CHRISTINA BURCH

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc The genetic basis of thermal reaction norm evolution in lab and natural phage populations
    Jennifer L Knies
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS Biol 4:e201. 2006
  2. ncbi request reprint Patterns of epistasis in RNA viruses: a review of the evidence from vaccine design
    C L Burch
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Evol Biol 16:1223-35. 2003
  3. pmc Experimental estimate of the abundance and effects of nearly neutral mutations in the RNA virus phi 6
    Christina L Burch
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27516, USA
    Genetics 176:467-76. 2007
  4. pmc Epistasis and its relationship to canalization in the RNA virus phi 6
    Christina L Burch
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genetics 167:559-67. 2004
  5. pmc High frequency of mutations that expand the host range of an RNA virus
    Martin T Ferris
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genetics 176:1013-22. 2007
  6. doi request reprint Hotter is better and broader: thermal sensitivity of fitness in a population of bacteriophages
    Jennifer L Knies
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am Nat 173:419-30. 2009
  7. pmc Architecture and secondary structure of an entire HIV-1 RNA genome
    Joseph M Watts
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
    Nature 460:711-6. 2009
  8. ncbi request reprint Sexual reproduction selects for robustness and negative epistasis in artificial gene networks
    Ricardo B R Azevedo
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Nature 440:87-90. 2006
  9. pmc Pleiotropic costs of niche expansion in the RNA bacteriophage phi 6
    Siobain Duffy
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520 8106, USA
    Genetics 172:751-7. 2006
  10. ncbi request reprint Evolution of host specificity drives reproductive isolation among RNA viruses
    Siobain Duffy
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
    Evolution 61:2614-22. 2007

Research Grants

  1. Viral evolution:mutational effects and interactions
    CHRISTINA BURCH; Fiscal Year: 2007

Collaborators

Detail Information

Publications10

  1. pmc The genetic basis of thermal reaction norm evolution in lab and natural phage populations
    Jennifer L Knies
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS Biol 4:e201. 2006
    ....
  2. ncbi request reprint Patterns of epistasis in RNA viruses: a review of the evidence from vaccine design
    C L Burch
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Evol Biol 16:1223-35. 2003
    ..RNA viruses are significant pathogens of human disease, and are tractable model systems for evolutionary studies--we discuss the relevance of our findings in both contexts...
  3. pmc Experimental estimate of the abundance and effects of nearly neutral mutations in the RNA virus phi 6
    Christina L Burch
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27516, USA
    Genetics 176:467-76. 2007
    ....
  4. pmc Epistasis and its relationship to canalization in the RNA virus phi 6
    Christina L Burch
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genetics 167:559-67. 2004
    ..In addition, our results suggest that genetic and environmental canalization have the same developmental basis and finally that an understanding of the nature of epistasis may first require an understanding of the nature of canalization...
  5. pmc High frequency of mutations that expand the host range of an RNA virus
    Martin T Ferris
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genetics 176:1013-22. 2007
    ..Thus, colonization of novel hosts is unlikely to be limited by an inability to produce appropriate mutations...
  6. doi request reprint Hotter is better and broader: thermal sensitivity of fitness in a population of bacteriophages
    Jennifer L Knies
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am Nat 173:419-30. 2009
    ..We found that the temperature sensitivity of fitness for phages is similar to that for insects...
  7. pmc Architecture and secondary structure of an entire HIV-1 RNA genome
    Joseph M Watts
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
    Nature 460:711-6. 2009
    ..These results emphasize that the HIV-1 genome and, potentially, many coding RNAs are punctuated by previously unrecognized regulatory motifs and that extensive RNA structure constitutes an important component of the genetic code...
  8. ncbi request reprint Sexual reproduction selects for robustness and negative epistasis in artificial gene networks
    Ricardo B R Azevedo
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Nature 440:87-90. 2006
    ..Our results suggest that sexual reproduction selects for conditions that favour its own maintenance, a case of evolution forging its own path...
  9. pmc Pleiotropic costs of niche expansion in the RNA bacteriophage phi 6
    Siobain Duffy
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520 8106, USA
    Genetics 172:751-7. 2006
    ..The possibility for cost-free niche expansion implies that varied ecological conditions may favor host shifts in RNA viruses...
  10. ncbi request reprint Evolution of host specificity drives reproductive isolation among RNA viruses
    Siobain Duffy
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
    Evolution 61:2614-22. 2007
    ..Furthermore, our data confirm the biological credibility of simple "no-gene" mechanisms of assortative mating, in which this trait arises as a pleiotropic effect of genes responsible for ecological adaptation...

Research Grants5

  1. Viral evolution:mutational effects and interactions
    CHRISTINA BURCH; Fiscal Year: 2007
    ..abstract_text> ..