A M Brownawell

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Calcium-dependent binding of the plasma protein apolipoprotein A-I to two members of the annexin family
    A M Brownawell
    Department of Pharmacology, University of Virginia, Charlottesville 22908, USA
    Biochemistry 35:6839-45. 1996
  2. ncbi Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)
    A M Brownawell
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 272:22182-90. 1997
  3. pmc Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX
    A M Brownawell
    Center for Cell Signaling, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 21:3534-46. 2001
  4. pmc Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins
    Amy M Brownawell
    Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 156:53-64. 2002
  5. ncbi The brain-specific double-stranded RNA-binding protein Staufen2: nucleolar accumulation and isoform-specific exportin-5-dependent export
    Paolo Macchi
    Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    J Biol Chem 279:31440-4. 2004
  6. ncbi Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3
    Carole Gwizdek
    Institut Jacques Monod, Unite Mixte de Recherche 7592, CNRS, Universités Paris VI et VII, 2 place Jussieu, Tour 43, Paris 75251 Cedex 05, France
    J Biol Chem 279:884-91. 2004
  7. ncbi A novel nuclear export signal in Smad1 is essential for its signaling activity
    Zhan Xiao
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Biol Chem 278:34245-52. 2003
  8. ncbi Exportin-5 mediates nuclear export of minihelix-containing RNAs
    Carole Gwizdek
    Institut Jacques Monod, Unite Mixte de Recherche 7592, CNRS, Universités Paris VI et VII, 2 place Jussieu, Tour 43, 75251 Paris Cedex 05, France
    J Biol Chem 278:5505-8. 2003
  9. ncbi The use of permeabilized cell systems to study nuclear transport
    Amy M Brownawell
    Department of Pharmacology, Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA
    Methods Mol Biol 189:209-29. 2002
  10. ncbi Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor
    Michael E Nemergut
    Department of Microbiology, The Center for Cell Signaling, The University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:17385-8. 2002

Collaborators

  • Ian G Macara
  • CARL CREUTZ
  • Edouard Bertrand
  • Carole Gwizdek
  • Ting Chen
  • Paolo Macchi
  • Batool Ossareh-Nazari
  • Catherine Dargemont
  • Zhan Xiao
  • Michael E Nemergut
  • Barbara Grunewald
  • Luc DesGroseillers
  • Stefan Evers
  • Michael A Kiebler
  • Harvey F Lodish
  • Alain Doglio
  • Mark E Lindsay

Detail Information

Publications11

  1. ncbi Calcium-dependent binding of the plasma protein apolipoprotein A-I to two members of the annexin family
    A M Brownawell
    Department of Pharmacology, University of Virginia, Charlottesville 22908, USA
    Biochemistry 35:6839-45. 1996
    ..Other annexins, such as annexin IV and annexin VI, do not exhibit this binding. The results suggest that certain annexins may function as extracellular binding sites for plasma proteins...
  2. ncbi Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)
    A M Brownawell
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 272:22182-90. 1997
    ..Therefore, the interaction between sorcin and synexin may serve to regulate the functions of these proteins on membrane surfaces in a Ca2+-dependent manner...
  3. pmc Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX
    A M Brownawell
    Center for Cell Signaling, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 21:3534-46. 2001
    ....
  4. pmc Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins
    Amy M Brownawell
    Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 156:53-64. 2002
    ..We propose that exportin-5 is not an RNA export factor but instead participates in the regulated translocation of dsRBD proteins to the cytoplasm where they interact with target mRNAs...
  5. ncbi The brain-specific double-stranded RNA-binding protein Staufen2: nucleolar accumulation and isoform-specific exportin-5-dependent export
    Paolo Macchi
    Max Planck Institute for Developmental Biology, D 72076 Tubingen, Germany
    J Biol Chem 279:31440-4. 2004
    ..It is tempting to speculate that Stau2(62) binds RNA in the nucleus and assembles into ribonucleoparticles, which are then exported via the Exportin-5 pathway to their final destination...
  6. ncbi Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3
    Carole Gwizdek
    Institut Jacques Monod, Unite Mixte de Recherche 7592, CNRS, Universités Paris VI et VII, 2 place Jussieu, Tour 43, Paris 75251 Cedex 05, France
    J Biol Chem 279:884-91. 2004
    ..Exportin-5 thus appears as the first example of a nuclear export receptor that mediates RNA export but also promotes transport of proteinaceous cargo through appropriate and specific RNA adaptors...
  7. ncbi A novel nuclear export signal in Smad1 is essential for its signaling activity
    Zhan Xiao
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Biol Chem 278:34245-52. 2003
    ..Although conserved in other R-Smads such as Smad3, NES2 is not functional in these R-Smads because CRM1 overexpression fails to target them to cytoplasm. Possible reasons for this discrepancy are discussed...
  8. ncbi Exportin-5 mediates nuclear export of minihelix-containing RNAs
    Carole Gwizdek
    Institut Jacques Monod, Unite Mixte de Recherche 7592, CNRS, Universités Paris VI et VII, 2 place Jussieu, Tour 43, 75251 Paris Cedex 05, France
    J Biol Chem 278:5505-8. 2003
    ....
  9. ncbi The use of permeabilized cell systems to study nuclear transport
    Amy M Brownawell
    Department of Pharmacology, Center for Cell Signaling, University of Virginia, Charlottesville, VA, USA
    Methods Mol Biol 189:209-29. 2002
  10. ncbi Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor
    Michael E Nemergut
    Department of Microbiology, The Center for Cell Signaling, The University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:17385-8. 2002
    ..By tethering Crm1 to catalytically enhanced RCC1, RanBP3 may lower the entropic barrier for the loading of Ran.GTP onto Crm1. We propose that this provides an additional mechanism by which RanBP3 facilitates export...
  11. pmc Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5
    Ting Chen
    Center for Cell Signaling, Department of Microbiology, Health Sciences Center, University of Virginia School of Medicine, Charlottesville, VA 22908 0577, USA
    Mol Cell Biol 24:6608-19. 2004
    ..Together, these data suggest that JAZ is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism...