MARY BUNGE

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. doi request reprint Realizing the maximum potential of Schwann cells to promote recovery from spinal cord injury
    Mary Bartlett Bunge
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Handb Clin Neurol 109:523-40. 2012
  2. pmc Novel combination strategies to repair the injured mammalian spinal cord
    Mary Bartlett Bunge
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Spinal Cord Med 31:262-9. 2008
  3. ncbi request reprint Bridging areas of injury in the spinal cord
    M B Bunge
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, FL 33101, USA
    Neuroscientist 7:325-39. 2001
  4. ncbi request reprint Transplantation strategies to promote repair of the injured spinal cord
    Mary Bartlett Bunge
    The Miami Project to Cure Paralysis, Department of Cell Biology, University of Miami School of Medicine, Miami, FL 33101, USA
    J Rehabil Res Dev 40:55-62. 2003
  5. ncbi request reprint Bridging the transected or contused adult rat spinal cord with Schwann cell and olfactory ensheathing glia transplants
    Mary Bartlett Bunge
    Chambers Family Electron Microscopy Laboratory, Miami Project to Cure Paralysis, Departments Cell Biology and Anatomy and Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
    Prog Brain Res 137:275-82. 2002
  6. ncbi request reprint Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord
    Toshihiro Takami
    The Chambers Family Laboratory of Electron Microscopy, The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 22:6670-81. 2002
  7. pmc Transduced Schwann cells promote axon growth and myelination after spinal cord injury
    Kevin L Golden
    The Miami Project to Cure Paralysis and the Neuroscience Program, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA
    Exp Neurol 207:203-17. 2007
  8. ncbi request reprint Transplantation of Schwann cells and olfactory ensheathing glia after spinal cord injury: does pretreatment with methylprednisolone and interleukin-10 enhance recovery?
    Damien Daniel Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33101, USA
    J Neurotrauma 21:1223-39. 2004
  9. ncbi request reprint Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue
    Bas Blits
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA
    Restor Neurol Neurosci 23:313-24. 2005
  10. ncbi request reprint Purified adult ensheathing glia fail to myelinate axons under culture conditions that enable Schwann cells to form myelin
    Giles W Plant
    The Chambers Family Electron Microscopy Laboratory, The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 22:6083-91. 2002

