Gilbert J Burckart

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Ciclosporin aerosol in lung transplantation
    Gilbert J Burckart
    University of Southern California, Department of Pharmacy, 1985 Zonal Avenue, PSC 100, Los Angeles, CA 90033, USA
    Expert Opin Investig Drugs 15:981-6. 2006
  2. ncbi request reprint Pharmacogenomics and lung transplantation: clinical implications
    G J Burckart
    Department of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Pharmacogenomics J 6:301-10. 2006
  3. ncbi request reprint Transplant pharmacy: 30 years of improving patient care
    Gilbert J Burckart
    Department of Pharmacy, University of Southern California, 1540 Alcazar St, CHP 217E, Los Angeles, CA 90033, USA
    Ann Pharmacother 41:1261-3. 2007
  4. ncbi request reprint Qualification of biomarkers for drug development in organ transplantation
    Gilbert J Burckart
    School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Am J Transplant 8:267-70. 2008
  5. ncbi request reprint Pharmacogenetics in transplant patients: can it predict pharmacokinetics and pharmacodynamics?
    Gilbert J Burckart
    University of Southern California School of Pharmacy, Los Angeles, USA
    Ther Drug Monit 28:23-30. 2006
  6. ncbi request reprint Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5 *3/*3 non-expressors
    Jian Wang
    University of Southern California, 1985, Zonal Ave, PSC 100, Los Angeles, CA 90033, USA
    Transpl Immunol 15:235-40. 2006
  7. ncbi request reprint Sequential analysis of tacrolimus dosing in adult lung transplant patients with ABCB1 haplotypes
    HongXia Zheng
    PharmD, University of Southern California, 1985 Zonal Avenue, PSC 100, Los Angeles, CA 90033 1086, USA
    J Clin Pharmacol 45:404-10. 2005
  8. doi request reprint Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis
    Paul M Beringer
    Department of Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Pharmacotherapy 28:883-94. 2008
  9. ncbi request reprint The impact of P-glycoprotein and Mrp2 on mycophenolic acid levels in mice
    Jian Wang
    Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, Los Angeles, CA 90089, United States
    Transpl Immunol 19:192-6. 2008
  10. doi request reprint Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine
    Shanshan Liu
    Department of Pharmacy, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Clin Pharmacol 48:957-65. 2008

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Ciclosporin aerosol in lung transplantation
    Gilbert J Burckart
    University of Southern California, Department of Pharmacy, 1985 Zonal Avenue, PSC 100, Los Angeles, CA 90033, USA
    Expert Opin Investig Drugs 15:981-6. 2006
    ....
  2. ncbi request reprint Pharmacogenomics and lung transplantation: clinical implications
    G J Burckart
    Department of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Pharmacogenomics J 6:301-10. 2006
  3. ncbi request reprint Transplant pharmacy: 30 years of improving patient care
    Gilbert J Burckart
    Department of Pharmacy, University of Southern California, 1540 Alcazar St, CHP 217E, Los Angeles, CA 90033, USA
    Ann Pharmacother 41:1261-3. 2007
  4. ncbi request reprint Qualification of biomarkers for drug development in organ transplantation
    Gilbert J Burckart
    School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Am J Transplant 8:267-70. 2008
    ....
  5. ncbi request reprint Pharmacogenetics in transplant patients: can it predict pharmacokinetics and pharmacodynamics?
    Gilbert J Burckart
    University of Southern California School of Pharmacy, Los Angeles, USA
    Ther Drug Monit 28:23-30. 2006
    ..At this point, treatment algorithms can be developed that will allow us to individualize a transplant patient's immunosuppressive therapy...
  6. ncbi request reprint Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5 *3/*3 non-expressors
    Jian Wang
    University of Southern California, 1985, Zonal Ave, PSC 100, Los Angeles, CA 90033, USA
    Transpl Immunol 15:235-40. 2006
    ..The objective of this study was to assess the effect of ABCB1 haplotypes from 3 distinct polymorphic sites on the tacrolimus level/dose [L/D] in lung transplant patients limited to CYP3A5 *3/*3 non-expressors...
