Research Topics
Genomes and GenesSpecies | Thomas A BuchananSummaryAffiliation: University of Southern California Country: USA Publications
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Publications
Gestational diabetes mellitus: risks and management during and after pregnancyThomas A Buchanan
Division of Endocrinology and Diabetes, Department of Medicine, Keck School of Medicine of the University of Southern California, 2250 Alcazar Street, CSC 205, Los Angeles, CA 90033, USA
Nat Rev Endocrinol 8:639-49. 2012..Family planning enables optimization of health in subsequent pregnancies. Breastfeeding may reduce obesity in children and is recommended. Families should be encouraged to help children adopt lifestyles that reduce the risk of obesity...
Actos Now for the prevention of diabetes (ACT NOW) studyRalph A DeFronzo
Texas Diabetes Institute and University of Texas Health Science Center, San Antonio, TX, USA
BMC Endocr Disord 9:17. 2009..TRIAL REGISTRATION: clinical trials.gov identifier: NCT00220961...
Use of medications to prevent type 2 diabetesThomas A Buchanan
Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Curr Diab Rep 5:237-9. 2005- Gestational diabetes mellitusThomas A Buchanan
Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9317, USA
J Clin Invest 115:485-91. 2005..Thus, GDM provides a unique opportunity to study the early pathogenesis of diabetes and to develop interventions to prevent the disease... - What is gestational diabetes?Thomas A Buchanan
Departments of Medicine, Obstetrics and Gynecology, and Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
Diabetes Care 30:S105-11. 2007 - Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetesAnny H Xiang
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA
Diabetes 55:517-22. 2006.... - (How) can we prevent type 2 diabetes?Thomas A Buchanan
Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA
Diabetes 56:1502-7. 2007 - Pancreatic beta-cell loss and preservation in type 2 diabetesThomas A Buchanan
University of Southern California, Kech School of Medicine, Los Angeles, California 90033, USA
Clin Ther 25:B32-46. 2003..For insulin-resistant patients, however, the balance between insulin supply and demand may fail from the progressive loss of pancreatic beta-cell function, eventually leading to type 2 diabetes mellitus... - Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic womenThomas A Buchanan
Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Diabetes 51:2796-803. 2002..The protective effect was associated with the preservation of pancreatic beta-cell function and appeared to be mediated by a reduction in the secretory demands placed on beta-cells by chronic insulin resistance... - Approach to the patient with gestational diabetes after deliveryThomas A Buchanan
Division of Endocrinology and Diabetes, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
J Clin Endocrinol Metab 96:3592-8. 2011..Children of women with GDM are at increased risk for obesity and diabetes. They should receive education, monitoring, and lifestyle advice to minimize obesity and diabetes risk... - Pharmacological treatment of insulin resistance at two different stages in the evolution of type 2 diabetes: impact on glucose tolerance and beta-cell functionAnny H Xiang
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
J Clin Endocrinol Metab 89:2846-51. 2004..These findings highlight the role of insulin resistance in the genesis of progressive beta-cell dysfunction during the evolution of type 2 diabetes... - Effect of pioglitazone on progression of subclinical atherosclerosis in non-diabetic premenopausal Hispanic women with prior gestational diabetesAnny H Xiang
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States
Atherosclerosis 199:207-14. 2008..Pioglitazone slows progression of subclinical atherosclerosis in young Hispanic women at increased risk for type 2 diabetes... - Effect of thiazolidinedione treatment on progression of subclinical atherosclerosis in premenopausal women at high risk for type 2 diabetesAnny H Xiang
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Room 6602 GNH, 1200 North State Street, Los Angeles, California 90089-9317, USA
J Clin Endocrinol Metab 90:1986-91. 2005..Troglitazone reduced the progression of subclinical atherosclerosis via a mechanism that involved unmeasured mediators of atherosclerosis, either in the circulation or directly in the arterial wall... - Replication of calpain-10 genetic association with carotid intima-media thicknessMark O Goodarzi
Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Atherosclerosis 205:503-5. 2009..A prior study in Hispanics found association of haplotypes in the diabetes gene calpain-10 (CAPN10) with carotid artery intima-media thickness (CIMT). This study sought to replicate this association in an independent cohort... - Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican AmericansMary Helen Black
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
Diabetes 57:1048-56. 2008.... - Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican AmericansXia Li
Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of USC, Los Angeles, California, USA