Research Grants

Collaborators

Detail Information

Publications32

  1. doi request reprint Realizing the maximum potential of Schwann cells to promote recovery from spinal cord injury
    Mary Bartlett Bunge
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Handb Clin Neurol 109:523-40. 2012
    ..Overall, the available evidence suggests that SCs, especially when used in combination with other treatments, offer one of the best hopes we have today of devising an effective treatment for spinal cord repair...
  2. pmc Novel combination strategies to repair the injured mammalian spinal cord
    Mary Bartlett Bunge
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Spinal Cord Med 31:262-9. 2008
    ..Thus, in two injury paradigms, these combination strategies as well as others studied in our laboratory have been found to be more effective than SCs alone and suggest ways in which clinical application may be developed...
  3. ncbi request reprint Bridging areas of injury in the spinal cord
    M B Bunge
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, FL 33101, USA
    Neuroscientist 7:325-39. 2001
    ..The compelling question today is: What combinations of the strategies discussed, or new ones, along with an initial neuroprotective treatment, will substantially improve outcome after spinal cord injury?..
  4. ncbi request reprint Transplantation strategies to promote repair of the injured spinal cord
    Mary Bartlett Bunge
    The Miami Project to Cure Paralysis, Department of Cell Biology, University of Miami School of Medicine, Miami, FL 33101, USA
    J Rehabil Res Dev 40:55-62. 2003
    ....
  5. ncbi request reprint Bridging the transected or contused adult rat spinal cord with Schwann cell and olfactory ensheathing glia transplants
    Mary Bartlett Bunge
    Chambers Family Electron Microscopy Laboratory, Miami Project to Cure Paralysis, Departments Cell Biology and Anatomy and Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
    Prog Brain Res 137:275-82. 2002
  6. ncbi request reprint Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord
    Toshihiro Takami
    The Chambers Family Laboratory of Electron Microscopy, The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 22:6670-81. 2002
    ..Thus, in addition to this functional improvement, our results show that an SC graft is more effective in promoting axonal sparing/regeneration than an SC/OEG or OEG graft in the moderately contused adult rat thoracic spinal cord...
  7. pmc Transduced Schwann cells promote axon growth and myelination after spinal cord injury
    Kevin L Golden
    The Miami Project to Cure Paralysis and the Neuroscience Program, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA
    Exp Neurol 207:203-17. 2007
    ..These results demonstrate the therapeutic potential for utilizing neurotrophin-transduced SCs to repair the injured spinal cord...
  8. ncbi request reprint Transplantation of Schwann cells and olfactory ensheathing glia after spinal cord injury: does pretreatment with methylprednisolone and interleukin-10 enhance recovery?
    Damien Daniel Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33101, USA
    J Neurotrauma 21:1223-39. 2004
    ....
  9. ncbi request reprint Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue
    Bas Blits
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA
    Restor Neurol Neurosci 23:313-24. 2005
    ..Furthermore, when the expression cassette is incorporated into the host genome ex vivo, this technique also may be used as a method to trace cells following implantation into tissues of interest...
  10. ncbi request reprint Purified adult ensheathing glia fail to myelinate axons under culture conditions that enable Schwann cells to form myelin
    Giles W Plant
    The Chambers Family Electron Microscopy Laboratory, The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 22:6083-91. 2002
    ..In sum, p75-selected EG from adult animals did not exhibit an SC-like relationship to axons and did not form myelin...
  11. ncbi request reprint Delayed transplantation of olfactory ensheathing glia promotes sparing/regeneration of supraspinal axons in the contused adult rat spinal cord
    Giles W Plant
    The Chambers Family Electron Microscopy Laboratory, The Miami Project to Cure Paralysis, Miami, Florida, USA
    J Neurotrauma 20:1-16. 2003
    ..Our results have relevant implications for future surgical repair strategies of the contused spinal cord...
  12. ncbi request reprint Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord
    Gizelda T B Casella
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33136, USA
    Exp Neurol 202:8-20. 2006
    ....
  13. ncbi request reprint Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord
    Matthijs F L Meijs
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurotrauma 21:1415-30. 2004
    ..Recovery of hind limb function was similar in both groups. Despite the neuroprotective effects of FGF-2, improved effects on axonal regeneration and functional recovery were not observed...
  14. ncbi request reprint Invariant mantling of growth cones by Schwann cell precursors characterize growing peripheral nerve fronts
    Ina B Wanner
    The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Glia 54:424-38. 2006
    ....
  15. ncbi request reprint Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery
    Damien D Pearse
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
    Glia 55:976-1000. 2007
    ....
  16. ncbi request reprint New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord
    Gizelda T B Casella
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33101, USA
    Exp Neurol 173:63-76. 2002
    ..In addition to providing a blood supply to the lesion site, protecting the demise of the newly formed vascular bridge might provide an early scaffold to hasten axonal regeneration across the injury site...
  17. pmc Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation
    Paula V Monje
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA
    Glia 57:947-61. 2009
    ..Overall, the results indicate that in the absence of neurons, cAMP can trigger SC re-differentiation concurrently with, but independently of, growth factor signaling...
