Shilpa J Buch

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NF-κBYY1 pathway
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 12:189-200. 2014
  2. pmc TRPC channel-mediated neuroprotection by PDGF involves Pyk2/ERK/CREB pathway
    H Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Differ 16:1681-93. 2009
  3. pmc Involvement of miR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells
    L Yang
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 4:e960. 2013
  4. pmc HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    PLoS ONE 8:e60170. 2013
  5. pmc Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e47572. 2012
  6. pmc Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction
    G Hu
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 3:e381. 2012
  7. pmc Morphine induces expression of platelet-derived growth factor in human brain microvascular endothelial cells: implication for vascular permeability
    Hongxiu Wen
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e21707. 2011
  8. pmc Cocaine potentiates astrocyte toxicity mediated by human immunodeficiency virus (HIV-1) protein gp120
    Yanjing Yang
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e13427. 2010
  9. pmc Growth factor signaling: implications for disease & therapeutics
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    J Neuroimmune Pharmacol 9:65-8. 2014
  10. doi request reprint Cannabinoid receptor 2 activation: a means to prevent monocyte-endothelium engagement
    Shilpa J Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska Electronic address
    Am J Pathol 183:1375-7. 2013

Research Grants

Collaborators

Detail Information

Publications19

  1. ncbi request reprint HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NF-κBYY1 pathway
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 12:189-200. 2014
    ..Taken together, these results demonstrate that HIV-1 Tat protein suppresses CX3CR1 expression in microglia via NF-κB-YY1 pathway and attenuates CX3CL1-induced functional response of microglia. ..
  2. pmc TRPC channel-mediated neuroprotection by PDGF involves Pyk2/ERK/CREB pathway
    H Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Differ 16:1681-93. 2009
    ..This effect was attenuated by pre-treatment of mice with the TRP blocker, thus underscoring the novel role of TRPC channels in the neuroprotection mediated by PDGF...
  3. pmc Involvement of miR-9/MCPIP1 axis in PDGF-BB-mediated neurogenesis in neuronal progenitor cells
    L Yang
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 4:e960. 2013
    ..These findings thus suggest that miR-9-mediated downregulation of MCPIP1 acts as a molecular switch regulation of neurogenesis. ..
  4. pmc HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy
    Ming Duan
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    PLoS ONE 8:e60170. 2013
    ..Taken together, these findings implicate that Tat-mediated induction of ICAM-1 expression plays a critical role in monocyte adhesion observed in HIV-1-associated cardiomyopathies...
  5. pmc Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e47572. 2012
    ..Taken together our findings lead to the suggestion that PDGF-CC could be developed as a therapeutic target to reverse Tat-mediated neurotoxicity with implications for HAD...
  6. pmc Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction
    G Hu
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 3:e381. 2012
    ..Understanding the regulation of PDGF-B expression may provide insights into the development of potential therapeutic targets for neuronal loss in HIV-1-infected opiate abusers...
  7. pmc Morphine induces expression of platelet-derived growth factor in human brain microvascular endothelial cells: implication for vascular permeability
    Hongxiu Wen
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e21707. 2011
    ..Understanding the regulation of PDGF expression may provide insights into the development of potential therapeutic targets for intervention of morphine-mediated neuroinflammation...
  8. pmc Cocaine potentiates astrocyte toxicity mediated by human immunodeficiency virus (HIV-1) protein gp120
    Yanjing Yang
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e13427. 2010
    ..Our results demonstrated that cocaine-mediated potentiation of gp120 toxicity involved regulation of oxidative stress, mitochondrial membrane potential and MAPK signaling pathways...
  9. pmc Growth factor signaling: implications for disease & therapeutics
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    J Neuroimmune Pharmacol 9:65-8. 2014
    ....
  10. doi request reprint Cannabinoid receptor 2 activation: a means to prevent monocyte-endothelium engagement
    Shilpa J Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska Electronic address
    Am J Pathol 183:1375-7. 2013
    ....
  11. pmc Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrins
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    FASEB J 27:1532-48. 2013
    ..nmMYLK is thus critical for eliciting microglial migration during the innate immune response...
  12. pmc Platelet-derived growth factor (PDGF)-BB-mediated induction of monocyte chemoattractant protein 1 in human astrocytes: implications for HIV-associated neuroinflammation
    Crystal Bethel-Brown
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroinflammation 9:262. 2012
    ..These results suggest that astrocyte activation by PDGF-BB exaggerates monocyte recruitment into the brain via MCP-1 and underscores the critical role astrocytes play in HAND...
  13. pmc Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Curr HIV Res 10:425-8. 2012
    ..This review summarizes previous studies on the mechanism(s) underlying the interplay of cocaine and HIV as it relates to the CNS...
  14. pmc Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
    Joel Mermis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Kansas Medical Center, Kansas City, USA
    Respir Res 12:103. 2011
    ..In this study, we explored the impact of HIV protein induced oxidative stress on production of hypoxia inducible factor (HIF)-1α and platelet-derived growth factor (PDGF), critical mediators implicated in the pathogenesis of HIV-PAH...
  15. pmc Neuroimmune pharmacology as an emerging curriculum for pre-medical students
    Shilpa J Buch
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:68-70. 2011
    ..The goal of this course is to expose pre-medical students to the field of NIP so that they are equipped with a solid foundation in these multidisciplinary fields for future clinical/academic careers...
  16. pmc Cocaine and HIV-1 interplay: molecular mechanisms of action and addiction
    Shilpa Buch
    Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center DRC 8011, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 6:503-15. 2011
    ..In this review, recent findings on the interplay of HIV infection and cocaine abuse and their possible implications in mode of action and/or addiction will be discussed...
  17. pmc HIV neuropathogenesis: a tight rope walk of innate immunity
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 5:489-95. 2010
    ..The ultimate outcome of HIV infection in the CNS will thus be dependent on the regulation of the net balance of cell-specific protective versus detrimental responses...
  18. doi request reprint Chronic SIV and morphine treatment increases heat shock protein 5 expression at the synapse
    Gurudutt Pendyala
    Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, USA
    J Neurovirol 21:592-8. 2015
    ..The upregulation of heat shock 70-kDa protein 5 in the SIV + morphine group points to increased cellular stress during SIV/morphine interaction thus leading to CNS dysfunction...
  19. pmc A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection
    Stephanie D Kraft-Terry
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Neuron 64:133-45. 2009
    ..Better understanding of the complexities of immune regulation during HAND can improve diagnosis and disease outcomes but is also relevant for the pathogenesis of a broad range of neurodegenerative disorders...

Research Grants1

  1. HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
    Shilpa J Buch; Fiscal Year: 2010
    ..Relevance: This proposal aims to: a) Explore the role of cocaine in accelerating the development of HFV Dementia and b) Develop therapeutic intervention strategies for the treatment of HAD in cocaine-abusers. ..