Rochelle Buffenstein

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research
    Yael H Edrey
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, 15355 Lambda Drive, San Antonio, TX 78245, USA
    ILAR J 52:41-53. 2011
  2. pmc Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat
    Karl A Rodriguez
    Sam and Ann Barshop Institute for Aging and Longevity Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e35890. 2012
  3. doi request reprint Endocrine function in naturally long-living small mammals
    Rochelle Buffenstein
    The Sam and Ann Barshop Institute for Longevity and Aging Studies and Department of Physiology, University of Texas Health Science Center at San Antonio, TX 78245, United States
    Mol Cell Endocrinol 299:101-11. 2009
  4. pmc The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms
    Rochelle Buffenstein
    Barshop Institute for Aging and Longevity Studies and Department of Physiology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, STCBM 2 2, San Antonio, TX 78245, USA
    Age (Dordr) 30:99-109. 2008
  5. doi request reprint Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
    Rochelle Buffenstein
    Department of Physiology and The Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Comp Physiol B 178:439-45. 2008
  6. pmc Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent
    Karl A Rodriguez
    Sam and Ann Barshop Institute for Aging and Longevity Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Dr San Antonio, TX 78245, USA
    Curr Pharm Des 17:2290-307. 2011
  7. pmc Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus
    Yun Shi
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Am J Physiol Regul Integr Comp Physiol 304:R343-55. 2013
  8. ncbi request reprint Stress resistance in the naked mole-rat: the bare essentials - a mini-review
    Kaitlyn N Lewis
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78209, USA
    Gerontology 58:453-62. 2012
  9. pmc The naked mole-rat response to oxidative stress: just deal with it
    Kaitlyn N Lewis
    1 Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Antioxid Redox Signal 19:1388-99. 2013
  10. pmc Cardiac function of the naked mole-rat: ecophysiological responses to working underground
    Kelly M Grimes
    Department of Physiology and the Sam and Ann Barshop Institute for Aging and Longevity Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Am J Physiol Heart Circ Physiol 306:H730-7. 2014

Research Grants

  1. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2003
  2. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2004
  3. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2005
  4. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research
    Yael H Edrey
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, 15355 Lambda Drive, San Antonio, TX 78245, USA
    ILAR J 52:41-53. 2011
    ..Elucidating these mechanisms will provide useful information for enhancing human life- and healthspan, making the naked mole rat a true "supermodel" for aging research and resistance to chronic age-associated diseases...
  2. pmc Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat
    Karl A Rodriguez
    Sam and Ann Barshop Institute for Aging and Longevity Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e35890. 2012
    ....
  3. doi request reprint Endocrine function in naturally long-living small mammals
    Rochelle Buffenstein
    The Sam and Ann Barshop Institute for Longevity and Aging Studies and Department of Physiology, University of Texas Health Science Center at San Antonio, TX 78245, United States
    Mol Cell Endocrinol 299:101-11. 2009
    ..Similarities with genetically manipulated long-lived rodent models of aging suggest that evolutionary well-conserved hormonal mechanisms are integrally involved in lifespan determination...
  4. pmc The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms
    Rochelle Buffenstein
    Barshop Institute for Aging and Longevity Studies and Department of Physiology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, STCBM 2 2, San Antonio, TX 78245, USA
    Age (Dordr) 30:99-109. 2008
    ..Therefore, contrary to accepted dogma, the role of oxidative stress as a determinant of longevity is still open to question...
  5. doi request reprint Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
    Rochelle Buffenstein
    Department of Physiology and The Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Comp Physiol B 178:439-45. 2008
    ..Clearly physiological and biochemical processes in this species have evolved to dramatically extend healthy lifespan. The challenge that lies ahead is to understand what these mechanisms are...
  6. pmc Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent
    Karl A Rodriguez
    Sam and Ann Barshop Institute for Aging and Longevity Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Dr San Antonio, TX 78245, USA
    Curr Pharm Des 17:2290-307. 2011
    ....