Obesity (Silver Spring) 17:729-36. 2009..066) and disposition index (DI) (Bonferroni P = 0.072). We conclude that rs11705701 in IGF2BP2 is associated with body fat and this effect on body fat influences insulin resistance which may contribute to T2DM risk... - Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitusLing Zheng
Department of Neurology, Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Am J Cardiol 99:956-60. 2007..The antiatherogenic effect of antihypertensive agents, including BP normalization and possible direct vascular wall protection, can be detected by CIMT progression using B-mode ultrasound in patients with DM... - Declining beta-cell compensation for insulin resistance in Hispanic women with recent gestational diabetes mellitus: association with changes in weight, adiponectin, and C-reactive proteinAnny H Xiang
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, California, USA
Diabetes Care 33:396-401. 2010..To identify factors associated with declining beta-cell compensation for insulin resistance... - Effect of peroxisome proliferator-activated receptor gamma agonist treatment on subclinical atherosclerosis in patients with insulin-requiring type 2 diabetesHoward N Hodis
Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, 90033, USA
Diabetes Care 29:1545-53. 2006..To determine the effect of thiazolidinedione treatment on subclinical atherosclerosis progression in insulin-requiring patients with clinical characteristics suggesting type 2 diabetes... - A longitudinal study of lipids and blood pressure in relation to method of contraception in Latino women with prior gestational diabetes mellitusAnny H Xiang
Keck School of Medicine, University of Southern California, Department of Preventive Medicine, 1540 Alcazar St, CHP 222, Los Angeles, CA 90033, USA
Diabetes Care 30:1952-8. 2007..To investigate the effect of nonhormonal contraception (NHC), combination oral contraception (COC), and depo-medroxyprogesterone acetate (DMPA) on lipids and blood pressure in women with recent gestational diabetes mellitus (GDM)... - Carotid intima-media thickness (cIMT) cosegregates with blood pressure and renal function in hypertensive Hispanic familiesYi Chun Chen
Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Atherosclerosis 198:160-5. 2008..Since cIMT is correlated with hypertension and microalbuminuria, we tested the hypothesis that there is a genetic basis for the observed relationship between cIMT, blood pressure (BP), and renal function within high risk families... - Coordinate changes in plasma glucose and pancreatic beta-cell function in Latino women at high risk for type 2 diabetesAnny H Xiang
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, CA, USA
Diabetes 55:1074-9. 2006..Only relatively late in this process do glucose levels rise rapidly and into the diabetic range... - Detailed physiological characterization of the development of type 2 diabetes in Hispanic women with prior gestational diabetes mellitusAnny H Xiang
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Diabetes 59:2625-30. 2010..To identify physiological and clinical variables associated with development of type 2 diabetes up to 12 years after pregnancies complicated by gestational diabetes... - Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of DiabeSoren Snitker
Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland, Baltimore School of Medicine, 660 W Redwood St, Howard Hall Rm 598 B, Baltimore, MD 21201 1596, USA
Diabetes Care 27:1365-8. 2004.... - Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-AmericansYu Hsiang Shu
Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
J Clin Endocrinol Metab 94:4094-102. 2009..Acid phosphatase locus 1 (ACP1) is a low molecular weight tyrosine phosphatase that has been shown to be an important regulator of insulin receptor signaling... - Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucoseXia Li
Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Diabetes 58:2946-53. 2009..GCK rs1799884 and G6PC2 rs560887 have been independently associated with fasting glucose, but their interaction on glucose-insulin relationships is not well characterized... - Long-acting injectable progestin contraception and risk of type 2 diabetes in Latino women with prior gestational diabetes mellitusAnny H Xiang
Keck School of Medicine, University of Southern California, Department of Preventive Medicine, 1540 Alcazar St, CHP 222, Los Angeles, CA 90033, USA
Diabetes Care 29:613-7. 2006.... - Deterioration in cardiometabolic risk markers in obese women during depot medroxyprogesterone acetate usePenina Segall-Gutierrez
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Contraception 85:36-41. 2012..The purpose of this 18-week prospective experimental study was to compare the impact of subcutaneous depot medroxyprogesterone acetate (DMPA-SC) on cardiometabolic markers in obese and normal-weight women... - Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican AmericansRichard M Watanabe
Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine, The University of Southern California, Los Angeles, California 90089 9011, USA
