THOMAS DUDLEY BROWN

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Loading paradigms--intentional and unintentional--for cell culture mechanostimulus
    T D Brown
    Department of Orthopaedic Surgery, University of Iowa, Iowa City 52242, USA
    Am J Med Sci 316:162-8. 1998
  2. ncbi request reprint Techniques for mechanical stimulation of cells in vitro: a review
    T D Brown
    Department of Orthopaedic Surgery, University of Iowa, Iowa City 52242, USA
    J Biomech 33:3-14. 2000
  3. ncbi request reprint Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease
    Thomas D Brown
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    J Orthop Trauma 20:739-44. 2006
  4. pmc 2009 Nicolas Andry Award: clinical biomechanics of third body acceleration of total hip wear
    Thomas D Brown
    Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242, USA
    Clin Orthop Relat Res 467:1885-97. 2009
  5. ncbi request reprint Toward better interaction between orthopaedists and researchers: a two-way street
    Thomas D Brown
    Department of Orthopaedic Surgery, Biomechanics Laboratory, University of Iowa, Iowa City, IA 52242, USA
    J Bone Joint Surg Am 84:1473-7. 2002
  6. ncbi request reprint Local head roughening as a factor contributing to variability of total hip wear: a finite element analysis
    Thomas D Brown
    Biomechanics Laboratory, Department of Orthopaedic Surgery, 2181 Westlawn, University of Iowa, Iowa City, IA 52242, USA
    J Biomech Eng 124:691-8. 2002
  7. ncbi request reprint Association of third body embedment with rim damage in retrieved acetabular liners
    Hannah J Lundberg
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    Clin Orthop Relat Res 465:133-9. 2007
  8. ncbi request reprint Problematic sites of third body embedment in polyethylene for total hip wear acceleration
    Hannah J Lundberg
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    J Biomech 39:1208-16. 2006
  9. ncbi request reprint What design factors influence wear behavior at the bearing surfaces in total joint replacements?
    Thomas D Brown
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USA
    J Am Acad Orthop Surg 16:S101-6. 2008
  10. ncbi request reprint Design factors influencing performance of constrained acetabular liners: finite element characterization
    Suzanne M Bouchard
    Orthopaedic Biomechanics Laboratory, Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn Bldg, Iowa City, IA 52242 1100, USA
    J Biomech 39:885-93. 2006

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Loading paradigms--intentional and unintentional--for cell culture mechanostimulus
    T D Brown
    Department of Orthopaedic Surgery, University of Iowa, Iowa City 52242, USA
    Am J Med Sci 316:162-8. 1998
    ..Temporal and spatial distributions of reactive normal and shear stresses are reported for typical duty cycles in these respective instruments...
  2. ncbi request reprint Techniques for mechanical stimulation of cells in vitro: a review
    T D Brown
    Department of Orthopaedic Surgery, University of Iowa, Iowa City 52242, USA
    J Biomech 33:3-14. 2000
    ....
  3. ncbi request reprint Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease
    Thomas D Brown
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    J Orthop Trauma 20:739-44. 2006
    ..The corresponding aggregate financial burden specifically of posttraumatic OA is Dollars 3.06 billion annually, or approximately 0.15% of the total U.S. health care direct cost outlay...
  4. pmc 2009 Nicolas Andry Award: clinical biomechanics of third body acceleration of total hip wear
    Thomas D Brown
    Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242, USA
    Clin Orthop Relat Res 467:1885-97. 2009
    ..Finally, a mechanism for third-body debris access to wear-critical locations on the bearing surface is identified analytically and corroborated in laboratory experiments and implant retrievals...
  5. ncbi request reprint Toward better interaction between orthopaedists and researchers: a two-way street
    Thomas D Brown
    Department of Orthopaedic Surgery, Biomechanics Laboratory, University of Iowa, Iowa City, IA 52242, USA
    J Bone Joint Surg Am 84:1473-7. 2002
  6. ncbi request reprint Local head roughening as a factor contributing to variability of total hip wear: a finite element analysis
    Thomas D Brown
    Biomechanics Laboratory, Department of Orthopaedic Surgery, 2181 Westlawn, University of Iowa, Iowa City, IA 52242, USA
    J Biomech Eng 124:691-8. 2002
    ....
