Affiliation: University of Tennessee
Bukovsky A, Ayala M, Dominguez R, Keenan J, Wimalasena J, McKenzie P, et al
. Postnatal androgenization induces premature aging of rat ovaries. Steroids. 2000;65:190-205 pubmed
..We suggest that mesenchymal cells regulate qualitative aspects of tissue-specific cells, and this function of mesenchymal cells is programmed during the critical period of development. ..
Bukovsky A, Ayala M, Dominguez R, Keenan J, Wimalasena J, Elder R, et al
. Changes of ovarian interstitial cell hormone receptors and behavior of resident mesenchymal cells in developing and adult rats with steroid-induced sterility. Steroids. 2002;67:277-89 pubmed
Bukovsky A, Svetlikova M, Caudle M. Oogenesis in cultures derived from adult human ovaries. Reprod Biol Endocrinol. 2005;3:17 pubmed
..In addition, other clinical applications aiming to utilize stem cells, and basic stem cell research as well, may employ totipotent embryonic stem cells developing from fertilized oocytes. ..
Bukovsky A, Caudle M, Carson R, Gaytan F, Huleihel M, Kruse A, et al
. Immune physiology in tissue regeneration and aging, tumor growth, and regenerative medicine. Aging (Albany NY). 2009;1:157-81 pubmed
..Thus successful stem cell therapy will depend on immune physiology in targeted tissues. From this point of view, regenerative medicine is more likely to be successful in acute rather than chronic tissue disorders. ..
Bukovsky A, Caudle M. Immune physiology of the mammalian ovary - a review. Am J Reprod Immunol. 2008;59:12-26 pubmed
Bukovsky A, Cekanova M, Caudle M, Wimalasena J, Foster J, Keenan J, et al
. Variability of placental expression of cyclin E low molecular weight variants. Biol Reprod. 2002;67:568-74 pubmed
..However, an enhanced expression of some cyclin E LMW proteins only might reflect an association of cyclin E isoforms with placental aging or an inefficient placental adaptation...
Bukovsky A, Cekanova M, Caudle M, Wimalasena J, Foster J, Henley D, et al
. Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol. Reprod Biol Endocrinol. 2003;1:13 pubmed
..This mechanism, however, may not operate in abnormal placentae, which show a lack of ER-alpha expression...
Bukovsky A, Indrapichate K, Fujiwara H, Cekanova M, Ayala M, Dominguez R, et al
. Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregn. Reprod Biol Endocrinol. 2003;1:46 pubmed
Bukovsky A, Caudle M, Gupta S, Svetlikova M, Selleck White R, Ayala A, et al
. Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries. Cell Cycle. 2008;7:683-6 pubmed
..Preparation for meiotic activity may have already occurred at the level of tunica albuginea stem cells, and meiotic prophase activity may continue and terminate in oocytes of newly formed primordial follicles. ..