William E Bunney

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Sleep improves memory: the effect of sleep on long term memory in early adolescence
    Katya Trudeau Potkin
    Department of Human Biology, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 7:e42191. 2012
  2. pmc Sample matching by inferred agonal stress in gene expression analyses of the brain
    Jun Z Li
    Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
    BMC Genomics 8:336. 2007
  3. ncbi request reprint Structured Interview for Assessing Perceptual Anomalies (SIAPA)
    W E Bunney
    Department of Psychiatry and Human Behavior, University of California, Irvine 92717, USA
    Schizophr Bull 25:577-92. 1999
  4. ncbi request reprint Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders
    William E Bunney
    Department of Psychiatry, University of California, Irvine 92697, USA
    Am J Psychiatry 160:657-66. 2003
  5. ncbi request reprint Molecular clock genes in man and lower animals: possible implications for circadian abnormalities in depression
    W E Bunney
    Department of Psychiatry, College of Medicine, D438 Medical Sciences Building 1, University of California Irvine, Irvine, CA 92697 1675, USA
    Neuropsychopharmacology 22:335-45. 2000
  6. pmc Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
    Maureen V Martin
    Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
    BMC Med Genomics 2:62. 2009
  7. doi request reprint Gating of a novel brain potential is associated with perceptual anomalies in bipolar disorder
    JULIE V PATTERSON
    Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, CA, USA
    Bipolar Disord 15:314-25. 2013
  8. pmc Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
    Hiroaki Tomita
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 1675, USA
    Biol Psychiatry 55:346-52. 2004
  9. pmc Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide
    Adolfo Sequeira
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 7:e35367. 2012
  10. pmc Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder
    Brandi Rollins
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e4913. 2009