  7. pmc Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus
    Yun Shi
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Am J Physiol Regul Integr Comp Physiol 304:R343-55. 2013
    ..Nonetheless, the age-dependent increase in protein carbonyls is more pronounced in short-lived M. musculus, which supports enhanced protein homeostasis in long-lived P. leucopus...
  8. ncbi request reprint Stress resistance in the naked mole-rat: the bare essentials - a mini-review
    Kaitlyn N Lewis
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78209, USA
    Gerontology 58:453-62. 2012
    ....
  9. pmc The naked mole-rat response to oxidative stress: just deal with it
    Kaitlyn N Lewis
    1 Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Antioxid Redox Signal 19:1388-99. 2013
    ..Here we explore how different species, including the longest lived rodent, the naked mole-rat, have defied the most predominant aging theory...
  10. pmc Cardiac function of the naked mole-rat: ecophysiological responses to working underground
    Kelly M Grimes
    Department of Physiology and the Sam and Ann Barshop Institute for Aging and Longevity Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Am J Physiol Heart Circ Physiol 306:H730-7. 2014
    ..The relatively low basal cardiac function and enhanced cardiac reserve of NMRs are likely to be ecophysiological adaptations to life in an energetically taxing environment. ..
  11. pmc Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination
    Ryan T Hamilton
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA
    PLoS ONE 8:e65725. 2013
    ..Collectively, these data strongly suggest for the first time that oxidation-mediated protein misfolding and aggregation of key myelin proteins may be linked to demyelination and reduced nerve conduction in peripheral neuropathies...
  12. pmc Attenuation of liver insoluble protein carbonyls: indicator of a longevity determinant?
    Arunabh Bhattacharya
    Barshop Institute of Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Aging Cell 10:720-3. 2011
    ..This observation suggests that attenuated accumulation of protein carbonyls in the nucleus, where they can affect multiple aspects of gene expression and DNA repair, might contribute to the longevity in mammalian species...
  13. doi request reprint Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease
    Yael H Edrey
    Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Neurobiol Aging 34:2352-60. 2013
    ..Understanding how NMRs acquire and tolerate high levels of Aβ with no plaque formation could provide useful insights into AD, and may elucidate protective mechanisms that delay AD progression. ..
  14. doi request reprint Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat
    Yael H Edrey
    Barshop Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Exp Gerontol 46:116-23. 2011
    ..Here we review what is known about their unique social structure, sensory systems, endocrinology and neurobiology, and highlight areas that may be pertinent to biogerontology...
  15. ncbi request reprint Oxidative damage and amyloid-β metabolism in brain regions of the longest-lived rodents
    Yael H Edrey
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas The Barshop Institute for Aging and Longevity Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas
    J Neurosci Res 92:195-205. 2014
    ..NMRs may therefore serve as natural models for understanding the relationship between oxidative stress and Aβ levels and its effects on the brain...
  16. pmc Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat
    Kelly M Grimes
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Gerontol A Biol Sci Med Sci 67:384-94. 2012
    ..These findings suggest that, notwithstanding the previously observed high lipid peroxidation in heart tissue, NMRs must possess mechanisms to stave off progression to fatal cardiac disease...
  17. pmc Nrf2, a guardian of healthspan and gatekeeper of species longevity
    Kaitlyn N Lewis
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, STCBM 2 2, San Antonio, TX 78245, USA
    Integr Comp Biol 50:829-43. 2010
    ..We hypothesize that this signaling pathway plays a critical role in the determination of species longevity and that this pathway may indeed be the master regulator of the aging process...
  18. pmc Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat
    Viviana I Perez
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 106:3059-64. 2009
    ..These pivotal mechanistic interspecies differences may contribute to the divergent aging profiles and strongly implicate maintenance of protein stability and integrity in successful aging...
  19. doi request reprint Comparative studies of oxidative stress and mitochondrial function in aging
    Yun Shi
    Department of Physiology, University of Texas Health Science Center at San Antonio, Texas, USA
    Integr Comp Biol 50:869-79. 2010
    ..Thus, there is need for more thorough and controlled investigations with more unconventional animal models for a deeper understanding of the role of oxidative stress in longevity...