  7. ncbi request reprint Association of third body embedment with rim damage in retrieved acetabular liners
    Hannah J Lundberg
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    Clin Orthop Relat Res 465:133-9. 2007
    ....
  8. ncbi request reprint Problematic sites of third body embedment in polyethylene for total hip wear acceleration
    Hannah J Lundberg
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    J Biomech 39:1208-16. 2006
    ..The data also showed that the supero-lateral aspect of the acetabular cup is consistently and by far the most problematic area for third body particle embedment...
  9. ncbi request reprint What design factors influence wear behavior at the bearing surfaces in total joint replacements?
    Thomas D Brown
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USA
    J Am Acad Orthop Surg 16:S101-6. 2008
    ..However, untoward complexities occurring in vivo, such as impingement or third-body challenge, can appreciably compromise wear performance even for implants that are well-designed in terms of bearing surface stress minimization...
  10. ncbi request reprint Design factors influencing performance of constrained acetabular liners: finite element characterization
    Suzanne M Bouchard
    Orthopaedic Biomechanics Laboratory, Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn Bldg, Iowa City, IA 52242 1100, USA
    J Biomech 39:885-93. 2006
    ..9 to 13.6 mm increased assembly force by 506 N and increased the dislocation moment by over 3.5 N-m, whereas the influence of other design parameters was much more modest...
  11. pmc Effects of implant design parameters on fluid convection, potentiating third-body debris ingress into the bearing surface during THA impingement/subluxation
    Hannah J Lundberg
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    J Biomech 40:1676-85. 2007
    ..Increased inset of the femoral head into the acetabular cup resulted both in higher fluid velocity and in transport of third-body debris further into the bearing space...
  12. pmc Cross-shear implementation in sliding-distance-coupled finite element analysis of wear in metal-on-polyethylene total joint arthroplasty: intervertebral total disc replacement as an illustrative application
    Curtis M Goreham-Voss
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    J Biomech 43:1674-81. 2010
    ..Going forward, this formulation permits systematically accounting for cross-shear effects in parametric computational wear studies of metal-on-polyethylene joint replacements, heretofore a substantial limitation of such analyses...
  13. ncbi request reprint How have wear testing and joint simulator studies helped to discriminate among materials and designs?
    Harry A McKellop
    Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital, Los Angeles, CA, USA
    J Am Acad Orthop Surg 16:S111-9. 2008
    ....
  14. ncbi request reprint Effects of acetabular component orientation on dislocation propensity for small-head-size total hip arthroplasty
    Mark E Nadzadi
    Department of Orthopaedic Surgery, Orthopaedic Biomechanics Laboratory, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242, USA
    Clin Biomech (Bristol, Avon) 17:32-40. 2002
    ..Examine the role of surgical orientation of the acetabular cup on posterior dislocation propensity for small-head-size total hip arthroplasty...
  15. ncbi request reprint Kinematics, kinetics, and finite element analysis of commonplace maneuvers at risk for total hip dislocation
    Mark E Nadzadi
    Orthopaedic Biomechanics Laboratory, Department of Orthopaedic Surgery, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242, USA
    J Biomech 36:577-91. 2003
    ..These new motion data hopefully will help facilitate systematic efforts to reduce the incidence of dislocation...
  16. ncbi request reprint Kinematic and contact stress analysis of posterior malleolus fractures of the ankle
    Daniel C Fitzpatrick
    Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    J Orthop Trauma 18:271-8. 2004
    ..To determine if there are measurable dynamic contact stress aberrations and kinematic abnormalities (instability) that have not been observed in conventional static loading studies of posterior malleolar ankle fractures...
  17. pmc Compliance-dependent load allocation between sensing versus non-sensing portions of a sheet-array contact stress sensor
    Jordan M Hartmann
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, Iowa 52242, USA
    Iowa Orthop J 29:43-7. 2009
    ....
  18. pmc Sliding direction dependence of polyethylene wear for metal counterface traverse of severe scratches
    Liam P Glennon
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    J Biomech Eng 130:051006. 2008
    ..However, the predominant manifestation of this wear volume was in the form of particles far beyond the most osteolytically potent size range...
