Research Topics
Genomes and Genes | Mark R BrownSummaryAffiliation: University of Georgia Country: USA Publications
| Collaborators
|
Detail Information
Publications
Identification of a steroidogenic neurohormone in female mosquitoesM R Brown
Department of Entomology, University of Georgia, Athens, Georgia 30602, USA
J Biol Chem 273:3967-71. 1998....- Identification of a Drosophila brain-gut peptide related to the neuropeptide Y familyM R Brown
Department of Entomology, University of Georgia, Athens 30602, USA
Peptides 20:1035-42. 1999..In situ hybridization and immunocytochemistry showed that Drosophila NPF was expressed in the brain and midgut of fly larvae and adults... 
Characterization and expression of the short neuropeptide F receptor in the African malaria mosquito, Anopheles gambiaeStephen F Garczynski
Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
Peptides 28:109-18. 2007..Membranes from female heads and thoraces exhibited prototypical high affinity binding for radiolabeled sNPF, indicating sNPFR is a bona fide endogenous receptor...
Molecular characterization of neuropeptide F from the eastern subterranean termite Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae)Andrew B Nuss
Department of Entomology, 413 Biological Sciences Building, University of Georgia, Athens, GA 30602 2603, USA
Peptides 31:419-28. 2010..Phylogenetic analysis of invertebrate NPF sequences reveals two separate groupings, with Ref NPF occurring within a clade composed exclusively of arthropods...- Two insulin-like peptide family members from the mosquito Aedes aegypti exhibit differential biological and receptor binding activitiesZhimou Wen
Department of Entomology, University of Georgia, Athens, GA 30602, USA
Mol Cell Endocrinol 328:47-55. 2010..Taken together, our results indicate that two members of the Ae. aegypti ILP family exhibit partially overlapping biological activity and different binding interactions with the MIR... - Insulin-like peptides and the target of rapamycin pathway coordinately regulate blood digestion and egg maturation in the mosquito Aedes aegyptiMonika Gulia-Nuss
Department of Entomology, University of Georgia, Athens, Georgia, United States of America
PLoS ONE 6:e20401. 2011..Both hormonal and nutritional factors are involved in regulating egg development in the mosquito, Aedes aegypti. However, the processes that regulate digestion of the blood meal remain unclear... - An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegyptiMark R Brown
Departments of Entomology and Cellular Biology, University of Georgia, Athens, GA 30602, USA
Proc Natl Acad Sci U S A 105:5716-21. 2008..Overall, our results identify ILP3 as a critical regulator of egg production by A. aegypti... - Ovary ecdysteroidogenic hormone activates egg maturation in the mosquito Georgecraigius atropalpus after adult eclosion or a blood mealMonika Gulia-Nuss
Department of Entomology, University of Georgia, Athens, GA 30602, USA
J Exp Biol 215:3758-67. 2012..atropalpus females and suggest the shift from blood meal-dependent to blood meal-independent release of OEH is a key factor in the evolution of autogeny in this species... - Molecular characterization of insulin-like peptides in the yellow fever mosquito, Aedes aegypti: expression, cellular localization, and phylogenyMichael A Riehle
Forbes 410, PO Box 210036, Department of Entomology, University of Arizona, Tucson, AZ 85721 0036, USA
Peptides 27:2547-60. 2006..aegypti, the African malaria mosquito (Anopheles gambiae), and Drosophila melanogaster is presented as a step towards understanding the structural and functional diversity of insect ILPs... - Neuropeptides and peptide hormones in Anopheles gambiaeMichael A Riehle
Department of Entomology, University of Georgia, Athens, GA 30602, USA
Science 298:172-5. 2002..gambiae, as in Drosophila melanogaster, Caenorhabditis elegans, and mammals. This genomic information provides a basis to expand understanding of hematophagy and pathogen transmission in this mosquito... - Neuropeptide F and the corn earworm, Helicoverpa zea: a midgut peptide revisitedYongqin Huang
