David Bull

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Aprotinin preserves myocardial biochemical function during cold storage through suppression of tumor necrosis factor
    D A Bull
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Thorac Cardiovasc Surg 119:242-50. 2000
  2. ncbi request reprint Improved biochemical preservation of lung slices during cold storage
    D A Bull
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah, 50 North Medical Drive, Salt Lake City, Utah 84132, USA
    J Surg Res 90:144-8. 2000
  3. ncbi request reprint Interleukin-18 production following murine cardiac transplantation: correlation with histologic rejection and the induction of INF-gamma
    D G Affleck
    Department of Surgery, University of Utah Health Sciences Center, School of Medicine 3C127, Salt Lake City, UT 84132, USA
    J Interferon Cytokine Res 21:1-9. 2001
  4. ncbi request reprint Coronary artery bypass grafting with cardiopulmonary bypass versus off-pump cardiopulmonary bypass grafting: does eliminating the pump reduce morbidity and cost?
    D A Bull
    Department of Surgery, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Ann Thorac Surg 71:170-3; discussion 173-5. 2001
  5. doi request reprint The impact of bridge-to-transplant ventricular assist device support on survival after cardiac transplantation
    David A Bull
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Thorac Cardiovasc Surg 140:169-73. 2010
  6. ncbi request reprint Effect of Terplex/VEGF-165 gene therapy on left ventricular function and structure following myocardial infarction. VEGF gene therapy for myocardial infarction
    David A Bull
    Division of Cardiothoracic Surgery, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    J Control Release 93:175-81. 2003
  7. ncbi request reprint Aprotinin and preservation of myocardial function after ischemia-reperfusion injury
    David A Bull
    Department of Surgery, Division of Cardiothoracic Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Ann Thorac Surg 75:S735-9. 2003
  8. ncbi request reprint Improved biochemical preservation of heart slices during cold storage
    D A Bull
    Division of Cardiothoracic Surgery, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Surg Investig 2:117-23. 2000
  9. pmc Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery
    Lane V Christensen
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112 5820, USA
    J Control Release 118:254-61. 2007
  10. ncbi request reprint Postoperative pericardial adhesion prevention using Carbylan-SX in a rabbit model
    Rafe C Connors
    Department of Surgery, Division of Cardiothoracic Surgery, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Surg Res 140:237-42. 2007

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Aprotinin preserves myocardial biochemical function during cold storage through suppression of tumor necrosis factor
    D A Bull
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Thorac Cardiovasc Surg 119:242-50. 2000
    ..Aprotinin may improve outcomes in cardiac surgery through suppression of inflammatory mediators. We hypothesized that aprotinin may exert its beneficial effects through suppression of tumor necrosis factor alpha...
  2. ncbi request reprint Improved biochemical preservation of lung slices during cold storage
    D A Bull
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah, 50 North Medical Drive, Salt Lake City, Utah 84132, USA
    J Surg Res 90:144-8. 2000
    ..We hypothesized that lung slices could be used to assess preservation of biochemical function during cold storage...
  3. ncbi request reprint Interleukin-18 production following murine cardiac transplantation: correlation with histologic rejection and the induction of INF-gamma
    D G Affleck
    Department of Surgery, University of Utah Health Sciences Center, School of Medicine 3C127, Salt Lake City, UT 84132, USA
    J Interferon Cytokine Res 21:1-9. 2001
    ..Beginning 6 days after transplantation, IL-12 and IL-18 appear to play a significant role in the induction of IFN-gamma in allogeneic heart transplants...
  4. ncbi request reprint Coronary artery bypass grafting with cardiopulmonary bypass versus off-pump cardiopulmonary bypass grafting: does eliminating the pump reduce morbidity and cost?
    D A Bull
    Department of Surgery, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Ann Thorac Surg 71:170-3; discussion 173-5. 2001
    ..Off-pump CABG (OPCAB) allows coronary revascularization without CPB. We hypothesized that OPCAB provides satisfactory graft patency while reducing complications and cost compared with CABG with CPB...
  5. doi request reprint The impact of bridge-to-transplant ventricular assist device support on survival after cardiac transplantation
    David A Bull
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Thorac Cardiovasc Surg 140:169-73. 2010
    ..To determine the impact of bridge-to-transplant ventricular assist device support on survival after cardiac transplantation...
