ADRIAAN WILLEM BRUIJNZEEL

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Biol Psychiatry 66:110-7. 2009
  2. pmc Anorexic effects of intra-VTA leptin are similar in low-fat and high-fat-fed rats but attenuated in a subgroup of high-fat-fed obese rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 1149 Newell Dr, Gainesville, FL 32611, USA
    Pharmacol Biochem Behav 103:573-81. 2013
  3. pmc Tobacco addiction and the dysregulation of brain stress systems
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 1149 S Newell Dr, Gainesville, FL 32611, USA
    Neurosci Biobehav Rev 36:1418-41. 2012
  4. pmc Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 100 S Newell Dr, Gainesville, Florida 32610, USA
    Pharmacol Biochem Behav 101:62-8. 2012
  5. doi request reprint Tobacco smoke diminishes neurogenesis and promotes gliogenesis in the dentate gyrus of adolescent rats
    Adrie W Bruijnzeel
    Department of Psychiatry, College of Medicine, McKnight Brain Institute, University of Florida, 100 S Newell Dr, Gainesville, FL 32610, USA
    Brain Res 1413:32-42. 2011
  6. pmc Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 100 S Newell Dr, Gainesville, FL 32610, USA
    Behav Brain Res 219:254-64. 2011
  7. pmc Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 100 S Newell Dr, P O Box 100256, Gainesville, FL 32610, USA
    Psychopharmacology (Berl) 212:485-99. 2010
  8. pmc Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Behav Brain Res 210:288-91. 2010
  9. pmc kappa-Opioid receptor signaling and brain reward function
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, 32610, USA
    Brain Res Rev 62:127-46. 2009
  10. pmc Effects of the CRF receptor antagonist D-Phe CRF(12-41) and the alpha2-adrenergic receptor agonist clonidine on stress-induced reinstatement of nicotine-seeking behavior in rats
    George Zislis
    University of Florida, Department of Psychiatry, Gainesville, FL 32610, USA
    Neuropharmacology 53:958-66. 2007

Research Grants

Collaborators

  • Mark S Gold
  • Rayna M Bauzo
  • Barry L Jacobs
  • J R Pauly
  • Hina P Shah
  • Daria Rylkova
  • Elysia Small
  • Hidetaka Yamada
  • Hartmut Derendorf
  • Sreedharan N Sabarinath
  • Catherine A Marcinkiewcz
  • Jiang Liu
  • Melissa Prado
  • George Zislis
  • Irma A van Tuijl
  • Jacqueline E Geier
  • Kim F M Keijzers
  • Kate R Yavarovich
  • Firas H Kobeissy
  • Mahendra Bishnoi
  • Jake J Davenport
  • Melissa M Prado
  • Shani K Isaac
  • Alex Marshall
  • Jeffrey Boissoneault
  • Shani Isaac
  • Hao Pan
  • Tina V Desai

