Antonin Bukovsky

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi request reprint Potential new strategies for the treatment of ovarian infertility and degenerative diseases with autologous ovarian stem cells
    Antonin Bukovsky
    University of Tennessee Graduate School of Medicine, Laboratory of Development, Differentiation and Cancer, and Department of Obstetrics and Gynecology, 1924 Alcoa Hwy R512, Knoxville, TN 37920, USA
    Expert Opin Biol Ther 6:341-65. 2006
  2. ncbi request reprint Cell commitment by asymmetric division and immune system involvement
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Dept OB GYN, UT Grad School Med, Knoxville, Tennessee 37920, USA
    Prog Mol Subcell Biol 45:179-204. 2007
  3. pmc Differential transferrin expression in placentae from normal and abnormal pregnancies: a pilot study
    Alena Kralova
    Institute of Biotechnology, Academy of Sciences of the Czech Republic, V, V, I, 142 20, Prague, Czech Republic
    Reprod Biol Endocrinol 6:27. 2008
  4. ncbi request reprint Postnatal androgenization induces premature aging of rat ovaries
    A Bukovsky
    Department of Obstetrics and Gynecology, University of Tennessee Medical Center, Graduate School of Medicine, Knoxville, TN, USA
    Steroids 65:190-205. 2000
  5. ncbi request reprint Immune system involvement in the regulation of ovarian function and augmentation of cancer
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Microsc Res Tech 69:482-500. 2006
  6. ncbi request reprint Immune physiology of the mammalian ovary - a review
    Antonin Bukovsky
    Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
    Am J Reprod Immunol 59:12-26. 2008
  7. ncbi request reprint Oogenesis from human somatic stem cells and a role of immune adaptation in premature ovarian failure
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    Curr Stem Cell Res Ther 1:289-303. 2006
  8. ncbi request reprint Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Cell Cycle 7:683-6. 2008
  9. ncbi request reprint Production of monoclonal antibodies against recombinant human zona pellucida glycoproteins: utility in immunolocalization of respective zona proteins in ovarian follicles
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    J Reprod Immunol 78:102-14. 2008
  10. doi request reprint Immune physiology and oogenesis in fetal and adult humans, ovarian infertility, and totipotency of adult ovarian stem cells
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine, Knoxville, Tennessee 37920, USA
    Birth Defects Res C Embryo Today 87:64-89. 2009

Detail Information

Publications31

  1. ncbi request reprint Potential new strategies for the treatment of ovarian infertility and degenerative diseases with autologous ovarian stem cells
    Antonin Bukovsky
    University of Tennessee Graduate School of Medicine, Laboratory of Development, Differentiation and Cancer, and Department of Obstetrics and Gynecology, 1924 Alcoa Hwy R512, Knoxville, TN 37920, USA
    Expert Opin Biol Ther 6:341-65. 2006
    ....
  2. ncbi request reprint Cell commitment by asymmetric division and immune system involvement
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Dept OB GYN, UT Grad School Med, Knoxville, Tennessee 37920, USA
    Prog Mol Subcell Biol 45:179-204. 2007
    ..The primary follicles persisting in premenopausal ovaries appear to accumulate genetic alterations, a cause of exponentially growing chromosomal abnormalities in the progeny of mothers between 38 years of age and menopause...
  3. pmc Differential transferrin expression in placentae from normal and abnormal pregnancies: a pilot study
    Alena Kralova
    Institute of Biotechnology, Academy of Sciences of the Czech Republic, V, V, I, 142 20, Prague, Czech Republic
    Reprod Biol Endocrinol 6:27. 2008
    ..One of the major iron transport proteins is transferrin, which is a blood plasma protein crucial for iron uptake. Its localization and expression may be one of the markers to distinguish placental dysfunction...