  6. ncbi request reprint Effect of Terplex/VEGF-165 gene therapy on left ventricular function and structure following myocardial infarction. VEGF gene therapy for myocardial infarction
    David A Bull
    Division of Cardiothoracic Surgery, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    J Control Release 93:175-81. 2003
    ....
  7. ncbi request reprint Aprotinin and preservation of myocardial function after ischemia-reperfusion injury
    David A Bull
    Department of Surgery, Division of Cardiothoracic Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Ann Thorac Surg 75:S735-9. 2003
    ..In all, review of this topic indicates that aprotinin may reduce aspects of ischemia-reperfusion injury and prospective clinical studies are needed to evaluate the impact of aprotinin on associated patient outcomes...
  8. ncbi request reprint Improved biochemical preservation of heart slices during cold storage
    D A Bull
    Division of Cardiothoracic Surgery, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Surg Investig 2:117-23. 2000
    ..We hypothesized that myocardial slices could be used to assess preservation of biochemical function during cold storage...
  9. pmc Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery
    Lane V Christensen
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112 5820, USA
    J Control Release 118:254-61. 2007
    ....
  10. ncbi request reprint Postoperative pericardial adhesion prevention using Carbylan-SX in a rabbit model
    Rafe C Connors
    Department of Surgery, Division of Cardiothoracic Surgery, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Surg Res 140:237-42. 2007
    ..This study evaluates whether Carbylan-SX can effectively reduce postoperative adhesions within the pericardial cavity...
  11. doi request reprint Utility of virtual crossmatch in sensitized patients awaiting heart transplantation
    Josef Stehlik
    U T A H Cardiac Transplant Program, University of Utah Hospital, and VA Salt Lake City Health Care System Cardiology Section, 500 Foothill Blvd, Salt Lake City, UT 84148, USA
    J Heart Lung Transplant 28:1129-34. 2009
    ..This study examined the accuracy of virtual crossmatch, in which recipient HLA-specific antibodies, identified by solid-phase assays, are compared to the prospective donor HLA-type in heart transplantation...
  12. pmc Ligation of the left circumflex coronary artery with subsequent MRI and histopathology in rabbits
    Norman Hu
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah, USA
    J Am Assoc Lab Anim Sci 49:838-44. 2010
    ..Understanding the 3-dimensional arrangement of the myocardial microstructure and how remodeling of the infarcted myocardium affects cardiac function in an animal model has important implications for the study of heart disease in humans...
  13. ncbi request reprint PDGF(BB) increases myocardial production of VEGF: shift in VEGF mRNA splice variants after direct injection of bFGF, PDGF(BB), and PDGF(AB)
    David G Affleck
    Department of Surgery, University of Utah Health Sciences Center, School of Medicine, Salt Lake City 84132, USA
    J Surg Res 107:203-9. 2002
    ..Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis. We hypothesized that a combination of recombinant angiogenic proteins might induce myocardial VEGF production and cause a shift in the mRNA signal produced...
  14. pmc Women and heart disease--physiologic regulation of gene delivery and expression: bioreducible polymers and ischemia-inducible gene therapies for the treatment of ischemic heart disease
    James W Yockman
    Dept of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Adv Drug Deliv Rev 61:863-70. 2009
    ..Toward this end, we describe the development of physiologic regulation of gene delivery and expression using bioreducible polymers and ischemia-inducible gene therapies for the potential treatment of ischemic heart disease in women...
  15. ncbi request reprint Early screening for antibody-mediated rejection in heart transplant recipients
    Abdallah G Kfoury
    LDS Hospital and Intermountain Healthcare, Salt Lake City, Utah 84143, USA
    J Heart Lung Transplant 26:1264-9. 2007
    ..In this study, we examine whether a pattern of repetitive AMR occurred early enough after transplantation to warrant prospective immunohistochemistry screening in all recently transplanted recipients...
  16. pmc Polymer transfected primary myoblasts mediated efficient gene expression and angiogenic proliferation
    Mei Ou
    Center for Controlled Chemical Delivery CCCD, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, United States
    J Control Release 142:61-9. 2010
    ..Polymer engineered primary myoblasts have potential for therapeutic application in the treatment of ischemic heart diseases...
