Shilpa J Buch

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint HIV-1 Tat Disrupts CX3CL1-CX3CR1 Axis in Microglia via the NF-κBYY1 Pathway
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 12:189-200. 2014
  2. pmc Involvement of miR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells
    L Yang
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 4:e960. 2013
  3. pmc HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    PLoS ONE 8:e60170. 2013
  4. pmc Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e47572. 2012
  5. pmc Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction
    G Hu
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 3:e381. 2012
  6. pmc Morphine induces expression of platelet-derived growth factor in human brain microvascular endothelial cells: implication for vascular permeability
    Hongxiu Wen
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e21707. 2011
  7. pmc TRPC channel-mediated neuroprotection by PDGF involves Pyk2/ERK/CREB pathway
    H Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Differ 16:1681-93. 2009
  8. pmc Cocaine potentiates astrocyte toxicity mediated by human immunodeficiency virus (HIV-1) protein gp120
    Yanjing Yang
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e13427. 2010
  9. pmc Growth factor signaling: implications for disease & therapeutics
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    J Neuroimmune Pharmacol 9:65-8. 2014
  10. ncbi request reprint Cannabinoid receptor 2 activation: a means to prevent monocyte-endothelium engagement
    Shilpa J Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska Electronic address
    Am J Pathol 183:1375-7. 2013

Collaborators

  • Pankaj Seth
  • TSUNG PING SU
  • H S Fox
  • Chao Wang
  • Crystal Bethel-Brown
  • Honghong Yao
  • John Wang
  • Kee Jun Kim
  • Ming Duan
  • L Yang
  • G Hu
  • Fuwang Peng
  • Hongxiu Wen
  • Joel Mermis
  • Yaman Lu
  • Yanjing Yang
  • Stephanie D Kraft-Terry
  • Yu Cai
  • Ke Liao
  • Xianming Chen
  • Y H Kook
  • J Chao
  • Guoku Hu
  • Y Gao
  • Amie K Lund
  • P D Cheney
  • S V Yelamanchili
  • Halis Kaan Akturk
  • H Wen
  • M Duan
  • A D Chaudhuri
  • Sonja Bartolome
  • Amy O'Brien-Ladner
  • Fang Li
  • Navneet K Dhillon
  • Haihua Gu
  • Ossama Tawfik
  • Bing Xue
  • Howard E Gendelman

Detail Information

Publications18

  1. ncbi request reprint HIV-1 Tat Disrupts CX3CL1-CX3CR1 Axis in Microglia via the NF-κBYY1 Pathway
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 12:189-200. 2014
    ..Taken together, these results demonstrate that HIV-1 Tat protein suppresses CX3CR1 expression in microglia via NF-κB-YY1 pathway and attenuates CX3CL1-induced functional response of microglia. ..
  2. pmc Involvement of miR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells
    L Yang
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 4:e960. 2013
    ..These findings thus suggest that miR-9-mediated downregulation of MCPIP1 acts as a molecular switch regulation of neurogenesis. ..
  3. pmc HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    PLoS ONE 8:e60170. 2013
    ..Taken together, these findings implicate that Tat-mediated induction of ICAM-1 expression plays a critical role in monocyte adhesion observed in HIV-1-associated cardiomyopathies...
  4. pmc Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e47572. 2012
    ..Taken together our findings lead to the suggestion that PDGF-CC could be developed as a therapeutic target to reverse Tat-mediated neurotoxicity with implications for HAD...
  5. pmc Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction
    G Hu
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 3:e381. 2012
    ..Understanding the regulation of PDGF-B expression may provide insights into the development of potential therapeutic targets for neuronal loss in HIV-1-infected opiate abusers...
  6. pmc Morphine induces expression of platelet-derived growth factor in human brain microvascular endothelial cells: implication for vascular permeability
    Hongxiu Wen
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e21707. 2011
    ..Understanding the regulation of PDGF expression may provide insights into the development of potential therapeutic targets for intervention of morphine-mediated neuroinflammation...
  7. pmc TRPC channel-mediated neuroprotection by PDGF involves Pyk2/ERK/CREB pathway
    H Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Differ 16:1681-93. 2009
    ..This effect was attenuated by pre-treatment of mice with the TRP blocker, thus underscoring the novel role of TRPC channels in the neuroprotection mediated by PDGF...
  8. pmc Cocaine potentiates astrocyte toxicity mediated by human immunodeficiency virus (HIV-1) protein gp120
    Yanjing Yang
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e13427. 2010
    ..Our results demonstrated that cocaine-mediated potentiation of gp120 toxicity involved regulation of oxidative stress, mitochondrial membrane potential and MAPK signaling pathways...
  9. pmc Growth factor signaling: implications for disease & therapeutics
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    J Neuroimmune Pharmacol 9:65-8. 2014
    ....
  10. ncbi request reprint Cannabinoid receptor 2 activation: a means to prevent monocyte-endothelium engagement
    Shilpa J Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska Electronic address
    Am J Pathol 183:1375-7. 2013
    ....
  11. pmc Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrins
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    FASEB J 27:1532-48. 2013
    ..nmMYLK is thus critical for eliciting microglial migration during the innate immune response...
  12. pmc Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation
    Crystal Bethel-Brown
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroinflammation 9:262. 2012
    ..These results suggest that astrocyte activation by PDGF-BB exaggerates monocyte recruitment into the brain via MCP-1 and underscores the critical role astrocytes play in HAND...
  13. pmc Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 10:425-8. 2012
    ..This review summarizes previous studies on the mechanism(s) underlying the interplay of cocaine and HIV as it relates to the CNS...
  14. pmc Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
    ..In this study, we explored the impact of HIV protein induced oxidative stress on production of hypoxia inducible factor (HIF)-1α and platelet-derived growth factor (PDGF), critical mediators implicated in the pathogenesis of HIV-PAH...
  15. doi request reprint Neuroimmune pharmacology as an emerging curriculum for pre-medical students
    Shilpa J Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:68-70. 2011
    ..The goal of this course is to expose pre-medical students to the field of NIP so that they are equipped with a solid foundation in these multidisciplinary fields for future clinical/academic careers...
  16. pmc Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:503-15. 2011
    ..In this review, recent findings on the interplay of HIV infection and cocaine abuse and their possible implications in mode of action and/or addiction will be discussed...
  17. pmc A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection
    Stephanie D Kraft-Terry
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Neuron 64:133-45. 2009
    ..Better understanding of the complexities of immune regulation during HAND can improve diagnosis and disease outcomes but is also relevant for the pathogenesis of a broad range of neurodegenerative disorders...
  18. pmc HIV neuropathogenesis: a tight rope walk of innate immunity
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 5:489-95. 2010
    ..The ultimate outcome of HIV infection in the CNS will thus be dependent on the regulation of the net balance of cell-specific protective versus detrimental responses...

