BENOIT BRUNEAU

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The heart's Da Vinci code: a Renaissance at Keystone
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, CA 94158, USA
    Development 134:1631-3. 2007
  2. pmc Reptilian heart development and the molecular basis of cardiac chamber evolution
    Kazuko Koshiba-Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nature 461:95-8. 2009
  3. pmc Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Nat Genet 44:343-7. 2012
  4. pmc Chromatin remodelling complex dosage modulates transcription factor function in heart development
    Jun K Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nat Commun 2:187. 2011
  5. pmc Signaling and transcriptional networks in heart development and regeneration
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, and Department of Pediatrics and Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Cold Spring Harb Perspect Biol 5:a008292. 2013
  6. ncbi request reprint Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Can J Physiol Pharmacol 89:533-7. 2011
  7. doi request reprint Chromatin remodeling in heart development
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, United States
    Curr Opin Genet Dev 20:505-11. 2010
  8. ncbi request reprint The developmental genetics of congenital heart disease
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease, and Department of Pediatrics, University of California San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
    Nature 451:943-8. 2008
  9. pmc Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors
    Jun K Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nature 459:708-11. 2009
  10. pmc Lessons for cardiac regeneration and repair through development
    Jeffrey M Alexander
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Trends Mol Med 16:426-34. 2010

Collaborators

Detail Information

Publications12

  1. ncbi request reprint The heart's Da Vinci code: a Renaissance at Keystone
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, CA 94158, USA
    Development 134:1631-3. 2007
    ....
  2. pmc Reptilian heart development and the molecular basis of cardiac chamber evolution
    Kazuko Koshiba-Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nature 461:95-8. 2009
    ..Our findings provide a molecular mechanism for the evolution of the amniote ventricle, and support the concept that altered expression of developmental regulators is a key mechanism of vertebrate evolution...
  3. pmc Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Nat Genet 44:343-7. 2012
    ..Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses...
  4. pmc Chromatin remodelling complex dosage modulates transcription factor function in heart development
    Jun K Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nat Commun 2:187. 2011
    ....
  5. pmc Signaling and transcriptional networks in heart development and regeneration
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, and Department of Pediatrics and Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Cold Spring Harb Perspect Biol 5:a008292. 2013
    ..Although we still have an incomplete picture of the mechanisms controlling development of the mammalian heart, our current knowledge has important implications for embryology and better understanding of human heart disease...
  6. ncbi request reprint Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Can J Physiol Pharmacol 89:533-7. 2011
    ..This review summarizes the dynamic expression of ANF in the developing heart and its usefulness in understanding the early molecular defects underlying CHDs...
  7. doi request reprint Chromatin remodeling in heart development
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, United States
    Curr Opin Genet Dev 20:505-11. 2010
    ....
  8. ncbi request reprint The developmental genetics of congenital heart disease
    Benoit G Bruneau
    Gladstone Institute of Cardiovascular Disease, and Department of Pediatrics, University of California San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
    Nature 451:943-8. 2008
    ..Recent studies have uncovered the genetic basis for some common forms of the disease and provide new insight into how the heart develops and how dysregulation of heart development leads to disease...
  9. pmc Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors
    Jun K Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nature 459:708-11. 2009
    ..The combined function of these factors establishes a robust mechanism for controlling cellular differentiation, and may allow reprogramming of new cardiomyocytes for regenerative purposes...
  10. pmc Lessons for cardiac regeneration and repair through development
    Jeffrey M Alexander
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Trends Mol Med 16:426-34. 2010
    ..Here, we focus on the recent advances in these areas of cardiac developmental research and their impact on the expanding field of regenerative medicine...
  11. pmc Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
    Masaki Ieda
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 142:375-86. 2010
    ..Reprogramming of endogenous or explanted fibroblasts might provide a source of cardiomyocytes for regenerative approaches...
  12. pmc miR-126 regulates angiogenic signaling and vascular integrity
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 15:272-84. 2008
    ..These findings illustrate that a single miRNA can regulate vascular integrity and angiogenesis, providing a new target for modulating vascular formation and function...

Research Grants7

  1. Chromatin remodeling complexes in heart development
    BENOIT GAETAN BRUNEAU; Fiscal Year: 2010
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  2. Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    BENOIT GAETAN BRUNEAU; Fiscal Year: 2010
    ..The results obtained will be relevant to human diseases that affect these processes, including arrhythmias after infarct and cardiac remodeling in heart failure. ..
  3. Chromatin remodeling complexes in heart development
    BENOIT BRUNEAU; Fiscal Year: 2006
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  4. Chromatin remodeling complexes in heart development
    BENOIT BRUNEAU; Fiscal Year: 2007
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  5. Chromatin remodeling complexes in heart development
    BENOIT BRUNEAU; Fiscal Year: 2009
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  6. Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    BENOIT BRUNEAU; Fiscal Year: 2009
    ..The results obtained will be relevant to human diseases that affect these processes, including arrhythmias after infarct and cardiac remodeling in heart failure. ..