Research Topics
| Claudio G BrunsteinSummaryAffiliation: University of Minnesota Country: USA Publications
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Detail Information
Publications
Reduced-intensity conditioning transplantation in acute leukemia: the effect of source of unrelated donor stem cells on outcomesClaudio G Brunstein
University of Minnesota, Minneapolis, MN 55455, USA
Blood 119:5591-8. 2012....
Hematology: ATG and Newton's third law of motionClaudio G Brunstein
Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Nat Rev Clin Oncol 7:9-10. 2010..The addition of ATG to prophylaxis regimens decreases the incidence of GVHD without compromising overall survival in these patients...
Future of cord blood for oncology usesC G Brunstein
Division of Hematology, Oncology and Transplantation, Department of Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Bone Marrow Transplant 44:699-707. 2009..We review here the background data on the utilization of UCB for the treatment of hematological malignancies, and discuss the current challenges and future directions in the field of UCB transplantation...- Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kineticsClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
Blood 117:1061-70. 2011..These results set the stage for a definitive study of UCB Treg to determine its potency in preventing allogeneic aGVHD. This study is registered at http://www.clinicaltrials.gov as NCT00602693... - Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood graftsClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
Blood 118:282-8. 2011..The trials are registered at www.clinicaltrials.gov under NCT00864227 (BMT CTN 0604) and NCT00849147 (BMT CTN 0603)... - Promising progression-free survival for patients low and intermediate grade lymphoid malignancies after nonmyeloablative umbilical cord blood transplantationClaudio G Brunstein
University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 15:214-22. 2009..Based on our data, we conclude that a nonmyeloablative conditioning regimen followed by UCB transplantation is an effective treatment for patients with advanced lymphoid malignancies who lack a suitable sibling donor... - Intra-BM injection to enhance engraftment after myeloablative umbilical cord blood transplantation with two partially HLA-matched unitsC G Brunstein
University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN 55455, USA
Bone Marrow Transplant 43:935-40. 2009..Survival was 47% at 1 year. Despite safety of administration, IBMI of one of two UCB units did not shorten the time to neutrophil engraftment and offers no advantage over conventional double unit transplantation... - Extending cord blood transplant to adults: dealing with problems and results overallClaudio G Brunstein
Blood and Marrow Transplant Program, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Semin Hematol 47:86-96. 2010..We review the background data and promising newer strategies that will further expand the utilization of UCB for the treatment of adults... - Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic diseaseClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis MN, USA
Blood 110:3064-70. 2007..01) and use of 2 UCB units (P = .07). These findings support the use of UCB after a nonmyeloablative conditioning as a strategy for extending the availability of transplantation therapy, particularly for older patients... - Umbilical cord blood transplantation for the treatment of hematologic malignanciesClaudio G Brunstein
Blood and Marrow Transplant Program and Division of Hematology, Oncology and Transplantation at the University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Cancer Control 18:222-36. 2011..As the number of UCB transplantation procedures has grown, an increasing number of publications have focused on disease-specific outcomes... - Expanding the role of umbilical cord blood transplantationClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
Br J Haematol 137:20-35. 2007..This article reviews the state of the art and future directions with umbilical cord blood as a source of haematopoietic stem cells for transplantation in both children and adults... - Umbilical cord blood transplantation for myeloid malignanciesClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
Curr Opin Hematol 14:162-9. 2007..To review the available data on the outcomes of pediatric and adult patients with acute myeloid leukemia, myelodysplastic syndrome and chronic myelogenous leukemia after umbilical cord blood transplantation... - Cord blood transplantation for adultsClaudio G Brunstein
Department of Medicine, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
Vox Sang 91:195-205. 2006..We review here the current state of the art on cord blood transplantation for adults, and discuss some of the newer strategies being pursued in order to improve its safety and efficacy... - Umbilical cord blood transplantation and bankingClaudio G Brunstein
Department of Medicine, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
Annu Rev Med 57:403-17. 2006..New approaches to enhance hematopoietic recovery by the use of accessory cells or direct intra-bone marrow injection are also reviewed... - Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantationClaudio G Brunstein
Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 108:2874-80. 2006..Use of ATG in recipients of an NMA preparative regimen warrants close monitoring for evidence of EBV reactivation and potentially preemptive therapy with rituximab... - Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcomeMichael B Tomblyn
Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
J Clin Oncol 27:3634-41. 2009..Analysis of hematopoietic cell transplantation (HCT) for high-risk or recurrent acute lymphoblastic leukemia (ALL) using different donor sources is confounded by variable conditioning and supportive care... - Unrelated cord blood transplantation in adult and pediatric acute lymphoblastic leukemia: effect of minimal residual disease on relapse and survivalVeronika Bachanova
