Marishka K Brown

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    BMC Neurosci 10:62. 2009
  2. doi request reprint Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons
    Flaubert Tchantchou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    J Alzheimers Dis 18:787-98. 2009
  3. pmc Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neurobiol Aging 31:1055-8. 2010
  4. doi request reprint A natural squamosamide derivative FLZ reduces amyloid-beta production by increasing non-amyloidogenic AbetaPP processing
    Yan Hou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 18:153-65. 2009
  5. ncbi request reprint Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans
    Zhiming Cao
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 62:1337-45. 2007
  6. doi request reprint Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta
    Laura E Dosanjh
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 19:681-90. 2010
  7. ncbi request reprint Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide
    Yanan Xu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 13:341-9. 2008
  8. pmc Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice
    Yan Hou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neuropharmacology 58:911-20. 2010
  9. ncbi request reprint Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:13102-13. 2006
  10. pmc Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways
    Young Beob Yu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9339. 2010

Collaborators

Detail Information

Publications20

  1. pmc Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    BMC Neurosci 10:62. 2009
    ..elegans. The wild type worms, as well as well-characterized 5-HT mutants, were fed with bilobalide in a range of concentrations, and several 5-HT controlled behaviors were tested...
  2. doi request reprint Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons
    Flaubert Tchantchou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    J Alzheimers Dis 18:787-98. 2009
    ..Despite a recent report showing that EGb 761 was insufficient in prevent dementia, its constituents still warrant future investigation...
  3. pmc Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neurobiol Aging 31:1055-8. 2010
    ....
  4. doi request reprint A natural squamosamide derivative FLZ reduces amyloid-beta production by increasing non-amyloidogenic AbetaPP processing
    Yan Hou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 18:153-65. 2009
    ..These findings suggest that FLZ reduces Abeta production by promoting AbetaPP non-amyloidogenic alpha-secretase processing. As such, FLZ may have therapeutic potential for the treatment of AD...
  5. ncbi request reprint Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans
    Zhiming Cao
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 62:1337-45. 2007
    ..elegans is a valid model system for testing therapeutic intervention for delaying the progress of sarcopenia...
  6. doi request reprint Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta
    Laura E Dosanjh
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 19:681-90. 2010
    ..elegans suggest that the model may be used to elucidate underlying pathological events related to development of AD and for pharmaceutical intervention...
  7. ncbi request reprint Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide
    Yanan Xu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 13:341-9. 2008
    ..Taken together, we provide a possible molecular mechanism for memory enhancing property of Gotu Kola extract for the first time...
  8. pmc Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice
    Yan Hou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neuropharmacology 58:911-20. 2010
    ..The present results suggest that stimulating BDNF and reducing Abeta toxicity by natural flavonols provide a therapeutic implication for treatment of AD...
  9. ncbi request reprint Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:13102-13. 2006
    ....
  10. pmc Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways
    Young Beob Yu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9339. 2010
    ..This issue may be addressed through the use of contemporary methodology and validated animal models...
  11. ncbi request reprint Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells
    Yanan Xu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, MD 21201, USA
    Eur J Neurosci 26:2931-9. 2007
    ..Actions of individual EGb 761 components provide further insights into direct mechanisms underlying the effect of EGb 761 on enhancing the cognitive performance of patients with AD...
  12. ncbi request reprint EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease
    Flaubert Tchantchou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    FASEB J 21:2400-8. 2007
    ....
  13. doi request reprint Modulating expression of brain heat shock proteins by estrogen in ovariectomized mice model of aging
    Yan Hou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Exp Gerontol 45:323-30. 2010
    ..These results suggest that estrogen deficiency during aging down-regulates heat stress-induced brain HSP70 expression, which reveals a previously unknown link between estrogen deficiency and stress response elements...
  14. doi request reprint Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide: in vitro and in vivo approaches
    Vamsi L M Madgula
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Planta Med 76:599-606. 2010
    ..A brain-to-plasma partition coefficient of 0.56 at 120 min indicated its possibility of brain uptake...
  15. pmc Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans
    Roongpetch Keowkase
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neuropharmacology 59:358-65. 2010
    ..We also found that fluoxetine increased thermal stress resistance and extended life span. These findings suggests that fluoxetine may have benefit for the treatment of AD by the reduction of proteotoxicity...
  16. doi request reprint Antidepressants modulate intracellular amyloid peptide species in N2a neuroblastoma cells
    Marwa Aboukhatwa
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 24:221-34. 2011
    ..These data could explain some of the beneficial effects of antidepressants in AD patients observed in clinical studies...
  17. pmc Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways
    Linhao Li
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, Maryland, 21201, USA
    Pharm Res 26:872-82. 2009
    ....
  18. pmc Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans
    Roongpetch Keowkase
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    Mol Neurodegener 5:59. 2010
    ..The purpose of these experiments was to more specifically investigate the neuroprotective capabilities of these lead compounds both in vitro and in vivo...
  19. ncbi request reprint Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine St, PH501, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 85:620-8. 2006
    ..Other protective mechanisms, in addition to their antioxidant properties, may underlie their differential beneficial effects on aging and physiological behaviors...
  20. pmc Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease
    Marwa Aboukhatwa
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine St, Baltimore, MD 21201, USA
    Mol Neurodegener 5:10. 2010
    ..Based on this preclinical and clinical evidence, antidepressants represent a rational complimentary strategy for the treatment of AD patients with depression comorbidity...