Mark R Brown

Summary

Affiliation: University of Georgia
Country: USA

Publications

  1. ncbi Identification of a Drosophila brain-gut peptide related to the neuropeptide Y family
    M R Brown
    Department of Entomology, University of Georgia, Athens 30602, USA
    Peptides 20:1035-42. 1999
  2. ncbi Identification of a steroidogenic neurohormone in female mosquitoes
    M R Brown
    Department of Entomology, University of Georgia, Athens, Georgia 30602, USA
    J Biol Chem 273:3967-71. 1998
  3. pmc Characterization and expression of the short neuropeptide F receptor in the African malaria mosquito, Anopheles gambiae
    Stephen F Garczynski
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Peptides 28:109-18. 2007
  4. doi Molecular characterization of neuropeptide F from the eastern subterranean termite Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae)
    Andrew B Nuss
    Department of Entomology, 413 Biological Sciences Building, University of Georgia, Athens, GA 30602 2603, USA
    Peptides 31:419-28. 2010
  5. pmc Two insulin-like peptide family members from the mosquito Aedes aegypti exhibit differential biological and receptor binding activities
    Zhimou Wen
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Mol Cell Endocrinol 328:47-55. 2010
  6. pmc Insulin-like peptides and the target of rapamycin pathway coordinately regulate blood digestion and egg maturation in the mosquito Aedes aegypti
    Monika Gulia-Nuss
    Department of Entomology, University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 6:e20401. 2011
  7. pmc An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti
    Mark R Brown
    Departments of Entomology and Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 105:5716-21. 2008
  8. pmc Ovary ecdysteroidogenic hormone activates egg maturation in the mosquito Georgecraigius atropalpus after adult eclosion or a blood meal
    Monika Gulia-Nuss
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    J Exp Biol 215:3758-67. 2012
  9. ncbi Molecular characterization of insulin-like peptides in the yellow fever mosquito, Aedes aegypti: expression, cellular localization, and phylogeny
    Michael A Riehle
    Forbes 410, PO Box 210036, Department of Entomology, University of Arizona, Tucson, AZ 85721 0036, USA
    Peptides 27:2547-60. 2006
  10. ncbi Neuropeptides and peptide hormones in Anopheles gambiae
    Michael A Riehle
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Science 298:172-5. 2002

