CHRISTINA BURCHSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
The genetic basis of thermal reaction norm evolution in lab and natural phage populationsJennifer L Knies
Department of Biology, University of North Carolina, Chapel Hill, North Carolina, USA
PLoS Biol 4:e201. 2006....
Patterns of epistasis in RNA viruses: a review of the evidence from vaccine designC L Burch
Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
J Evol Biol 16:1223-35. 2003..RNA viruses are significant pathogens of human disease, and are tractable model systems for evolutionary studies--we discuss the relevance of our findings in both contexts...
Experimental estimate of the abundance and effects of nearly neutral mutations in the RNA virus phi 6Christina L Burch
Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27516, USA
Genetics 176:467-76. 2007....- Epistasis and its relationship to canalization in the RNA virus phi 6Christina L Burch
Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Genetics 167:559-67. 2004..In addition, our results suggest that genetic and environmental canalization have the same developmental basis and finally that an understanding of the nature of epistasis may first require an understanding of the nature of canalization... - High frequency of mutations that expand the host range of an RNA virusMartin T Ferris
Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Genetics 176:1013-22. 2007..Thus, colonization of novel hosts is unlikely to be limited by an inability to produce appropriate mutations... 
Hotter is better and broader: thermal sensitivity of fitness in a population of bacteriophagesJennifer L Knies
Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
Am Nat 173:419-30. 2009..We found that the temperature sensitivity of fitness for phages is similar to that for insects...- Architecture and secondary structure of an entire HIV-1 RNA genomeJoseph M Watts
Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
Nature 460:711-6. 2009..These results emphasize that the HIV-1 genome and, potentially, many coding RNAs are punctuated by previously unrecognized regulatory motifs and that extensive RNA structure constitutes an important component of the genetic code... - Sexual reproduction selects for robustness and negative epistasis in artificial gene networksRicardo B R Azevedo
Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
Nature 440:87-90. 2006..Our results suggest that sexual reproduction selects for conditions that favour its own maintenance, a case of evolution forging its own path... - Pleiotropic costs of niche expansion in the RNA bacteriophage phi 6Siobain Duffy
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520 8106, USA
Genetics 172:751-7. 2006..The possibility for cost-free niche expansion implies that varied ecological conditions may favor host shifts in RNA viruses... - Evolution of host specificity drives reproductive isolation among RNA virusesSiobain Duffy
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
Evolution 61:2614-22. 2007..Furthermore, our data confirm the biological credibility of simple "no-gene" mechanisms of assortative mating, in which this trait arises as a pleiotropic effect of genes responsible for ecological adaptation...
Research Grants
- Viral evolution:mutational effects and interactionsCHRISTINA BURCH; Fiscal Year: 2007..abstract_text> ..