Ilia N Buhtoiarov

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Pleasant memories: remembering immune protection while forgetting about graft-versus-host disease
    Paul M Sondel
    Department of Pediatrics, University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53792, USA
    J Clin Invest 112:25-7. 2003
  2. ncbi Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects
    Ilia N Buhtoiarov
    Department of Human Oncology and Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 176:309-18. 2006
  3. pmc Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides
    Ilia N Buhtoiarov
    Department of Human Oncology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 4672, USA
    Immunology 120:412-23. 2007
  4. pmc Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules
    Ilia N Buhtoiarov
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 182:1940-53. 2009
  5. ncbi In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages
    Hillary D Lum
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    J Leukoc Biol 79:1181-92. 2006
  6. ncbi CD40 ligation activates murine macrophages via an IFN-gamma-dependent mechanism resulting in tumor cell destruction in vitro
    Ilia N Buhtoiarov
    Department of Human Oncology and UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 174:6013-22. 2005
  7. pmc Tumoristatic effects of anti-CD40 mAb-activated macrophages involve nitric oxide and tumour necrosis factor-alpha
    Hillary D Lum
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Immunology 118:261-70. 2006
  8. pmc Intratumoral immunocytokine treatment results in enhanced antitumor effects
    Erik E Johnson
    Department of Surgery, University of Wisconsin, Madison, WI, 53792, USA
    Cancer Immunol Immunother 57:1891-902. 2008
  9. pmc Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia
    Qing Li Wu
    Department of Pathology and Laboratory Medicine, Pediatrics University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Immunol 182:6771-8. 2009
  10. doi CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumors
    Alexander L Rakhmilevich
    The Department of Human Oncology, University of Wisconsin, K4 413 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Cancer Immunol Immunother 57:1151-60. 2008

Collaborators

Detail Information

Publications16

  1. pmc Pleasant memories: remembering immune protection while forgetting about graft-versus-host disease
    Paul M Sondel
    Department of Pediatrics, University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53792, USA
    J Clin Invest 112:25-7. 2003
  2. ncbi Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects
    Ilia N Buhtoiarov
    Department of Human Oncology and Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 176:309-18. 2006
    ....
  3. pmc Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides
    Ilia N Buhtoiarov
    Department of Human Oncology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 4672, USA
    Immunology 120:412-23. 2007
    ..Taken together, our results indicate that the growth control of weakly immunogenic tumours during CpG-immunotherapy is mediated predominantly by Mphi, rather than T cells or NK cells...
  4. pmc Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules
    Ilia N Buhtoiarov
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 182:1940-53. 2009
    ..These results suggest that contact with certain tumor cells via CD40, NKG2D, and CD18 molecules on the Mphi may facilitate Mphi-mediated antitumor immune surveillance...
  5. ncbi In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages
    Hillary D Lum
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    J Leukoc Biol 79:1181-92. 2006
    ..Taken together, our results show that anti-CD40 mAb immunotherapy of mice can inhibit tumor growth in the absence of T cells, NK cells, and PMN through the involvement of activated Mphi...
  6. ncbi CD40 ligation activates murine macrophages via an IFN-gamma-dependent mechanism resulting in tumor cell destruction in vitro
    Ilia N Buhtoiarov
    Department of Human Oncology and UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 174:6013-22. 2005
    ..IFN-gamma production by macrophages was dependent on IL-12. Taken together, the results show that murine macrophages are activated directly by anti-CD40 mAb to secrete IFN-gamma and mediate tumor cell destruction...
  7. pmc Tumoristatic effects of anti-CD40 mAb-activated macrophages involve nitric oxide and tumour necrosis factor-alpha
    Hillary D Lum
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Immunology 118:261-70. 2006
    ..Taken together, these results suggest that NO and TNF-alpha are involved in, but not solely responsible for, the antitumour effects of macrophages after activation by CD40 ligation...
  8. pmc Intratumoral immunocytokine treatment results in enhanced antitumor effects
    Erik E Johnson
    Department of Surgery, University of Wisconsin, Madison, WI, 53792, USA
    Cancer Immunol Immunother 57:1891-902. 2008
    ..Further testing is required to determine how to potentially incorporate IT administration of IC into an antitumor regimen that optimizes local and systemic anticancer therapy...
  9. pmc Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia
    Qing Li Wu
    Department of Pathology and Laboratory Medicine, Pediatrics University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Immunol 182:6771-8. 2009
    ..Our results suggest a novel immunotherapeutic strategy for CLL that may be effective even in the face of tumor or chemotherapy-induced T cell immunodeficiency...
  10. doi CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumors
    Alexander L Rakhmilevich
    The Department of Human Oncology, University of Wisconsin, K4 413 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Cancer Immunol Immunother 57:1151-60. 2008
    ..Taken together, our results indicate that antitumor effects induced by alphaCD40, even against immunogenic tumors, can be observed in the absence of T cells and may involve macrophages...
  11. doi Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface
    Jennifer A A Gubbels
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI 53711, USA
    Cancer Immunol Immunother 60:1789-800. 2011
    ..These findings demonstrate that the IL-2 component of the IC allows IL2Rs to function not only as receptors for this cytokine but also as facilitators of peritoneal NK cell binding to IC-coated tumor cells...
  12. pmc Radiofrequency ablation combined with KS-IL2 immunocytokine (EMD 273066) results in an enhanced antitumor effect against murine colon adenocarcinoma
    Erik E Johnson
    Departments of Surgery, Human Oncology, and Pediatrics and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792, USA
    Clin Cancer Res 15:4875-84. 2009
    ..Radiofrequency ablation (RFA) is a common treatment modality for surgically unresectable tumors. However, there is a high rate of both local and systemic recurrence...
  13. pmc Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages
    Ilia N Buhtoiarov
    Department of Human Oncology, University of Wisconsin, Madison, WI 53705 2275, USA
    Immunology 132:226-39. 2011
    ..Together, the results show that CT and anti-CD40 + CpG-ODN IT synergize in the induction of anti-tumour effects which are associated with the phenotypic repolarization of tumour-associated Mφ...
  14. pmc Enhanced T-cell-independent antitumor effect of cyclophosphamide combined with anti-CD40 mAb and CpG in mice
    Erik E Johnson
    Paul P Carbone Comprehensive Cancer Center, Department of Surgery, University of Wisconsin, Madison, WI, USA
    J Immunother 34:76-84. 2011
    ..These results suggest that therapeutic strategies to activate macrophages may have potential for clinical application in cancer patients receiving chemotherapy...
  15. pmc Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting
    Ilia N Buhtoiarov
    UW Carbone Cancer Center, 4159 MACC Fund UW Childhood Cancer Research Wing, WIMR, 1111 Highland Ave, Madison, WI 53705 2275, USA
    J Leukoc Biol 89:625-38. 2011
    ..These studies demonstrate that once IC binds to the tumor, it is present on the tumor surface for a prolonged time, inducing the recruitment of NK cells to the tumor site, followed by tumor cell killing...
  16. ncbi Enhanced activity of hu14.18-IL2 immunocytokine against murine NXS2 neuroblastoma when combined with interleukin 2 therapy
    Zane C Neal
    Department of Human Oncology, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Clin Cancer Res 10:4839-47. 2004
    ..Animals showing prolonged tumor eradication of established tumors after the combined hu14.18-IL2 plus IL-2 regimen exhibited a protective T-cell-dependent antitumor memory response against NXS2 rechallenge...