Jeffrey D Browning

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    Lidia S Szczepaniak
    DW Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
    Am J Physiol Endocrinol Metab 288:E462-8. 2005
  2. pmc Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction
    Jeffrey D Browning
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, TX, USA
    Hepatology 48:1487-96. 2008
  3. pmc Use of (2)H(2)O for estimating rates of gluconeogenesis: determination and correction of error due to transaldolase exchange
    Jeffrey D Browning
    The Advanced Imaging Research Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Am J Physiol Endocrinol Metab 303:E1304-12. 2012
  4. pmc The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men
    Jeffrey D Browning
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Lipid Res 53:577-86. 2012
  5. doi request reprint New imaging techniques for non-alcoholic steatohepatitis
    Jeffrey D Browning
    Department of Internal Medicine and Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8568, USA
    Clin Liver Dis 13:607-19. 2009
  6. pmc Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans
    Jeffrey D Browning
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Lipid Res 51:3359-63. 2010
  7. pmc Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction
    Jeffrey D Browning
    Departments of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Am J Clin Nutr 93:1048-52. 2011
  8. ncbi request reprint A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content
    Jeffrey D Browning
    Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9085, USA
    Hepatology 44:487-8. 2006
  9. ncbi request reprint Statins and hepatic steatosis: perspectives from the Dallas Heart Study
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine and Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9085, USA
    Hepatology 44:466-71. 2006
  10. pmc Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
    Santhosh Satapati
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Lipid Res 53:1080-92. 2012

