E M Bulger

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Management of severe head injury: institutional variations in care and effect on outcome
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, WA, USA
    Crit Care Med 30:1870-6. 2002
  2. doi request reprint Emergency department ventilation effects outcome in severe traumatic brain injury
    Keir J Warner
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
    J Trauma 64:341-7. 2008
  3. ncbi request reprint Hypertonic resuscitation after severe injury: is it of benefit?
    Eileen M Bulger
    Department of Surgery, Harborview Medical Center, University of Washington, Box 359796, 325 9th Avenue, Seattle, WA 98104, USA
    Adv Surg 46:73-85. 2012
  4. pmc Impact of prehospital mode of transport after severe injury: a multicenter evaluation from the Resuscitation Outcomes Consortium
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, Washington 98005, USA
    J Trauma Acute Care Surg 72:567-73; discussion 573-5; quiz 803. 2012
  5. ncbi request reprint National variability in out-of-hospital treatment after traumatic injury
    Eileen M Bulger
    Harborview Injury Prevention and Research Center, Seattle, WA 98104, USA
    Ann Emerg Med 49:293-301. 2007
  6. ncbi request reprint Prehospital care of the injured: what's new
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, Box 359796, 325 9th Avenue, Seattle, WA 98104, USA
    Surg Clin North Am 87:37-53, vi. 2007
  7. pmc Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    Ann Surg 245:635-41. 2007
  8. ncbi request reprint Childhood crash injury patterns associated with restraint misuse: implications for field triage
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Prehosp Disaster Med 23:9-15. 2008
  9. doi request reprint Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial
    Eileen M Bulger
    Department of Surgery, Campus Box 359796, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
    Arch Surg 143:139-48; discussion 149. 2008
  10. pmc Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, USA
    JAMA 304:1455-64. 2010

Research Grants

Detail Information

Publications54

  1. ncbi request reprint Management of severe head injury: institutional variations in care and effect on outcome
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, WA, USA
    Crit Care Med 30:1870-6. 2002
    ....
  2. doi request reprint Emergency department ventilation effects outcome in severe traumatic brain injury
    Keir J Warner
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
    J Trauma 64:341-7. 2008
    ..We sought to determine whether achieving ventilation into a target range would translate into better outcomes in patients with TBI...
  3. ncbi request reprint Hypertonic resuscitation after severe injury: is it of benefit?
    Eileen M Bulger
    Department of Surgery, Harborview Medical Center, University of Washington, Box 359796, 325 9th Avenue, Seattle, WA 98104, USA
    Adv Surg 46:73-85. 2012
    ..Assessment of long-term neurologic outcome in this patient population remains the gold standard in determining benefit...
  4. pmc Impact of prehospital mode of transport after severe injury: a multicenter evaluation from the Resuscitation Outcomes Consortium
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, Washington 98005, USA
    J Trauma Acute Care Surg 72:567-73; discussion 573-5; quiz 803. 2012
    ..We sought to evaluate the impact of mode of transport on outcome based on analysis of data from two randomized trials of prehospital hypertonic resuscitation...
  5. ncbi request reprint National variability in out-of-hospital treatment after traumatic injury
    Eileen M Bulger
    Harborview Injury Prevention and Research Center, Seattle, WA 98104, USA
    Ann Emerg Med 49:293-301. 2007
    ..We define the variability in the out-of-hospital treatment provided to trauma patients in the United States...
  6. ncbi request reprint Prehospital care of the injured: what's new
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, Box 359796, 325 9th Avenue, Seattle, WA 98104, USA
    Surg Clin North Am 87:37-53, vi. 2007
    ..Through additional research, the best practice and optimal EMS system design will continue to be defined...
  7. pmc Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    Ann Surg 245:635-41. 2007
    ..To determine the effect of resuscitation with hypertonic saline/dextran (HSD) on the innate immune response after injury...
