Research Topics
Genomes and GenesSpecies | Marishka K BrownSummaryAffiliation: University of Maryland Country: USA Publications
| Collaborators
|
Detail Information
Publications
Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegansMarishka K Brown
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
BMC Neurosci 10:62. 2009..elegans. The wild type worms, as well as well-characterized 5-HT mutants, were fed with bilobalide in a range of concentrations, and several 5-HT controlled behaviors were tested...
Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neuronsFlaubert Tchantchou
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
J Alzheimers Dis 18:787-98. 2009..Despite a recent report showing that EGb 761 was insufficient in prevent dementia, its constituents still warrant future investigation...- Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomersYanjue Wu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
Neurobiol Aging 31:1055-8. 2010.... - A natural squamosamide derivative FLZ reduces amyloid-beta production by increasing non-amyloidogenic AbetaPP processingYan Hou
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
J Alzheimers Dis 18:153-65. 2009..These findings suggest that FLZ reduces Abeta production by promoting AbetaPP non-amyloidogenic alpha-secretase processing. As such, FLZ may have therapeutic potential for the treatment of AD... 
Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegansZhiming Cao
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
J Gerontol A Biol Sci Med Sci 62:1337-45. 2007..elegans is a valid model system for testing therapeutic intervention for delaying the progress of sarcopenia...- Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-betaLaura E Dosanjh
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
J Alzheimers Dis 19:681-90. 2010..elegans suggest that the model may be used to elucidate underlying pathological events related to development of AD and for pharmaceutical intervention... - Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptideYanan Xu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
J Alzheimers Dis 13:341-9. 2008..Taken together, we provide a possible molecular mechanism for memory enhancing property of Gotu Kola extract for the first time... - Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD miceYan Hou
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
Neuropharmacology 58:911-20. 2010..The present results suggest that stimulating BDNF and reducing Abeta toxicity by natural flavonols provide a therapeutic implication for treatment of AD... - Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegansYanjue Wu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
J Neurosci 26:13102-13. 2006.... - Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathwaysYoung Beob Yu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
PLoS ONE 5:e9339. 2010..This issue may be addressed through the use of contemporary methodology and validated animal models... - Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cellsYanan Xu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, MD 21201, USA
Eur J Neurosci 26:2931-9. 2007..Actions of individual EGb 761 components provide further insights into direct mechanisms underlying the effect of EGb 761 on enhancing the cognitive performance of patients with AD... - EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's diseaseFlaubert Tchantchou
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
FASEB J 21:2400-8. 2007.... - Modulating expression of brain heat shock proteins by estrogen in ovariectomized mice model of agingYan Hou
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
Exp Gerontol 45:323-30. 2010..These results suggest that estrogen deficiency during aging down-regulates heat stress-induced brain HSP70 expression, which reveals a previously unknown link between estrogen deficiency and stress response elements... - Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide: in vitro and in vivo approachesVamsi L M Madgula
National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
Planta Med 76:599-606. 2010..A brain-to-plasma partition coefficient of 0.56 at 120 min indicated its possibility of brain uptake... - Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegansRoongpetch Keowkase
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
Neuropharmacology 59:358-65. 2010..We also found that fluoxetine increased thermal stress resistance and extended life span. These findings suggests that fluoxetine may have benefit for the treatment of AD by the reduction of proteotoxicity... - Antidepressants modulate intracellular amyloid peptide species in N2a neuroblastoma cellsMarwa Aboukhatwa
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
J Alzheimers Dis 24:221-34. 2011..These data could explain some of the beneficial effects of antidepressants in AD patients observed in clinical studies... - Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathwaysLinhao Li
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, Maryland, 21201, USA
Pharm Res 26:872-82. 2009.... - Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegansRoongpetch Keowkase
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
Mol Neurodegener 5:59. 2010..The purpose of these experiments was to more specifically investigate the neuroprotective capabilities of these lead compounds both in vitro and in vivo... - Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegansMarishka K Brown
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N. Pine St, PH501, Baltimore, MD 21201, USA
Pharmacol Biochem Behav 85:620-8. 2006..Other protective mechanisms, in addition to their antioxidant properties, may underlie their differential beneficial effects on aging and physiological behaviors... - Antidepressants are a rational complementary therapy for the treatment of Alzheimer's diseaseMarwa Aboukhatwa
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine St, Baltimore, MD 21201, USA
Mol Neurodegener 5:10. 2010..Based on this preclinical and clinical evidence, antidepressants represent a rational complimentary strategy for the treatment of AD patients with depression comorbidity...