Department of Cellular Biology, University of Georgia, 302B Franklin House, Athens, GA 30602, USA
Peptides 32:483-92. 2011..As with the vertebrate homologs, NPF may arise both centrally and peripherally to modulate the physiology of feeding and digestion of Lepidoptera... - Characterization of neuropeptide F and its receptor from the African malaria mosquito, Anopheles gambiaeStephen F Garczynski
Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
Peptides 26:99-107. 2005..RT-PCR analysis revealed Ang-NPF and Ang-NPFR transcripts in all life stages. Ang-NPF and Ang-NPFR may be strategically positioned for signaling in relation to nutritional status in the African malaria mosquito... - Signaling and function of insulin-like peptides in insectsQi Wu
Department of Cellular Biology, University of Georgia, Athens
Annu Rev Entomol 51:1-24. 2006.... - Structural studies of Drosophila short neuropeptide F: Occurrence and receptor binding activityStephen F Garczynski
Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
Peptides 27:575-82. 2006..These findings extend understanding of the relationship between structure and function of sNPFs... - Blood feeding and insulin-like peptide 3 stimulate proliferation of hemocytes in the mosquito Aedes aegyptiJulio Castillo
Department of Entomology, University of Georgia, Athens, Georgia, United States of America
PLoS Pathog 7:e1002274. 2011..Our results also indicate that blood feeding enhances resistance to E. coli at lower levels of infection but reduces tolerance at higher levels of infection... - Expression of genes encoding proteins involved in ecdysteroidogenesis in the female mosquito, Aedes aegyptiDouglas H Sieglaff
Department of Entomology, University of Georgia, Athens, GA 30602, USA
Insect Biochem Mol Biol 35:471-90. 2005..This study shows for the first time that transcription of a few key genes for proteins involved in ecdysteroid biosynthesis is positively correlated with the rise in ecdysteroid production by ovaries of a female insect... - Adipokinetic hormones in the African malaria mosquito, Anopheles gambiae: identification and expression of genes for two peptides and a putative receptorChristian Kaufmann
Department of Entomology, University of Georgia, Athens, GA 30602, USA
Insect Biochem Mol Biol 36:466-81. 2006..Accordingly, Anoga-AKH-I was detected in extracts of female heads and thoraces by HPLC and an AKH radioimmunoassay, whereas Anoga-AKH-II was detected only in heads... - Localization of an insulin-like peptide in brains of two fliesC Cao
Department of Entomology, University of Georgia, Athens 30602, USA
Cell Tissue Res 304:317-21. 2001..aegypti females. These specific localizations substantiate the existence of an endogenous insulin-like peptide in Drosophila and suggest that a similar peptide is present in the distantly related mosquitoes... - Distribution of neuropeptide F-like immunoreactivity in the Eastern Subterranean termite, Reticulitermes flavipesAndrew B Nuss
Department of Entomology, University of Georgia, Athens, GA, USA
J Insect Sci 8:1-18. 2008..This distribution suggests NPF-like peptides coordinate feeding and digestion in all castes of this termite species... - Larval feeding duration affects ecdysteroid levels and nutritional reserves regulating pupal commitment in the yellow fever mosquito Aedes aegypti (Diptera: Culicidae)Aparna Telang
Department of Entomology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
J Exp Biol 210:854-64. 2007..This model should facilitate the exploitation of current and novel insect growth regulators that are among favored strategies for vector population suppression... - Regulation of carbohydrate metabolism and flight performance by a hypertrehalosaemic hormone in the mosquito Anopheles gambiaeChristian Kaufmann
Department of Entomology, University of Georgia, Athens, GA 30602, USA
J Insect Physiol 54:367-77. 2008..Taken together, these results show that a primary role for the neurohormone, Anoga-AKH-I, is to elevate trehalose levels in the haemolymph of female mosquitoes... - Effects of larval nutrition on the endocrinology of mosquito egg developmentAparna Telang
