K E Brummel-Ziedins

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint The resuscitative fluid you choose may potentiate bleeding
    Kathleen Brummel-Ziedins
    Department of Biochemistry, School of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    J Trauma 61:1350-8. 2006
  2. pmc From principle to practice: bridging the gap in patient profiling
    Jonathan H Foley
    Department of Biochemistry, University of Vermont, Burlington, Vermont, United States of America
    PLoS ONE 8:e54728. 2013
  3. pmc Defining the boundaries of normal thrombin generation: investigations into hemostasis
    Christopher M Danforth
    Department of Mathematics and Statistics, Center for Complex Systems, Vermont Advanced Computing Center, University of Vermont, Burlington, Vermont, United States of America
    PLoS ONE 7:e30385. 2012
  4. ncbi request reprint Developing individualized coagulation profiling of disease risk: thrombin generation dynamic models of the pro and anticoagulant balance
    Kathleen E Brummel-Ziedins
    University of Vermont, Department of Biochemistry, 208 South Park Drive, Colchester, Vermont 05446 Electronic address
    Thromb Res 133:S9-S11. 2014
  5. doi request reprint Depletion of systemic concentrations of coagulation factors in blood from patients with atherosclerotic vascular disease
    Kathleen E Brummel-Ziedins
    Department of Biochemistry, College of Medicine, University of Vermont, Colchester, VT 05446, USA
    Coron Artery Dis 24:468-74. 2013
  6. pmc The prothrombotic phenotypes in familial protein C deficiency are differentiated by computational modeling of thrombin generation
    Kathleen E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, Vermont, United States of America
    PLoS ONE 7:e44378. 2012
  7. pmc Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation
    Kathleen E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, Burlington Vermont, United States of America
    PLoS ONE 7:e29178. 2012
  8. ncbi request reprint Thrombin generation in acute coronary syndrome and stable coronary artery disease: dependence on plasma factor composition
    K Brummel-Ziedins
    Department of Biochemistry, University of Vermont, VT 05446, USA
    J Thromb Haemost 6:104-10. 2008
  9. pmc Thrombin generation and bleeding in haemophilia A
    K E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, College of Medicine, Colchester, VT 05446, USA
    Haemophilia 15:1118-25. 2009
  10. pmc Empirical and theoretical phenotypic discrimination
    K E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, Colchester, VT 05446, USA
    J Thromb Haemost 7:181-6. 2009

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The resuscitative fluid you choose may potentiate bleeding
    Kathleen Brummel-Ziedins
    Department of Biochemistry, School of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    J Trauma 61:1350-8. 2006
    ..Little is known about how various resuscitative paradigms affect the coagulation cascade, which is essential to controlling hemorrhagic shock...
  2. pmc From principle to practice: bridging the gap in patient profiling
    Jonathan H Foley
    Department of Biochemistry, University of Vermont, Burlington, Vermont, United States of America
    PLoS ONE 8:e54728. 2013
    ..Ultimately, our method is designed to visualize individualized patient profiles which are becoming evermore important as personalized medicine strategies become routine clinical practice...
  3. pmc Defining the boundaries of normal thrombin generation: investigations into hemostasis
    Christopher M Danforth
    Department of Mathematics and Statistics, Center for Complex Systems, Vermont Advanced Computing Center, University of Vermont, Burlington, Vermont, United States of America
    PLoS ONE 7:e30385. 2012
    ....
  4. ncbi request reprint Developing individualized coagulation profiling of disease risk: thrombin generation dynamic models of the pro and anticoagulant balance
    Kathleen E Brummel-Ziedins
    University of Vermont, Department of Biochemistry, 208 South Park Drive, Colchester, Vermont 05446 Electronic address
    Thromb Res 133:S9-S11. 2014
    ..This plasma composition based computational modeling can provide a mechanism based bridge between empirical global assays of coagulation and individualized risk prediction. ..
  5. doi request reprint Depletion of systemic concentrations of coagulation factors in blood from patients with atherosclerotic vascular disease
    Kathleen E Brummel-Ziedins
    Department of Biochemistry, College of Medicine, University of Vermont, Colchester, VT 05446, USA
    Coron Artery Dis 24:468-74. 2013
    ..A novel computational model was used to predict whether differences in the activity of coagulation factors would alter the generation of thrombin...
  6. pmc The prothrombotic phenotypes in familial protein C deficiency are differentiated by computational modeling of thrombin generation
    Kathleen E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, Vermont, United States of America
    PLoS ONE 7:e44378. 2012
    ..In addition, variations within the plasma composition of each individual can further segregate out increased procoagulant phenotypes, with gender-associated plasma compositional differences playing a large role...
  7. pmc Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation
    Kathleen E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, Burlington Vermont, United States of America
    PLoS ONE 7:e29178. 2012
    ..Analysis of fXa generation is a phenotypic characteristic which may prove to be a more sensitive discriminator than thrombin generation among all individuals...