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    Lidia S Szczepaniak
    DW Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
    Am J Physiol Endocrinol Metab 288:E462-8. 2005
    ..6%. Thus MRS provides a sensitive, quantitative, noninvasive method to measure HTGC and, when applied to a large urban US population, revealed a strikingly high prevalence of hepatic steatosis...
  2. pmc Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction
    Jeffrey D Browning
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, TX, USA
    Hepatology 48:1487-96. 2008
    ..However, the relationship between these two pathways is modified by carbohydrate restriction, suggesting an increased reliance of the hepatocyte on energy generated outside of the TCA cycle when GNG(PEP) is maximal...
  3. pmc Use of (2)H(2)O for estimating rates of gluconeogenesis: determination and correction of error due to transaldolase exchange
    Jeffrey D Browning
    The Advanced Imaging Research Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Am J Physiol Endocrinol Metab 303:E1304-12. 2012
    ....
  4. pmc The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men
    Jeffrey D Browning
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Lipid Res 53:577-86. 2012
    ..This sexual dimorphism was related to differential fasting plasma FA concentrations but not to whole body or hepatic utilization of this substrate...
  5. doi request reprint New imaging techniques for non-alcoholic steatohepatitis
    Jeffrey D Browning
    Department of Internal Medicine and Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8568, USA
    Clin Liver Dis 13:607-19. 2009
    ..The purpose of this article is to review the strengths and weakness of current clinical and experimental imaging modalities for noninvasive detection of NAFLD, with an emphasis on NASH...
  6. pmc Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans
    Jeffrey D Browning
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Lipid Res 51:3359-63. 2010
    ..Inasmuch as cholesterol synthesis and PCSK9 are both regulated by SREBP-2, these results suggest that plasma PCSK9 levels may serve as a surrogate marker of hepatic SREBP-2 activity in humans...
  7. pmc Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction
    Jeffrey D Browning
    Departments of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Am J Clin Nutr 93:1048-52. 2011
    ..This is due, in part, to increased hepatic synthesis of fat from carbohydrates via lipogenesis. Although weight loss is currently recommended to treat NAFLD, little attention has been given to dietary carbohydrate restriction...
  8. ncbi request reprint A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content
    Jeffrey D Browning
    Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9085, USA
    Hepatology 44:487-8. 2006
  9. ncbi request reprint Statins and hepatic steatosis: perspectives from the Dallas Heart Study
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine and Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9085, USA
    Hepatology 44:466-71. 2006
    ..Individuals meeting criteria for statin therapy are likely to have coexistent hepatic steatosis...
  10. pmc Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
    Santhosh Satapati
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Lipid Res 53:1080-92. 2012
    ....
  11. pmc Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism
    Santhosh Satapati
    The Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diabetes 57:2012-21. 2008
    ..The purpose of this study is to determine whether abnormal mitochondrial metabolism plays a role in the dysregulation of both hepatic fat and glucose metabolism during diabetes...
  12. pmc Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
    Nishanth E Sunny
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 14:804-10. 2011
    ..These data indicate that mitochondrial oxidative metabolism is ~2-fold greater in those with NAFLD, providing a potential link between IHTG content, oxidative stress, and liver damage...
  13. pmc Ethnic differences in hepatic steatosis: an insulin resistance paradox?
    Richard Guerrero
    Department of Internal Medicine, Dallas, TX, USA
    Hepatology 49:791-801. 2009
    ....
  14. ncbi request reprint Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    Hepatology 40:1387-95. 2004
    ..In conclusion, the significant ethnic and sex differences in the prevalence of hepatic steatosis documented in this study may have a profound impact on susceptibility to steatosis-related liver disease...
  15. pmc Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
    Shawn C Burgess
    The Advanced Imaging Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9085, USA
    Cell Metab 5:313-20. 2007
    ..However, PEPCK flux correlated tightly with TCA cycle activity, suggesting that under some conditions in mice, PEPCK expression must coordinate with hepatic energy metabolism to control gluconeogenesis...
  16. pmc Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet
    Nishanth E Sunny
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8568, USA
    Am J Physiol Endocrinol Metab 298:E1226-35. 2010
    ..We conclude that mitochondrial fat oxidation is stimulated rather than impaired during the initiation of hepatic insulin resistance in mice...
  17. pmc Molecular mediators of hepatic steatosis and liver injury
    Jeffrey D Browning
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390 9046, USA
    J Clin Invest 114:147-52. 2004
    ..Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis...
  18. doi request reprint Adiponectin as an independent predictor of the presence and degree of hepatic steatosis in the Dallas Heart Study
    Aslan T Turer
    University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8521, USA
    J Clin Endocrinol Metab 97:E982-6. 2012
    ..OBJECTIVES AND MAIN OUTCOME MEASURES: The objective of this study was to establish whether an independent relationship exists between serum adiponectin concentrations and liver fat...
  19. ncbi request reprint Ethnic differences in the prevalence of cryptogenic cirrhosis
    Jeffrey D Browning
    Department of Internal Medicine, Division of Digestive and Liver Diseases, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9151, USA
    Am J Gastroenterol 99:292-8. 2004
    ..S. ethnic groups. This study was performed to assess the demographic characteristics of patients with CC at a U.S. county hospital with a racially and ethnically diverse patient population...
  20. doi request reprint T2 measurement of J-coupled metabolites in the human brain at 3T
    Sandeep K Ganji
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    NMR Biomed 25:523-9. 2012
    ..T(2)(†)s of glutamate and myo-inositol were measured as 181 ± 16 and 197 ± 14 ms (mean ± SD, N = 5) for medial occipital cortices, and 180 ± 12 and 196 ± 17 ms for left occipital cortices, respectively...
  21. ncbi request reprint A case of diarrhea, ataxia, and capsule endoscope retention
    Richard Guerrero
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Dig Dis Sci 52:3174-7. 2007
  22. pmc Complicating factors in the application of the "average method" for determining the contribution of gluconeogenesis
    Shawn C Burgess
    J Appl Physiol 104:1852-3; author reply 1854-5. 2008

Research Grants2

  1. Non-Alcoholic Fatty Liver Disease Ethnicity and Hepatic Metabolism
    Jeffrey Browning; Fiscal Year: 2007
    ..e., obesity, diabetes, metabolic syndrome). Therefore, a second objective of this research will be to define ethnic differences in hepatic metabolism and relate these differences to the risk of developing hepatic steatosis. ..