Shawn Burgess

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
    Matthew J Potthoff
    Departments of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Physiol Gastrointest Liver Physiol 304:G371-80. 2013
  2. pmc Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
    Shawn C Burgess
    The Advanced Imaging Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
    Cell Metab 5:313-20. 2007
  3. ncbi request reprint Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting
    Shawn C Burgess
    Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
    Am J Physiol Endocrinol Metab 289:E53-61. 2005
  4. ncbi request reprint Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 279:48941-9. 2004
  5. ncbi request reprint Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Anal Biochem 318:321-4. 2003
  6. ncbi request reprint Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas 75235 9085, USA
    Anal Biochem 312:228-34. 2003
  7. pmc Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR
    Natasha Hausler
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Biochem J 394:465-73. 2006
  8. ncbi request reprint Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy
    Brian C Weis
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 51:649-54. 2004
  9. pmc FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    Matthew J Potthoff
    Department of Pharmacology, Howard Hughes Medical Institute, Advanced Imaging Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:10853-8. 2009
  10. ncbi request reprint Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Anal Biochem 327:149-55. 2004

Collaborators

Detail Information

Publications38

  1. pmc Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
    Matthew J Potthoff
    Departments of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Physiol Gastrointest Liver Physiol 304:G371-80. 2013
    ..We conclude that colesevelam administration functions through a dual mechanism, which includes TGR5/GLP-1-dependent suppression of hepatic glycogenolysis and FXR-dependent cholesterol reduction...
  2. pmc Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
    Shawn C Burgess
    The Advanced Imaging Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
    Cell Metab 5:313-20. 2007
    ..However, PEPCK flux correlated tightly with TCA cycle activity, suggesting that under some conditions in mice, PEPCK expression must coordinate with hepatic energy metabolism to control gluconeogenesis...
  3. ncbi request reprint Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting
    Shawn C Burgess
    Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
    Am J Physiol Endocrinol Metab 289:E53-61. 2005
    ..The techniques used here are amenable to use as a secondary or tertiary tool for studying mouse models with disruptions of intermediary metabolism...
  4. ncbi request reprint Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 279:48941-9. 2004
    ..Inhibition of the TCA cycle and fatty acid oxidation due to increased TCA cycle intermediate concentrations and reduced mitochondrial red-ox state lead to the development of steatosis...
  5. ncbi request reprint Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Anal Biochem 318:321-4. 2003
  6. ncbi request reprint Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine
    Shawn C Burgess
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas 75235 9085, USA
    Anal Biochem 312:228-34. 2003
    ..The method should find use in metabolic studies of infants and other populations where blood sampling is either limited or problematic...
  7. pmc Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR
    Natasha Hausler
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Biochem J 394:465-73. 2006
    ..The tight correlation of these two pathways under multiple conditions suggest that interventions which increase or decrease hepatic tricarboxylic-acid-cycle flux will have a concomitant effect on gluconeogenesis and vice versa...
  8. ncbi request reprint Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy
    Brian C Weis
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 51:649-54. 2004
    ..42 +/- 0.12 (P < 0.05) among subjects with lipoatrophy, and the TCA cycle contribution was reduced. Lipoatrophy was associated with an abnormal profile of glucose production as assessed by (13)C and (2)H NMR of plasma and urine...
  9. pmc FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    Matthew J Potthoff
    Department of Pharmacology, Howard Hughes Medical Institute, Advanced Imaging Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:10853-8. 2009
    ..These results reveal an unexpected relationship between FGF21 and PGC-1alpha and demonstrate an important role for FGF21 in coordinately regulating carbohydrate and fatty acid metabolism during the progression from fasting to starvation...
  10. ncbi request reprint Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Anal Biochem 327:149-55. 2004
    ..6), and TCA cycle flux (49.1+/-16.8). In a separate group of rats, glucose production was not different in the absence of (2)H(2)O and [U-(13)C]propionate, demonstrating that these tracers do not alter the measurement of glucose turnover...
  11. pmc Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism
    Santhosh Satapati
    The Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diabetes 57:2012-21. 2008
    ..The purpose of this study is to determine whether abnormal mitochondrial metabolism plays a role in the dysregulation of both hepatic fat and glucose metabolism during diabetes...