Research Grants

Detail Information

Publications40

  1. pmc Sleep improves memory: the effect of sleep on long term memory in early adolescence
    Katya Trudeau Potkin
    Department of Human Biology, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 7:e42191. 2012
    ..Declarative memory is significantly improved by sleep in a sample of normal adolescents...
  2. pmc Sample matching by inferred agonal stress in gene expression analyses of the brain
    Jun Z Li
    Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
    BMC Genomics 8:336. 2007
    ..This problem is analogous to the one encountered in genetic association studies, where self-reported race and ethnicity are often imprecise proxies for an individual's actual genetic ancestry...
  3. ncbi request reprint Structured Interview for Assessing Perceptual Anomalies (SIAPA)
    W E Bunney
    Department of Psychiatry and Human Behavior, University of California, Irvine 92717, USA
    Schizophr Bull 25:577-92. 1999
    ..The data indicate that the putative phenomenological correlates of sensory gating may be reliably measured and tested with the Structured Interview for Assessing Perceptual Anomalies...
  4. ncbi request reprint Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders
    William E Bunney
    Department of Psychiatry, University of California, Irvine 92697, USA
    Am J Psychiatry 160:657-66. 2003
    ..Instead of studying one gene at a time, microarrays provide the opportunity to analyze thousands of genes at once...
  5. ncbi request reprint Molecular clock genes in man and lower animals: possible implications for circadian abnormalities in depression
    W E Bunney
    Department of Psychiatry, College of Medicine, D438 Medical Sciences Building 1, University of California Irvine, Irvine, CA 92697 1675, USA
    Neuropsychopharmacology 22:335-45. 2000
    ....
  6. pmc Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
    Maureen V Martin
    Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
    BMC Med Genomics 2:62. 2009
    ..The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives...
  7. doi request reprint Gating of a novel brain potential is associated with perceptual anomalies in bipolar disorder
    JULIE V PATTERSON
    Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, CA, USA
    Bipolar Disord 15:314-25. 2013
    ..In order to evaluate the phenomenological significance of P85 gating, the current study examined reports of perceptual anomalies and their relationship to the P50 and P85 physiological measures of sensory gating...
  8. pmc Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
    Hiroaki Tomita
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 1675, USA
    Biol Psychiatry 55:346-52. 2004
    ..Reducing the variance due to agonal factors is critical in investigating small but validated gene expression differences in messenger RNA levels between psychiatric patients and control subjects...
  9. pmc Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide
    Adolfo Sequeira
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 7:e35367. 2012
    ..Our results thus suggest that suicide-specific expression changes in mood disorders involve both glucocorticoids regulated metallothioneins and serotonergic signaling in different regions of the brain...
  10. pmc Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder
    Brandi Rollins
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e4913. 2009
    ..Several mutations in mitochondrial DNA (mtDNA) sequence have been reported in SZ and BD patients...
  11. pmc Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex
    Ilaria Guella
    Functional Genomics Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
    J Psychiatr Res 47:1215-21. 2013
    ..This study offers additional support for involvement of miR-137 and downstream targets as mechanisms of risk for psychiatric disorders. ..
  12. pmc Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population
    Emily Moon
    Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA
    Schizophr Res 131:52-7. 2011
    ..The previous genetic relationship between expression of a putative brain-specific isoform of NRG1 type IV and SNP variation was replicated in postmortem samples in our preliminary study...
  13. pmc Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex
    Ilaria Guella
    Functional Genomics Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
    Schizophr Res 152:111-6. 2014
    ....
  14. pmc Mitochondrial involvement in psychiatric disorders
    Ling Shao
    Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine CA, USA
    Ann Med 40:281-95. 2008
    ....
  15. pmc Methodological considerations for gene expression profiling of human brain
    Mary Atz
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA
    J Neurosci Methods 163:295-309. 2007
    ..We find that clinical, tissue, RNA, and microarray quality are all useful variables for collection and consideration in study design, analysis, and interpretation of gene expression results in human postmortem studies...
  16. pmc Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes
    Marquis P Vawter
    Department of Psychiatry, University of California, Irvine CA, USA
    Neuropsychopharmacology 29:373-84. 2004
    ..Studies of the protein expression of these sex-chromosome-linked genes in brain tissue are required to address the functional consequences of the observed gene expression differences...
  17. doi request reprint Neuropsychological performance as endophenotypes in extended schizophrenia families from the Central Valley of Costa Rica
    Hilary Bertisch
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    Psychiatr Genet 19:45-52. 2009
    ....
  18. doi request reprint Mechanisms of rapid antidepressant effects of sleep deprivation therapy: clock genes and circadian rhythms
    Blynn G Bunney
    Department of Psychiatry, School of Medicine, University of California, Irvine, California, USA
    Biol Psychiatry 73:1164-71. 2013
    ..The fact that chronotherapies, including SDT and sleep phase advance, are dramatically effective suggests that altered clock gene machinery may represent a core pathophysiological defect in a subset of mood disorder patients...
  19. ncbi request reprint Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder
    Joseph C Wu
    Department of Psychiatry and Human Behavior, University of California at Irvine School of Medicine, Room 109, Irvine Hall, Irvine, CA 92697 3960, USA
    Biol Psychiatry 66:298-301. 2009
    ..This study evaluates the combined efficacy of three established circadian-related treatments (SD, bright light [BL]), sleep phase advance [SPA]) as adjunctive treatment to lithium and antidepressants...
  20. ncbi request reprint Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, California 92697 1675, USA
    Neurochem Res 29:1245-55. 2004
    ..These results confirm earlier reports and suggest abnormalities of specific genes related to metabolic and protease activities in the DLPFC might be considered as part of a molecular pathway in male patients with schizophrenia...
  21. ncbi request reprint P50 sensory gating ratios in schizophrenics and controls: a review and data analysis
    JULIE V PATTERSON
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92868, USA
    Psychiatry Res 158:226-47. 2008
