Research Topics
Genomes and GenesSpecies | Ilia N BuhtoiarovSummaryAffiliation: University of Wisconsin Country: USA Publications
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Detail Information
Publications
Pleasant memories: remembering immune protection while forgetting about graft-versus-host diseasePaul M Sondel
Department of Pediatrics, University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53792, USA
J Clin Invest 112:25-7. 2003
Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effectsIlia N Buhtoiarov
Department of Human Oncology and Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
J Immunol 176:309-18. 2006....- Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotidesIlia N Buhtoiarov
Department of Human Oncology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 4672, USA
Immunology 120:412-23. 2007..Taken together, our results indicate that the growth control of weakly immunogenic tumours during CpG-immunotherapy is mediated predominantly by Mphi, rather than T cells or NK cells... - Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 moleculesIlia N Buhtoiarov
Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
J Immunol 182:1940-53. 2009..These results suggest that contact with certain tumor cells via CD40, NKG2D, and CD18 molecules on the Mphi may facilitate Mphi-mediated antitumor immune surveillance... - In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophagesHillary D Lum
Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
J Leukoc Biol 79:1181-92. 2006..Taken together, our results show that anti-CD40 mAb immunotherapy of mice can inhibit tumor growth in the absence of T cells, NK cells, and PMN through the involvement of activated Mphi... - CD40 ligation activates murine macrophages via an IFN-gamma-dependent mechanism resulting in tumor cell destruction in vitroIlia N Buhtoiarov
Department of Human Oncology and UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
J Immunol 174:6013-22. 2005..IFN-gamma production by macrophages was dependent on IL-12. Taken together, the results show that murine macrophages are activated directly by anti-CD40 mAb to secrete IFN-gamma and mediate tumor cell destruction... - Tumoristatic effects of anti-CD40 mAb-activated macrophages involve nitric oxide and tumour necrosis factor-alphaHillary D Lum
Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
Immunology 118:261-70. 2006..Taken together, these results suggest that NO and TNF-alpha are involved in, but not solely responsible for, the antitumour effects of macrophages after activation by CD40 ligation... - Intratumoral immunocytokine treatment results in enhanced antitumor effectsErik E Johnson
Department of Surgery, University of Wisconsin, Madison, WI, 53792, USA
Cancer Immunol Immunother 57:1891-902. 2008..Further testing is required to determine how to potentially incorporate IT administration of IC into an antitumor regimen that optimizes local and systemic anticancer therapy... - Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemiaQing Li Wu
Department of Pathology and Laboratory Medicine, Pediatrics University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
J Immunol 182:6771-8. 2009..Our results suggest a novel immunotherapeutic strategy for CLL that may be effective even in the face of tumor or chemotherapy-induced T cell immunodeficiency... 
CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumorsAlexander L Rakhmilevich
The Department of Human Oncology, University of Wisconsin, K4 413 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
Cancer Immunol Immunother 57:1151-60. 2008..Taken together, our results indicate that antitumor effects induced by alphaCD40, even against immunogenic tumors, can be observed in the absence of T cells and may involve macrophages...- Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interfaceJennifer A A Gubbels
Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI 53711, USA
Cancer Immunol Immunother 60:1789-800. 2011..These findings demonstrate that the IL-2 component of the IC allows IL2Rs to function not only as receptors for this cytokine but also as facilitators of peritoneal NK cell binding to IC-coated tumor cells... - Radiofrequency ablation combined with KS-IL2 immunocytokine (EMD 273066) results in an enhanced antitumor effect against murine colon adenocarcinomaErik E Johnson
Departments of Surgery, Human Oncology, and Pediatrics and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
Clin Cancer Res 15:4875-84. 2009..Radiofrequency ablation (RFA) is a common treatment modality for surgically unresectable tumors. However, there is a high rate of both local and systemic recurrence... - Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophagesIlia N Buhtoiarov
Department of Human Oncology, University of Wisconsin, Madison, WI 53705 2275, USA
Immunology 132:226-39. 2011..Together, the results show that CT and anti-CD40 + CpG-ODN IT synergize in the induction of anti-tumour effects which are associated with the phenotypic repolarization of tumour-associated Mφ... - Enhanced T-cell-independent antitumor effect of cyclophosphamide combined with anti-CD40 mAb and CpG in miceErik E Johnson
Paul P Carbone Comprehensive Cancer Center, Department of Surgery, University of Wisconsin, Madison, WI, USA
J Immunother 34:76-84. 2011..These results suggest that therapeutic strategies to activate macrophages may have potential for clinical application in cancer patients receiving chemotherapy... - Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targetingIlia N Buhtoiarov
UW Carbone Cancer Center, 4159 MACC Fund UW Childhood Cancer Research Wing, WIMR, 1111 Highland Ave, Madison, WI 53705 2275, USA
J Leukoc Biol 89:625-38. 2011..These studies demonstrate that once IC binds to the tumor, it is present on the tumor surface for a prolonged time, inducing the recruitment of NK cells to the tumor site, followed by tumor cell killing... - Enhanced activity of hu14.18-IL2 immunocytokine against murine NXS2 neuroblastoma when combined with interleukin 2 therapyZane C Neal
Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA
Clin Cancer Res 10:4839-47. 2004..Animals showing prolonged tumor eradication of established tumors after the combined hu14.18-IL2 plus IL-2 regimen exhibited a protective T-cell-dependent antitumor memory response against NXS2 rechallenge...