J V Bruckner

Summary

Affiliation: University of Georgia
Country: USA

Publications

  1. ncbi request reprint Acute, short-term, and subchronic oral toxicity of 1,1,1-trichloroethane in rats
    J V Bruckner
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602 2352, USA
    Toxicol Sci 60:363-72. 2001
  2. doi request reprint Influence of exposure route and oral dosage regimen on 1, 1-dichloroethylene toxicokinetics and target organ toxicity
    J V Bruckner
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy and Interdisciplinary Toxicology Program, University of Georgia, Athens, Georgia 30602 2352, USA
    J Pharmacol Exp Ther 333:519-27. 2010
  3. ncbi request reprint The Acute Exposure Guideline Level (AEGL) program: applications of physiologically based pharmacokinetic modeling
    James V Bruckner
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602 2354, USA
    J Toxicol Environ Health A 67:621-34. 2004
  4. ncbi request reprint Mechanisms of circadian rhythmicity of carbon tetrachloride hepatotoxicity
    James V Bruckner
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens 30602 2352, USA
    J Pharmacol Exp Ther 300:273-81. 2002
  5. ncbi request reprint Acute, subacute, and subchronic oral toxicity studies of 1,1-dichloroethane in rats: application to risk evaluation
    S Muralidhara
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602 2352, USA
    Toxicol Sci 64:135-45. 2001
  6. ncbi request reprint Rapid determination of the synthetic pyrethroid insecticide, deltamethrin, in rat plasma and tissues by HPLC
    Kyu Bong Kim
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, 30602, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 834:141-8. 2006
  7. ncbi request reprint Determination of deltamethrin and its metabolite 3-phenoxybenzoic acid in male rat plasma by high-performance liquid chromatography
    Yan Ding
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 810:221-7. 2004
  8. ncbi request reprint Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats
    Kyu Bong Kim
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30605, USA
    Toxicology 234:194-202. 2007
  9. doi request reprint Presystemic elimination of trichloroethylene in rats following environmentally relevant oral exposures
    Y Liu
    College of Pharmacy, University of Georgia, Athens, GA 30602 2352, USA
    Drug Metab Dispos 37:1994-8. 2009
  10. ncbi request reprint Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity
    Sathanandam S Anand
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA
    Drug Metab Dispos 34:389-97. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Acute, short-term, and subchronic oral toxicity of 1,1,1-trichloroethane in rats
    J V Bruckner
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602 2352, USA
    Toxicol Sci 60:363-72. 2001
    ..Oral TRI appears to have very limited capacity to induce P450s or to cause liver injury in male S-D rats, even when administered repeatedly by gavage in near-lethal or lethal dosages under conditions intended to maximize hepatic effects...
  2. doi request reprint Influence of exposure route and oral dosage regimen on 1, 1-dichloroethylene toxicokinetics and target organ toxicity
    J V Bruckner
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy and Interdisciplinary Toxicology Program, University of Georgia, Athens, Georgia 30602 2352, USA
    J Pharmacol Exp Ther 333:519-27. 2010
    ..These findings demonstrate the TK and target organ toxicity of DCE vary substantially between different exposure routes, as well as dosage regimens, making direct extrapolations untenable in health risk assessments...
  3. ncbi request reprint The Acute Exposure Guideline Level (AEGL) program: applications of physiologically based pharmacokinetic modeling
    James V Bruckner
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602 2354, USA
    J Toxicol Environ Health A 67:621-34. 2004
    ..AEGLs for 18 chemicals have been published, and it is anticipated that 40 to 50 chemicals will be evaluated annually...
  4. ncbi request reprint Mechanisms of circadian rhythmicity of carbon tetrachloride hepatotoxicity
    James V Bruckner
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens 30602 2352, USA
    J Pharmacol Exp Ther 300:273-81. 2002
    ..These findings provide additional support for acetone's physiological role in CYP2E1 induction and for CYP2E1's role in modulating CCl(4) chronotoxicity in rats...