  19. ncbi request reprint Interfragmentary surface area as an index of comminution energy: proof of concept in a bone fracture surrogate
    Christina L Beardsley
    Department of Biomedical Engineering, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242, USA
    J Biomech 35:331-8. 2002
    ..1 x 10(10)J/m(3) (or 12.5-80.2J/specimen). The results of this study provide confirmation that comminution severity can indeed be measured on a continuous scale, based on energy absorption (another clinically meaningful index)...
  20. pmc Field variable associations with scratch orientation dependence of UHMWPE wear: a finite element analysis
    Matthew C Paul
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    J Biomech Eng 130:061019. 2008
    ..Such stress/strain metrics could be useful in global computational models of wear acceleration, as surrogates to incorporate anisotropy of local metal surface roughening...
  21. pmc Implementation of discrete element analysis for subject-specific, population-wide investigations of habitual contact stress exposure
    Donald D Anderson
    Orthopaedic Biomechanics Laboratory, Department of Orthopaedics and Rehabilitation, as well as the Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA
    J Appl Biomech 26:215-23. 2010
    ..g., a meniscus). This article describes an implementation of DEA that makes it feasible to perform subject-specific modeling in articular joints in large population-based studies...
  22. pmc Stability differentials for proximal vs distal fusion of total hip arthroplasty femoral impaction grafts
    Anneliese D Heiner
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, Iowa 52242, USA
    J Arthroplasty 23:921-6. 2008
    ..This proximal graft fusion also resulted in a stem stability that was similar to that of fusing the entire graft. These results emphasize the importance of proximal fixation of an impaction-grafted femoral stem...
  23. pmc Patient-specific finite element analysis of chronic contact stress exposure after intraarticular fracture of the tibial plafond
    Wendy Li
    Department of Biomedical Engineering, The University of Iowa, 2181 Westlawn Building, Iowa City, Iowa 52242, USA
    J Orthop Res 26:1039-45. 2008
    ..The patient-specific FE models represent substantial progress toward elucidating the relationship between altered contact stresses and the outcome of patients treated for intraarticular fractures...
  24. pmc Cemented total hip replacement cable debris and acetabular construct durability
    Aaron J Altenburg
    University of Iowa, Iowa City, and Des Moines Orthopaedic Surgeons, West Des Moines, Iowa 52242, USA
    J Bone Joint Surg Am 91:1664-70. 2009
    ....
  25. pmc Effects of episodic subluxation events on third body ingress and embedment in the THA bearing surface
    Anneliese D Heiner
    Department of Orthopaedics and Rehabilitation, Biomechanics Laboratory, University of Iowa, 2181 Westlawn, Iowa City, IA 52242, USA
    J Biomech 41:2090-6. 2008
    ..Since both third body particles and subluxation frequently occur in contemporary total hip arthroplasty, their potent synergy needs to be factored prominently into strategies to minimize wear...
  26. pmc Instability-associated changes in contact stress and contact stress rates near a step-off incongruity
    Todd O McKinley
    Department of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Bone Joint Surg Am 90:375-83. 2008
    ..It was hypothesized that joint instability, superimposed on articular incongruity, would cause significant increases in contact stresses and contact stress rates...
  27. pmc Quantifying tibial plafond fracture severity: absorbed energy and fragment displacement agree with clinical rank ordering
    Donald D Anderson
    Department of Orthopaedics and Rehabilitation, The University of Iowa, 2181 Westlawn Building, Iowa City, Iowa 52242, USA
    J Orthop Res 26:1046-52. 2008
    ....
  28. pmc Correlation of dynamic cartilage contact stress aberrations with severity of instability in ankle incongruity
    Yuki Tochigi
    Department of Orthopedics and Rehabilitation, University of Iowa, 2181 Westlawn, Iowa City, IA 52242 1100, USA
    J Orthop Res 26:1186-93. 2008
    ..Given this linear relationship, even small instability events presumably involve appreciable abnormality in dynamic joint contact mechanics...