Collaborators

Detail Information

Publications32

  1. ncbi Identification of a Drosophila brain-gut peptide related to the neuropeptide Y family
    M R Brown
    Department of Entomology, University of Georgia, Athens 30602, USA
    Peptides 20:1035-42. 1999
    ..In situ hybridization and immunocytochemistry showed that Drosophila NPF was expressed in the brain and midgut of fly larvae and adults...
  2. ncbi Identification of a steroidogenic neurohormone in female mosquitoes
    M R Brown
    Department of Entomology, University of Georgia, Athens, Georgia 30602, USA
    J Biol Chem 273:3967-71. 1998
    ....
  3. pmc Characterization and expression of the short neuropeptide F receptor in the African malaria mosquito, Anopheles gambiae
    Stephen F Garczynski
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Peptides 28:109-18. 2007
    ..Membranes from female heads and thoraces exhibited prototypical high affinity binding for radiolabeled sNPF, indicating sNPFR is a bona fide endogenous receptor...
  4. doi Molecular characterization of neuropeptide F from the eastern subterranean termite Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae)
    Andrew B Nuss
    Department of Entomology, 413 Biological Sciences Building, University of Georgia, Athens, GA 30602 2603, USA
    Peptides 31:419-28. 2010
    ..Phylogenetic analysis of invertebrate NPF sequences reveals two separate groupings, with Ref NPF occurring within a clade composed exclusively of arthropods...
  5. pmc Two insulin-like peptide family members from the mosquito Aedes aegypti exhibit differential biological and receptor binding activities
    Zhimou Wen
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Mol Cell Endocrinol 328:47-55. 2010
    ..Taken together, our results indicate that two members of the Ae. aegypti ILP family exhibit partially overlapping biological activity and different binding interactions with the MIR...
  6. pmc Insulin-like peptides and the target of rapamycin pathway coordinately regulate blood digestion and egg maturation in the mosquito Aedes aegypti
    Monika Gulia-Nuss
    Department of Entomology, University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 6:e20401. 2011
    ..Both hormonal and nutritional factors are involved in regulating egg development in the mosquito, Aedes aegypti. However, the processes that regulate digestion of the blood meal remain unclear...
  7. pmc An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti
    Mark R Brown
    Departments of Entomology and Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 105:5716-21. 2008
    ..Overall, our results identify ILP3 as a critical regulator of egg production by A. aegypti...
  8. pmc Ovary ecdysteroidogenic hormone activates egg maturation in the mosquito Georgecraigius atropalpus after adult eclosion or a blood meal
    Monika Gulia-Nuss
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    J Exp Biol 215:3758-67. 2012
    ..atropalpus females and suggest the shift from blood meal-dependent to blood meal-independent release of OEH is a key factor in the evolution of autogeny in this species...
  9. ncbi Molecular characterization of insulin-like peptides in the yellow fever mosquito, Aedes aegypti: expression, cellular localization, and phylogeny
    Michael A Riehle
    Forbes 410, PO Box 210036, Department of Entomology, University of Arizona, Tucson, AZ 85721 0036, USA
    Peptides 27:2547-60. 2006
    ..aegypti, the African malaria mosquito (Anopheles gambiae), and Drosophila melanogaster is presented as a step towards understanding the structural and functional diversity of insect ILPs...
  10. ncbi Neuropeptides and peptide hormones in Anopheles gambiae
    Michael A Riehle
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Science 298:172-5. 2002
    ..gambiae, as in Drosophila melanogaster, Caenorhabditis elegans, and mammals. This genomic information provides a basis to expand understanding of hematophagy and pathogen transmission in this mosquito...
  11. doi Neuropeptide F and the corn earworm, Helicoverpa zea: a midgut peptide revisited
    Yongqin Huang
    Department of Cellular Biology, University of Georgia, 302B Franklin House, Athens, GA 30602, USA
    Peptides 32:483-92. 2011
    ..As with the vertebrate homologs, NPF may arise both centrally and peripherally to modulate the physiology of feeding and digestion of Lepidoptera...
  12. ncbi Characterization of neuropeptide F and its receptor from the African malaria mosquito, Anopheles gambiae
    Stephen F Garczynski
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Peptides 26:99-107. 2005
    ..RT-PCR analysis revealed Ang-NPF and Ang-NPFR transcripts in all life stages. Ang-NPF and Ang-NPFR may be strategically positioned for signaling in relation to nutritional status in the African malaria mosquito...
  13. ncbi Signaling and function of insulin-like peptides in insects
    Qi Wu
    Department of Cellular Biology, University of Georgia, Athens
    Annu Rev Entomol 51:1-24. 2006
    ....
  14. ncbi Structural studies of Drosophila short neuropeptide F: Occurrence and receptor binding activity
    Stephen F Garczynski
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Peptides 27:575-82. 2006
    ..These findings extend understanding of the relationship between structure and function of sNPFs...
  15. pmc Blood feeding and insulin-like peptide 3 stimulate proliferation of hemocytes in the mosquito Aedes aegypti
    Julio Castillo
    Department of Entomology, University of Georgia, Athens, Georgia, United States of America
    PLoS Pathog 7:e1002274. 2011
    ..Our results also indicate that blood feeding enhances resistance to E. coli at lower levels of infection but reduces tolerance at higher levels of infection...
  16. ncbi Expression of genes encoding proteins involved in ecdysteroidogenesis in the female mosquito, Aedes aegypti
    Douglas H Sieglaff
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Insect Biochem Mol Biol 35:471-90. 2005
    ..This study shows for the first time that transcription of a few key genes for proteins involved in ecdysteroid biosynthesis is positively correlated with the rise in ecdysteroid production by ovaries of a female insect...
  17. ncbi Adipokinetic hormones in the African malaria mosquito, Anopheles gambiae: identification and expression of genes for two peptides and a putative receptor