  5. ncbi request reprint Acute, subacute, and subchronic oral toxicity studies of 1,1-dichloroethane in rats: application to risk evaluation
    S Muralidhara
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602 2352, USA
    Toxicol Sci 64:135-45. 2001
    ..One g/kg orally (po) was found to be the acute, subacute, and subchronic LOAEL for DCE, under the conditions of this investigation. In each instance, 0.5 g/kg was the NOAEL...
  6. ncbi request reprint Rapid determination of the synthetic pyrethroid insecticide, deltamethrin, in rat plasma and tissues by HPLC
    Kyu Bong Kim
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, 30602, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 834:141-8. 2006
    ..This method can be quite useful for DLM pharmacokinetic and tissue distribution studies, for which multiple plasma and tissue samples have to be analyzed quickly with high reproducibility...
  7. ncbi request reprint Determination of deltamethrin and its metabolite 3-phenoxybenzoic acid in male rat plasma by high-performance liquid chromatography
    Yan Ding
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 810:221-7. 2004
    ..The inter-day (n = 15) precision (%R.S.D.) and accuracy (%Error) for 3-PBAcid ranged from 5.4 to 14.5% and from 5.1 to 12.8%, respectively. Finally, this method was applied to a toxicokinetic study of deltamethrin in the rat...
  8. ncbi request reprint Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats
    Kyu Bong Kim
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30605, USA
    Toxicology 234:194-202. 2007
    ..In summary, limited dissolution of the highly lipophilic DLM particles in the AL suspension severely limited DLM's GI absorption, bioavailability, target organ deposition and acute neurotoxic potency...
  9. doi request reprint Presystemic elimination of trichloroethylene in rats following environmentally relevant oral exposures
    Y Liu
    College of Pharmacy, University of Georgia, Athens, GA 30602 2352, USA
    Drug Metab Dispos 37:1994-8. 2009
    ....
  10. ncbi request reprint Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity
    Sathanandam S Anand
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA
    Drug Metab Dispos 34:389-97. 2006
    ..The present study provides evidence that the limited metabolic capacity of immature rats contributes to elevated systemic exposure and ensuing neurotoxic effects of DLM...
  11. ncbi request reprint Characterization of deltamethrin metabolism by rat plasma and liver microsomes
    Sathanandam S Anand
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA
    Toxicol Appl Pharmacol 212:156-66. 2006
    ..CYP1A2, CYP1A1, and CYP2C11 in decreasing order of importance quantitatively, metabolized deltamethrin. Intrinsic clearance by liver CYP450s (35.5) was more efficient than that by liver (12.0) or plasma carboxylesterases (2.4)...
  12. ncbi request reprint Toxicokinetics and tissue distribution of deltamethrin in adult Sprague-Dawley rats
    Kyu Bong Kim
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, Georgia 30602, USA
    Toxicol Sci 101:197-205. 2008
    ..Much remains to be learned about physiological/biochemical processes and barriers that govern the GI absorption, transport, brain deposition, and elimination of DLM and other pyrethroids in laboratory animals and humans...
  13. ncbi request reprint Tissue dosimetry expansion and cross-validation of rat and mouse physiologically based pharmacokinetic models for trichloroethylene
    Deborah A Keys
    Department of Environmental Health Science, University of Georgia, Athens 30602, USA
    Toxicol Sci 76:35-50. 2003
    ..This model expansion and validation increases both the utility and our confidence in the current use of rodent TCE PBPK models in human health risk assessment...
  14. ncbi request reprint Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat
    Jeffrey W Fisher
    University of Georgia, Interdisciplinary Toxicology Program, Athens, Georgia 30602, USA
    Toxicol Sci 90:87-95. 2006
    ..However, the dose-response characteristics of the HPT axis are nonlinear and complex, requiring sophisticated tools, such as PBPK models, to characterize dose response...
  15. ncbi request reprint Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male Sprague-Dawley rat
    Ahmad Mirfazaelian
    Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia 30602 2102, USA
    Toxicol Sci 93:432-42. 2006
    ..The current model can serve as a foundation for construction of models for other pyrethroids and can be improved as more definitive information on DLT kinetic processes becomes available...
