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Genomes and Genes | Richard K BruickSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxiaR K Bruick
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9152, USA
Proc Natl Acad Sci U S A 97:9082-7. 2000..These observations indicate that Nip3 may play a dedicated role in the pathological progression of hypoxia-mediated apoptosis, as observed after ischemic injury...
Transcription. Oxygen sensing gets a second windRichard K Bruick
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3.124, Dallas, TX 75390-9152, USA
Science 295:807-8. 2002- Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factorRichard K Bruick
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9152, USA
Genes Dev 17:2614-23. 2003 - Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanismsSrinivas Chollangi
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 287:23710-7. 2012..Instead, the isolated domain appears competent to incorporate iron only at or near the time of its own synthesis. These observations have important implications for mechanisms by which these metabolites are sensed within mammalian cells... - Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factorJinsong Yang
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9038, USA
J Biol Chem 280:36047-54. 2005..Because disruption of individual PAS domains compromise HIF function independent of the mechanism of HIF induction, these data demonstrate the potential utility of targeting these domains for therapeutic applications... - Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4Abdullah Ozer
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
Cell Cycle 4:1153-6. 2005..Furthermore, the identification of a link between ING4 and HIF may shed light on a mechanism by which misregulation of ING4 in tumors promotes angiogenesis, loss of contact inhibition, and changes in cellular proliferation and survival... - The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)Abdullah Ozer
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
Proc Natl Acad Sci U S A 102:7481-6. 2005..These data support a model in which, in addition to regulating HIF stability, HIF prolyl hydroxylases can modulate HIF function through the recruitment of ING4, a likely component of a chromatin-remodeling complex... - Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factorThomas H Scheuermann
Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 106:450-5. 2009..Given the essential role of PAS domains in forming active HIF heterodimers, these results suggest a presently uncharacterized ligand-mediated mechanism for regulating HIF2 activity in endogenous and clinical settings... - Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factorPaul J A Erbel
Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 100:15504-9. 2003.... - Hypoxia-inducible factors Per/ARNT/Sim domains: structure and functionThomas H Scheuermann
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Methods Enzymol 435:3-24. 2007..This review highlights strategies for the biophysical and biochemical characterization of the PAS domains found within both HIF subunits and provides a platform for future efforts to exploit these domains in therapeutic settings... 
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasisAmeen A Salahudeen
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 326:722-6. 2009..These observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis...- Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)Joel W Thompson
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
J Biol Chem 287:7357-65. 2012..Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor... - Protein degradation and iron homeostasisJoel W Thompson
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Biochim Biophys Acta 1823:1484-90. 2012..Moreover, these multiple pathways intersect with one another in larger regulatory networks to maintain iron homeostasis. This article is part of a Special Issue entitled: Cell Biology of Metals... - Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathwayCharles E Dann
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas 75390, USA
Proc Natl Acad Sci U S A 99:15351-6. 2002..Furthermore, the structure reveals the presence of a FIH-1 homodimer that forms in solution and is essential for FIH activity... - Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysisKatsumi Iizuka
Department of Biochemistry, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
Proc Natl Acad Sci U S A 101:7281-6. 2004.... - Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigsAndrew D Nguyen
Departments of Molecular Genetics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
J Biol Chem 282:27436-46. 2007..These results define a novel oxygen-sensing mechanism mediated by the combined actions of methylated intermediates in cholesterol synthesis and the hypoxia-activated transcription factor HIF-1alpha... - Dioxygenases as O2-dependent regulators of the hypoxic response pathwayCharles E Dann
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9038, USA
Biochem Biophys Res Commun 338:639-47. 2005..As such, these oxygenases fill a role as environmental and metabolic sensors, a paradigm that may extend to other biological pathways... - Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?Abdullah Ozer
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9038, USA
Nat Chem Biol 3:144-53. 2007..The discovery of protein regulation via hydroxylation raises the possibility that other Fe(II)- and 2-oxoglutarate-dependent dioxygenases might also serve in a similar capacity... - A conserved family of prolyl-4-hydroxylases that modify HIFR K Bruick
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
Science 294:1337-40. 2001..These findings indicate that HPH is an essential component of the pathway through which cells sense oxygen... - JMJD6 is a histone arginine demethylaseBingsheng Chang
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
Science 318:444-7. 2007..These findings may help explain the many developmental defects observed in the JMJD6(-/-) knockout mice... - A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liverH Yamashita
Dallas Veterans Affairs Medical Center and Department of Biochemistry, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
Proc Natl Acad Sci U S A 98:9116-21. 2001..ChREBP is likely critical for the optimal long-term storage of excess carbohydrates as fats, and may contribute to the imbalance between nutrient utilization and storage characteristic of obesity... - F-box and Leucine-rich Repeat Protein 5 (FBXL5) Is Required for Maintenance of Cellular and Systemic Iron HomeostasisJulio C Ruiz
From the Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038 and
J Biol Chem 288:552-60. 2013..These results confirm the role of FBXL5 in the in vivo maintenance of cellular and systemic iron homeostasis and reveal a privileged role for the intestine in their regulation by virtue of its unique FBXL5 iron sensitivity... - Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talkAmeen A Salahudeen
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 903, USA
Ann N Y Acad Sci 1177:30-8. 2009..Here, we describe regulatory factors for each pathway that sense both iron and oxygen availability and coordinate the maintenance of mammalian iron and oxygen homeostasis at both the cellular and systemic levels... - Laurenditerpenol, a new diterpene from the tropical marine alga Laurenciaintricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cellsKaleem A Mohammed
Department of Pharmacognosy, National Center for Natural Products Research, and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, USA
J Nat Prod 67:2002-7. 2004..Compound 1 inhibits HIF-1 by blocking the induction of the oxygen-regulated HIF-1alpha protein. Mitochondrial respiration studies revealed that 1 suppresses oxygen consumption... - Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stressKonstantin Salnikow
NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
J Biol Chem 279:40337-44. 2004.... - FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factorDavid Lando
Department of Molecular BioSciences Biochemistry and the Centre for the Molecular Genetics of Development, Adelaide University SA 5005, Australia
Genes Dev 16:1466-71. 2002..Together with the recently discovered prolyl hydroxylases that regulate HIF stability, this class of oxygen-dependent enzymes comprises critical regulatory components of the hypoxic response pathway... - Saururus cernuus lignans--potent small molecule inhibitors of hypoxia-inducible factor-1Chowdhury Faiz Hossain
Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA
Biochem Biophys Res Commun 333:1026-33. 2005..In addition, preliminary structure-activity studies suggest specific structural requirements for this class of HIF-1 inhibitors... - Identification and characterization of a novel RNA binding protein that associates with the 5'-untranslated region of the chloroplast psbA mRNADwight Barnes
Department of Cell Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Biochemistry 43:8541-50. 2004.... - Proceedings of the Oxygen Homeostasis/Hypoxia MeetingBennett Kaufman
TRI Inc, Rockville, Maryland, USA
Cancer Res 64:3350-6. 2004