Research Grants14

  1. Mechanism and Therapy of SHIV Encephalitis in Macaques
    Shilpa Buch; Fiscal Year: 2003
    ..6P. 4) Optimization of LDC containing antisense IL-4, PDGF-B & MCP-1 DNAs for in vivo gene delivery in small animals, such as mice before aiming gene therapy in infected macaques. ..
  2. Morphine and the Neuropathogenesis of SIV in Macaques
    Shilpa J Buch; Fiscal Year: 2009
    ..Some studies show that morphine worsens the infections, while others claim amelioration of the infection. The SIV-Macaque-Model of HIV pathogenesis will be used to explore the mechanisms of this drug on infection in the brain. ..
  3. Cocaine & HIV: Role of PDGF/PDGF-Receptor Axis in Blood Brain Barrier Disruption
    Kee Jun Kim; Fiscal Year: 2010
    ..This proposal is aimed at understanding molecular mechanisms involved in the combined deleterious effects of HIV-1 and cocaine in the brain with the ultimate goal of testing novel therapeutics. ..
  4. Morphine and the Neuropathogenesis of SIV in Macaques
    Shilpa J Buch; Fiscal Year: 2010
    ..Some studies show that morphine worsens the infections, while others claim amelioration of the infection. The SIV-Macaque-Model of HIV pathogenesis will be used to explore the mechanisms of this drug on infection in the brain. ..
  5. Mechanism and Therapy of HIV Encephalitis
    Shilpa Buch; Fiscal Year: 2009
    ....
  6. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2010
    ..Relevance: This proposal aims to: a) Explore the role of cocaine in accelerating the development of HFV Dementia and b) Develop therapeutic intervention strategies for the treatment of HAD in cocaine-abusers. ..
  7. Mechanism and Therapy of HIV Encephalitis
    Shilpa J Buch; Fiscal Year: 2010
    ....
  8. Cocaine & HIV: Role of PDGF/PDGF-Receptor Axis in Blood Brain Barrier Disruption
    Shilpa Buch; Fiscal Year: 2009
    ..This proposal is aimed at understanding molecular mechanisms involved in the combined deleterious effects of HIV-1 and cocaine in the brain with the ultimate goal of testing novel therapeutics. ..
  9. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa Buch; Fiscal Year: 2006
    ..Relevance: This proposal aims to: a) Explore the role of cocaine in accelerating the development of HFV Dementia and b) Develop therapeutic intervention strategies for the treatment of HAD in cocaine-abusers. ..
  10. Mechanism and Therapy of SHIV Encephalitis in Macaques
    Shilpa Buch; Fiscal Year: 2006
    ..6P. 4) Optimization of LDC containing antisense IL-4, PDGF-B & MCP-1 DNAs for in vivo gene delivery in small animals, such as mice before aiming gene therapy in infected macaques. ..
  11. Mechanism and Therapy of SHIV Encephalitis in Macaques
    Shilpa Buch; Fiscal Year: 2005
    ..6P. 4) Optimization of LDC containing antisense IL-4, PDGF-B & MCP-1 DNAs for in vivo gene delivery in small animals, such as mice before aiming gene therapy in infected macaques. ..
  12. Mechanism and Therapy of SHIV Encephalitis in Macaques
    Shilpa Buch; Fiscal Year: 2004
    ..6P. 4) Optimization of LDC containing antisense IL-4, PDGF-B & MCP-1 DNAs for in vivo gene delivery in small animals, such as mice before aiming gene therapy in infected macaques. ..
  13. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2009
    ..Relevance: This proposal aims to: a) Explore the role of cocaine in accelerating the development of HFV Dementia and b) Develop therapeutic intervention strategies for the treatment of HAD in cocaine-abusers. ..