Research Topics
| Jeffrey D BrowningSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general populationLidia S Szczepaniak
DW Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
Am J Physiol Endocrinol Metab 288:E462-8. 2005..6%. Thus MRS provides a sensitive, quantitative, noninvasive method to measure HTGC and, when applied to a large urban US population, revealed a strikingly high prevalence of hepatic steatosis...
Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restrictionJeffrey D Browning
Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, TX, USA
Hepatology 48:1487-96. 2008..This modification is associated with a reorganization of hepatic energy metabolism suggestive of enhanced hepatic beta-oxidation...
Use of (2)H(2)O for estimating rates of gluconeogenesis: determination and correction of error due to transaldolase exchangeJeffrey D Browning
The Advanced Imaging Research Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Am J Physiol Endocrinol Metab 303:E1304-12. 2012....- The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and menJeffrey D Browning
Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
J Lipid Res 53:577-86. 2012..This sexual dimorphism was related to differential fasting plasma FA concentrations but not to whole body or hepatic utilization of this substrate... - New imaging techniques for non-alcoholic steatohepatitisJeffrey D Browning
Department of Internal Medicine and Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8568, USA
Clin Liver Dis 13:607-19. 2009..The purpose of this article is to review the strengths and weakness of current clinical and experimental imaging modalities for noninvasive detection of NAFLD, with an emphasis on NASH... - Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humansJeffrey D Browning
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
J Lipid Res 51:3359-63. 2010..Inasmuch as cholesterol synthesis and PCSK9 are both regulated by SREBP-2, these results suggest that plasma PCSK9 levels may serve as a surrogate marker of hepatic SREBP-2 activity in humans... - Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restrictionJeffrey D Browning
Departments of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Am J Clin Nutr 93:1048-52. 2011..This is due, in part, to increased hepatic synthesis of fat from carbohydrates via lipogenesis. Although weight loss is currently recommended to treat NAFLD, little attention has been given to dietary carbohydrate restriction... - A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride contentJeffrey D Browning
Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9085, USA
Hepatology 44:487-8. 2006 - Statins and hepatic steatosis: perspectives from the Dallas Heart StudyJeffrey D Browning
Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine and Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9085, USA
Hepatology 44:466-71. 2006..Individuals meeting criteria for statin therapy are likely to have coexistent hepatic steatosis... - Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liverSanthosh Satapati
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
J Lipid Res 53:1080-92. 2012.... - Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolismSanthosh Satapati
The Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Diabetes 57:2012-21. 2008..The purpose of this study is to determine whether abnormal mitochondrial metabolism plays a role in the dysregulation of both hepatic fat and glucose metabolism during diabetes... - Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver diseaseNishanth E Sunny
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell Metab 14:804-10. 2011..These data indicate that mitochondrial oxidative metabolism is ~2-fold greater in those with NAFLD, providing a potential link between IHTG content, oxidative stress, and liver damage... - Ethnic differences in hepatic steatosis: an insulin resistance paradox?Richard Guerrero
Department of Internal Medicine, Dallas, TX, USA
Hepatology 49:791-801. 2009.... - Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicityJeffrey D Browning
Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9046, USA
Hepatology 40:1387-95. 2004..In conclusion, the significant ethnic and sex differences in the prevalence of hepatic steatosis documented in this study may have a profound impact on susceptibility to steatosis-related liver disease... - Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liverShawn C Burgess
The Advanced Imaging Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
Cell Metab 5:313-20. 2007..However, PEPCK flux correlated tightly with TCA cycle activity, suggesting that under some conditions in mice, PEPCK expression must coordinate with hepatic energy metabolism to control gluconeogenesis... - Progressive adaptation of hepatic ketogenesis in mice fed a high-fat dietNishanth E Sunny
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
Am J Physiol Endocrinol Metab 298:E1226-35. 2010..We conclude that mitochondrial fat oxidation is stimulated rather than impaired during the initiation of hepatic insulin resistance in mice... - Molecular mediators of hepatic steatosis and liver injuryJeffrey D Browning
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390-9046, USA
J Clin Invest 114:147-52. 2004..Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis... - Adiponectin as an independent predictor of the presence and degree of hepatic steatosis in the Dallas Heart StudyAslan T Turer
University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8521, USA
J Clin Endocrinol Metab 97:E982-6. 2012..OBJECTIVES AND MAIN OUTCOME MEASURES: The objective of this study was to establish whether an independent relationship exists between serum adiponectin concentrations and liver fat... - Ethnic differences in the prevalence of cryptogenic cirrhosisJeffrey D Browning
Department of Internal Medicine, Division of Digestive and Liver Diseases, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9151, USA
Am J Gastroenterol 99:292-8. 2004..However, the current findings also indicate that this form of cirrhosis is unexpectedly rare among African Americans... - T2 measurement of J-coupled metabolites in the human brain at 3TSandeep K Ganji
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
NMR Biomed 25:523-9. 2012..T(2)(†)s of glutamate and myo-inositol were measured as 181 ± 16 and 197 ± 14 ms (mean ± SD, N = 5) for medial occipital cortices, and 180 ± 12 and 196 ± 17 ms for left occipital cortices, respectively... - A case of diarrhea, ataxia, and capsule endoscope retentionRichard Guerrero
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Dig Dis Sci 52:3174-7. 2007 - Complicating factors in the application of the "average method" for determining the contribution of gluconeogenesisShawn C Burgess
J Appl Physiol 104:1852-3; author reply 1854-5. 2008
Research Grants
- Non-Alcoholic Fatty Liver Disease Ethnicity and Hepatic MetabolismJeffrey Browning; Fiscal Year: 2007..e., obesity, diabetes, metabolic syndrome). Therefore, a second objective of this research will be to define ethnic differences in hepatic metabolism and relate these differences to the risk of developing hepatic steatosis. ..