Andrew J Burghardt

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3 Building, Suite 203, 1700 4th St, San Francisco, CA, 94158, USA
    Ann Biomed Eng 41:2553-64. 2013
  2. pmc Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 28:524-36. 2013
  3. pmc High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3 Building, Suite 203, San Francisco, California 94158, USA
    J Clin Endocrinol Metab 95:5045-55. 2010
  4. pmc A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 25:2558-71. 2010
  5. ncbi request reprint The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography
    Kevin A Davis
    Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA, USA
    Calcif Tissue Int 81:364-71. 2007
  6. pmc Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures
    Janina M Patsch
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    J Bone Miner Res 28:313-24. 2013
  7. pmc Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    J Bone Miner Res 25:983-93. 2010
  8. pmc Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD
    Galateia J Kazakia
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, USA
    J Biomech 44:257-66. 2011
  9. doi request reprint Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women
    Jenny Folkesson
    Musculoskeletal Quantitative Imaging Research Group MQIR, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Bone 48:611-21. 2011
  10. pmc Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis
    Galateia J Kazakia
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    Bone 52:623-31. 2013

Collaborators

Detail Information

Publications38

  1. pmc Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3 Building, Suite 203, 1700 4th St, San Francisco, CA, 94158, USA
    Ann Biomed Eng 41:2553-64. 2013
    ..MIN and JSW.SD were 370 and 110 μm, respectively. This study suggests that in vivo quantification of 3D joint space morphology from HR-pQCT, could improve early detection of joint damage in rheumatological diseases...
  2. pmc Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 28:524-36. 2013
    ..The data generated from this study will contribute to the future design and validation of standardized procedures that are broadly translatable to multicenter study designs...
  3. pmc High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3 Building, Suite 203, San Francisco, California 94158, USA
    J Clin Endocrinol Metab 95:5045-55. 2010
    ..Cross-sectional epidemiological studies have found that patients with type 2 diabetes mellitus (T2DM) have a higher incidence of certain fragility fractures despite normal or elevated bone mineral density (BMD)...
  4. pmc A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 25:2558-71. 2010
    ..48, p < .05). These findings suggest a more pronounced response to ALN in the tibia than in the radius, driven by trabecular and endocortical changes...
  5. ncbi request reprint The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography
    Kevin A Davis
    Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA, USA
    Calcif Tissue Int 81:364-71. 2007
    ..Furthermore, while the direct 3D Ct.Th method is less sensitive to threshold effects, both methods are moderate predictors of mechanical strength, with the annular method being the stronger correlate...
  6. pmc Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures
    Janina M Patsch
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    J Bone Miner Res 28:313-24. 2013
    ..9%, p = 0.060) at the ultradistal radius. The results of our study suggest that severe deficits in cortical bone quality are responsible for fragility fractures in postmenopausal diabetic women...
  7. pmc Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    J Bone Miner Res 25:983-93. 2010
    ..The biomechanical significance of these structural differences increases with age for men and women and provides discriminatory information for menopause-related bone quality effects...
  8. pmc Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD
    Galateia J Kazakia
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, USA
    J Biomech 44:257-66. 2011
    ..Overlap of these indices among osteoporotic status groups reflects the reported incidence of osteoporotic fracture in subjects classified as osteopenic or normal...
  9. doi request reprint Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women
    Jenny Folkesson
    Musculoskeletal Quantitative Imaging Research Group MQIR, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Bone 48:611-21. 2011
    ..Treatment effects were observed in the distal tibia after 24 months. The BE-FCM method increased correlations to HR-pQCT-based parameters...
  10. pmc Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis
    Galateia J Kazakia
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    Bone 52:623-31. 2013
    ..We show that spatially-resolved analysis is able to identify cortical sub-regions with increased sensitivity to the effects of gender and aging...
  11. doi request reprint Contribution of the intra-specimen variations in tissue mineralization to PTH- and raloxifene-induced changes in stiffness of rat vertebrae
    Sarah K Easley
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, CA CA 94720 1740, USA
    Bone 46:1162-9. 2010
    ....
  12. doi request reprint In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T
    Roland Krug
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    J Magn Reson Imaging 27:854-9. 2008
    ....
  13. ncbi request reprint In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging
    Galateia J Kazakia
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, California 94158, USA
    J Bone Miner Res 23:463-74. 2008
    ..Significant but moderate correlations and 2- to 4-fold discrepancies in parameter values were detected, suggesting that differences in acquisition and analysis must be considered when interpreting data from these imaging modalities...
  14. pmc Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?
    Thomas Baum
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94107, USA
    J Magn Reson Imaging 35:117-24. 2012
    ....
  15. pmc Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study
    Roland Krug
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    J Magn Reson Imaging 34:691-5. 2011
    ..To implement and examine the feasibility of a three-dimensional (3D) ultrashort TE (UTE) sequence on a 7 Tesla (T) clinical MR scanner in comparison with 3T MRI at high isotropic resolution...
  16. pmc Morphology of the human vertebral endplate
    Azucena G Rodriguez
    Department of Orthopaedic Surgery, University of California, San Francisco, California 94143, USA
    J Orthop Res 30:280-7. 2012
    ..Since ischemic disc cell behavior is commonly associated with degenerative change, this may be related to other factors such as the quality of vertebral capillaries, as opposed to decreased permeability of intervening tissues...
  17. pmc Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia
    Miki Sode
    Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
    Bone 46:1652-60. 2010
    ..Therefore, a combined approach of investigating the entire region, each subregion, and the cortical compartment may offer more complete information...
  18. doi request reprint Noninvasive imaging of bone microarchitecture
    Janina M Patsch
    Musculoskeletal Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Ann N Y Acad Sci 1240:77-87. 2011
    ....
  19. pmc Quantitative characterization of subject motion in HR-pQCT images of the distal radius and tibia
    Miki Sode
    Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley, San Francisco and Berkeley, CA, USA
    Bone 48:1291-7. 2011
    ..The results of this study may provide a basis for establishing a threshold for motion artifacts in accordance to the study design as well as a standardized quality control protocol across operators and imaging centers...
  20. pmc High-resolution imaging techniques for the assessment of osteoporosis
    Roland Krug
    MQIR, Department of Radiology and Biomedical Imaging, University of California San Francisco, UCSF China Basin Landing, 185 Berry Street, San Francisco, CA 94107, USA
    Radiol Clin North Am 48:601-21. 2010
    ..Details regarding imaging protocols as well as image postprocessing methods for bone structure quantification are discussed...
  21. doi request reprint Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography
    Kiranjit Sekhon
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107, USA
    Bone 45:473-9. 2009
    ..Our results confirm that geometric and densitometric variations influence the accuracy of HR-pQCT vBMD(trab) measurements, and must be considered when interpreting data across populations or time-points...
  22. pmc Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography
    Andrew J Burghardt
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
    Calcif Tissue Int 83:129-38. 2008
    ..80). In cortical bone specimens, the correlation was somewhat weaker when a global threshold was applied (R (2) = 0.67) compared to the local threshold method (R (2) = 0.78)...
  23. pmc Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
    Bone 47:519-28. 2010
    ..The results of this study provide informative data for the design of future clinical studies of bone quality...
  24. ncbi request reprint Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements
    Roland Krug
    MQIR, Department of Radiology, University of California, San Francisco, CA 94143 2520, USA
    Magn Reson Imaging 25:392-8. 2007
    ....
  25. ncbi request reprint A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, CA 94158, USA
    Ann Biomed Eng 35:1678-86. 2007
    ....
  26. doi request reprint Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis
    Waraporn Srikhum
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, UCSF University of California, San Francisco, CA, USA
    J Rheumatol 40:408-16. 2013
    ....
  27. doi request reprint Computational identification and quantification of trabecular microarchitecture classes by 3-D texture analysis-based clustering
    Alexander Valentinitsch
    Computational Image Analysis and Radiology Lab, Department of Radiology, Medical University of Vienna, Vienna, Austria
    Bone 54:133-40. 2013
    ..In conclusion, we could demonstrate that 3D-texture analysis and feature clustering seems to be a promising new HR-pQCT post-processing tool with good reproducibility, even between two different scanners...
  28. pmc Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis
    James R Pinney
    UC Berkeley UCSF Graduate Program in Bioengineering, San Francisco, CA 94158 2330, USA
    Magn Reson Imaging 30:271-82. 2012
    ....
  29. pmc The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure
    Willy Tjong
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94107, USA
    Med Phys 39:1893-903. 2012
    ....
  30. pmc Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment
    Bjorn Jobke
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e23638. 2011
    ....
  31. pmc Resolution dependence of the non-metric trabecular structure indices
    Miki Sode
    Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley, San Francisco and Berkeley, CA, USA
    Bone 42:728-36. 2008
    ..g. relative resolution, the size of the treatment effect to detect, and specimen type). The results of this study provide an upper bound for the accuracy of the non-metric indices under limited resolution scenarios...
  32. doi request reprint Structural analysis of cortical porosity applied to HR-pQCT data
    Willy Tjong
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94107
    Med Phys 41:013701. 2014
    ..The aim of this study was to introduce a novel topological analysis of the cortical pore network for HR-pQCT data and determine the influence of resolution on measures of cortical pore network microstructure and topology...
  33. pmc High-resolution computed tomography for clinical imaging of bone microarchitecture
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, Campus Box 2520, QB3 Building, 2nd Floor, Suite 203, 1700 4th Street, San Francisco, CA 94158, USA
    Clin Orthop Relat Res 469:2179-93. 2011
    ..However, many technical and practical challenges remain to translate these techniques into established clinical outcomes...
  34. ncbi request reprint Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, QB3 Byers Hall, Suite 203, 1700 4th Street, San Francisco, CA 94158, USA
    Bone 40:160-8. 2007
    ..The advantages unique to SR-microCT allow for 3D visualization and quantification of pre-natal bone microstructure and mineral density in mice which was not previously possible...
  35. pmc Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats
    Mohammad Shahnazari
    Department of Internal Medicine, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Bone 46:1267-74. 2010
    ....
  36. pmc Heterogeneity of bone microstructure in the femoral head in patients with osteoporosis: an ex vivo HR-pQCT study
    Ko Chiba
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    Bone 56:139-46. 2013
    ..We analyze trabecular bone microstructure in the femoral head with osteoporosis (OP) using high resolution peripheral quantitative CT (HR-pQCT) to investigate its regional characteristics...
  37. pmc Human disc nucleus properties and vertebral endplate permeability
    Azucena G Rodriguez
    Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA
    Spine (Phila Pa 1976) 36:512-20. 2011
    ..Experimental quantification of relationships between vertebral endplate morphology, permeability, disc cell density, glycosaminoglycan (GAG) content, and degeneration in samples harvested from human cadaveric spines...
  38. doi request reprint Vascular patterning and permeability in prostate cancer models with differing osteogenic properties
    Hagit Dafni
    Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    NMR Biomed 25:843-51. 2012
    ....