  8. ncbi request reprint Childhood crash injury patterns associated with restraint misuse: implications for field triage
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Prehosp Disaster Med 23:9-15. 2008
    ....
  9. doi request reprint Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial
    Eileen M Bulger
    Department of Surgery, Campus Box 359796, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
    Arch Surg 143:139-48; discussion 149. 2008
    ..The purpose of this study was to evaluate the effect of hypertonicity on organ injury after blunt trauma...
  10. pmc Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, USA
    JAMA 304:1455-64. 2010
    ..Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and modulate inflammatory response to reduce subsequent neuronal injury and thus have potential benefit in resuscitation of patients with traumatic brain injury (TBI)...
  11. pmc Increased neutrophil adenosine a3 receptor expression is associated with hemorrhagic shock and injury severity in trauma patients
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104, USA
    Shock 36:435-9. 2011
    ..Hypertonic saline increases A3 expression of PMNs from healthy volunteers and less severely injured patients...
  12. ncbi request reprint The use of neuromuscular blocking agents to facilitate prehospital intubation does not impair outcome after traumatic brain injury
    Eileen M Bulger
    Departments of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
    J Trauma 58:718-23; discussion 723-4. 2005
    ..We sought to determine the effect of the use of NMBAs to facilitate prehospital intubation on outcome after TBI...
  13. pmc Oxandrolone does not improve outcome of ventilator dependent surgical patients
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle 98104, USA
    Ann Surg 240:472-8; discussion 478-80. 2004
    ..Oxandrolone is an anabolic steroid that attenuates loss of lean body mass and improves wound healing in burn patients. We hypothesized that oxandrolone would improve outcome for ventilator-dependent surgical patients...
  14. ncbi request reprint Antioxidants in critical illness
    E M Bulger
    Department of Surgery, Box 359796, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
    Arch Surg 136:1201-7. 2001
    ..We focus on the results of these interventions in animal models and human trials, when available...
  15. ncbi request reprint The morbidity of penetrating colon injury
    Eileen M Bulger
    Department of Surgery, Harborview Medical Center, University of Washington, Box 359796, 325 Ninth Avenue, Seattle, WA 98104, USA
    Injury 34:41-6. 2003
    ..The purpose of this study is to define the current morbidity and mortality associated with penetrating colon injury and to determine the impact of management strategy on outcome...
  16. ncbi request reprint Myodesis: a novel approach to the repair of complex traumatic hernias
    Eileen M Bulger
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle 98104, USA
    J Trauma 52:756-8. 2002
  17. ncbi request reprint Rib fractures in the elderly
    E M Bulger
    Harborview Medical Center, Seattle, Washington 98104 2499, USA
    J Trauma 48:1040-6; discussion 1046-7. 2000
    ....
  18. ncbi request reprint Dithiocarbamates enhance tumor necrosis factor-alpha production by rabbit alveolar macrophages, despite inhibition of NF-kappaB
    E M Bulger
    Department of Surgery, University of Washington, Seattle 98195, USA
    Shock 9:397-405. 1998
    ..On the basis of these results, we conclude NF-kappaB may be necessary but, in contrast to prior analyzes, is not sufficient for optimal response of the alveolar Mphi to endotoxin...
  19. doi request reprint Specific abbreviated injury scale values are responsible for the underestimation of mortality in penetrating trauma patients by the injury severity score
    Susan E Rowell
    Department of Surgery, Oregon Health and Science University, Portland, Oregon 97227, USA
    J Trauma 71:S384-8. 2011
    ..We hypothesized that the mechanism-based difference in mortality could be attributed to certain ISS ranges and specific AIS values by body region...
  20. doi request reprint Gender-based differences in mortality in response to high product ratio massive transfusion
    Susan E Rowell
    Department of Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 71:S375-9. 2011
    ..This has not been examined independently in women and men. A gender dichotomy in outcome after severe injury is known to exist. This study examined gender-related differences in mortality after high product ratio massive transfusion...