Blood and Marrow Transplant Program, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 18:963-8. 2012..05; disease-free survival, 55%; 95% CI, 43%-66%; P = .02). Our data suggest that in patients with ALL, achieving an MRD-negative state before UCBT improves outcomes... - Does the hematopoietic cell transplantation specific comorbidity index predict transplant outcomes? A validation study in a large cohort of umbilical cord blood and matched related donor transplantsNavneet S Majhail
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 14:985-92. 2008..The HCT-CI, although a useful tool for capturing pretransplant comorbidity and risk-assessment, needs to be further validated prior to adopting it for routine clinical use... - Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factorsMargaret L Macmillan
Blood and Marrow Transplant Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Blood 113:2410-5. 2009..This study is registered at (http://www.clinicaltrials.gov) under the identifiers NCT00305682 and NCT00309842... - Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donorNavneet S Majhail
Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 14:282-9. 2008..A careful review of existing comorbidities is necessary when considering older patients for HCT... - Prolonged survival in adults with acute lymphoblastic leukemia after reduced-intensity conditioning with cord blood or sibling donor transplantationVeronika Bachanova
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Blood 113:2902-5. 2009..01). For adults with ALL in CR, reduced intensity conditioning allografting results in modest TRM, limited risk of relapse, and promising leukemia-free survival. Clinical trial numbers are NCT00365287, NCT00305682, and NCT00303719... - Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord bloodClaudio G Brunstein
University of Minnesota Medical Center, Minneapolis, MN, USA
Blood 116:4693-9. 2010..For patients without an available HLA matched donor, the use of 2 partially HLA-matched UCB units is a suitable alternative... - Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 unitsMichael R Verneris
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Blood 114:4293-9. 2009..This trial was registered at http://clinicaltrials.gov as NCT00309842... - Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensityClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Blood 113:5628-34. 2009..8; 95% CI, 1.0-3.1; P = .05). Our results do not support the selection of UCB units based on KIR-L status and suggest that KIR-L mismatching should be avoided in reduced intensity UCB transplantation... - Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation (HSCT): higher response rate in recipients of unrelated donor (URD) umbilical cord blood (UCB)Mukta Arora
Blood and Marrow Transplant Program, Departments of Medicine and Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 13:1145-52. 2007..In addition, progressive onset of cGVHD was a significant predictor of increased mortality in URD cohort. These data suggest that cGVHD following UCB transplant may be more responsive to therapy and also lead to a lower NRM... - Monitoring and preemptive rituximab therapy for Epstein-Barr virus reactivation after antithymocyte globulin containing nonmyeloablative conditioning for umbilical cord blood transplantationAnne H Blaes
University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 16:287-91. 2010.... - Costs of hematopoietic cell transplantation: comparison of umbilical cord blood and matched related donor transplantation and the impact of posttransplant complicationsNavneet S Majhail
University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 15:564-73. 2009..These costs are primarily driven by severe posttransplant complications, graft failure, and prolonged inpatient stay. Strategies to enhance engraftment will decrease the costs of UCB transplantation... - Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphomaNavneet S Majhail
Blood and Marrow Transplant Program, Division of Medical and Pediatric Hematology, University of Minnesota, Minneapolis, 55455, USA
Blood 107:3804-7. 2006..67). Our results suggest comparable outcomes for reduced-intensity allo-SCT using UCB or MSD in adults at high risk with advanced Hodgkin lymphoma... - Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantationJill C Beck
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 16:215-22. 2010..01) and lower OS (P=.02). Thus, although recipient CMV serostatus and CMV reactivation have little demonstrable impact on UCB transplant outcomes, the development of CMV disease remains a risk, associated with inferior outcomes... - Anti-HLA antibodies in double umbilical cord blood transplantationClaudio G Brunstein
Blood and Marrow Transplantation Program, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 17:1704-8. 2011..Further studies are needed to fully understand the value of anti-HLA antibody testing in dUCB graft selection and its impact on transplantation outcomes... - Effect of conditioning regimen intensity on acute myeloid leukemia outcomes after umbilical cord blood transplantationBetul Oran
Department of Medicine, University of Minnesota Blood and Marrow Transplantation Program, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 17:1327-34. 2011..UCB with RIC extends the use of allogeneic HCT for older and frail patients without excessive TRM with greater benefit for patients in CR1 and CR2 with longer CR1... - Relapse of lymphoma after allogeneic hematopoietic cell transplantation: management strategies and outcomeKitsada Wudhikarn
Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 17:1497-504. 2011..Novel treatments can control lymphoma with acceptable morbidity. Particularly for patients with later relapse, ongoing treatment after relapse can yield meaningful benefit and prolonged survival... - Double umbilical cord blood transplantationNavneet S Majhail
Department of Medicine, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Curr Opin Immunol 18:571-5. 2006..Transplantation with two unrelated UCB units is feasible, safe and effective and can overcome the limitation of cell dose of single UCB units... - Transfusion-related acute lung injury during plasma exchange: Suspecting the unsuspectedSabeen Askari
Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, USA
J Clin Apher 17:93-6. 2002..Diagnosing TRALI has implications not only for the plasma exchange recipient, but also for the management of donors found to have leukocyte antibodies...