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Genomes and Genes | Antonin BukovskySummaryAffiliation: University of Tennessee Country: USA Publications
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Publications
Potential new strategies for the treatment of ovarian infertility and degenerative diseases with autologous ovarian stem cellsAntonin Bukovsky
University of Tennessee Graduate School of Medicine, Laboratory of Development, Differentiation and Cancer, and Department of Obstetrics and Gynecology, 1924 Alcoa Hwy R512, Knoxville, TN 37920, USA
Expert Opin Biol Ther 6:341-65. 2006....- Cell commitment by asymmetric division and immune system involvementAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Dept OB GYN, UT Grad School Med, Knoxville, Tennessee 37920, USA
Prog Mol Subcell Biol 45:179-204. 2007..The primary follicles persisting in premenopausal ovaries appear to accumulate genetic alterations, a cause of exponentially growing chromosomal abnormalities in the progeny of mothers between 38 years of age and menopause... 
Differential transferrin expression in placentae from normal and abnormal pregnancies: a pilot studyAlena Kralova
Institute of Biotechnology, Academy of Sciences of the Czech Republic, V, V, I, 142 20, Prague, Czech Republic
Reprod Biol Endocrinol 6:27. 2008..One of the major iron transport proteins is transferrin, which is a blood plasma protein crucial for iron uptake. Its localization and expression may be one of the markers to distinguish placental dysfunction...- Postnatal androgenization induces premature aging of rat ovariesA Bukovsky
Department of Obstetrics and Gynecology, University of Tennessee Medical Center, Graduate School of Medicine, Knoxville, TN, USA
Steroids 65:190-205. 2000..We suggest that mesenchymal cells regulate qualitative aspects of tissue-specific cells, and this function of mesenchymal cells is programmed during the critical period of development... - Immune system involvement in the regulation of ovarian function and augmentation of cancerAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
Microsc Res Tech 69:482-500. 2006..These data indicate that vascular pericytes, MDC, T cells, and immunoglobulins may play an important role in the regulation of ovarian physiology and contribute to the augmentation of ovarian cancer growth... - Immune physiology of the mammalian ovary - a reviewAntonin Bukovsky
Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
Am J Reprod Immunol 59:12-26. 2008.... - Oogenesis from human somatic stem cells and a role of immune adaptation in premature ovarian failureAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
Curr Stem Cell Res Ther 1:289-303. 2006.... - Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovariesAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
Cell Cycle 7:683-6. 2008..Preparation for meiotic activity may have already occurred at the level of tunica albuginea stem cells, and meiotic prophase activity may continue and terminate in oocytes of newly formed primordial follicles... 
Production of monoclonal antibodies against recombinant human zona pellucida glycoproteins: utility in immunolocalization of respective zona proteins in ovarian folliclesAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
J Reprod Immunol 78:102-14. 2008..Altogether, these studies document generation of MAbs exhibiting high specificity for human zona proteins, which will be useful reagents to study their immunobiology...- Immune physiology and oogenesis in fetal and adult humans, ovarian infertility, and totipotency of adult ovarian stem cellsAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine, Knoxville, Tennessee 37920, USA
Birth Defects Res C Embryo Today 87:64-89. 2009..Such treatment may also stimulate the transdifferentiation of autologous neural stem cell precursors into neural stem cells useful for topical or systemic regenerative treatment... - Immune physiology in tissue regeneration and aging, tumor growth, and regenerative medicineAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, TN 37920, USA
Aging (Albany NY) 1:157-81. 2009..Thus successful stem cell therapy will depend on immune physiology in targeted tissues. From this point of view, regenerative medicine is more likely to be successful in acute rather than chronic tissue disorders... - Can ovarian infertility be treated with bone marrow- or ovary-derived germ cells?Antonin Bukovsky
Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Tennessee, USA
Reprod Biol Endocrinol 3:36. 2005.... - Oogenesis in adult mammals, including humans: a reviewAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer and Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, 37920, USA
Endocrine 26:301-16. 2005.... - Oogenesis in cultures derived from adult human ovariesAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, USA
Reprod Biol Endocrinol 3:17. 2005..In addition, other clinical applications aiming to utilize stem cells, and basic stem cell research as well, may employ totipotent embryonic stem cells developing from fertilized oocytes... - Changes of ovarian interstitial cell hormone receptors and behavior of resident mesenchymal cells in developing and adult rats with steroid-induced sterilityAntonin Bukovsky
Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
Steroids 67:277-89. 2002.... - The role of the host-tumor interface and cell hybridization in invasive cancerA Bukovsky
Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville 37920, USA
Med Hypotheses 57:729-35. 2001..Novel approaches to cancer prevention and control may depend on a better understanding of the mechanisms by which normal cellular growth are controlled, and hybridization prevented... - Variability of placental expression of cyclin E low molecular weight variantsAntonin Bukovsky
Laboratory for Development, Differentiation, and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
Biol Reprod 67:568-74. 2002..However, an enhanced expression of some cyclin E LMW proteins only might reflect an association of cyclin E isoforms with placental aging or an inefficient placental adaptation... - Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiolAntonin Bukovsky
Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
Reprod Biol Endocrinol 1:13. 2003..This mechanism, however, may not operate in abnormal placentae, which show a lack of ER-alpha expression... - Dominant role of monocytes in control of tissue function and agingA Bukovsky
Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
Med Hypotheses 55:337-47. 2000..The ability of monocytes to preserve tissue cells in the functional state declines with age, and this is accompanied by functional decline of various tissues within the body, and an increased incidence of degenerative diseases... - Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy,Antonin Bukovsky
Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
Reprod Biol Endocrinol 1:46. 2003.... - Origin of germ cells and formation of new primary follicles in adult human ovariesAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
Reprod Biol Endocrinol 2:20. 2004..An essential mission of such follicular turnover might be elimination of spontaneous or environmentally induced genetic alterations of oocytes in resting primary follicles... - Association of mesenchymal cells and immunoglobulins with differentiating epithelial cellsA Bukovsky
Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
BMC Dev Biol 1:11. 2001..We studied epitopes of mesenchymal cells and their products (immunoglobulins) in stratified epithelium of uterine ectocervix, which is one of the prototypes of complete cellular differentiation from stem into the aged cells... - Placental expression of estrogen receptor beta and its hormone binding variant--comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cellsAntonin Bukovsky
Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
Reprod Biol Endocrinol 1:36. 2003..Our data also indicate that asymmetric segregation of ER-alpha may play a role in asymmetric division of estrogen-dependent cells... - Study origin of germ cells and formation of new primary follicles in adult human and rat ovariesAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
Methods Mol Biol 450:233-65. 2008..As part of this chapter, we present in detail protocols utilized to analyze oogenesis in humans and to study interspecies differences when compared to the ovaries of rat females... - Sex steroid-mediated reprogramming of vascular smooth muscle cells to stem cells and neurons: possible utilization of sex steroid combinations for regenerative treatment without utilization of in vitro developed stem cellsAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, TN, USA
Cell Cycle 8:4079-84. 2009..e., without a need of in vitro developed stem cells... - Steroid-mediated differentiation of neural/neuronal cells from epithelial ovarian precursors in vitroAntonin Bukovsky
Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
Cell Cycle 7:3577-83. 2008.... - Ovarian germ cellsAntonin Bukovsky
Laboratory of Development, Differenciation and Cancer, The University of Tennessee Graduate School of Medicine, Knoxville, USA
Methods Enzymol 419:208-58. 2006..It then provides detailed protocols for the separation and cultivation of adult ovarian stem cells... - How can female germline stem cells contribute to the physiological neo-oogenesis in mammals and why menopause occurs?Antonin Bukovsky
Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
Microsc Microanal 17:498-505. 2011.... - Removal of Cdk inhibitors through both sequestration and downregulation in zearalenone-treated MCF-7 breast cancer cellsShamila Ahamed
Department of Obstetrics and Gynecology, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee, USA
Mol Carcinog 34:45-58. 2002..These studies suggest that both sequestration of Cdk inhibitors by cyclin D1/Cdk4 complexes and downregulation of p27(KIP1) play major roles in the induction of Cdk2 activity and S phase entry elicited by estrogens in MCF-7 cells... - Bone marrow derived cells and alternative pathways of oogenesis in adult rodentsAntonin Bukovsky
Cell Cycle 6:2306-9. 2007..An alternative origin of PGCs from the medullary region may explain why ovaries with destructed OSE are still capable of forming new primordial follicles...