibiaMiki Sode
Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
Bone 46:1652-60. 2010..Therefore, a combined approach of investigating the entire region, each subregion, and the cortical compartment may offer more complete information... - Quantitative characterization of subject motion in HR-pQCT images of the distal radius and tibiaMiki Sode
Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley, San Francisco and Berkeley, CA, USA
Bone 48:1291-7. 2011..The results of this study may provide a basis for establishing a threshold for motion artifacts in accordance to the study design as well as a standardized quality control protocol across operators and imaging centers... - Noninvasive imaging of bone microarchitectureJanina M Patsch
Musculoskeletal Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
Ann N Y Acad Sci 1240:77-87. 2011.... - High-resolution imaging techniques for the assessment of osteoporosisRoland Krug
MQIR, Department of Radiology and Biomedical Imaging, University of California San Francisco, UCSF China Basin Landing, 185 Berry Street, San Francisco, CA 94107, USA
Radiol Clin North Am 48:601-21. 2010..Details regarding imaging protocols as well as image postprocessing methods for bone structure quantification are discussed... - Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomographyAndrew J Burghardt
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
Calcif Tissue Int 83:129-38. 2008..80). In cortical bone specimens, the correlation was somewhat weaker when a global threshold was applied (R (2) = 0.67) compared to the local threshold method (R (2) = 0.78)... - Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomographyKiranjit Sekhon
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107, USA
Bone 45:473-9. 2009..Our results confirm that geometric and densitometric variations influence the accuracy of HR-pQCT vBMD(trab) measurements, and must be considered when interpreting data across populations or time-points... - Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fracturesJanina M Patsch
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
J Bone Miner Res 28:313-24. 2013..9%, p = 0.060) at the ultradistal radius. The results of our study suggest that severe deficits in cortical bone quality are responsible for fragility fractures in postmenopausal diabetic women... - Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?Thomas Baum
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94107, USA
J Magn Reson Imaging 35:117-24. 2012.... - Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurementsRoland Krug
MQIR, Department of Radiology, University of California, San Francisco, CA 94143 2520, USA
Magn Reson Imaging 25:392-8. 2007.... - A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular boneAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, CA 94158, USA
Ann Biomed Eng 35:1678-86. 2007.... - Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCTAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
Bone 47:519-28. 2010..The results of this study provide informative data for the design of future clinical studies of bone quality... - Computational identification and quantification of trabecular microarchitecture classes by 3-D texture analysis-based clusteringAlexander Valentinitsch
Computational Image Analysis and Radiology Lab, Department of Radiology, Medical University of Vienna, Vienna, Austria
Bone 54:133-40. 2013..In conclusion, we could demonstrate that 3D-texture analysis and feature clustering seems to be a promising new HR-pQCT post-processing tool with good reproducibility, even between two different scanners... - Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritisJames R Pinney
UC Berkeley UCSF Graduate Program in Bioengineering, San Francisco, CA 94158 2330, USA
Magn Reson Imaging 30:271-82. 2012.... - The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructureWilly Tjong
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94107, USA
Med Phys 39:1893-903. 2012.... - Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatmentBjorn Jobke
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e23638. 2011.... - Resolution dependence of the non-metric trabecular structure indicesMiki Sode
Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley, San Francisco and Berkeley, CA, USA
Bone 42:728-36. 2008..g. relative resolution, the size of the treatment effect to detect, and specimen type). The results of this study provide an upper bound for the accuracy of the non-metric indices under limited resolution scenarios... - Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysisGalateia J Kazakia
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
Bone 52:623-31. 2013..We show that spatially-resolved analysis is able to identify cortical sub-regions with increased sensitivity to the effects of gender and aging... - High-resolution computed tomography for clinical imaging of bone microarchitectureAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, Campus Box 2520, QB3 Building, 2nd Floor, Suite 203, 1700 4th Street, San Francisco, CA 94158, USA
Clin Orthop Relat Res 469:2179-93. 2011..However, many technical and practical challenges remain to translate these techniques into established clinical outcomes... - Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopyAndrew J Burghardt
Musculoskeletal Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, QB3 Byers Hall, Suite 203, 1700 4th Street, San Francisco, CA 94158, USA
Bone 40:160-8. 2007..The advantages unique to SR-microCT allow for 3D visualization and quantification of pre-natal bone microstructure and mineral density in mice which was not previously possible... - Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged ratsMohammad Shahnazari
Department of Internal Medicine, University of California, Davis Medical Center, Sacramento, CA 95817, USA
Bone 46:1267-74. 2010.... - Quantitative and Semiquantitative Bone Erosion Assessment on High-resolution Peripheral Quantitative Computed Tomography in Rheumatoid ArthritisWaraporn Srikhum
From the Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, UCSF University of California, San Francisco, USA
J Rheumatol 40:408-16. 2013.... - Human disc nucleus properties and vertebral endplate permeabilityAzucena G Rodriguez
Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA
Spine (Phila Pa 1976) 36:512-20. 2011..Experimental quantification of relationships between vertebral endplate morphology, permeability, disc cell density, glycosaminoglycan (GAG) content, and degeneration in samples harvested from human cadaveric spines... - Vascular patterning and permeability in prostate cancer models with differing osteogenic propertiesHagit Dafni
Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
NMR Biomed 25:843-51. 2012....