  20. pmc Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber)
    Sitai Liang
    Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Aging Cell 9:626-35. 2010
    ..The unique reaction of NMR cells to oncogene expression may form part of the cancer resistance of this species...
  21. pmc Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology
    Miranda E Orr
    Department of Physiology and The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Neurobiol Aging 35:1233-42. 2014
    ..Therefore, early interventions to modulate mTOR activity in individuals at high risk of developing diabetes may decrease their AD susceptibility. ..
  22. ncbi request reprint High oxidative damage levels in the longest-living rodent, the naked mole-rat
    Blazej Andziak
    Department of Biology, City College of the City University of New York, New York, NY 10031, USA
    Aging Cell 5:463-71. 2006
    ..Given that NMRs live an order of magnitude longer than predicted based on their body size, our findings strongly suggest that mechanisms other than attenuated oxidative stress explain the impressive longevity of this species...
  23. ncbi request reprint Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice
    Nazar Labinskyy
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 291:H2698-704. 2006
    ....
  24. ncbi request reprint Disparate patterns of age-related changes in lipid peroxidation in long-lived naked mole-rats and shorter-lived mice
    Blazej Andziak
    Department of Biology, The City College of the City University of New York, New York, NY 10031, USA
    Aging Cell 5:525-32. 2006
    ..These data suggest that the patterns of age-related changes in levels of markers of oxidative stress are species specific, and that the pronounced longevity of naked mole-rats is independent of oxidative stress parameters...
  25. ncbi request reprint Vascular aging in the longest-living rodent, the naked mole rat
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 293:H919-27. 2007
    ..Thus long-living NMRs can maintain a youthful vascular function and cellular oxidant-antioxidant phenotype relatively longer and are better protected against aging-induced oxidative stress than shorter-living rats...
  26. ncbi request reprint The naked mole rat--a new record for the oldest living rodent
    Rochelle Buffenstein
    Department of Biology, City College of the City University of New York, New York, NY 10031, USA
    Sci Aging Knowledge Environ 2002:pe7. 2002
    ..He died in April 2002, indicating that he lived for more than 28 years. As such, his life-span surpassed the previous longevity record for a rodent, which was held by a porcupine (Hystrix brachyura) that lived for 27 years and 4 months...
  27. ncbi request reprint Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function
    Timothy P O'Connor
    Department of Biology, City College of City University of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    Comp Biochem Physiol A Mol Integr Physiol 133:835-42. 2002
    ..Since lifetime energy expenditure is an important index of potential exposure to oxidative damage, naked mole-rats may be valuable for studying mechanisms of aging...
  28. ncbi request reprint Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat
    Blazej Andziak
    Department of Biology, City College of New York, 138th St and Convent Avenue, New York, NY 10031, USA
    Mech Ageing Dev 126:1206-12. 2005
    ..Maintenance of constant antioxidant defenses with age in NMRs concurs with previous physiological data, suggesting delayed aging in this species...
  29. ncbi request reprint The pancreas of the naked mole-rat (Heterocephalus glaber): an ultrastructural and immunocytochemical study of the endocrine component of thermoneutral and cold acclimated animals
    Beverley Kramer
    School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
    Gen Comp Endocrinol 139:206-14. 2004
    ..Immunoreactivity of alpha and beta cells was more intense in cold-acclimated than in thermoneutral animals, possibly indicative of a change in hormonal production in animals housed at a lower temperature...
  30. ncbi request reprint The naked mole-rat: a new long-living model for human aging research
    Rochelle Buffenstein
    Department of Biology, City College of CUNY, Convent Ave at 138th St, New York, NY 10031, USA
    J Gerontol A Biol Sci Med Sci 60:1369-77. 2005
    ..Young naked mole-rats surprisingly have high levels of accrued oxidative damage. With their similar longevity quotient to humans, these rodents may provide a novel opportunity to examine mechanisms modulating aging...