  21. doi request reprint Variations between level I trauma centers in 24-hour mortality in severely injured patients requiring a massive transfusion
    Charles E Wade
    Department of Surgery, and The Center for Translational Injury Research, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma 71:S389-93. 2011
    ..We hypothesized differences among centers in 24-hour mortality could predominantly be accounted for by differences in transfusion practices as well as patient characteristics...
  22. doi request reprint Effect of high product ratio massive transfusion on mortality in blunt and penetrating trauma patients
    Susan E Rowell
    Department of Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 71:S353-7. 2011
    ..This study was performed to determine whether mortality after high product ratio massive transfusion is different in blunt and penetrating trauma patients...
  23. doi request reprint A high fresh frozen plasma: packed red blood cell transfusion ratio decreases mortality in all massively transfused trauma patients regardless of admission international normalized ratio
    Lisa M Brown
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143 0470, USA
    J Trauma 71:S358-63. 2011
    ..Therefore, we hypothesized that patients with elevated International Normalized Ratio (INR) on arrival to the hospital may benefit more from transfusion with a high ratio of FFP:PRBC than those with a lower INR...
  24. doi request reprint Timing of intubation and ventilator-associated pneumonia following injury
    Heather L Evans
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, 98104, USA
    Arch Surg 145:1041-6. 2010
    ....
  25. ncbi request reprint Trauma patients receiving CPR: predictors of survival
    John J Pickens
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle 98104 2420, USA
    J Trauma 58:951-8. 2005
    ....
  26. doi request reprint A normal platelet count may not be enough: the impact of admission platelet count on mortality and transfusion in severely injured trauma patients
    Lisa M Brown
    Department of Surgery, University of California, San Francisco, California, USA
    J Trauma 71:S337-42. 2011
    ..The purpose of this study was to examine the relationship between admission platelet count and outcomes after trauma...
  27. pmc Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trial
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, WA
    Ann Surg 253:431-41. 2011
    ..To determine whether out-of-hospital administration of hypertonic fluids would improve survival after severe injury with hemorrhagic shock...
  28. ncbi request reprint Describing a problem: rear seatback failure and unsecured cargo
    Samuel P Mandell
    Department of Trauma Surgery, Harborview Medical Center, Seattle, Washington, USA
    Prehosp Disaster Med 25:152-7. 2010
    ..However, it has been shown that unrestrained rear passengers pose a danger to front seat occupants. The association of rear seatback failures and intrusions with mortality and serious injury were examined...
  29. doi request reprint Examination of the impact of airbags on renal injury using a national database
    Thomas G Smith
    Harborview Injury Prevention and Research Center, Harborview Medical Center at the University of Washington Medical Center, Seattle, WA, USA
    J Am Coll Surg 211:355-60. 2010
    ..To evaluate the efficacy of airbags in reducing renal injuries in MVC, we analyzed renal injury rates in vehicles with and without airbags using the Crash Injury Research and Engineering Network (CIREN) database...
  30. doi request reprint Motor vehicle mismatch: a national perspective
    Samuel P Mandell
    Department of Trauma Surgery, Harborview Medical Center, Seattle, Washington, USA
    Inj Prev 16:309-14. 2010
    ..To determine the RR of the severe injury associated with light truck vehicle (LTV) versus passenger vehicle (PV) mismatch following motor vehicle collisions across the USA...
  31. ncbi request reprint Predictors of morbidity after traumatic pancreatic injury
    Lillian S Kao
    Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA
    J Trauma 55:898-905. 2003
    ....
  32. ncbi request reprint An analysis of advanced prehospital airway management
    Eileen M Bulger
    Department of Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
    J Emerg Med 23:183-9. 2002
    ..In this study, only 1.1% of patients required a surgical airway. We attribute this low rate to the use of paralytic agents. The availability of paralytic agents also allows expansion of the indications for prehospital airway control...