  29. pmc A method for the estimation of normative bone surface area to aid in objective CT-based fracture severity assessment
    Thaddeus P Thomas
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    Iowa Orthop J 28:9-13. 2008
    ..90 concordance with the original analysis. The results from this study suggest that normative bone surface area can be incorporated into the novel CT-based objective fracture severity assessment technique...
  30. pmc Baseline articular contact stress levels predict incident symptomatic knee osteoarthritis development in the MOST cohort
    Neil A Segal
    Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, Iowa, USA
    J Orthop Res 27:1562-8. 2009
    ..The presence of differences in estimated contact stress 15 months prior to incidence suggests a biomechanical mechanism for symptomatic tibiofemoral OA and supports the ability to identify risk by subject-specific biomechanical modeling...
  31. pmc Distribution and progression of chondrocyte damage in a whole-organ model of human ankle intra-articular fracture
    Yuki Tochigi
    Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, 52242, USA
    J Bone Joint Surg Am 93:533-9. 2011
    ..In this study, the distribution and progression of fracture-associated cell-level cartilage damage were assessed using a novel whole-organ model of human ankle intra-articular fracture...
  32. pmc Implementing capsule representation in a total hip dislocation finite element model
    Kristofer J Stewart
    Departments of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory, University of Iowa, IA 52242, USA
    Iowa Orthop J 24:1-8. 2004
    ..This model is intended to help put implant design and surgical technique decisions on a firmer scientific basis, in terms of reducing the likelihood of dislocation...
  33. pmc Effect of implantation accuracy on ankle contact mechanics with a metallic focal resurfacing implant
    Donald D Anderson
    Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA 52242 1100, USA
    J Bone Joint Surg Am 92:1490-500. 2010
    ..Focal resurfacing with a metallic implant has shown promise in other joints. We studied the effect of implantation accuracy on ankle contact mechanics after focal resurfacing of a defect in the talar dome...
  34. pmc Traveling-load calibration of grid-array transient contact stress sensors
    Lu Kang
    Biomechanics Laboratory, Departments of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242 1100, USA
    J Biomech 43:2237-40. 2010
    ..Sensel-specific calibration curves are rapidly and easily generated using this new approach and compare favorably to those obtained with less expeditious conventional platen-based protocols...
  35. doi request reprint Day-to-day variability of median nerve location within the carpal tunnel
    Jessica E Goetz
    Department of Orthopaedics and Rehabilitation, Orthopedic Biomechanics Lab, University of Iowa, Iowa City, IA 52242, USA
    Clin Biomech (Bristol, Avon) 25:660-5. 2010
    ..Magnetic resonance imaging (MRI)-based investigations have documented typical locations of the median nerve within the carpal tunnel; however, it is unclear whether those locations are consistent within an individual on different days...
  36. pmc Objective CT-based metrics of articular fracture severity to assess risk for posttraumatic osteoarthritis
    Thaddeus P Thomas
    Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA, USA
    J Orthop Trauma 24:764-9. 2010
    ..It was hypothesized that an injury severity metric that included objective measures of articular disruption, of fracture energy, and of fragment displacement/dispersal would be a useful predictor of PTOA...
  37. pmc Is elevated contact stress predictive of post-traumatic osteoarthritis for imprecisely reduced tibial plafond fractures?
    Donald D Anderson
    Department of Orthopaedics and Rehabilitation, The University of Iowa, 2181 Westlawn Building, Iowa City, Iowa 52242, USA
    J Orthop Res 29:33-9. 2011
    ..These findings, albeit in a small population, support the existence of a contact stress exposure threshold above which incongruously reduced tibial plafond fractures are highly likely to develop PTOA...
  38. pmc Tensile engagement of the peri-ankle ligaments in stance phase
    Yuki Tochigi
    Orthopaedic Biomechanics Laboratory, Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn, Iowa City, IA 52242 1100, USA
    Foot Ankle Int 26:1067-73. 2005
    ..The contribution of the peri-ankle ligaments to ankle motion control is not yet well understood. Knowledge of the tensile engagement of the peri-ankle ligaments during stance phase is necessary to achieve physiologic motion patterns...
