MICHAEL D BULGER

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Maps for Changing Landscapes: Viewing Epigenomic Signatures through Differentiation
    Michael Bulger
    Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA Electronic address
    Cell Stem Cell 11:581-2. 2012
  2. ncbi request reprint Hyperacetylated chromatin domains: lessons from heterochromatin
    Michael Bulger
    Center for Pediatric Biomedical Research and Department of Biochemistry and Biophysics, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 280:21689-92. 2005
  3. pmc Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression
    George Fromm
    Departments of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Box 703, 601 Elmwood Ave, Rochester, NY14642, USA
    Blood 114:3479-88. 2009
  4. pmc Enhancers: the abundance and function of regulatory sequences beyond promoters
    Michael Bulger
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Dev Biol 339:250-7. 2010
  5. pmc Functional and mechanistic diversity of distal transcription enhancers
    Michael Bulger
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, NY 14627, USA
    Cell 144:327-39. 2011
  6. pmc "Maturational" globin switching in primary primitive erythroid cells
    Paul D Kingsley
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 107:1665-72. 2006
  7. pmc IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung
    Se Ran Yang
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 38:689-98. 2008
  8. doi request reprint A spectrum of gene regulatory phenomena at mammalian beta-globin gene loci
    George Fromm
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Cell Biol 87:781-90. 2009
  9. pmc RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke
    Se Ran Yang
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 40:147-58. 2009

Research Grants

Collaborators

  • I Rahman
  • J Palis
  • S B Maggirwar
  • George Fromm
  • Se Ran Yang
  • Jian dong Li
  • Samantha Valvo
  • Hongwei Yao
  • Saravanan Rajendrasozhan
  • Indika Edirisinghe
  • Paul D Kingsley
  • Jennifer Fields
  • Rachel Byron
  • Sangwoon Chung
  • Richard P Phipps
  • Christina de Vries
  • Mark Groudine
  • Patricia J Sime
  • Michael J McCabe
  • M A Bender
  • Steven Fiering
  • Samuel Caito
  • Ryan Henry
  • David Adenuga
  • Aruna Kode
  • Rachel L Emerson
  • Laura A Bloedorn
  • Kathleen E McGrath
  • Jeffrey Malik
  • Timothy P Bushnell

Detail Information

Publications9

  1. doi request reprint Maps for Changing Landscapes: Viewing Epigenomic Signatures through Differentiation
    Michael Bulger
    Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA Electronic address
    Cell Stem Cell 11:581-2. 2012
    ..2012), Wamstad et al. (2012), and Paige et al. (2012) track such signatures during cellular differentiation, revealing a richer understanding of gene regulation and providing hints of new phenomena...
  2. ncbi request reprint Hyperacetylated chromatin domains: lessons from heterochromatin
    Michael Bulger
    Center for Pediatric Biomedical Research and Department of Biochemistry and Biophysics, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 280:21689-92. 2005
    ....
  3. pmc Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression
    George Fromm
    Departments of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Box 703, 601 Elmwood Ave, Rochester, NY14642, USA
    Blood 114:3479-88. 2009
    ..These data narrow the range of possible mechanisms by which hyperacetylated domains form...
  4. pmc Enhancers: the abundance and function of regulatory sequences beyond promoters
    Michael Bulger
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Dev Biol 339:250-7. 2010
    ..In addition, we examine the available evidence for the mechanism by which such elements communicate or interact with the promoters they regulate...
  5. pmc Functional and mechanistic diversity of distal transcription enhancers
    Michael Bulger
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, NY 14627, USA
    Cell 144:327-39. 2011
    ..However, mechanisms for enhancer function are emerging that do not fit solely within such a model, suggesting that enhancers as a class of DNA regulatory element may be functionally and mechanistically diverse...
  6. pmc "Maturational" globin switching in primary primitive erythroid cells
    Paul D Kingsley
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 107:1665-72. 2006
    ..Globin switching during ontogeny is due not only to the sequential appearance of primitive and definitive lineages but also to changes in globin expression as primitive erythroblasts mature in the bloodstream...
  7. pmc IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung
    Se Ran Yang
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 38:689-98. 2008
    ..Taken together, these data suggest that IKK alpha plays a key role in CS-induced pro-inflammatory gene transcription through phospho-acetylation of both RelA/p65 and histone H3...
  8. doi request reprint A spectrum of gene regulatory phenomena at mammalian beta-globin gene loci
    George Fromm
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Cell Biol 87:781-90. 2009
    ..In this review, we provide an overview of transcriptional activation, silencing, chromatin structure, and the function of distal regulatory elements involved in the normal developmental regulation of beta-globin gene expression...
  9. pmc RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke
    Se Ran Yang
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 40:147-58. 2009
    ..Rapid degradation of RelB signals for RelA/p65 activation and loss of its protective ability to suppress the proinflammatory cytokine release in lymphoid B cells...

Research Grants5

  1. Function of active chromatin domains in erythropoiesis
    MICHAEL D BULGER; Fiscal Year: 2010
    ..As such, it has relevance to disorders in which tissue-specific gene expression is disrupted - which include a number of cancers - as well as gene therapy approaches involving stable transgene expression in specific cell types. ..
  2. Function of active chromatin domains in erythropoiesis
    Michael Bulger; Fiscal Year: 2009
    ..As such, it has relevance to disorders in which tissue-specific gene expression is disrupted - which include a number of cancers - as well as gene therapy approaches involving stable transgene expression in specific cell types. ..