  33. doi request reprint Single-dose etomidate for rapid sequence intubation may impact outcome after severe injury
    Keir J Warner
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    J Trauma 67:45-50. 2009
    ..We hypothesized that etomidate may alter the occurrence of acute respiratory distress syndrome (ARDS) in injury victims...
  34. doi request reprint The utility of early end-tidal capnography in monitoring ventilation status after severe injury
    Keir J Warner
    Department of Trauma Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
    J Trauma 66:26-31. 2009
    ..Thus, we hypothesize that EtCO2 will demonstrate a poor reflection of actual ventilation status after severe injury...
  35. doi request reprint Paramedic training for proficient prehospital endotracheal intubation
    Keir J Warner
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Prehosp Emerg Care 14:103-8. 2010
    ..Multiple studies demonstrate variable endotracheal intubation (ETI) success by prehospital providers. Data describing how many ETI training experiences are required to achieve high success rates are sparse...
  36. doi request reprint Severity of injury and outcomes among obese trauma patients with fractures of the femur and tibia: a crash injury research and engineering network study
    Rajshri Maheshwari
    Department of Orthopaedics and Sports Medicine, University ofWashington, 1959 NE Pacific St, PO Box 356500, Seattle, WA 98195, USA
    J Orthop Trauma 23:634-9. 2009
    ..To understand the influence of obesity on the morbidity and mortality outcomes of patients who have sustained fractures of the femur and tibia...
  37. doi request reprint Paramedic use of needle thoracostomy in the prehospital environment
    Keir J Warner
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Prehosp Emerg Care 12:162-8. 2008
    ..The purpose of this study is to evaluate a cohort of patients undergoing NT by paramedics for tension pneumothorax and review the indications for use, complications, and emergency department outcomes of NT...
  38. doi request reprint Prehospital management of the difficult airway: a prospective cohort study
    Keir J Warner
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    J Emerg Med 36:257-65. 2009
    ..Patient anatomy is a primary factor in failed ETI. Among the advanced procedures, cricothyroidotomy had the highest success rate and should not be delayed by other interventions...
  39. doi request reprint The evolution of the diagnostic work-up for stab wounds to the back and flank
    Tam N Pham
    Department of Surgery, University of Washington, Harborview Medical Centre, Seattle, WA 98104, United States
    Injury 40:48-53. 2009
    ..This study aims to review the evolution of the diagnostic work-up for stab wounds to the back and flank...
  40. doi request reprint Mortality and injury patterns associated with roof crush in rollover crashes
    Samuel P Mandell
    Department of Trauma Surgery, Harborview Medical Center, Seattle, WA 98104 1520, USA
    Accid Anal Prev 42:1326-31. 2010
    ..We sought to explore the relationship between these injuries and the degree of roof crush...
  41. pmc Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
    ....
  42. doi request reprint High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients
    Chitra N Sambasivan
    Division of Trauma, Critical Care and Acute Care Surgery, Department of Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 71:S329-36. 2011
    ..We aimed to determine the effect of high ratios of fresh frozen plasma (FFP) and platelets (PLT) to packed red blood cells (PRBC) in nonmassively transfused patients...
  43. ncbi request reprint The impact of prehospital ventilation on outcome after severe traumatic brain injury
    Keir J Warner
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    J Trauma 62:1330-6; discussion 1336-8. 2007
    ..We sought to determine the incidence of hyperventilation among a cohort of trauma patients undergoing prehospital intubation and the impact of ventilation on outcome after severe TBI...
  44. ncbi request reprint An argument for Vitamin E supplementation in the management of systemic inflammatory response syndrome
    Eileen M Bulger
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Shock 19:99-103. 2003
    ....
  45. ncbi request reprint Intracellular antioxidant activity is necessary to modulate the macrophage response to endotoxin
    Eileen M Bulger
    University of Washington, Department of Surgery, Seattle 98104, USA
    Shock 18:58-63. 2002
    ....