  18. doi request reprint Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI
    Jenny Fortun
    The Miami Project to Cure Paralysis, University of Miami, Miller School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 26:941-53. 2009
    ....
  19. ncbi request reprint From animal models to humans: strategies for promoting CNS axon regeneration and recovery of limb function after spinal cord injury
    Lawrence Moon
    The Miami Project to Cure Paralysis, Miami, FL, USA
    J Neurol Phys Ther 29:55-69. 2005
    ..Finally we discuss ways in which animal studies might be improved and what the future may hold for physical therapists involved in rehabilitation of humans with SCI...
  20. ncbi request reprint Labeled Schwann cell transplantation: cell loss, host Schwann cell replacement, and strategies to enhance survival
    Caitlin E Hill
    Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Glia 53:338-43. 2006
    ..In all cases, transplantation of SCs resulted in extensive infiltration of endogenous p75+ cells into the injury site, suggesting that endogenous SCs may play an important role in the repair observed after SC transplantation...
  21. ncbi request reprint cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury
    Damien D Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA
    Nat Med 10:610-6. 2004
    ..These findings show that cAMP levels are key for protection, growth and myelination of injured CNS axons in vivo and recovery of function...
  22. ncbi request reprint Inhibition of tumour necrosis factor-alpha by antisense targeting produces immunophenotypical and morphological changes in injury-activated microglia and macrophages
    Damien D Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, PO Box 016960 R 48, Miami, FL 33101, USA
    Eur J Neurosci 20:3387-96. 2004
    ..However, at the peak of microglial activation after injury, the activation state of microglia/macrophages is not stable and this process may still be reversible by blocking TNF-alpha...
  23. ncbi request reprint Methylprednisolone and interleukin-10 reduce gray matter damage in the contused Fischer rat thoracic spinal cord but do not improve functional outcome
    Toshihiro Takami
    The Chambers Family Laboratory of Electron Microscopy, The Miami Project to Cure Paralysis, Miami, Florida, USA
    J Neurotrauma 19:653-66. 2002
    ....
  24. pmc A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model
    Alberto Pinzon
    The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, 1095 NW 14 th Terrace, LPLC 2 30, Miami, FL 33136, USA
    Brain Res 1243:146-51. 2008
    ....
  25. ncbi request reprint Direct gene therapy for repair of the spinal cord
    Bas Blits
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 23:508-20. 2006
    ..The limitations and successes of direct gene transfer for spinal cord repair are discussed in this review...
  26. ncbi request reprint Forskolin increases neuregulin receptors in human Schwann cells without increasing receptor mRNA
    Nevis L Fregien
    Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33136, USA
    Glia 49:24-35. 2005
    ..These results suggest that forskolin/heregulin synergy might derive, at least in part, from post-transcriptional effects leading to increased steady-state receptor levels...
  27. pmc A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury
    Alberto Pinzon
    Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Exp Neurol 213:129-36. 2008
    ..With these results, although we cannot conclude that there will be no beneficial effect in different SCI models, we caution researchers that the use of rhEPO requires further investigation before implementing clinical trials...
  28. ncbi request reprint The role of proteoglycans in Schwann cell/astrocyte interactions and in regeneration failure at PNS/CNS interfaces
    Barbara Grimpe
    Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Cell Neurosci 28:18-29. 2005
    ..Our results help to explain why regeneration fails at PNS/CNS glial boundaries...
  29. pmc Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?
    Gregoire Courtine
    Department of Physiological Science and Neurobiology, and Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Nat Med 13:561-6. 2007
  30. pmc Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes
    Jason F Talbott
    The MD PhD Program, University of Louisville, Louisville, KY 40292, USA
    Exp Neurol 192:11-24. 2005
    ..In vivo electrophysiology demonstrated a limited and unsustained functional recovery concurrent with endogenous remyelination following EB-induced lesions...
  31. pmc Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells
    Qilin Cao
    Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky 40202, USA
    J Neurosci 25:6947-57. 2005
    ..Therefore, combined treatment with neurotrophins and GRP grafts can facilitate functional recovery after traumatic SCI and may prove to be a useful therapeutic strategy to repair the injured spinal cord...
  32. ncbi request reprint Improved immunocytochemical identification of neural, endothelial, and inflammatory cell types in paraffin-embedded injured adult rat spinal cord
    Gizelda T B Casella
    Institute of Orthopedics and Traumatology of the Hospital of Clinics of the University of São Paulo Medical School, Sao Paulo, Brazil
    J Neurosci Methods 139:1-11. 2004
    ..Amplification of the primary signal with TSA or ABP/DABA was also found to be beneficial...

Research Grants10

  1. CYTOLOGICAL STUDIES OF DEVELOPING AND MATURE NEURONS
    Mary Bartlett Bunge; Fiscal Year: 2010
    ..The completion of these experiments will improve our understanding of how cAMP regulates normal SC proliferation and myelination, specifically, and signaling from receptor tyrosine kinases in general. ..
  2. CYTOLOGICAL STUDIES OF DEVELOPING AND MATURE NEURONS
    MARY BUNGE; Fiscal Year: 2004
    ..These studies explore the potential for use of human SCs in clinical applications, while expanding our knowledge of the biological and molecular properties of Schwann cells. ..