  16. ncbi request reprint Trace level determination of trichloroethylene from liver, lung and kidney tissues by gas chromatography-magnetic sector mass spectrometry
    Stacy D Brown
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, 30602 2352, Athens, GA, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 783:319-25. 2003
    ..The % RSD and % Error for the assay falls within the acceptable range (<15% for middle and high QC points and <20% for low QC points), and the recovery is high from all tissues (>79%)...
  17. ncbi request reprint Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry
    Amy D Delinsky
    University of Georgia, College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences, Athens, GA 30602, USA
    Rapid Commun Mass Spectrom 19:1075-83. 2005
    ..Levels of DCA found in rats dosed with 2 g/kg TCE were 17.2 ng/mL (liver), 262.4 ng/mL (kidney), 175.1 ng/mL (lung), and 39.5 ng/mL (blood)...
  18. doi request reprint Determination of trichloroethylene in biological samples by headspace solid-phase microextraction gas chromatography/mass spectrometry
    Yongzhen Liu
    Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA 30602 2352, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 863:26-35. 2008
    ..Stability tests including autosampler temperature and freeze and thaw of specimens were also investigated. This validated method was successfully applied to study the toxicokinetics of TCE following administration of a low oral dose...
  19. doi request reprint Trace level determination of trichloroethylene in biological samples by headspace solid-phase microextraction gas chromatography/negative chemical ionization mass spectrometry
    Yongzhen Liu
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 2352, USA
    Rapid Commun Mass Spectrom 22:797-806. 2008
    ..This validated method was successfully applied to study the toxicokinetics of TCE following oral administration of extremely low doses of this potential human carcinogen to small test animals (rats)...
  20. ncbi request reprint Plasma binding of trichloroacetic acid in mice, rats, and humans under cancer bioassay and environmental exposure conditions
    Michael H Lumpkin
    Clayton Group Services, Inc, Athens, Goergia, USA
    Drug Metab Dispos 31:1203-7. 2003
    ..These findings suggest that the practice of using total blood levels of TCA as a dose metric in interspecies extrapolation of cancer risks needs to be re-examined...
  21. doi request reprint Optimization, validation and application of a method for the determination of trichloroethylene in rat plasma by headspace solid-phase microextraction gas chromatography mass spectrometry
    Yongzhen Liu
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 2352, USA
    Biomed Chromatogr 22:977-84. 2008
    ..996 or greater. The precision and accuracy for intra-day and inter-day were better than 8.0%. This validated method was successfully applied to study the toxicokinetic behavior of TCE following low levels of oral administration...
  22. doi request reprint Bayesian analysis of a physiologically based pharmacokinetic model for perchloroethylene in humans
    Junshan Qiu
    Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, USA
    J Toxicol Environ Health A 73:74-91. 2010
    ..The 95th percentile for the fraction PCE metabolized at a concentration of 1 ppb was estimated to be 1.89%...
  23. doi request reprint In situ derivatization/solid-phase microextraction coupled with gas chromatography/negative chemical ionization mass spectrometry for the determination of trichloroethylene metabolites in rat blood
    Yongzhen Liu
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 2352, USA
    Rapid Commun Mass Spectrom 22:1023-31. 2008
    ..This validated method was successfully applied to study the toxicokinetic behavior of TCE metabolites following a 1 mg/kg oral dose of TCE...
  24. ncbi request reprint A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid
    Amy D Delinsky
    University of Georgia, College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences, Athens, GA 30602, USA
    Biomed Chromatogr 19:617-39. 2005
    ..Additional aspects of analytical methods such as method validation, species preservation and future directions in the analysis of TCE and its metabolites are also discussed...
  25. ncbi request reprint Organ growth functions in maturing male Sprague-Dawley rats
    Ahmad Mirfazaelian
    Department of Pharmaceutics, School of Pharmacy, University of Tehran, Tehran, Iran
    J Toxicol Environ Health A 70:429-38. 2007
    ..The GMM-based organ growth and %BW fraction profiles were in general agreement with our empirical data as well as previous studies. The GMM model gave adequately precise weight predictions at all ages for all the tissues/organs examined...