Georgette M Buga

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation
    Georgette M Buga
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 30:283-9. 2010
  2. ncbi request reprint D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet
    Georgette M Buga
    Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1679, USA
    J Lipid Res 49:192-205. 2008
  3. ncbi request reprint D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet
    Georgette M Buga
    Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1679, USA
    J Lipid Res 47:2148-60. 2006
  4. pmc High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Room A2 237 CHS, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 32:2553-60. 2012
  5. pmc Multiple indications for anti-inflammatory apolipoprotein mimetic peptides
    Brian J Van Lenten
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Curr Opin Investig Drugs 9:1157-62. 2008
  6. pmc D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Lipid Res 53:437-45. 2012
  7. pmc Peptide Mimetics of Apolipoproteins Improve HDL Function
    Mohamad Navab
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679
    J Clin Lipidol 1:142-7. 2007
  8. pmc Apolipoprotein A-I mimetic peptides
    Brian J Van Lenten
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Atheroscler Rep 11:52-7. 2009
  9. ncbi request reprint Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP
    Louis J Ignarro
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90095 1735, USA
    Nitric Oxide 7:83-90. 2002
  10. ncbi request reprint Nebivolol: a selective beta(1)-adrenergic receptor antagonist that relaxes vascular smooth muscle by nitric oxide- and cyclic GMP-dependent mechanisms
    Louis J Ignarro
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90095 1735, USA
    Nitric Oxide 7:75-82. 2002

Collaborators

Detail Information

Publications13

  1. pmc L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation
    Georgette M Buga
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 30:283-9. 2010
    ..CONCLUSIONS: By binding plasma-oxidized lipids that cause platelet hyperreactivity in hyperlipidemic mice, L-4F decreases platelet aggregation...
  2. ncbi request reprint D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet
    Georgette M Buga
    Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1679, USA
    J Lipid Res 49:192-205. 2008
    ..We conclude that D-4F reduced renal oxidized phospholipids, resulting in lower expression of SREBP-1c, which, in turn, resulted in lower triglyceride content and reduced renal inflammation...
  3. ncbi request reprint D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet
    Georgette M Buga
    Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1679, USA
    J Lipid Res 47:2148-60. 2006
    ..05). We conclude that a WD induces brain arteriole inflammation and cognitive impairment that is ameliorated by oral D-4F without altering plasma lipids, blood pressure, or arteriole lumen size...
  4. pmc High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Room A2 237 CHS, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 32:2553-60. 2012
    ..Studies with apolipoprotein A-I mimetic peptides suggest that the small intestine is a major tissue regulating systemic inflammation in mouse models of atherosclerosis and may be important for determining the functionality of HDL...
  5. pmc Multiple indications for anti-inflammatory apolipoprotein mimetic peptides
    Brian J Van Lenten
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Curr Opin Investig Drugs 9:1157-62. 2008
    ....
  6. pmc D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Lipid Res 53:437-45. 2012
    ..05). We conclude that D-4F administration reduces levels of free metabolites of arachidonic and linoleic acids in the small intestine and this is associated with decreased inflammation in LDL receptor deficient mice...
  7. pmc Peptide Mimetics of Apolipoproteins Improve HDL Function
    Mohamad Navab
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679
    J Clin Lipidol 1:142-7. 2007
    ..Some of these are now entering the clinical arena as interventions in pharmacologic and pharmacodynamic studies...
  8. pmc Apolipoprotein A-I mimetic peptides
    Brian J Van Lenten
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Atheroscler Rep 11:52-7. 2009
    ....
  9. ncbi request reprint Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP
    Louis J Ignarro
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90095 1735, USA
    Nitric Oxide 7:83-90. 2002
    ..These observations confirm previous findings that DFMO and NO interfere with RASMC proliferation by inhibiting ODC and polyamine production and provide evidence that nebivolol works by the same mechanism...
  10. ncbi request reprint Nebivolol: a selective beta(1)-adrenergic receptor antagonist that relaxes vascular smooth muscle by nitric oxide- and cyclic GMP-dependent mechanisms
    Louis J Ignarro
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90095 1735, USA
    Nitric Oxide 7:75-82. 2002
    ..Additional experiments ruled out other endothelium-independent vasorelaxant mechanisms. In conclusion, the vasodilator responses to nebivolol involve NO and cyclic GMP in both vascular endothelial and smooth muscle cells...
  11. ncbi request reprint Estrogen receptor-mediated vascular responsiveness to nebivolol: a novel endothelium-related mechanism of therapeutic vasorelaxation
    Hermes J Garban
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 90095 1735, USA
    J Cardiovasc Pharmacol 43:638-44. 2004
    ..In conclusion, the endothelium-dependent vascular response to nebivolol is attributed partially to its interaction with ER...
  12. ncbi request reprint Inhibitors of nitric oxide promote microvascular thrombosis
    Babak Azizzadeh
    Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Arch Facial Plast Surg 5:31-5. 2003
    ..Recent evidence indicates that nitric oxide (NO) plays a critical role in preventing thrombosis by inhibiting platelet adhesion and aggregation. The role of NO in microvascular anastomotic thrombosis has not been studied...
  13. ncbi request reprint Immunosuppressive effects of interleukin-12 coexpression in melanoma antigen gene-modified dendritic cell vaccines
    Antoni Ribas
    Department of Surgery, University of California at Los Angeles, 90095 1782, USA
    Cancer Gene Ther 9:875-83. 2002
    ..In conclusion, in this animal model, IL-12 production by gene-modified DC leads to a cytokine-induced dose-dependent inhibition of antigen-specific antitumor protection...