Richard K Bruick

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9152, USA
    Proc Natl Acad Sci U S A 97:9082-7. 2000
  2. ncbi Transcription. Oxygen sensing gets a second wind
    Richard K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 295:807-8. 2002
  3. ncbi Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor
    Richard K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9152, USA
    Genes Dev 17:2614-23. 2003
  4. pmc Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms
    Srinivas Chollangi
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 287:23710-7. 2012
  5. ncbi Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor
    Jinsong Yang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    J Biol Chem 280:36047-54. 2005
  6. ncbi Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4
    Abdullah Ozer
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Cell Cycle 4:1153-6. 2005
  7. pmc The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)
    Abdullah Ozer
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 102:7481-6. 2005
  8. pmc Allosteric inhibition of hypoxia inducible factor-2 with small molecules
    Thomas H Scheuermann
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Chem Biol 9:271-6. 2013
  9. pmc Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor
    Jamie L Rogers
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, United States
    J Med Chem 56:1739-47. 2013
  10. pmc F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis
    Julio C Ruiz
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    J Biol Chem 288:552-60. 2013

Collaborators

Detail Information

Publications32

  1. pmc Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9152, USA
    Proc Natl Acad Sci U S A 97:9082-7. 2000
    ..These observations indicate that Nip3 may play a dedicated role in the pathological progression of hypoxia-mediated apoptosis, as observed after ischemic injury...
  2. ncbi Transcription. Oxygen sensing gets a second wind
    Richard K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 295:807-8. 2002
  3. ncbi Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor
    Richard K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9152, USA
    Genes Dev 17:2614-23. 2003
  4. pmc Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms
    Srinivas Chollangi
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 287:23710-7. 2012
    ..Instead, the isolated domain appears competent to incorporate iron only at or near the time of its own synthesis. These observations have important implications for mechanisms by which these metabolites are sensed within mammalian cells...
  5. ncbi Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor
    Jinsong Yang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    J Biol Chem 280:36047-54. 2005
    ..Because disruption of individual PAS domains compromise HIF function independent of the mechanism of HIF induction, these data demonstrate the potential utility of targeting these domains for therapeutic applications...
  6. ncbi Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4
    Abdullah Ozer
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Cell Cycle 4:1153-6. 2005
    ..Furthermore, the identification of a link between ING4 and HIF may shed light on a mechanism by which misregulation of ING4 in tumors promotes angiogenesis, loss of contact inhibition, and changes in cellular proliferation and survival...
  7. pmc The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)
    Abdullah Ozer
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 102:7481-6. 2005
    ..These data support a model in which, in addition to regulating HIF stability, HIF prolyl hydroxylases can modulate HIF function through the recruitment of ING4, a likely component of a chromatin-remodeling complex...
  8. pmc Allosteric inhibition of hypoxia inducible factor-2 with small molecules
    Thomas H Scheuermann
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Chem Biol 9:271-6. 2013
    ..These chemical tools establish the molecular basis for selective regulation of HIF-2, providing potential therapeutic opportunities to intervene in HIF-2-driven tumors, such as renal cell carcinomas...
  9. pmc Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor
    Jamie L Rogers
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, United States
    J Med Chem 56:1739-47. 2013
    ..These results may serve as a foundation for discovering therapeutic agents that function by a novel mode of action. ..
  10. pmc F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis
    Julio C Ruiz
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    J Biol Chem 288:552-60. 2013
    ..These results confirm the role of FBXL5 in the in vivo maintenance of cellular and systemic iron homeostasis and reveal a privileged role for the intestine in their regulation by virtue of its unique FBXL5 iron sensitivity...
  11. ncbi Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function
    Thomas H Scheuermann
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Methods Enzymol 435:3-24. 2007
    ..This review highlights strategies for the biophysical and biochemical characterization of the PAS domains found within both HIF subunits and provides a platform for future efforts to exploit these domains in therapeutic settings...
  12. pmc Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor
    Thomas H Scheuermann
    Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:450-5. 2009
    ..Given the essential role of PAS domains in forming active HIF heterodimers, these results suggest a presently uncharacterized ligand-mediated mechanism for regulating HIF2 activity in endogenous and clinical settings...
  13. pmc An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis
    Ameen A Salahudeen
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 326:722-6. 2009
    ..These observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis...
  14. pmc Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor
    Paul J A Erbel
    Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 100:15504-9. 2003
    ....
  15. pmc Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)
    Joel W Thompson
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:7357-65. 2012
    ..Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor...
  16. pmc Protein degradation and iron homeostasis
    Joel W Thompson
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Biochim Biophys Acta 1823:1484-90. 2012
    ..Moreover, these multiple pathways intersect with one another in larger regulatory networks to maintain iron homeostasis. This article is part of a Special Issue entitled: Cell Biology of Metals...
  17. pmc Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway
    Charles E Dann
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas 75390, USA
    Proc Natl Acad Sci U S A 99:15351-6. 2002
    ..Furthermore, the structure reveals the presence of a FIH-1 homodimer that forms in solution and is essential for FIH activity...
  18. ncbi Dioxygenases as O2-dependent regulators of the hypoxic response pathway
    Charles E Dann
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9038, USA
    Biochem Biophys Res Commun 338:639-47. 2005
    ..As such, these oxygenases fill a role as environmental and metabolic sensors, a paradigm that may extend to other biological pathways...
  19. pmc Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    Katsumi Iizuka
    Department of Biochemistry, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 101:7281-6. 2004
    ....
  20. ncbi Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?
    Abdullah Ozer
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9038, USA
    Nat Chem Biol 3:144-53. 2007
    ..The discovery of protein regulation via hydroxylation raises the possibility that other Fe(II)- and 2-oxoglutarate-dependent dioxygenases might also serve in a similar capacity...
  21. ncbi Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs
    Andrew D Nguyen
    Departments of Molecular Genetics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Biol Chem 282:27436-46. 2007
    ..These results define a novel oxygen-sensing mechanism mediated by the combined actions of methylated intermediates in cholesterol synthesis and the hypoxia-activated transcription factor HIF-1alpha...
  22. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
    ..These findings indicate that HPH is an essential component of the pathway through which cells sense oxygen...
  23. pmc Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules
    Yirui Guo
    Departments of Biophysics and Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8816, United States
    ACS Chem Biol 8:626-35. 2013
    ..Overall, our data identify small molecule regulators for this important complex and highlight the utility of pursuing parallel strategies to develop protein/protein inhibitors...
  24. ncbi JMJD6 is a histone arginine demethylase
    Bingsheng Chang
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Science 318:444-7. 2007
    ..These findings may help explain the many developmental defects observed in the JMJD6(-/-) knockout mice...
  25. pmc A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
    H Yamashita
    Dallas Veterans Affairs Medical Center and Department of Biochemistry, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 98:9116-21. 2001
    ..ChREBP is likely critical for the optimal long-term storage of excess carbohydrates as fats, and may contribute to the imbalance between nutrient utilization and storage characteristic of obesity...
  26. pmc Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk
    Ameen A Salahudeen
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 903, USA
    Ann N Y Acad Sci 1177:30-8. 2009
    ..Here, we describe regulatory factors for each pathway that sense both iron and oxygen availability and coordinate the maintenance of mammalian iron and oxygen homeostasis at both the cellular and systemic levels...
  27. ncbi Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress
    Konstantin Salnikow
    NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 279:40337-44. 2004
    ....
  28. pmc Laurenditerpenol, a new diterpene from the tropical marine alga Laurenciaintricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells
    Kaleem A Mohammed
    Department of Pharmacognosy, National Center for Natural Products Research, and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677 1848, USA
    J Nat Prod 67:2002-7. 2004
    ..Compound 1 inhibits HIF-1 by blocking the induction of the oxygen-regulated HIF-1alpha protein. Mitochondrial respiration studies revealed that 1 suppresses oxygen consumption...
  29. pmc Saururus cernuus lignans--potent small molecule inhibitors of hypoxia-inducible factor-1
    Chowdhury Faiz Hossain
    Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677 1848, USA
    Biochem Biophys Res Commun 333:1026-33. 2005
    ..In addition, preliminary structure-activity studies suggest specific structural requirements for this class of HIF-1 inhibitors...
  30. pmc FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    David Lando
    Department of Molecular BioSciences Biochemistry and the Centre for the Molecular Genetics of Development, Adelaide University SA 5005, Australia
    Genes Dev 16:1466-71. 2002
    ..Together with the recently discovered prolyl hydroxylases that regulate HIF stability, this class of oxygen-dependent enzymes comprises critical regulatory components of the hypoxic response pathway...
  31. ncbi Identification and characterization of a novel RNA binding protein that associates with the 5'-untranslated region of the chloroplast psbA mRNA
    Dwight Barnes
    Department of Cell Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 43:8541-50. 2004
    ....
  32. ncbi Proceedings of the Oxygen Homeostasis/Hypoxia Meeting
    Bennett Kaufman
    TRI Inc, Rockville, Maryland, USA
    Cancer Res 64:3350-6. 2004