Scott J Bultman
Affiliation: University of North Carolina
Bultman S, Jobin C. Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?. Cell Host Microbe. 2014;16:143-145 pubmed publisher
..In a recent issue of Cell, Belcheva etÂ al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intestinal epithelial cells, suggesting that it can act as an oncometabolite. ..
Bultman S. A Reversible Epigenetic Link between Obesity and Cancer Risk. Trends Endocrinol Metab. 2018;29:529-531 pubmed publisher
..These findings have implications that are encouraging for weight loss and cancer prevention. ..
Greathouse K, Harris C, Bultman S. Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile. Cell Metab. 2015;21:9-10 pubmed publisher
..In a recent article in Nature, Buffie et al. (2014) demonstrate that the ability of C. scindens to synthesize secondary bile acids is crucial to providing resistance to C. difficile infection. ..
Donohoe D, Holley D, Collins L, Montgomery S, Whitmore A, Hillhouse A, et al
. A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner. Cancer Discov. 2014;4:1387-97 pubmed publisher
Bultman S. The microbiome and its potential as a cancer preventive intervention. Semin Oncol. 2016;43:97-106 pubmed publisher
..Data from basic research studies also support the idea that probiotics and prebiotics could be plausible chemoprevention strategies that may be utilized to a greater extent in the future. ..
Liang X, Bultman S. Ticking in Place for the Microbiome to Message Out. Cell Metab. 2016;24:775-777 pubmed publisher
..This oscillation, together with the host circadian clock, co-regulates the colonic and hepatic epigenome and transcriptome. ..
Bultman S, Gebuhr T, Magnuson T. A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005;19:2849-61 pubmed
..Not only does this mutation establish a role for Brg1 during organogenesis, it also demonstrates that ATPase activity can be uncoupled from chromatin remodeling. ..
Bultman S, Gebuhr T, Pan H, Svoboda P, Schultz R, Magnuson T. Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev. 2006;20:1744-54 pubmed
..Depletion of maternal BRG1 did not affect global levels of histone acetylation, whereas dimethyl-H3K4 levels were reduced. These data provide a framework for understanding the mechanism of ZGA. ..
Bultman S, Herschkowitz J, Godfrey V, Gebuhr T, Yaniv M, Perou C, et al
. Characterization of mammary tumors from Brg1 heterozygous mice. Oncogene. 2008;27:460-8 pubmed
..We were also unable to detect a genetic interaction between the Brg1+/- and Rb+/- tumor phenotypes. These latter findings do not support a BRG1-RB interaction in vivo. ..