  7. ncbi request reprint Sequential analysis of tacrolimus dosing in adult lung transplant patients with ABCB1 haplotypes
    HongXia Zheng
    PharmD, University of Southern California, 1985 Zonal Avenue, PSC 100, Los Angeles, CA 90033 1086, USA
    J Clin Pharmacol 45:404-10. 2005
    ..Sequential analysis of drug dosing and haplotypes relationships can provide important information about the induction or inhibition of drug-drug and disease-drug interactions among specific haplotypes...
  8. doi request reprint Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis
    Paul M Beringer
    Department of Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Pharmacotherapy 28:883-94. 2008
    ..To determine whether upregulation of P-glycoprotein is responsible for the enhanced renal clearance of dicloxacillin in patients with cystic fibrosis...
  9. ncbi request reprint The impact of P-glycoprotein and Mrp2 on mycophenolic acid levels in mice
    Jian Wang
    Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, Los Angeles, CA 90089, United States
    Transpl Immunol 19:192-6. 2008
    ..Drug-transporter interactions must be considered in patients receiving mycophenolic acid products...
  10. doi request reprint Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine
    Shanshan Liu
    Department of Pharmacy, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Clin Pharmacol 48:957-65. 2008
    ..Probenecid administration significantly reduced the total body and renal clearance of fexofenadine. ABCB1 3435 C/T was associated with an elevated efflux activity compared with C/C subjects...
  11. ncbi request reprint A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity
    Jian Wang
    Department of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Pharmacogenet Genomics 17:283-90. 2007
    ..Therefore, the objective of this study was to identify and functionally characterize IMPDH2 variants...
  12. doi request reprint A novel method for monitoring glucocorticoid-induced changes of the glucocorticoid receptor in kidney transplant recipients
    Yan Chen
    University of Southern California, Los Angeles, CA, USA
    Transpl Immunol 20:249-52. 2009
    ....
  13. ncbi request reprint Tacrolimus dosing in adult lung transplant patients is related to cytochrome P4503A5 gene polymorphism
    HongXia Zheng
    School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 100, Los Angeles, CA 90033, USA
    J Clin Pharmacol 44:135-40. 2004
    ..This was not uniformly true for MDR1. The authors therefore conclude that tacrolimus dosing in adult lung transplant patients is associated with CYP3A5 gene polymorphisms...
  14. doi request reprint Evaluation of hepatic impairment dosing recommendations in FDA-approved product labels
    Yang Chang
    School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Clin Pharmacol 53:962-6. 2013
    ..Updating the FDA guidance on PK studies in patients with impaired hepatic function could provide a standardized approach to improve the clinical usefulness of this dosing information for practitioners. ..
  15. ncbi request reprint The impact of pharmacogenomic factors on acute persistent rejection in adult lung transplant patients
    H X Zheng
    School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 100, Los Angeles, CA 90033, USA
    Transpl Immunol 14:37-42. 2005
    ..Future prospective treatment algorithms should be developed that will incorporate the knowledge of gene polymorphisms into treatment regimens to improve the outcome following lung transplantation...
  16. ncbi request reprint The impact of pharmacogenomic factors on steroid dependency in pediatric heart transplant patients using logistic regression analysis
    H X Zheng
    School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Pediatr Transplant 8:551-7. 2004
    ..This approach identifies pharmacogenomic factors, which can be studied more extensively in larger data sets, and used in prospective studies to individualize immunosuppressive therapy following solid organ transplantation...
  17. ncbi request reprint Evaluation of renal drug dosing: prescribing information and clinical pharmacist approaches
    Thomas C Dowling
    Department of Pharmacy Practice and Science, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Pharmacotherapy 30:776-86. 2010
    ....
  18. ncbi request reprint Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506)
    P N V Tata
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    Xenobiotica 39:757-65. 2009
    ..From the current in-vitro metabolism studies, the pattern of tacroliums metabolism in baboons closely resembled that in humans and thus it is ideal for studying tacroliums metabolism-related work of clinical relevance...
  19. ncbi request reprint Effect of age and postoperative time on cytochrome p450 enzyme activity following liver transplantation
    Shanshan Liu
    School of Pharmacy, University of Southern California, 1985 Zonal Ave, PSC 100, Los Angeles, CA 90033, USA
    J Clin Pharmacol 45:666-73. 2005
    ..CYP2D6 capacity was impaired after 30 days postoperatively. Younger and older OLTx patients experienced similar changes in major CYP450 enzyme capacity following liver transplantation...