University of Arizona, Department of Biochemistry and Molecular Biophysics, Tucson, AZ 85721, USA
J Exp Biol 209:645-55. 2006..Ecdysteroid production was initiated in newly emerged Oc. atropalpus females, which have higher protein reserves and which develop eggs without a blood meal, which is required by A. aegypti females to complete egg development... - Distribution of ovary ecdysteroidogenic hormone I in the nervous system and gut of mosquitoesM R Brown
Department of Entomology, University of Georgia, Athens, GA 30602, USA
J Insect Sci 1:3. 2001.... - Characterization of a functional neuropeptide F receptor from Drosophila melanogasterStephen F Garczynski
Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
Peptides 23:773-80. 2002..Whole-mount in situ hybridization revealed that DmNPFR1 RNA is expressed in CNS and midgut of Drosophila larvae. DmNPFR1, a new invertebrate Y-receptor homolog, apparently is a functional receptor for DmNPF... - Neuropeptide F and its expression in the yellow fever mosquito, Aedes aegyptiDawn M Stanek
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
Peptides 23:1367-78. 2002..Immunocytochemistry and Northern blots confirmed that both the brain and midgut of females are likely sources of NPF, found at its highest hemolymph titer before and 24 h after a blood meal... - Insulin receptor expression during development and a reproductive cycle in the ovary of the mosquito Aedes aegyptiMichael A Riehle
Department of Entomology, 413 Biological Sciences, University of Georgia - Athens, Athens, GA 30602, USA
Cell Tissue Res 308:409-20. 2002..Notably, MIR protein and transcript were not detected in eggs, larvae, pupae, or pharate adults... - Approaches to radioiodination of insect neuropeptidesJoe W Crim
Department of Cellular Biology, University of Georgia, Athens 30602, USA
Peptides 23:2045-51. 2002..Labeling of the FMRFamide-related peptide (YGGFMRFa), with chloramine-T apparently formed the methionine sulfoxide, which subsequently could be reduced with dithiothreitol. Products of high specific activity typically are achievable... - Characterization of the AeaHP gene and its expression in the mosquito Aedes aegypti (Diptera: Culicidae)Travis H Stracker
Department of Entomology, University of Georgia, Athens 30602, USA
J Med Entomol 39:331-42. 2002..Based on these results, neurosecretory cells and midgut endocrine cells are likely sources of Aea-HPs shown to reach highest hemolymph titer at the same time as host seeking is inhibited in female Ae. aegypti during a reproductive cycle... - Gonadal ecdysteroidogenesis in arthropoda: occurrence and regulationMark R Brown
Department of Entomology, University of Georgia, Athens, Georgia 30602, USA
Annu Rev Entomol 54:105-25. 2009.... - Evaluation of novel and traditional measures for vigor of laboratory-cultured termites, Reticulitermes flavipes (Kollar)Timothy J Arquette
Department of Entomology, The University of Georgia, Athens, GA 30602, USA
J Insect Physiol 52:51-66. 2006..Low body water percentage was concluded to be an indicator of weak groups of termites... - Comparison of the localization of Bacillus thuringiensis Cry1A delta-endotoxins and their binding proteins in larval midgut of tobacco hornworm, Manduca sextaJiang Chen
Department of Entomology, University of Georgia, Athens, GA 30602-2603, USA
Cell Tissue Res 321:123-9. 2005..Binding of Cry1Ac was much stronger in the posterior region than in the anterior and middle regions. Thus, binding sites for Bt proteins and Cry1A toxins are co-localized on the microvilli of M. sexta midgut epithelial cells... - Infection by a symbiotic polydnavirus induces wasting and inhibits metamorphosis of the moth Pseudoplusia includensA J Pruijssers
Department of Entomology, University of Georgia, Athens, GA 30602, USA
J Exp Biol 212:2998-3006. 2009..Taken together, our results suggest MdBV causes alterations in metabolic physiology, which prevent the host from achieving critical weight. This in turn inhibits the endocrine events that normally trigger metamorphosis...