  31. ncbi request reprint The use of a novel and simple method of revealing neural fibers to show the regression of the lateral geniculate nucleus in the naked mole-rat (Heterocephalus glaber)
    Jun Xiao
    Biology Department, The City College of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    Brain Res 1077:81-9. 2006
    ....
  32. ncbi request reprint Oxidative stress in vascular senescence: lessons from successfully aging species
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Front Biosci 13:5056-70. 2008
    ....
  33. pmc Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes
    A J Hulbert
    Metabolic Research Centre, University of Wollongong, Wollongong, NSW 2522, Australia
    Mech Ageing Dev 127:653-7. 2006
    ..It is suggested that peroxidation-resistant membranes may be an important component of extended longevity...
  34. ncbi request reprint Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice
    A J Hulbert
    Department of Biology, City College of the City University of New York, Convent Ave at 138 St, New York, NY 10031, USA
    J Gerontol A Biol Sci Med Sci 61:1009-18. 2006
    ....
  35. ncbi request reprint Hemoglobin-oxygen-affinity and acid-base properties of blood from the fossorial mole-rat, Cryptomys hottentotus pretoriae
    W J van Aardt
    School of Environmental Sciences and Development, North West University, Potchefstroom Campus, Potchefstroom, 2520, South Africa
    Comp Biochem Physiol A Mol Integr Physiol 147:50-6. 2007
    ..h. pretoriae to maintain an adequate oxygen supply to the tissues in a potentially hypoxic burrow atmospheres, but that the blood of this species shows no exceptional CO2 sensitivity or buffering capacity...
  36. ncbi request reprint Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
    Adrian J Lambert
    Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Aging Cell 6:607-18. 2007
    ..These findings indicate that enhanced longevity may be causally associated with low free radical production by mitochondria across species over two classes of vertebrate homeotherms...
  37. ncbi request reprint Life and death: metabolic rate, membrane composition, and life span of animals
    A J Hulbert
    Metabolic Research Centre, Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia
    Physiol Rev 87:1175-213. 2007
    ..The more limited information for ectothermic animals and treatments that extend life span (e.g., caloric restriction) are also reviewed...
  38. ncbi request reprint Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): a comparative study using shotgun lipidomics
    Todd W Mitchell
    Metabolic Research Centre, University of Wollongong, NSW, Australia
    Exp Gerontol 42:1053-62. 2007
    ..Both characteristics possibly contribute to the exceptional longevity of naked mole-rats and may indicate a special role for peroxisomes in this extended longevity...
  39. pmc Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress
    Adam B Salmon
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA
    J Gerontol A Biol Sci Med Sci 63:232-41. 2008
    ..The sensitivity of both Snell dwarf and NMR cells to ER stress suggests that alterations in the unfolded protein response might modulate cell survival and aging rate...
  40. ncbi request reprint Thermogenic changes with chronic cold exposure in the naked mole-rat (Heterocephalus glaber)
    Ryan Woodley
    Department of Anatomical Sciences, Medical School of the University of the Witwatersrand, 7 York Road, Park Town, 2193, South Africa
    Comp Biochem Physiol A Mol Integr Physiol 133:827-34. 2002
    ..05). Rapid heat loss across their uninsulated integument may necessitate continuous maximal stimulation of brown adipose tissue (BAT), and as such, prevent any further increase in thermogenic capacity following cold exposure...

Research Grants4

  1. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2003
    ..These inter-species contrasts involving seven species with varying longevity will be used to test the ubiquity of proximate theories of aging. ..
  2. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2004
    ..These inter-species contrasts involving seven species with varying longevity will be used to test the ubiquity of proximate theories of aging. ..
  3. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2005
    ..These inter-species contrasts involving seven species with varying longevity will be used to test the ubiquity of proximate theories of aging. ..
  4. Mechanisms of Aging in the Long-lived Naked Mole-Rat
    Rochelle Buffenstein; Fiscal Year: 2006
    ..These inter-species contrasts involving seven species with varying longevity will be used to test the ubiquity of proximate theories of aging. ..