  46. ncbi request reprint Hypertonic saline modulates innate immunity in a model of systemic inflammation
    Kristan L Staudenmayer
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
    Shock 23:459-63. 2005
    ..In vivo HTS prevents excessive AM activation during systemic inflammation. This suppression is mediated through alternate pathways and does not induce the classic MAPK signaling cascade...
  47. ncbi request reprint Bilateral anterior abdominal bipedicle flap with permanent prosthesis for the massive abdominal skin-grafted hernia
    Stephen R Sullivan
    Division of Plastic and Reconstructive Surgery, University of Washington, Harborville Medical Center, 325 9th Avenue, Box 359796, Seattle, WA 98104 9796, USA
    Am J Surg 193:651-5. 2007
    ..Most repair methods provide inadequate closure of large full-thickness abdominal wall defects. We describe our method of repair using bilateral anterior abdominal bipedicle flaps over permanent mesh...
  48. ncbi request reprint Epidural analgesia improves outcome after multiple rib fractures
    Eileen M Bulger
    Departments of Surgery and Anesthesiology, Harborview Medical Center, University of Washington, Seattle, WA 98005, USA
    Surgery 136:426-30. 2004
    ..Rib fractures are common and associated with significant pulmonary morbidity. We hypothesized that epidural analgesia would provide superior pain relief, and reduce the risk of subsequent pneumonia...
  49. doi request reprint Predicting death in necrotizing soft tissue infections: a clinical score
    Daniel A Anaya
    Division of General Surgery, Michael E DeBakey Veterans Affairs Medical Center, Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Surg Infect (Larchmt) 10:517-22. 2009
    ..The goal of this study was to develop a clinical score based on data available at the time of initial assessment to aid in stratifying patients according to their risk of death...
  50. ncbi request reprint The macrophage response to endotoxin requires platelet activating factor
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, USA
    Shock 17:173-9. 2002
    ..Macrophage cytokine production in response to endotoxin is PAF dependent. This effect involves the inhibition of TNF gene transcription and concomitant inhibition of NF-kappaB...
  51. pmc The random dialing survey as a tool for community consultation for research involving the emergency medicine exception from informed consent
    Eileen M Bulger
    University of Washington, Seattle, WA, USA
    Ann Emerg Med 53:341-50, 350.e1-2. 2009
    ..Previous studies have noted difficulty in engaging the community. We seek to describe the experience with random dialing surveys as a tool for community consultation across 5 metropolitan regions in the United States...
  52. ncbi request reprint Paramedic rapid sequence intubation for severe traumatic brain injury: perspectives from an expert panel
    Daniel P Davis
    Department of Emergency Medicine, University of California at San Diego, San Diego, California 92103 8676, and Trauma Services, Inova Regional Trauma Center, Inova Fairfax Hospital, Falls Church, VA, USA
    Prehosp Emerg Care 11:1-8. 2007
    ....
  53. ncbi request reprint Risk factors for hepatic morbidity following nonoperative management: multicenter study
    Rosemary A Kozar
    University of Texas, Houston 77030, USA
    Arch Surg 141:451-8; discussion 458-9. 2006
    ..Early risk factors for hepatic-related morbidity in patients undergoing initial nonoperative management of complex blunt hepatic injuries can be accurately identified...
  54. doi request reprint Mass casualty triage: an evaluation of the data and development of a proposed national guideline
    E Brooke Lerner
    Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Disaster Med Public Health Prep 2:S25-34. 2008
    ..It incorporates aspects from all of the existing triage systems to create a single overarching guide for unifying the mass casualty triage process across the United States...

Research Grants7

  1. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
    ..abstract_text> ..
  2. Hypertonic Modulation of Inflammation following Injury
    Eileen Bulger; Fiscal Year: 2007
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  3. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..