Shilpa J Buch

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: Involvement of β1 integrins
    Honghong Yao
    2Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    FASEB J 27:1532-48. 2013
  2. ncbi Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation
    Crystal Bethel-Brown
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroinflammation 9:262. 2012
  3. ncbi Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 10:425-8. 2012
  4. ncbi Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
  5. ncbi Neuroimmune pharmacology as an emerging curriculum for pre-medical students
    Shilpa J Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:68-70. 2011
  6. ncbi Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:503-15. 2011
  7. ncbi HIV neuropathogenesis: a tight rope walk of innate immunity
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 5:489-95. 2010
  8. ncbi A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection
    Stephanie D Kraft-Terry
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Neuron 64:133-45. 2009

Research Grants

  1. Cocaine & HIV: Role of PDGF/PDGF-Receptor Axis in Blood Brain Barrier Disruption
    Kee Jun Kim; Fiscal Year: 2010
  2. Morphine and the Neuropathogenesis of SIV in Macaques
    Shilpa J Buch; Fiscal Year: 2010
  3. Mechanism and Therapy of HIV Encephalitis
    Shilpa Buch; Fiscal Year: 2009
  4. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2010
  5. Mechanism and Therapy of HIV Encephalitis
    Shilpa J Buch; Fiscal Year: 2010
  6. Cocaine & HIV: Role of PDGF/PDGF-Receptor Axis in Blood Brain Barrier Disruption
    Shilpa Buch; Fiscal Year: 2009
  7. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa Buch; Fiscal Year: 2006
  8. Mechanism and Therapy of SHIV Encephalitis in Macaques
    Shilpa Buch; Fiscal Year: 2006
  9. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2009

Collaborators

  • Honghong Yao
  • Pankaj Seth
  • Kee Jun Kim
  • Crystal Bethel-Brown
  • Joel Mermis
  • Stephanie D Kraft-Terry
  • Guoku Hu
  • Bing Xue
  • Sonja Bartolome
  • Haihua Gu
  • Navneet K Dhillon
  • Amy O'Brien-Ladner
  • Fang Li
  • Ossama Tawfik
  • Howard E Gendelman
  • Howard S Fox

Detail Information

Publications8

  1. ncbi Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: Involvement of β1 integrins
    Honghong Yao
    2Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    FASEB J 27:1532-48. 2013
    ..Yao, H., Duan, M., Yang, L., Buch, S. Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: Involvement of β1 integrins...
  2. ncbi Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation
    Crystal Bethel-Brown
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroinflammation 9:262. 2012
    ..These results suggest that astrocyte activation by PDGF-BB exaggerates monocyte recruitment into the brain via MCP-1 and underscores the critical role astrocytes play in HAND...
  3. ncbi Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 10:425-8. 2012
    ..This review summarizes previous studies on the mechanism(s) underlying the interplay of cocaine and HIV as it relates to the CNS...
  4. ncbi Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
    ..In this study, we explored the impact of HIV protein induced oxidative stress on production of hypoxia inducible factor (HIF)-1α and platelet-derived growth factor (PDGF), critical mediators implicated in the pathogenesis of HIV-PAH...
  5. ncbi Neuroimmune pharmacology as an emerging curriculum for pre-medical students
    Shilpa J Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:68-70. 2011
    ..The goal of this course is to expose pre-medical students to the field of NIP so that they are equipped with a solid foundation in these multidisciplinary fields for future clinical/academic careers...
  6. ncbi Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:503-15. 2011
    ..In this review, recent findings on the interplay of HIV infection and cocaine abuse and their possible implications in mode of action and/or addiction will be discussed...
  7. ncbi HIV neuropathogenesis: a tight rope walk of innate immunity
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 5:489-95. 2010
    ..The ultimate outcome of HIV infection in the CNS will thus be dependent on the regulation of the net balance of cell-specific protective versus detrimental responses...
  8. ncbi A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection
    Stephanie D Kraft-Terry
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Neuron 64:133-45. 2009
    ..Better understanding of the complexities of immune regulation during HAND can improve diagnosis and disease outcomes but is also relevant for the pathogenesis of a broad range of neurodegenerative disorders...

Research Grants14

  1. Cocaine & HIV: Role of PDGF/PDGF-Receptor Axis in Blood Brain Barrier Disruption
    Kee Jun Kim; Fiscal Year: 2010
    ..This proposal is aimed at understanding molecular mechanisms involved in the combined deleterious effects of HIV-1 and cocaine in the brain with the ultimate goal of testing novel therapeutics. ..
  2. Morphine and the Neuropathogenesis of SIV in Macaques
    Shilpa J Buch; Fiscal Year: 2010
    ..Some studies show that morphine worsens the infections, while others claim amelioration of the infection. The SIV-Macaque-Model of HIV pathogenesis will be used to explore the mechanisms of this drug on infection in the brain. ..
  3. Mechanism and Therapy of HIV Encephalitis
    Shilpa Buch; Fiscal Year: 2009
    ....
  4. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2010
    ..Relevance: This proposal aims to: a) Explore the role of cocaine in accelerating the development of HFV Dementia and b) Develop therapeutic intervention strategies for the treatment of HAD in cocaine-abusers. ..
  5. Mechanism and Therapy of HIV Encephalitis
    Shilpa J Buch; Fiscal Year: 2010
    ....
  6. Cocaine & HIV: Role of PDGF/PDGF-Receptor Axis in Blood Brain Barrier Disruption
    Shilpa Buch; Fiscal Year: 2009
    ..This proposal is aimed at understanding molecular mechanisms involved in the combined deleterious effects of HIV-1 and cocaine in the brain with the ultimate goal of testing novel therapeutics. ..
  7. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa Buch; Fiscal Year: 2006
    ..Relevance: This proposal aims to: a) Explore the role of cocaine in accelerating the development of HFV Dementia and b) Develop therapeutic intervention strategies for the treatment of HAD in cocaine-abusers. ..
  8. Mechanism and Therapy of SHIV Encephalitis in Macaques
    Shilpa Buch; Fiscal Year: 2006
    ..6P. 4) Optimization of LDC containing antisense IL-4, PDGF-B & MCP-1 DNAs for in vivo gene delivery in small animals, such as mice before aiming gene therapy in infected macaques. ..
  9. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2009
    ..Relevance: This proposal aims to: a) Explore the role of cocaine in accelerating the development of HFV Dementia and b) Develop therapeutic intervention strategies for the treatment of HAD in cocaine-abusers. ..