Detail Information

Publications21

  1. pmc Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Biol Psychiatry 66:110-7. 2009
    ..The aim of these studies was to investigate the role of CRF1 and CRF2 receptors in the deficit in brain reward function associated with precipitated nicotine withdrawal and stress-induced reinstatement of nicotine-seeking...
  2. pmc Anorexic effects of intra-VTA leptin are similar in low-fat and high-fat-fed rats but attenuated in a subgroup of high-fat-fed obese rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 1149 Newell Dr, Gainesville, FL 32611, USA
    Pharmacol Biochem Behav 103:573-81. 2013
    ..However, HF-fed DIO rats are less sensitive to the effects of leptin in the VTA than HF-fed DR rats. Leptin resistance in the VTA might contribute to overeating and weight gain when exposed to a HF diet...
  3. pmc Tobacco addiction and the dysregulation of brain stress systems
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 1149 S Newell Dr, Gainesville, FL 32611, USA
    Neurosci Biobehav Rev 36:1418-41. 2012
    ..Drugs that decrease the activity of brain stress systems may diminish nicotine withdrawal and improve smoking cessation rates...
  4. pmc Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 100 S Newell Dr, Gainesville, Florida 32610, USA
    Pharmacol Biochem Behav 101:62-8. 2012
    ..These studies suggest that CRF1 receptor antagonists may diminish the dysphoria associated with smoking cessation by blocking CRF1 receptors in the CeA...
  5. doi request reprint Tobacco smoke diminishes neurogenesis and promotes gliogenesis in the dentate gyrus of adolescent rats
    Adrie W Bruijnzeel
    Department of Psychiatry, College of Medicine, McKnight Brain Institute, University of Florida, 100 S Newell Dr, Gainesville, FL 32610, USA
    Brain Res 1413:32-42. 2011
    ..These effects may play a role in the increased risk for depression and cognitive impairment in adolescent smokers...
  6. pmc Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 100 S Newell Dr, Gainesville, FL 32610, USA
    Behav Brain Res 219:254-64. 2011
    ..These studies suggest that a small increase in leptin or insulin levels in the VTA leads to a decrease in brain reward function. A relatively large increase in insulin or leptin levels in the VTA or Arc decreases food intake...
  7. pmc Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, 100 S Newell Dr, P O Box 100256, Gainesville, FL 32610, USA
    Psychopharmacology (Berl) 212:485-99. 2010
    ..Increased noradrenergic transmission has been reported to play an important role in opioid withdrawal, but little is known about the role of noradrenergic transmission in nicotine withdrawal...
  8. pmc Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Behav Brain Res 210:288-91. 2010
    ..This indicates that the dysphoria associated with alcohol withdrawal is at least partly mediated by the activation of central CRF receptors...
  9. pmc kappa-Opioid receptor signaling and brain reward function
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, 32610, USA
    Brain Res Rev 62:127-46. 2009
    ....
  10. pmc Effects of the CRF receptor antagonist D-Phe CRF(12-41) and the alpha2-adrenergic receptor agonist clonidine on stress-induced reinstatement of nicotine-seeking behavior in rats
    George Zislis
    University of Florida, Department of Psychiatry, Gainesville, FL 32610, USA
    Neuropharmacology 53:958-66. 2007
    ..These data provide support for the hypothesis that an increased activity of brain CRF and norepinephrine systems mediates stress-induced relapse to nicotine-seeking behavior...
  11. doi request reprint Effects of fentanyl dose and exposure duration on the affective and somatic signs of fentanyl withdrawal in rats
    Jiang Liu
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Neuropharmacology 55:812-8. 2008
    ..These studies suggest that the magnitude and duration of the negative affective signs of fentanyl withdrawal depend on the dose of fentanyl administered and not on the duration of fentanyl administration...
  12. pmc Preadolescent tobacco smoke exposure leads to acute nicotine dependence but does not affect the rewarding effects of nicotine or nicotine withdrawal in adulthood in rats
    Hidetaka Yamada
    Department of Psychiatry, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Pharmacol Biochem Behav 95:401-9. 2010
    ....
  13. pmc Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats
    Catherine A Marcinkiewcz
    Department of Psychiatry, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Neuropsychopharmacology 34:1743-52. 2009
    ..These studies indicate that the negative emotional state associated with precipitated nicotine withdrawal is at least partly mediated by an increased release of CRF in the CeA and the Nacc shell...
  14. pmc Deficit in brain reward function and acute and protracted anxiety-like behavior after discontinuation of a chronic alcohol liquid diet in rats
    Daria Rylkova
    Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, 100 S Newell Dr, Gainesville, FL 32610, USA
    Psychopharmacology (Berl) 203:629-40. 2009
    ..Discontinuation of chronic and excessive alcohol consumption leads to a dysphoric state in humans. It is not known if there are changes in brain reward function after the discontinuation of an alcohol liquid in rats...
  15. ncbi request reprint Neurobiological mechanisms in addictive and psychiatric disorders
    Adrie W Bruijnzeel
    Department of Psychiatry, University of Florida College of Medicine, P O Box 100183, Gainesville, FL 32610 0183, USA
    Psychiatr Clin North Am 27:661-74. 2004
    ..Conversely, professional treatment of pre-existing psychiatric disorders may decrease the use of illicit substances...
  16. pmc Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats
    Daria Rylkova
    Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
    Neuropeptides 42:215-27. 2008
    ..In addition, NPY decreases the sensitivity to rewarding electrical stimuli via an Y1 dependent mechanism...
  17. ncbi request reprint The effects of buprenorphine on fentanyl withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, 100 S Newell Dr, 100256, Gainesville, FL 32610 0244, USA
    Psychopharmacology (Berl) 191:931-41. 2007
    ..Fentanyl is a potent mu-opioid receptor agonist that is widely used for the treatment of severe chronic pain. Discontinuation of fentanyl administration has been shown to induce a negative emotional state...
  18. ncbi request reprint Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neuropsychopharmacology 32:955-63. 2007
    ..These data provide support for the hypothesis that a hyperactivity of brain CRF systems may at least partly mediate the initiation of the negative affective aspects of nicotine withdrawal...
  19. ncbi request reprint The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence
    Adrie W Bruijnzeel
    Department of Psychiatry, University of Florida, McKnight Brain Institute, 100 S Newell Dr PO Box 100256, Gainesville, FL 32610, USA
    Brain Res Brain Res Rev 49:505-28. 2005
    ....
  20. ncbi request reprint Severe deficit in brain reward function associated with fentanyl withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, College of Medicine, University of Florida, Gainesville, Florida 32610 0244, USA
    Biol Psychiatry 59:477-80. 2006
    ..The aim of these studies was to investigate the effects of fentanyl withdrawal on brain reward function and somatic withdrawal signs...
  21. pmc Tobacco smoke exposure induces nicotine dependence in rats
    Elysia Small
    Department of Psychiatry, College of Medicine, McKnight Brain Institute, University of Florida, 100 S Newell Dr, PO Box 100256, Gainesville, FL 32610, USA
    Psychopharmacology (Berl) 208:143-58. 2010
    ..Therefore, animal models are needed that allow the investigation of chronic exposure to the full spectrum of tobacco smoke constituents...

Research Grants3

  1. Nicotine withdrawal and relapse: role of neuroadaptations in brain stress systems
    ADRIAAN WILLEM BRUIJNZEEL; Fiscal Year: 2010
    ..These novel treatments may aid in improving smoking cessation rates. ..