  39. ncbi request reprint Cartilage thickness in cadaveric ankles: measurement with double-contrast multi-detector row CT arthrography versus MR imaging
    Georges Y El-Khoury
    Departments of Radiology and Orthopaedics and Rehabilitation, University of Iowa, Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Radiology 233:768-73. 2004
    ....
  40. ncbi request reprint A laboratory simulation for morselized bone graft fusion: apparent modulus under operatively based femoral impaction kinetics
    Anneliese D Heiner
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    J Biomech 38:811-8. 2005
    ....
  41. ncbi request reprint Contact stress transients during functional loading of ankle stepoff incongruities
    Todd O McKinley
    Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, 01021 JPP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Biomech 39:617-26. 2006
    ..Measuring contact stresses and contact stress gradients during motion allowed potential incongruity-associated pathologic changes in loading that occur over the complete motion cycle to be investigated...
  42. pmc Clinical biomechanics of wear in total hip arthroplasty
    John J Callaghan
    Department of Orthopaedic Surgery, University of Iowa College of Medicine, Iowa City 52242, USA
    Iowa Orthop J 23:1-12. 2003
    ....
  43. pmc Intra-articular contact stress distributions at the ankle throughout stance phase-patient-specific finite element analysis as a metric of degeneration propensity
    Donald D Anderson
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    Biomech Model Mechanobiol 5:82-9. 2006
    ....
  44. ncbi request reprint A biomechanical analysis of polyethylene liner cementation into a fixed metal acetabular shell
    Geoffrey F Haft
    Department of Biomedical Engineering, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242, USA
    J Bone Joint Surg Am 85:1100-10. 2003
    ..One treatment option is to cement a new liner into the fixed shell. The purpose of this study was to evaluate technical variables to improve the mechanical strength of such cemented liner constructs...
  45. pmc Clinical tip: development of an ankle distraction device compatible with MRI and radiography
    Thomas E Baer
    University of Iowa, Orthopaedics and Rehabilitation, Iowa City, 52242, USA
    Foot Ankle Int 27:472-4. 2006
  46. ncbi request reprint The role of the interosseous talocalcaneal ligament in subtalar joint stability
    Yuki Tochigi
    Department of Orthopaedics and Rehabilitation, University of Iowa, USA
    Foot Ankle Int 25:588-96. 2004
    ..Clinical effects of ITCL failure remain unclear because of insufficient understanding of the role of the ligament...
  47. pmc Stability of fused versus nonfused THA femoral impaction grafts
    Anneliese D Heiner
    University of Iowa, Department of Orthopaedics and Rehabilitation, Biomechanics Laboratory, 2181 Westlawn Building, Iowa City, Iowa 52242, USA
    J Orthop Res 25:351-60. 2007
    ..These results indicate that most of the opportunity to reduce femoral stem micromotion and migration lies proximal, and that steps to enhance impaction graft remodeling and fusion are most effectively focused proximally...
  48. ncbi request reprint Perspectives on chondrocyte mechanobiology and osteoarthritis
    Joseph A Buckwalter
    University of Iowa, Department of Orthopaedics and Rehabilitation, Iowa City, IA 52242, USA
    Biorheology 43:603-9. 2006
    ....
  49. ncbi request reprint Nonidentical and outlier duty cycles as factors accelerating UHMWPE wear in THA: a finite element exploration
    Hannah J Lundberg
    Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory, University of Iowa, 2181 Westlawn, University of Iowa, Iowa City, Iowa 52242, USA
    J Orthop Res 25:30-43. 2007
    ..5th and 2.5th percentiles of a population of normal subjects. The resulting wear showed an increase or decrease closely proportional to the percentage by which each input (force or range of motion) was changed...
  50. ncbi request reprint Incongruity-dependent changes of contact stress rates in human cadaveric ankles
    Todd O McKinley
    University of Iowa Department of Orthopaedics and Rehabilitation, Iowa City, IA 52242, USA
    J Orthop Trauma 20:732-8. 2006
    ..Incongruity-associated changes in contact stress rates and incongruity-associated instability events may be important pathomechanical determinants of post-traumatic arthritis...