Diabetes 56:1481-5. 2007..We examined variation in a 0.1-Mb region surrounding marker DG10S478 for association with diabetes-related quantitative traits in 132 Mexican-American families of a proband with previous gestational diabetes mellitus (GDM)... - Insulin resistance and preeclampsia in gestational diabetes mellitusMartin N Montoro
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, USA
Diabetes Care 28:1995-2000. 2005..To compare the degree of insulin resistance in women with gestational diabetes mellitus (GDM) who do and do not develop preeclampsia... - Time from diagnosis of type 2 diabetes to initiation of insulin therapy is related to carotid artery intima-media thicknessLing Zheng
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP-218, Los Angeles, CA 90089-9010, USA
Atherosclerosis 170:293-9. 2003..Longitudinal data are needed to determine the effect of early initiation of insulin therapy on the progression of subclinical atherosclerosis among persons with diabetes... - Genetics of gestational diabetes mellitus and type 2 diabetesRichard M Watanabe
Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089-9011, USA
Diabetes Care 30:S134-40. 2007 - Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight lossKaren L Herbst
Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USA
Fertil Steril 85:1794-802. 2006.... - A better index of body adiposityRichard N Bergman
Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Obesity (Silver Spring) 19:1083-9. 2011..It can be used in the clinical setting even in remote locations with very limited access to reliable scales. The BAI estimates %adiposity directly... - Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes MellitusBoyd E Metzger
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Diabetes Care 30:S251-60. 2007 - Obese adolescents show impaired meal responses of the appetite-regulating hormones ghrelin and PYYSteven D Mittelman
Division of Endocrinology, Diabetes and Metabolism, Children s Hospital Los Angeles, Los Angeles, California, USA
Obesity (Silver Spring) 18:918-25. 2010..Thus, meal-related changes in active ghrelin and PYY are blunted in obese as compared to lean Hispanic subjects. This blunting could contribute to the development or worsening of obesity... - Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parentAnny H Xiang
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
Arterioscler Thromb Vasc Biol 22:843-8. 2002..Heritability is particularly evident in younger family members, suggesting that acquired factors contribute progressively to IMT variability with aging... - Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6qCorina Shtir
Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089, USA
Hum Hered 63:17-25. 2007..The purpose of this study was to examine carefully heterogeneity underlying evidence for linkage to type 2 diabetes (T2DM) on chromosome 6q from two sets of FUSION families... - The ratio of plasminogen activator inhibitor type-1 activity to the concentration of plasminogen activator inhibitor type-1 protein in diabetes: adding insult to injuryBurton E Sobel
Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA
Coron Artery Dis 13:275-81. 2002..This study was performed to delineate the relationship between plasminogen activator inhibitor type-1 (PAI-1) activity and PAI-1 protein to characterize the functional importance of elevated PAI-1 in diabetes... - The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young menAtam B Singh
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 87:136-43. 2002..Long-term studies are needed to determine whether T supplementation of older men with low T levels affects atherosclerosis progression... - Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohortTasha E Fingerlin
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
Diabetes 51:1644-8. 2002..We conclude that variation in these three SNPs in the calpain-10 gene is unlikely to confer susceptibility to type 2 diabetes in this Finnish cohort... - Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitusUte M Schaefer-Graf
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, USA
Am J Obstet Gynecol 186:751-6. 2002..Diabetic education should begin during pregnancy, especially for women who are identified to be at a high risk when they are highly motivated and under medical care... - Fasting plasma glucose test at the first prenatal visit as a screen for gestational diabetesDavid A Sacks
Department of Obstetrics and Gynecology, Kaiser Foundation Hospital, Bellflower, California 90740, USA
Obstet Gynecol 101:1197-203. 2003..To determine whether the fasting plasma glucose test administered at the first prenatal visit could serve as an efficient screen for gestational diabetes... - Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levelsWei Min Chen
Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
J Clin Invest 118:2620-8. 2008.... - Association of insulin sensitivity and glucose tolerance with the c.825C>T variant of the G protein beta-3 subunit geneDaniel Kopf
Department of Endocrinology and Metabolism, University of Magdeburg, Magdeburg, Germany
