Research Topics
Species | Ralph C BuddSummaryAffiliation: University of Vermont Country: USA Publications
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Publications
Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activationAustin Dohrman
Immunobiology Program, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
J Immunol 174:5270-8. 2005..This provides a partial explanation of why caspase activity is required to initiate proliferation of resting T cells...
Death receptors couple to both cell proliferation and apoptosisRalph C Budd
Division of Immunobiology, Department of Medicine, Given Medical Building, D-305, The University of Vermont College of Medicine, Burlington, Vermont 05405-0068, USA
J Clin Invest 109:437-41. 2002- Expression level of c-FLIP versus Fas determines susceptibility to Fas ligand-induced cell death in murine thymoma EL-4 cellsTakao Kataoka
Department of Bioengineering, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
Exp Cell Res 273:256-64. 2002..These findings demonstrate that susceptibility to FasL-induced cell death mainly depends on the expression level of c-FLIP versus cell-surface Fas... - Reduced myocarditis following Coxsackievirus infection in cellular FLICE inhibitory protein--long form-transgenic miceSally Huber
Department of Pathology, The University of Vermont College of Medcine, Burlington, VT, USA
Immunology 119:541-50. 2006..It also produced a Tc2 cytokine profile. These effects of c-FLIP collectively served to diminish the severity of CVB3-induced myocarditis... - Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1Yabing Chen
Department of Medicine and Cardiovascular Research Institute, University of Vermont, Burlington, USA
Arterioscler Thromb Vasc Biol 26:1777-83. 2006..Because apoptosis and proliferation appear to be linked, we sought to determine whether increased PAI-1 would affect VSMC proliferation... - Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferiCuixia Shi
Immunobiology Program, The University of Vermont College of Medicine, Given Medical Building, Burlington, VT 05405 0068, USA
Infect Immun 74:1156-60. 2006..In addition, C3Hgld mice developed a greatly reduced incidence and severity of arthritis. The findings document a contribution of FasL to the host inflammatory response to B. burgdorferi... - The death receptor Fas (CD95/APO-1) mediates the deletion of T lymphocytes undergoing homeostatic proliferationKaren A Fortner
Immunobiology Division, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
J Immunol 175:4374-82. 2005..As Fas-deficient lpr mice manifest no significant abnormalities in thymic negative selection or in foreign Ag-induced peripheral T cell deletion, their lymphadenopathy may result from unrestrained homeostatic proliferation... - Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8Austin Dohrman
Immunobiology Program, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
J Immunol 175:311-8. 2005..c-FLIP(L) is thus not only an inhibitor of cell death by Fas, it can also act as a principal activator of caspases independently of Fas... 
Attenuation of apoptosis and the eye of the beholderBurton E Sobel
Cardiovascular Research Institute, University of Vermont College of Medicine, Burlington, Vermont, USA
Coron Artery Dis 19:55-8. 2008....- Gammadelta T cells promote a Th1 response during coxsackievirus B3 infection in vivo: role of Fas and Fas ligandSally Huber
Department of Pathology, College of Medicine, The University of Vermont, Burlington, VT 05405, USA
J Virol 76:6487-94. 2002..These results demonstrate that Fas/FasL interactions conferred by gammadelta T cells on lymphocyte subpopulations may regulate the cytokine response to CVB3 infection and pathogenicity... - The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytesSusanne M A Lens
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Mol Cell Biol 22:5419-33. 2002..Thus, a major role of c-FLIP(L) in vivo is the modulation of T-cell proliferation by decreasing the T-cell receptor signaling threshold... - Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activationRavi S Misra
Immunobiology Program, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405 0068, USA
J Biol Chem 282:19365-74. 2007..The current findings define a link among TCR, caspases, and the NF-kappaB pathway that occurs in a sequestered lipid raft environment in T cells... - High expression of Fas ligand by synovial fluid-derived gamma delta T cells in Lyme arthritisKaren Roessner
Department of Medicine Immunobiology, The University of Vermont College of Medicine, Burlington, VT 05405, USA
J Immunol 170:2702-10. 2003..In this capacity, certain gamma delta T cell subsets may serve as cytolytic sentinels at sites of inflammation, and perhaps at epithelial barriers... - Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammationWenfang Wu
Immunobiology Program, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
J Immunol 172:4724-32. 2004..Taken together, these results show that c-FLIP(L) can influence cytokine gene expression to promote Th2-driven allergic reaction, in addition to its traditional role of blocking caspase activation induced by death receptors... - Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1Yabing Chen
Department of Medicine, The University of Vermont, Burlington, Vermont 05405, USA
J Cell Biochem 92:178-88. 2004..Accordingly, attenuated apoptosis resulting from elevated expression of PAI-1 by VSMC may be attributable, at least in part, to reversible inhibition of caspase-3 by active PAI-1... - Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunityPeter D Hughes
Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
Immunity 28:197-205. 2008..These results identify critical overlapping roles for Fas and Bim in T cell death in immune response shutdown and prevention of immunopathology and thereby resolve a long-standing controversy... - The CD95 receptor: apoptosis revisitedMarcus E Peter
Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
Cell 129:447-50. 2007..Recent evidence suggests, however, that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions... - c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survivalJennifer Hinshaw-Makepeace
Immunobiology Program, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
Eur J Immunol 38:54-63. 2008..Consequently, T cells from c-FLIP(S)-transgenic mice undergo more rapid cell death both spontaneously and after activation. The findings suggest that c-FLIP(S) functions to reduce the expansion of T cells during an immune response... - cFLIP regulation of lymphocyte activation and developmentRalph C Budd
Immunobiology Program, Department of Medicine, The University of Vermont College of Medicine, Burlington, Vermont 50405, USA
Nat Rev Immunol 6:196-204. 2006.... - Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3Wenfang Wu
Immunobiology Program, Department of Medicine, The University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Biol Chem 281:10682-90. 2006..Our findings reveal a new post-transcriptional regulation of NFATc2 that operates, not only during apoptosis, but also in non-apoptotic effector T cells... - Lyme arthritis synovial gammadelta T cells instruct dendritic cells via fas ligandCheryl Collins
Immunobiology Program, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT 50405, USA
J Immunol 175:5656-65. 2005..They also underscore the view that as levels of c-FLIP increase, Fas signaling can be diverted from induction of apoptosis to pathways leading to cell effector function... - Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substratesRavi S Misra
University of Vermont, Immunobiology Program, College of Medicine, Burlington, VT 05405, USA
J Immunol 174:3999-4009. 2005..The current findings define the level of caspase activity and substrates during initiation of T cell cycling... - Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathwayCheryl Collins
Immunobiology Program, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT 50405, USA
J Immunol 181:2392-8. 2008..Furthermore, B. burgdorferi stimulation of monocytes via TLR, and secondary activation of gammadelta T cells, are both caspase-dependent...