  17. doi request reprint Effects of the 2006 U.S. thoracic organ allocation change: analysis of local impact on organ procurement and heart transplantation
    Jose N Nativi
    U T A H Cardiac Transplant Program, Salt Lake City, Utah, USA
    J Heart Lung Transplant 29:235-9. 2010
    ..As such, organs would be allocated to the sickest recipients with highest listing status across the region. Our aim was to determine the impact of the new policy on the procurement and transplant process within our program...
  18. pmc Primary cardiomyocyte-targeted bioreducible polymer for efficient gene delivery to the myocardium
    Hye Y Nam
    Center for Controlled Chemical Delivery CCCD, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Biomaterials 31:8081-7. 2010
    ..These findings demonstrate the utility of the addition of a primary cardiomyocyte (PCM) specific peptide modification to a bioreducible polymer for targeted delivery of Fas siRNA to inhibit cardiomyocyte apoptosis...
  19. ncbi request reprint Outcomes after esophagectomy: a ten-year prospective cohort
    Stephen H Bailey
    Veterans Affairs Medical Center, University of Utah Medical School, Salt Lake City, Utah 84132, USA
    Ann Thorac Surg 75:217-22; discussion 222. 2003
    ..We used this database to assess risk factors for morbidity and mortality after esophagectomy in Veterans Affairs Medical Centers from 1991 to 2001...
  20. ncbi request reprint Comparing outcomes after transthoracic and transhiatal esophagectomy: a 5-year prospective cohort of 17,395 patients
    Rafe C Connors
    Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Am Coll Surg 205:735-40. 2007
    ..To definitively answer this question, we used the Nationwide Inpatient Sample database to compare morbidity and mortality after THE and TTE...
  21. pmc A family of bioreducible poly(disulfide amine)s for gene delivery
    Mei Ou
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Biomaterials 30:5804-14. 2009
    ..All of these agents showed greater transfection activity than commercialized bPEI 25 kDa. The poly(disulfide amine)s are promising safe and efficient non-viral vectors for gene delivery...
  22. pmc VEGF siRNA delivery system using arginine-grafted bioreducible poly(disulfide amine)
    Sun Hwa Kim
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Mol Pharm 6:718-26. 2009
    ..These results demonstrate that the VEGF siRNA/poly(CBA-DAH-R) polyplex delivery system may useful for siRNA-based approaches for cancer therapy...
  23. pmc Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity
    Mei Ou
    Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, 421 Wakara Way, University of Utah, Salt Lake City, UT 84112, USA
    Bioconjug Chem 19:626-33. 2008
    ..Furthermore, MTT assay indicated that all three poly(disulfide amine)s/pDNA polyplexes were significantly less toxic than bPEI/pDNA complexes...
  24. ncbi request reprint Multivariate predictors of heart transplantation outcomes in the era of chronic mechanical circulatory support
    Stavros G Drakos
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Ann Thorac Surg 83:62-7. 2007
    ..Determining which pretransplantation (TX) characteristics predict the development of chronic renal dysfunction (CRD) or death after heart TX would enable more accurate risk assessment at the time of candidate evaluation...
  25. ncbi request reprint Hypoxia-inducible gene expression system using the erythropoietin enhancer and 3'-untranslated region for the VEGF gene therapy
    Minhyung Lee
    Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea
    J Control Release 115:113-9. 2006
    ..The results suggest that the VEGF plasmid with the Epo enhancer and the Epo 3'-UTR may be useful for gene therapy for ischemic diseases...
  26. ncbi request reprint Sp1-dependent regulation of the RTP801 promoter and its application to hypoxia-inducible VEGF plasmid for ischemic disease
    Minhyung Lee
    Clinical Research Center, College of Medicine, Inha University, Inchon 400 711, Korea
    Pharm Res 21:736-41. 2004
    ..In this study, we identified the cis-regulatory element for the hypoxia induction of the RTP801 promoter. In addition, pRTP801-VEGF was evaluated as a therapeutic plasmid in vitro...

Research Grants7

  1. Polymer Carrier for Ischemia-Inducible Gene Therapy
    David Bull; Fiscal Year: 2007
    ..abstract_text> ..
  2. Gene- and Cell-based therapies for LVAD patients
    David Bull; Fiscal Year: 2007
    ..End of Abstract) ..