J Diabetes Complications 22:205-9. 2008..We examined the association of insulin sensitivity with the c.825C>T variant of the g-protein beta-3 subunit (GNB3), a candidate gene of hypertension, in families of Mexican-American hypertensive patients... - Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivityUtpal B Pajvani
Department of Cell Biology, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Biol Chem 279:12152-62. 2004..These observations suggest that the HMW adiponectin complex is the active form of this protein, which we directly demonstrate in vivo by its ability to depress serum glucose levels in a dose-dependent manner... - Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genesCristen J Willer
Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor 48109 2029, USA
Diabetes 56:256-64. 2007..03), although we also replicated 4 of 58 SNPs from genes that had only one previous report of association... - Sequence variation in PPARG may underlie differential response to troglitazoneJohanna K Wolford
Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
Diabetes 54:3319-25. 2005..05). Three variants were also associated with changes in Si as a continuous variable. Our results suggest that PPARG variation may underlie response to TZD therapy in women at risk for type 2 diabetes... - Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in FinnsKaren L Mohlke
Department of Genetics, University of North Carolina, 4109 F Neurosciences Research Building, 103 Mason Farm Road, CB 7264, 27599 7264, Chapel Hill, NC, USA
Hum Genet 118:245-54. 2005..Furthermore, our data do not support a reported maternal inheritance pattern of T2DM but instead show a strong effect of recall bias... - A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variantsLaura J Scott
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
Science 316:1341-5. 2007..This brings the number of T2D loci now confidently identified to at least 10... - Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological functionBeilei Lei
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Naunyn Schmiedebergs Arch Pharmacol 371:229-39. 2005..This finding has potentially important implications in many areas of medicine and can be used to guide alpha(1a)AR SNP choice for future clinical studies... - Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapyErika M Young
Department of Medicine and Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202-2879, USA
Cardiovasc Toxicol 4:179-86. 2004..This improvement occurred independent of development of insulin resistance, which occurred only with indinavir... - Prevention of type 2 diabetes: what is it really?Thomas A Buchanan
Diabetes Care 26:1306-8. 2003 - Counterpoint: glucose monitoring in gestational diabetes: lots of heat, not much lightThomas A Buchanan
Diabetes Care 26:948-9. 2003 - Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitusDavid C Calverley
Divisions of Hematology and Medical Oncology, University of Colorado Health Science Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Br J Haematol 121:139-42. 2003..Increased platelet FcR-mediated sensitivity to collagen may contribute to cardiovascular morbidity and mortality in diabetes... - C-reactive protein and glycemic control in adults with diabetesDana E King
Department of Family Medicine, Medical University of South Carolina, Charleston 29425, USA
Diabetes Care 26:1535-9. 2003..The purpose of this study was to determine the relation between CRP and HbA(1c) in a large national sample of individuals with diabetes... - A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14Kaisa Silander
Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
Diabetes 53:821-9. 2004.... - Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in FinnsLori L Bonnycastle
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 2152, USA
Diabetes 55:2534-40. 2006..Our data suggest that common variants in several MODY genes play a modest role in type 2 diabetes susceptibility...
Research Grants
- Genetics of Beta Cell Failure in Mexican AmericansThomas Buchanan; Fiscal Year: 2003..abstract_text> ..
- Genetics of Beta Cell Failure in Mexican AmericansThomas Buchanan; Fiscal Year: 2006..abstract_text> ..
- PATHOGENESIS OF TYPE 2 DIABETES IN LATINO WOMENThomas Buchanan; Fiscal Year: 2006..The information will be important for the design of strategies to identify high-risk individuals and reduce their risk of type 2 diabetes. ..
- Genetics of Beta Cell Failure in Mexican AmericansThomas Buchanan; Fiscal Year: 2007..abstract_text> ..
- Planning Grant for Institutional Clinical and Translational Science AwardThomas Buchanan; Fiscal Year: 2006....
- PATHOGENESIS OF TYPE 2 DIABETES IN LATINO WOMENThomas Buchanan; Fiscal Year: 2002....
- PATHOGENESIS OF NIDDM IN MEXICAN-AMERICAN WOMENThomas Buchanan; Fiscal Year: 1993..Our results should identify early metabolic defects in Mexican-American women who are at high risk for NIDDM. In future studies, those defects can be targeted for interventions aimed at delaying or preventing the onset of NIDDM...
- Genetics of Beta Cell Failure in Mexican AmericansAnny H Xiang; Fiscal Year: 2010..The results will also help to guide the development of new approaches to the prediction, prevention and early treatment of type 2 diabetes in this high-risk ethnic group. ..