  51. ncbi request reprint Contribution of articular surface geometry to ankle stabilization
    Yuki Tochigi
    Orthopaedic Biomechanics Laboratory, Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, 2181 Westlawn, Iowa City, IA 52242 1100, USA
    J Bone Joint Surg Am 88:2704-13. 2006
    ..In the present study, it was hypothesized that, in the ankle under axial loading, contact-stress changes in response to alterations of external load involve reproducible and specific patterns to maintain ankle stability...
  52. ncbi request reprint A voxel-based formulation for contact finite element analysis
    Nicole M Grosland
    Department of Orthopaedic Surgery, 2181WL Orthopaedic Biomechanics Laboratory, The University of Iowa, Iowa City, IA 52242, USA
    Comput Methods Biomech Biomed Engin 5:21-32. 2002
    ..Close approximations to Hertzian analytical solutions were obtained for spherical and cylindrical geometries meshed in this manner, and an illustrative anatomical contact problem of the human hip joint is presented...
  53. pmc Physical validation of a patient-specific contact finite element model of the ankle
    Donald D Anderson
    Department of Orthopaedics, University of Iowa, Iowa City, IA, USA Biomedical Engineering, The University of Iowa, Iowa City, IA, USA
    J Biomech 40:1662-9. 2007
    ..g., those from an intact versus those with residual intra-articular fracture incongruity)...
  54. ncbi request reprint Fractures of the olecranon: an in vitro study of elbow joint stresses after tension-band wire fixation versus proximal fracture fragment excision
    Berton R Moed
    Department of Orthopaedic Surgery, Wayne State University, Detroit, Michigan, USA
    J Trauma 53:1088-93. 2002
    ..One treatment outcome measure of joint function is residual intra-articular stress. The purpose of this study was to evaluate the effect of these two types of olecranon fracture treatment on humeroulnar joint stress...
  55. ncbi request reprint Spatial distribution of hip capsule structural and material properties
    Kristofer J Stewart
    Orthopaedic Biomechanics Laboratory, Department of Orthopaedic Surgery, University of Iowa, Iowa City, IA 52242 1100, USA
    J Biomech 35:1491-8. 2002
    ..01) average tangent structural stiffness values in the posterior-inferior portion of the capsule. Explorations of hip stability using numerical models can now be enhanced by incorporation of these experimental capsule data...
  56. ncbi request reprint Orthopaedic crossfire--Larger femoral heads: a triumph of hope over reason! In the affirmative
    John J Callaghan
    University of Iowa College of Medicine, Department of Orthopaedic Surgery, 01073 JPP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Arthroplasty 18:82-4. 2003
    ..Thus, with polyethylene on metal bearing surfaces, less wear should occur when smaller head sizes are used. Careful, precise component positioning is important to prevent dislocation...
  57. pmc A finite element exploration of cartilage stress near an articular incongruity during unstable motion
    Curtis M Goreham-Voss
    Department of Mechanical Engineering, University of Iowa, Iowa City, IA 52242, USA
    J Biomech 40:3438-47. 2007
    ..1 to 117.9 MPa/s for unstable motion. In the most rapidly loaded sections of cartilage, the fluid was found to carry nearly all of the normal load, with the pressurization of the fluid resulting in high solid matrix tangential stresses...
  58. pmc The apparent critical isotherm for cryoinsult-induced osteonecrotic lesions in emu femoral heads
    Jessica E Goetz
    Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242 1100, USA
    J Biomech 41:2197-205. 2008
    ..Series-wide, a critical isotherm of 3.5 degrees C best corresponded to the boundary of the osteonecrotic lesions...
  59. pmc Interfragmentary surface area as an index of comminution severity in cortical bone impact
    Christina L Beardsley
    Department of Biomedical Engineering, The University of Iowa, Iowa City, 52242, USA
    J Orthop Res 23:686-90. 2005
    ..This study confirms that comminution severity of bone fractures can indeed be measured on a continuous scale, based on energy absorption. This lays a foundation for similar assessments in human injuries...
  60. ncbi request reprint Focal cryogen insults for inducing segmental osteonecrosis: computational and experimental assessments of thermal fields
    Karen L Reed
    Department of Orthopaedic Surgery, Orthopaedics Biomechanics Laboratory, University of Iowa, 2181 Westlawn Building, 52242, Iowa City, IA, USA
    J Biomech 36:1317-26. 2003
    ..The cryo-insult probe successfully produced segmental lesions in the emu model of sizes comparable to the computed freeze front diameters...