  4. ncbi request reprint Postnatal androgenization induces premature aging of rat ovaries
    A Bukovsky
    Department of Obstetrics and Gynecology, University of Tennessee Medical Center, Graduate School of Medicine, Knoxville, TN, USA
    Steroids 65:190-205. 2000
    ..We suggest that mesenchymal cells regulate qualitative aspects of tissue-specific cells, and this function of mesenchymal cells is programmed during the critical period of development...
  5. ncbi request reprint Immune system involvement in the regulation of ovarian function and augmentation of cancer
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Microsc Res Tech 69:482-500. 2006
    ..These data indicate that vascular pericytes, MDC, T cells, and immunoglobulins may play an important role in the regulation of ovarian physiology and contribute to the augmentation of ovarian cancer growth...
  6. ncbi request reprint Immune physiology of the mammalian ovary - a review
    Antonin Bukovsky
    Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
    Am J Reprod Immunol 59:12-26. 2008
    ....
  7. ncbi request reprint Oogenesis from human somatic stem cells and a role of immune adaptation in premature ovarian failure
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    Curr Stem Cell Res Ther 1:289-303. 2006
    ....
  8. ncbi request reprint Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Cell Cycle 7:683-6. 2008
    ..Preparation for meiotic activity may have already occurred at the level of tunica albuginea stem cells, and meiotic prophase activity may continue and terminate in oocytes of newly formed primordial follicles...
  9. ncbi request reprint Production of monoclonal antibodies against recombinant human zona pellucida glycoproteins: utility in immunolocalization of respective zona proteins in ovarian follicles
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    J Reprod Immunol 78:102-14. 2008
    ..Altogether, these studies document generation of MAbs exhibiting high specificity for human zona proteins, which will be useful reagents to study their immunobiology...
  10. doi request reprint Immune physiology and oogenesis in fetal and adult humans, ovarian infertility, and totipotency of adult ovarian stem cells
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine, Knoxville, Tennessee 37920, USA
    Birth Defects Res C Embryo Today 87:64-89. 2009
    ..Such treatment may also stimulate the transdifferentiation of autologous neural stem cell precursors into neural stem cells useful for topical or systemic regenerative treatment...
  11. pmc Immune physiology in tissue regeneration and aging, tumor growth, and regenerative medicine
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, TN 37920, USA
    Aging (Albany NY) 1:157-81. 2009
    ..Thus successful stem cell therapy will depend on immune physiology in targeted tissues. From this point of view, regenerative medicine is more likely to be successful in acute rather than chronic tissue disorders...
  12. pmc Can ovarian infertility be treated with bone marrow- or ovary-derived germ cells?
    Antonin Bukovsky
    Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Tennessee, USA
    Reprod Biol Endocrinol 3:36. 2005
    ....
  13. ncbi request reprint Oogenesis in adult mammals, including humans: a review
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer and Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, 37920, USA
    Endocrine 26:301-16. 2005
    ....
  14. pmc Oogenesis in cultures derived from adult human ovaries
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, USA
    Reprod Biol Endocrinol 3:17. 2005
    ..In addition, other clinical applications aiming to utilize stem cells, and basic stem cell research as well, may employ totipotent embryonic stem cells developing from fertilized oocytes...
  15. ncbi request reprint Changes of ovarian interstitial cell hormone receptors and behavior of resident mesenchymal cells in developing and adult rats with steroid-induced sterility
    Antonin Bukovsky
    Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    Steroids 67:277-89. 2002
    ....
  16. ncbi request reprint The role of the host-tumor interface and cell hybridization in invasive cancer
    A Bukovsky
    Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville 37920, USA
    Med Hypotheses 57:729-35. 2001
    ..Novel approaches to cancer prevention and control may depend on a better understanding of the mechanisms by which normal cellular growth are controlled, and hybridization prevented...
  17. ncbi request reprint Variability of placental expression of cyclin E low molecular weight variants
    Antonin Bukovsky
    Laboratory for Development, Differentiation, and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    Biol Reprod 67:568-74. 2002
    ..However, an enhanced expression of some cyclin E LMW proteins only might reflect an association of cyclin E isoforms with placental aging or an inefficient placental adaptation...
  18. pmc Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol
    Antonin Bukovsky
    Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Reprod Biol Endocrinol 1:13. 2003
    ..This mechanism, however, may not operate in abnormal placentae, which show a lack of ER-alpha expression...
  19. ncbi request reprint Dominant role of monocytes in control of tissue function and aging
    A Bukovsky
    Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Med Hypotheses 55:337-47. 2000
    ..The ability of monocytes to preserve tissue cells in the functional state declines with age, and this is accompanied by functional decline of various tissues within the body, and an increased incidence of degenerative diseases...
  20. pmc Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy,
    Antonin Bukovsky
    Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    Reprod Biol Endocrinol 1:46. 2003
    ....
  21. pmc Origin of germ cells and formation of new primary follicles in adult human ovaries
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Reprod Biol Endocrinol 2:20. 2004
    ..An essential mission of such follicular turnover might be elimination of spontaneous or environmentally induced genetic alterations of oocytes in resting primary follicles...
  22. pmc Association of mesenchymal cells and immunoglobulins with differentiating epithelial cells
    A Bukovsky
    Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    BMC Dev Biol 1:11. 2001
    ..We studied epitopes of mesenchymal cells and their products (immunoglobulins) in stratified epithelium of uterine ectocervix, which is one of the prototypes of complete cellular differentiation from stem into the aged cells...
  23. pmc Placental expression of estrogen receptor beta and its hormone binding variant--comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells
    Antonin Bukovsky
    Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Reprod Biol Endocrinol 1:36. 2003
    ..Our data also indicate that asymmetric segregation of ER-alpha may play a role in asymmetric division of estrogen-dependent cells...
  24. doi request reprint Study origin of germ cells and formation of new primary follicles in adult human and rat ovaries
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
    Methods Mol Biol 450:233-65. 2008
    ..As part of this chapter, we present in detail protocols utilized to analyze oogenesis in humans and to study interspecies differences when compared to the ovaries of rat females...
  25. ncbi request reprint Sex steroid-mediated reprogramming of vascular smooth muscle cells to stem cells and neurons: possible utilization of sex steroid combinations for regenerative treatment without utilization of in vitro developed stem cells
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, TN, USA
    Cell Cycle 8:4079-84. 2009
    ..e., without a need of in vitro developed stem cells...
  26. ncbi request reprint Steroid-mediated differentiation of neural/neuronal cells from epithelial ovarian precursors in vitro
    Antonin Bukovsky
    Laboratory of Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Cell Cycle 7:3577-83. 2008
    ....
  27. ncbi request reprint Ovarian germ cells
    Antonin Bukovsky
    Laboratory of Development, Differenciation and Cancer, The University of Tennessee Graduate School of Medicine, Knoxville, USA
    Methods Enzymol 419:208-58. 2006
    ..It then provides detailed protocols for the separation and cultivation of adult ovarian stem cells...
  28. doi request reprint How can female germline stem cells contribute to the physiological neo-oogenesis in mammals and why menopause occurs?
    Antonin Bukovsky
    Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Microsc Microanal 17:498-505. 2011
    ....
  29. ncbi request reprint Removal of Cdk inhibitors through both sequestration and downregulation in zearalenone-treated MCF-7 breast cancer cells
    Shamila Ahamed
    Department of Obstetrics and Gynecology, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee, USA
    Mol Carcinog 34:45-58. 2002
    ..These studies suggest that both sequestration of Cdk inhibitors by cyclin D1/Cdk4 complexes and downregulation of p27(KIP1) play major roles in the induction of Cdk2 activity and S phase entry elicited by estrogens in MCF-7 cells...
  30. ncbi request reprint Bone marrow derived cells and alternative pathways of oogenesis in adult rodents
    Antonin Bukovsky
    Cell Cycle 6:2306-9. 2007
    ..An alternative origin of PGCs from the medullary region may explain why ovaries with destructed OSE are still capable of forming new primordial follicles...