    Christian Kaufmann
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Insect Biochem Mol Biol 36:466-81. 2006
    ..Accordingly, Anoga-AKH-I was detected in extracts of female heads and thoraces by HPLC and an AKH radioimmunoassay, whereas Anoga-AKH-II was detected only in heads...
  18. ncbi Localization of an insulin-like peptide in brains of two flies
    C Cao
    Department of Entomology, University of Georgia, Athens 30602, USA
    Cell Tissue Res 304:317-21. 2001
    ..aegypti females. These specific localizations substantiate the existence of an endogenous insulin-like peptide in Drosophila and suggest that a similar peptide is present in the distantly related mosquitoes...
  19. pmc Distribution of neuropeptide F-like immunoreactivity in the Eastern Subterranean termite, Reticulitermes flavipes
    Andrew B Nuss
    Department of Entomology, University of Georgia, Athens, GA, USA
    J Insect Sci 8:1-18. 2008
    ..This distribution suggests NPF-like peptides coordinate feeding and digestion in all castes of this termite species...
  20. ncbi Larval feeding duration affects ecdysteroid levels and nutritional reserves regulating pupal commitment in the yellow fever mosquito Aedes aegypti (Diptera: Culicidae)
    Aparna Telang
    Department of Entomology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    J Exp Biol 210:854-64. 2007
    ..This model should facilitate the exploitation of current and novel insect growth regulators that are among favored strategies for vector population suppression...
  21. pmc Regulation of carbohydrate metabolism and flight performance by a hypertrehalosaemic hormone in the mosquito Anopheles gambiae
    Christian Kaufmann
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    J Insect Physiol 54:367-77. 2008
    ..Taken together, these results show that a primary role for the neurohormone, Anoga-AKH-I, is to elevate trehalose levels in the haemolymph of female mosquitoes...
  22. ncbi Effects of larval nutrition on the endocrinology of mosquito egg development
    Aparna Telang
    University of Arizona, Department of Biochemistry and Molecular Biophysics, Tucson, AZ 85721, USA
    J Exp Biol 209:645-55. 2006
    ..Ecdysteroid production was initiated in newly emerged Oc. atropalpus females, which have higher protein reserves and which develop eggs without a blood meal, which is required by A. aegypti females to complete egg development...
  23. pmc Distribution of ovary ecdysteroidogenic hormone I in the nervous system and gut of mosquitoes
    M R Brown
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    J Insect Sci 1:3. 2001
    ....
  24. ncbi Characterization of a functional neuropeptide F receptor from Drosophila melanogaster
    Stephen F Garczynski
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Peptides 23:773-80. 2002
    ..Whole-mount in situ hybridization revealed that DmNPFR1 RNA is expressed in CNS and midgut of Drosophila larvae. DmNPFR1, a new invertebrate Y-receptor homolog, apparently is a functional receptor for DmNPF...
  25. ncbi Neuropeptide F and its expression in the yellow fever mosquito, Aedes aegypti
    Dawn M Stanek
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Peptides 23:1367-78. 2002
    ..Immunocytochemistry and Northern blots confirmed that both the brain and midgut of females are likely sources of NPF, found at its highest hemolymph titer before and 24 h after a blood meal...
  26. ncbi Insulin receptor expression during development and a reproductive cycle in the ovary of the mosquito Aedes aegypti
    Michael A Riehle
    Department of Entomology, 413 Biological Sciences, University of Georgia Athens, Athens, GA 30602, USA
    Cell Tissue Res 308:409-20. 2002
    ..Notably, MIR protein and transcript were not detected in eggs, larvae, pupae, or pharate adults...
  27. ncbi Approaches to radioiodination of insect neuropeptides
    Joe W Crim
    Department of Cellular Biology, University of Georgia, Athens 30602, USA
    Peptides 23:2045-51. 2002
    ..Labeling of the FMRFamide-related peptide (YGGFMRFa), with chloramine-T apparently formed the methionine sulfoxide, which subsequently could be reduced with dithiothreitol. Products of high specific activity typically are achievable...
  28. ncbi Characterization of the AeaHP gene and its expression in the mosquito Aedes aegypti (Diptera: Culicidae)
    Travis H Stracker
    Department of Entomology, University of Georgia, Athens 30602, USA
    J Med Entomol 39:331-42. 2002
    ..Based on these results, neurosecretory cells and midgut endocrine cells are likely sources of Aea-HPs shown to reach highest hemolymph titer at the same time as host seeking is inhibited in female Ae. aegypti during a reproductive cycle...
  29. doi Gonadal ecdysteroidogenesis in arthropoda: occurrence and regulation
    Mark R Brown
    Department of Entomology, University of Georgia, Athens, Georgia 30602, USA
    Annu Rev Entomol 54:105-25. 2009
    ....
  30. ncbi Evaluation of novel and traditional measures for vigor of laboratory-cultured termites, Reticulitermes flavipes (Kollar)
    Timothy J Arquette
    Department of Entomology, The University of Georgia, Athens, GA 30602, USA
    J Insect Physiol 52:51-66. 2006
    ..Low body water percentage was concluded to be an indicator of weak groups of termites...
  31. ncbi Comparison of the localization of Bacillus thuringiensis Cry1A delta-endotoxins and their binding proteins in larval midgut of tobacco hornworm, Manduca sexta
    Jiang Chen
    Department of Entomology, University of Georgia, Athens, GA 30602 2603, USA
    Cell Tissue Res 321:123-9. 2005
    ..Binding of Cry1Ac was much stronger in the posterior region than in the anterior and middle regions. Thus, binding sites for Bt proteins and Cry1A toxins are co-localized on the microvilli of M. sexta midgut epithelial cells...
  32. pmc Infection by a symbiotic polydnavirus induces wasting and inhibits metamorphosis of the moth Pseudoplusia includens
    A J Pruijssers
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    J Exp Biol 212:2998-3006. 2009
    ..Taken together, our results suggest MdBV causes alterations in metabolic physiology, which prevent the host from achieving critical weight. This in turn inhibits the endocrine events that normally trigger metamorphosis...