    ..Standards of P50 collection and measurement would help determine whether the gating ratio can be sufficiently reliable to be labeled an endophenotype, and suggestions are made toward this goal...
  22. doi request reprint Rapid-acting antidepressant strategies: mechanisms of action
    Blynn G Bunney
    Department of Psychiatry, University of California Irvine, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Int J Neuropsychopharmacol 15:695-713. 2012
    ..Further findings are reviewed that ketamine, in addition to its role as an NMDA antagonist, can also alter circadian rhythms. Thus, ketamine may share a critical mechanism with SDT...
  23. pmc Mitochondrial mutations and polymorphisms in psychiatric disorders
    Adolfo Sequeira
    Functional Genomics Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, CA, USA
    Front Genet 3:103. 2012
    ..The study in mtDNA of common polymorphisms, somatic mutations, and rare mutations in larger populations may lead to a better understanding of the pathophysiology of psychiatric disorders...
  24. ncbi request reprint Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA 92697 1675, USA
    Schizophr Res 67:41-52. 2004
    ..The present study offers support for examination of gene expression patterns using lymphocytic RNA for complex neuropsychiatric disorders from large cohorts of patients...
  25. doi request reprint An initial report of a new biological marker for bipolar disorder: P85 evoked brain potential
    JULIE V PATTERSON
    Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, California 92868, USA
    Bipolar Disord 11:596-609. 2009
    ..The goal of this research was to determine how gating of an auditory brain potential at 85 ms (P85), not previously examined in sensory gating studies, differentiated control and patient groups...
  26. ncbi request reprint Sleep deprivation PET correlations of Hamilton symptom improvement ratings with changes in relative glucose metabolism in patients with depression
    Joseph C Wu
    UC Irvine Department of Psychiatry and Human Behavior, Irvine, California 92697 3960, United States
    J Affect Disord 107:181-6. 2008
    ..In addition, we also studied the effect of concomitant antidepressant medication in conjunction with sleep depression...
  27. pmc Ketamine influences CLOCK:BMAL1 function leading to altered circadian gene expression
    Marina M Bellet
    Center for Epigenetics and Metabolism, School of Medicine, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e23982. 2011
    ..Our results reveal a yet unsuspected molecular mode of action of ketamine and thereby may suggest possible pharmacological antidepressant strategies...
  28. pmc Therapeutic effects of individualized alpha frequency transcranial magnetic stimulation (alphaTMS) on the negative symptoms of schizophrenia
    Yi Jin
    Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, USA
    Schizophr Bull 32:556-61. 2006
    ..These results affirm that the resonant features of alpha frequency EEG play an important role in the pathophysiology of schizophrenia and merit further investigation as a particularly efficacious frequency for rTMS treatments...
  29. ncbi request reprint Frontal lobe metabolic decreases with sleep deprivation not totally reversed by recovery sleep
    Joseph C Wu
    UC Irvine Department of Psychiatry and Human Behavior, Irvine, CA, USA
    Neuropsychopharmacology 31:2783-92. 2006
    ..Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity...
  30. ncbi request reprint MRNA expression patterns and distribution of white matter neurons in dorsolateral prefrontal cortex of depressed patients differ from those in schizophrenia patients
    Margherita Molnar
    Center for Neuroscience, University of California, Davis, California 95616, USA
    Biol Psychiatry 53:39-47. 2003
    ..Schizophrenia, bipolar illness, and major depressive disorder have distinct presentations, but share some common symptoms. Hence, some common cellular and molecular abnormalities may be identifiable in these disorders...
  31. ncbi request reprint Psychological pain: a review of evidence
    Steven Mee
    Department of Psychiatry, Long Beach VA Medical Center, 5901 E 7th Street, 116A, CA 90822, USA
    J Psychiatr Res 40:680-90. 2006
    ..Future research on the role of psychological pain and its interaction with nociceptive pathways may provide novel clues to the understanding and treatment of depression and other psychiatric illnesses...
  32. ncbi request reprint Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia
    Schahram Akbarian
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry and Bioinformatics Unit, Information Services, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Arch Gen Psychiatry 62:829-40. 2005
    ..Cellular metabolism regulates chromatin structure, including covalent histone modifications, which are epigenetic regulators of gene expression...
  33. ncbi request reprint Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions
    Jun Z Li
    Department of Genetics, Stanford University School of Medicine, California 94305, USA
    Hum Mol Genet 13:609-16. 2004
    ..These findings shed light on critical molecular mechanisms that are engaged during different forms of terminal stress, and may suggest clinical targets of protection or restoration...
  34. ncbi request reprint SNPs on chips: the hidden genetic code in expression arrays
    Elzbieta Sliwerska
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 2220, USA
    Biol Psychiatry 61:13-6. 2007
    ..Many Affymetrix chips contain thousands of SNPs that are both common and in the central probe region affecting hybridization, and thus have the potential to confound expression analysis...
  35. ncbi request reprint Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia
    Katherine A Albert
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, USA
    Arch Gen Psychiatry 59:705-12. 2002
    ..Thus, DARPP-32 occupies a key regulatory position, and may play an important role in the pathophysiological changes in dopamine and glutamate function reported in patients with schizophrenia...
  36. doi request reprint World Psychiatric Association Pharmacopsychiatry Section statement on comparative effectiveness of antipsychotics in the treatment of schizophrenia
    Rajiv Tandon
    University of Florida, Tallahassee, USA
    Schizophr Res 100:20-38. 2008
    ....
  37. pmc Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
    Manhong Dai
    Molecular and Behavioural Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Nucleic Acids Res 33:e175. 2005
    ..It will be beneficial to re-analyze existing GeneChip data with updated probe set definitions...
  38. ncbi request reprint Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statement
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:3-23. 2008
    ..It is the major problem facing efforts to identify the possible 'suicidal effects' of antidepressants...
  39. ncbi request reprint Application of microarray technology in primate behavioral neuroscience research
    Adriaan M Karssen
    Department of Psychiatry and Behavioral Sciences, Stanford University, USA
    Methods 38:227-34. 2006
    ....

Research Grants2

  1. Project 5: High-Throughput Analysis of Gene Regulation
    WILLIAM BUNNEY; Fiscal Year: 2007
    ..abstract_text> ..