  12. ncbi request reprint Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 278:28427-33. 2003
    ..Liver glycogen repletion was also brisk throughout the study period, reaching approximately 30 micromol/g at 3 h. These data demonstrate that Fru-2,6-P2 does not inhibit gluconeogenesis significantly in vivo...
  13. ncbi request reprint Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver
    Shawn C Burgess
    Department of Biochemistry, Advanced Imaging Research Center, University of Texas Southwestern Medical School and Veterans Affairs, 5323 Harry Hines Blvd, Dallas, TX 75390 8854, USA
    J Biol Chem 283:1670-8. 2008
    ..Overall, the shift from fat utilization to pyruvate and lactate utilization resulted in a decrease in the energy of ATP hydrolysis and a hypo-energetic state in the livers of ChREBP(-/-) mice...
  14. ncbi request reprint Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase
    Daniela Rogoff
    University of Texas Southwestern Medical Center, 5223 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    Endocrinology 148:5072-80. 2007
    ..Comparison with other animal models of adrenal insufficiency suggests that many of the observed abnormalities can be explained by blunted intracellular corticosterone actions, despite elevated circulating levels of this hormone...
  15. ncbi request reprint A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content
    Jeffrey D Browning
    Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9085, USA
    Hepatology 44:487-8. 2006
  16. ncbi request reprint Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy
    Kimberly A Stowe
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    FEBS Lett 580:4282-7. 2006
    ..24 micromol/g dry wt/min, similar to the rate of oxidation of long-chain fatty acids, 0.16 micromol/g dry wt/min. Isoproterenol decreased the rate of de novo triglyceride synthesis and increased the rate of fatty acid oxidation...
  17. pmc Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction
    Jeffrey D Browning
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, TX, USA
    Hepatology 48:1487-96. 2008
    ..However, the relationship between these two pathways is modified by carbohydrate restriction, suggesting an increased reliance of the hepatocyte on energy generated outside of the TCA cycle when GNG(PEP) is maximal...
  18. pmc 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)
    Danhong Lu
    Touchstone Center for Diabetes Research, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 99:2708-13. 2002
    ..These findings indicate that exchange of pyruvate with TCA cycle intermediates, rather than oxidation of pyruvate via acetyl-CoA, correlates with glucose-stimulated insulin secretion...
  19. ncbi request reprint Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance
    Eunsook S Jin
    Mary Nell and Ralph B Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 53:1479-83. 2005
    ....
  20. ncbi request reprint Adiabatic JHSQC for 13C isotopomer analysis
    Matthew E Merritt
    University of Texas Southwestern Medical Center, Advanced Imaging Research Center, 2201 Inwood Road, NE 4 204, Dallas, TX 775390 8568, USA
    Magn Reson Chem 44:463-6. 2006
    ..This new experiment allows the sensitivity gains from inverse detection to be realized in a time-efficient manner for the experimentalist...
  21. ncbi request reprint Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose
    Eunsook S Jin
    The Mary Nell and Ralph B Rogers Magnetic Resonance Center, 5801 Forest Park Road, Dallas, TX 75235 9085, USA
    Am J Physiol Endocrinol Metab 288:E654-62. 2005
    ..The differing mechanisms of excess glucose production in these models were easily distinguished by integrated 2H and 13C NMR analysis of plasma glucose...
  22. ncbi request reprint Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra
    Matthew Merritt
    Department of Radiology, The Mary Nell and Ralph B Rogers Magnetic Resonance Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    Magn Reson Med 50:659-63. 2003
    ..The combined MCMC Bayesian methodology is operationally simple and requires little intervention from the operator...
  23. ncbi request reprint Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 5:415-25. 2007
    ..These findings demonstrate an unexpected role for the PPARalpha-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation...
  24. pmc Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice
    Shawn C Burgess
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9085, USA
    J Biol Chem 281:19000-8. 2006
    ....
  25. pmc Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet
    Nishanth E Sunny
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
    Am J Physiol Endocrinol Metab 298:E1226-35. 2010
    ..We conclude that mitochondrial fat oxidation is stimulated rather than impaired during the initiation of hepatic insulin resistance in mice...
  26. ncbi request reprint Lung preservation solution substrate composition affects rat lung oxidative metabolism during hypothermic storage
    Matthias Peltz
    Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8879, USA
    Respir Physiol Neurobiol 148:275-83. 2005
    ..These data suggest that altering the substrate composition of the preservation solution influences lung metabolism during allograft preservation for transplantation...
  27. pmc Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart
    Xinxin Yu
    Department of Physiology, Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:1767-72. 2005
    ..This mouse model will be useful to elucidate the role of reduced fatty acid supply in the pathogenesis of heart failure and related disorders...
  28. ncbi request reprint Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy
    Guixiang Zhao
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Am J Physiol Heart Circ Physiol 294:H936-43. 2008
    ..These results demonstrate that cardiac-specific overexpression of PDK4 is sufficient to cause a loss of metabolic flexibility that exacerbates cardiomyopathy caused by the calcineurin stress-activated pathway...
  29. ncbi request reprint Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation
    Pengxiang She
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 52:1649-54. 2003
    ....
  30. pmc Complicating factors in the application of the "average method" for determining the contribution of gluconeogenesis
    Shawn C Burgess
    J Appl Physiol 104:1852-3; author reply 1854-5. 2008
  31. ncbi request reprint Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue
    Anne Boucher
    Sarah W Stedman Nutrition and Metabolism Center and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:27263-71. 2004
    ..We conclude that chronic exposure of islet beta-cells to fatty acids grossly alters a mitochondrial pathway of pyruvate metabolism that is important for normal GSIS...
  32. pmc Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism
    Sarah M Ronnebaum
    Sarah W Stedman Nutrition and Metabolism Center and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27704, USA
    J Biol Chem 283:14248-56. 2008
    ..In sum, chronic, but not acute, suppression of ACC1 activity impairs GSIS via inhibition of glucose rather than lipid metabolism. These findings raise concerns about the use of ACC inhibitors for diabetes therapy...
  33. ncbi request reprint Evidence that processes other than gluconeogenesis may influence the ratio of deuterium on the fifth and third carbons of glucose: implications for the use of 2H2O to measure gluconeogenesis in humans
    Gerlies Bock
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Diabetes 57:50-5. 2008
    ..The current studies determined whether C3 and C5 glucose enrichment is influenced by processes other than gluconeogenesis...
  34. ncbi request reprint Hepatic UDP-glucose 13C isotopomers from [U-13C]glucose: a simple analysis by 13C NMR of urinary menthol glucuronide
    Ana C Mendes
    Department of Chemistry, University of Coimbra, Coimbra, Portugal
    Magn Reson Med 56:1121-5. 2006
    ..9% +/- 0.2%. From these data, flux of plasma glucose to hepatic UDPG was estimated to be 15% +/- 4% that of endogenous glucose production (EGP), and the Cori cycle accounted for at least 32% +/- 10% of GP...
  35. ncbi request reprint A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion
    Sarah M Ronnebaum
    Sarah W Stedman Nutrition and Metabolism Center and Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27704, USA
    J Biol Chem 281:30593-602. 2006
    ..Based on these studies, we propose that a pyruvate cycling pathway involving ICDc plays an important role in control of GSIS...
  36. ncbi request reprint Perfusion preservation maintains myocardial ATP levels and reduces apoptosis in an ex vivo rat heart transplantation model
    Matthias Peltz
    Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center at Dallas, 75390 8879, USA
    Surgery 138:795-805. 2005
    ..We evaluated representative extracellular (Celsior) and intracellular (University of Wisconsion) storage solutions using static and perfusion protective strategies over a clinically relevant preservation period...
  37. ncbi request reprint The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism
    Stephanie Chevalier
    McGill Nutrition and Food Science Centre, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Ave West, Montreal, Quebec, Canada, H3A 1A1
    Diabetes 55:675-81. 2006
    ..Due to increased protein turnover rates, greater supply of gluconeogenic amino acids to the liver may trigger their preferential use over glycogen for glucose production...
  38. ncbi request reprint Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion
    Jamie W Joseph
    Sarah W Stedman Nutrition and Metabolism Center and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27704, USA
    J Biol Chem 282:31592-600. 2007
    ..These findings demonstrate that a normal rate of flux of glucose carbons through CL and FAS is not required for GSIS in insulinoma cell lines or rat islets...

Research Grants4

  1. Factors Controlling Metabolic Flux in the Liver by NMR Isotopomer Analysis
    Shawn Burgess; Fiscal Year: 2009
    ..Ultimately, this knowledge is critical for development and interpretation of molecular or pharmacological interventions that modulate these pathways, either by design or happenstance. ..
  2. Factors Controlling Metabolic Flux in the Liver by NMR Isotopomer Analysis
    Shawn C Burgess; Fiscal Year: 2010
    ..Ultimately, this knowledge is critical for development and interpretation of molecular or pharmacological interventions that modulate these pathways, either by design or happenstance. ..
  3. Factors Controlling Metabolic Flux in the Liver by NMR Isotopomer Analysis
    Shawn C Burgess; Fiscal Year: 2010
    ..Nuclear magnetic resonance (NMR) isotopomer analysis will be used to measure metabolic fluxes and these techniques will be corroborated by simultaneous hepatic mass balance determinations. Project Description Page 6 ..