  20. ncbi request reprint IMPDH1 gene polymorphisms and association with acute rejection in renal transplant patients
    J Wang
    Department of Pharmacy, University of Southern California, Los Angeles, California, USA
    Clin Pharmacol Ther 83:711-7. 2008
    ..Future studies of the multifactorial nature of acute rejection must consider IMPDH1 polymorphisms in MPA-treated patients...
  21. ncbi request reprint P-glycoprotein (P-gp) is upregulated in peripheral T-cell subsets from solid organ transplant recipients
    V S Donnenberg
    Department of Medicine, School of Pharmacy, University of Pittsburgh, Pennsylvania 15213, USA
    J Clin Pharmacol 41:1271-9. 2001
    ....
  22. ncbi request reprint The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients
    HongXia Zheng
    Schools of Pharmacy and Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Immunol 63:765-70. 2002
    ..001). We conclude that (a) a significantly larger number of MDR1 3435 CC HTx patients remain on steroids at 1 year after transplantation, and (b) the MDR1 C3435T genotype is associated with the G2677 genotype in pediatric HTx patients...
  23. ncbi request reprint Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and MDR1 gene polymorphisms
    HongXia Zheng
    Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 3:477-83. 2003
    ....
  24. ncbi request reprint Genetic polymorphisms impact the risk of acute rejection in pediatric heart transplantation: a multi-institutional study
    Diana M Girnita
    Department of Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh, PA, USA
    Transplantation 85:1632-9. 2008
    ....
  25. ncbi request reprint New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process
    Shiew Mei Huang
    Office of Clinical Pharmacology, CDER, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    J Clin Pharmacol 48:662-70. 2008
    ....
  26. ncbi request reprint A randomized trial of inhaled cyclosporine in lung-transplant recipients
    Aldo T Iacono
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA
    N Engl J Med 354:141-50. 2006
    ..Topical delivery of cyclosporine in addition to conventional systemic immunosuppression might help prevent acute and chronic rejection events...
  27. ncbi request reprint Cyclosporine monitoring. 1986
    Gilbert J Burckart
    Ann Pharmacother 41:1277-80. 2007
  28. ncbi request reprint P-glycoprotein activity is decreased in CD4+ but not CD8+ lung allograft-infiltrating T cells during acute cellular rejection
    Vera S Donnenberg
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Transplantation 77:1699-706. 2004
    ..Modulation of P-glycoprotein (P-gp) activity in graft-infiltrating T cells may alter their susceptibility to immunosuppression...
  29. ncbi request reprint Looking beneath the surface of the CYP3A5 polymorphism
    Gilbert J Burckart
    Pediatr Transplant 11:239-40. 2007
  30. ncbi request reprint Interleukin-10 production genotype protects against acute persistent rejection after lung transplantation
    Hong Xia Zheng
    Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Heart Lung Transplant 23:541-6. 2004
    ..The objective of this study was to determine whether cytokine genotypes TNF-alpha, IL-10, IL-6, interferon-gamma, and transforming growth factor beta were associated with acute persistent rejection after lung transplantation...
  31. ncbi request reprint Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure
    Joseph A Carcillo
    Division of Critical Care Medicine, Children s Hospital of Pittsburgh, 3705 5th Ave, Pittsburgh, PA 15123, USA
    Intensive Care Med 29:980-4. 2003
    ..Because interleukin-6 and nitric oxide production increases in children with sepsis-induced multiple organ failure, we hypothesized impaired CYP 450 mediated drug metabolism in this population...
  32. ncbi request reprint Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients
    Diana M Girnita
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Transplantation 82:1774-80. 2006
    ..Allograft failure in African-Americans remains higher than in Caucasians. Single nucleotide polymorphisms (SNPs) have been associated with altered allograft outcomes...
  33. ncbi request reprint Pharmacokinetic study of mycophenolic acid in Korean kidney transplant patients
    Eun Kyung Cho
    Graduate School of Clinical Pharmacy, Sookmyung Women s University, 53 12 Chungpadong 2 ka, Yongsan gu, Seoul, 140 742 Korea
    J Clin Pharmacol 44:743-50. 2004
    ..MPA concentrations of predose and 1- and 8-hour postdose were positively correlated with AUC...