Scott J Bultman

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?
    Scott J Bultman
    Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27516, USA Electronic address
    Cell Host Microbe 16:143-5. 2014
  2. pmc The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner
    Daniel W Serber
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e31346. 2012
  3. pmc BRG1 directly regulates nucleosome structure and chromatin looping of the alpha globin locus to activate transcription
    Shin Il Kim
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Medical Sciences Center, Madison, WI, USA
    Nucleic Acids Res 37:6019-27. 2009
  4. pmc A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
    Scott J Bultman
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Genes Dev 19:2849-61. 2005
  5. pmc Maternal BRG1 regulates zygotic genome activation in the mouse
    Scott J Bultman
    Department of Genetics and the Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genes Dev 20:1744-54. 2006
  6. ncbi request reprint Characterization of mammary tumors from Brg1 heterozygous mice
    S J Bultman
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Oncogene 27:460-8. 2008
  7. doi request reprint The BRG1 chromatin remodeler regulates widespread changes in gene expression and cell proliferation during B cell activation
    Darcy W Holley
    Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina
    J Cell Physiol 229:44-52. 2014
  8. pmc Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development
    Stephanie L Smith-Roe
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mamm Genome 24:21-9. 2013
  9. pmc Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart
    Monte S Willis
    120 Mason Farm Rd, Genetic Medicine Bldg, Room 5060, Chapel Hill, NC 27516 7264, USA
    Circ Res 111:e111-22. 2012
  10. pmc BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression
    Stephanie M Cohen
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 38:6906-19. 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?
    Scott J Bultman
    Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27516, USA Electronic address
    Cell Host Microbe 16:143-5. 2014
    ..In a recent issue of Cell, Belcheva et al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intestinal epithelial cells, suggesting that it can act as an oncometabolite. ..
  2. pmc The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner
    Daniel W Serber
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e31346. 2012
    ....
  3. pmc BRG1 directly regulates nucleosome structure and chromatin looping of the alpha globin locus to activate transcription
    Shin Il Kim
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Medical Sciences Center, Madison, WI, USA
    Nucleic Acids Res 37:6019-27. 2009
    ..These data also demonstrate that chromatin looping between the MRE and alpha2 promoter is required as part of the transcriptional activation mechanism...
  4. pmc A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
    Scott J Bultman
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Genes Dev 19:2849-61. 2005
    ..Not only does this mutation establish a role for Brg1 during organogenesis, it also demonstrates that ATPase activity can be uncoupled from chromatin remodeling...
  5. pmc Maternal BRG1 regulates zygotic genome activation in the mouse
    Scott J Bultman
    Department of Genetics and the Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genes Dev 20:1744-54. 2006
    ..Depletion of maternal BRG1 did not affect global levels of histone acetylation, whereas dimethyl-H3K4 levels were reduced. These data provide a framework for understanding the mechanism of ZGA...
  6. ncbi request reprint Characterization of mammary tumors from Brg1 heterozygous mice
    S J Bultman
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Oncogene 27:460-8. 2008
    ..We were also unable to detect a genetic interaction between the Brg1+/- and Rb+/- tumor phenotypes. These latter findings do not support a BRG1-RB interaction in vivo...
  7. doi request reprint The BRG1 chromatin remodeler regulates widespread changes in gene expression and cell proliferation during B cell activation
    Darcy W Holley
    Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina
    J Cell Physiol 229:44-52. 2014
    ....
  8. pmc Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development
    Stephanie L Smith-Roe
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mamm Genome 24:21-9. 2013
    ..Taken together, these results support the idea that BRG1 and BRM have overlapping functions for certain developmental processes but not others during embryogenesis...
  9. pmc Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart
    Monte S Willis
    120 Mason Farm Rd, Genetic Medicine Bldg, Room 5060, Chapel Hill, NC 27516 7264, USA
    Circ Res 111:e111-22. 2012
    ..BRG1 is required for vascular endothelial cell (VEC) development and embryonic survival, whereas BRM is dispensable...
  10. pmc BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression
    Stephanie M Cohen
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 38:6906-19. 2010
    ..This novel function of BRG1 is consistent with its requirement during embryogenesis and its role as a tumor suppressor to maintain genome stability and prevent cancer...
  11. pmc The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation
    Dallas R Donohoe
    Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell 48:612-26. 2012
    ..These findings link a common metabolite to epigenetic mechanisms that are differentially utilized by normal and cancerous cells because of their inherent metabolic differences...
  12. pmc Microbial regulation of glucose metabolism and cell-cycle progression in mammalian colonocytes
    Dallas R Donohoe
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e46589. 2012
    ..These data reveal a mechanism by which microbiota regulate glucose utilization to influence energy homeostasis and cell-cycle progression of mammalian host cells...
  13. pmc Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression
    Dallas R Donohoe
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Cell Physiol 227:3169-77. 2012
    ..And as co-factors, energy metabolites act as rheostats to modulate the activity of epigenetic enzymes and upregulate/downregulate transcription as appropriate to maintain homeostasis...
  14. pmc The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
    Dallas R Donohoe
    Department of Genetics, University of North Carolina at Chapel Hill, 27599 7264, USA
    Cell Metab 13:517-26. 2011
    ..The mechanism is due to butyrate acting as an energy source rather than as an HDAC inhibitor...
  15. pmc SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease
    Ariana Bevilacqua
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Cardiovasc Pathol 23:85-91. 2014
    ....
  16. pmc The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration
    Danielle R Cook
    Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Genes Cancer 2:932-42. 2011
    ..In summary, our results establish the unique role of Ect2 in development and normal cell proliferation...
  17. pmc Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation
    Shin Il Kim
    University of Wisconsin School of Medicine, Department of Pharmacology, 383 Medical Sciences Center, Madison, WI 53706, USA
    Mol Cell Biol 27:4551-65. 2007
    ..These studies defined a hierarchical order of GATA-1-triggered events at a complex locus and establish a novel mechanism of long-range gene regulation...

Research Grants4

  1. Dietary Fiber, Gut Microflora, & Epigenetic Events that Prevent Colorectal Cancer
    Scott J Bultman; Fiscal Year: 2010
    ..This work should elucidate the mechanisim of the fiber effect on CRC susceptibility and may lead to new preventative strategies for CRC. ..
  2. Dietary Fiber, Gut Microflora, & Epigenetic Events that Prevent Colorectal Cancer
    Scott Bultman; Fiscal Year: 2007
    ..This work should elucidate the mechanisim of the fiber effect on CRC susceptibility and may lead to new preventative strategies for CRC. ..
  3. Dietary Fiber, Gut Microflora, & Epigenetic Events that Prevent Colorectal Cancer
    Scott Bultman; Fiscal Year: 2009
    ..This work should elucidate the mechanisim of the fiber effect on CRC susceptibility and may lead to new preventative strategies for CRC. ..