  61. pmc Automated objective scoring of histologically apparent cartilage degeneration using a custom image analysis program
    S Farshid Moussavi-Harami
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, Iowa 52242 1100, USA
    J Orthop Res 27:522-8. 2009
    ..While limitations exist with image processing techniques, the new algorithm provides an objective and automated method for analyzing cartilage histology sections, consistent with human observer grading...
  62. pmc Hip joint contact force in the emu (Dromaius novaehollandiae) during normal level walking
    Jessica E Goetz
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, USA
    J Biomech 41:770-8. 2008
    ..The interspecies similarity in hip contact forces makes the emu a biomechanically attractive animal in which to model loading-dependent human orthopaedic hip disorders...
  63. pmc Loading and boundary condition influences in a poroelastic finite element model of cartilage stresses in a triaxial compression bioreactor
    Nicole A Kallemeyn
    Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City 52242, USA
    Iowa Orthop J 26:5-16. 2006
    ..In the triaxial setting, however, a cartilage explant's physical testing environment departs from the ideal homogeneous stress state that would occur from strict linear superposition of the applied axial and transverse pressure...
  64. ncbi request reprint Polyethylene liner cementation into fixed acetabular shells
    Geoffrey F Haft
    Department of Orthopaedics, University of Iowa Health Care, Iowa City, Iowa 52242, USA
    J Arthroplasty 17:167-70. 2002
    ..This approach to treating the patient with a fixed cementless shell and a worn polyethylene liner can provide a durable construct with minimal morbidity...

Research Grants28

  1. Wear Analysis of Intervertebral Total Disc Replacements
    Thomas Brown; Fiscal Year: 2007
    ..abstract_text> ..
  2. Implant/Construct Interactions in the Biomechanics of Total Hip Dislocation
    Thomas Brown; Fiscal Year: 2007
    ..Realistic finite element analysis is an ideal vehicle for systematically assessing the complex interactions of the many factors influencing dislocation propensity, toward the goal of reducing this troublesome complication. ..
  3. Local Biomechanics of Median Nerve Insult in Carpal Tunnel Syndrome
    Thomas Brown; Fiscal Year: 2007
    ....
  4. Wear Analysis of Intervertebral Total Disc Replacements
    Thomas Brown; Fiscal Year: 2009
    ..abstract_text> ..
  5. Implant/Construct Interactions in the Biomechanics of Total Hip Dislocation
    Thomas Brown; Fiscal Year: 2009
    ..Realistic finite element analysis is an ideal vehicle for systematically assessing the complex interactions of the many factors influencing dislocation propensity, toward the goal of reducing this troublesome complication. ..
  6. Quantifying 3rd Body Challenge in Total Hip Arthroplasty
    THOMAS DUDLEY BROWN; Fiscal Year: 2010
    ..It is important to find ways to minimize these 3rd body particles, and to develop implants that are more resistant to 3rd body damage. ..
  7. Wear Analysis of Intervertebral Total Disc Replacements
    Thomas Brown; Fiscal Year: 2009
    ....
  8. NONLINEAR COMPUTATIONAL BIOMECHANICS OF THE HIP
    Thomas Brown; Fiscal Year: 2004
    ..This partnership proposes to bring together a critical mass of engineers and surgeons, to achieve clinically grounded advances in nonlinear numerical simulations of surgery of the hip. ..
  9. Mechanisms of Third Body Acceleration of THA Wear
    Thomas Brown; Fiscal Year: 2005
    ..abstract_text> ..
  10. The Emu as a Model for Necrotic Femoral Head Collapse
    Thomas Brown; Fiscal Year: 2006
    ..At the project's conclusion, we expect to have filled a longstanding need in the field of osteonecrosis research: an animal model suitable for systematic study of human-implementable interventions to forestall femoral head collapse. ..
  11. Local Biomechanics of Median Nerve Insult in Carpal Tunnel Syndrome
    THOMAS DUDLEY BROWN; Fiscal Year: 2010
    ....