  8. ncbi request reprint Thrombin generation in acute coronary syndrome and stable coronary artery disease: dependence on plasma factor composition
    K Brummel-Ziedins
    Department of Biochemistry, University of Vermont, VT 05446, USA
    J Thromb Haemost 6:104-10. 2008
    ..We investigated whether thrombin generation based on circulating coagulation protein levels, could distinguish between acute and stable coronary artery disease (CAD)...
  9. pmc Thrombin generation and bleeding in haemophilia A
    K E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, College of Medicine, Colchester, VT 05446, USA
    Haemophilia 15:1118-25. 2009
    ..6 +/- 1.3, 4.7 +/- 0.7 and 5.6 +/- 1.3 min. Our empirical study in CTI-inhibited whole blood shows that the MaxL of thrombin generation appears to correlate with the bleeding phenotype of haemophilia A...
  10. pmc Empirical and theoretical phenotypic discrimination
    K E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, Colchester, VT 05446, USA
    J Thromb Haemost 7:181-6. 2009
    ....
  11. pmc Discordant fibrin formation in hemophilia
    K E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, VT, USA
    J Thromb Haemost 7:825-32. 2009
    ..The conversion of fibrinogen to fibrin and its crosslinking to form a stable clot are key events in providing effective hemostasis...
  12. pmc Anticoagulation by factor Xa inhibitors
    T Orfeo
    Department of Biochemistry, University of Vermont, Colchester, VT, USA
    J Thromb Haemost 8:1745-53. 2010
    ..Therapeutic agents that regulate blood coagulation are critical to the management of thrombotic disorders, with the selective targeting of factor (F) Xa emerging as a promising approach...
  13. pmc The influence of prophylactic factor VIII in severe haemophilia A
    M Gissel
    Department of Biochemistry, University of Vermont, Colchester, VT, USA
    Haemophilia 18:193-9. 2012
    ..The combination of each individual's coagulation factors (outside of fVIII) determine each individual's baseline thrombin potential and may affect bleeding risk...
  14. pmc Thrombin generation profiles in deep venous thrombosis
    K E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, VT 05405, USA
    J Thromb Haemost 3:2497-505. 2005
    ..Reliable markers and methods to predict risk for thrombosis are essential to clinical management...
  15. pmc Thrombin activatable fibrinolysis inhibitor activation and bleeding in haemophilia A
    J H Foley
    The Department of Biochemistry, University of Vermont, Burlington, VT, USA
    Haemophilia 18:e316-22. 2012
    ..Measuring TAFIa along with thrombin generation can potentially be useful to evaluate the differential bleeding phenotype in haemophilia A...
  16. pmc Measuring the mechanical properties of blood clots formed via the tissue factor pathway of coagulation
    J H Foley
    Department of Biochemistry, University of Vermont, Burlington, Colchester, VT 05446, USA
    Anal Biochem 422:46-51. 2012
    ..Our Tf reagent reproducibly induces coagulation, making it an ideal tool to quantify the processes that contribute to mechanical clot strength in whole blood...
  17. doi request reprint Activated protein C inhibitor for correction of thrombin generation in hemophilia A blood and plasma1
    K E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, Burlington, VT, USA
    J Thromb Haemost 9:2262-7. 2011
    ..Replacement therapy for hemophilic patient treatment is costly, because of the high price of pharmacologic products, and is not affordable for the majority of patients in developing countries...
  18. ncbi request reprint Thrombin generation: phenotypic quantitation
    K E Brummel-Ziedins
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, VT 05405, USA
    J Thromb Haemost 2:281-8. 2004
    ..Overall, these data suggest that thrombin generated in whole blood exclusively by tissue factor stimulation can be used as an integrative phenotypic marker to determine an individual's response to a tissue factor challenge...
  19. pmc Characteristics of fibrin formation and clot stability in individuals with congenital type IIb protein C deficiency
    J H Foley
    Department of Biochemistry, University of Vermont, Burlington, United States
    Thromb Res 129:e142-6. 2012
    ..Since PC deficient clots are both denser and show a greater degree of resistance to fibrinolysis, these clots would likely resist fibrinolysis and potentiate fibrin deposition observed in thrombosis...
  20. ncbi request reprint Models of blood coagulation
    Kenneth G Mann
    Department of Biochemistry, 208 South Park Drive, Suite 2, University of Vermont, College of Medicine, Colchester, VT 05446, USA
    Blood Cells Mol Dis 36:108-17. 2006
    ..Ideally, our results will provide descriptions which predict the behavior of the biological blood coagulation system under normal and pathologic conditions...
  21. ncbi request reprint Blood coagulation at the site of microvascular injury in healthy and coumadin-treated subjects heterogenous for factor V Leiden mutation
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, Crakow, Poland
    Thromb Haemost 98:1024-30. 2007
    ..Inactivation of FVa by the APC mechanism is attenuated significantly in carriers of FV Leiden but the magnitude of this effect is smaller than that observed in most purified systems...