Laura J Brown

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line
    Laura J Brown
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 284:35359-67. 2009
  2. ncbi request reprint Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases
    Laura J Brown
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 277:32899-904. 2002
  3. pmc Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion
    Michael J MacDonald
    Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA Electronic address
    Biochim Biophys Acta 1830:5104-11. 2013
  4. pmc Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets
    Michael J MacDonald
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 286:18383-96. 2011
  5. ncbi request reprint Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion
    Michael J MacDonald
    Children Diabetes Center, Univesity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Physiol Cell Physiol 294:C442-50. 2008
  6. ncbi request reprint Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion
    Michael J MacDonald
    Childrens Diabetes Center, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Am J Physiol Endocrinol Metab 288:E1-15. 2005
  7. ncbi request reprint Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase
    Laura J Brown
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 277:32892-8. 2002

Collaborators

Detail Information

Publications7

  1. pmc Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line
    Laura J Brown
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 284:35359-67. 2009
    ..The maintenance of robust insulin secretion after lowering expression of either one of these malic enzymes is consistent with the redundancy of pathways of pyruvate cycling and/or cytosolic NADPH production in insulinoma cells...
  2. ncbi request reprint Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases
    Laura J Brown
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 277:32899-904. 2002
    ....
  3. pmc Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion
    Michael J MacDonald
    Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA Electronic address
    Biochim Biophys Acta 1830:5104-11. 2013
    ..There are three isocitrate dehydrogenases (IDHs) in the pancreatic insulin cell; IDH1 (cytosolic) and IDH2 (mitochondrial) use NADP(H). IDH3 is mitochondrial, uses NAD(H) and was believed to be the IDH that supports the citric acid cycle...
  4. pmc Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets
    Michael J MacDonald
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 286:18383-96. 2011
    ....
  5. ncbi request reprint Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion
    Michael J MacDonald
    Children Diabetes Center, Univesity of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Physiol Cell Physiol 294:C442-50. 2008
    ..The results suggest that, besides citrate, some of the products of anaplerosis are SC-CoAs, which may be precursors of molecules involved in insulin secretion...
  6. ncbi request reprint Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion
    Michael J MacDonald
    Childrens Diabetes Center, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Am J Physiol Endocrinol Metab 288:E1-15. 2005
    ..Thus citrate oscillations may synchronize mitochondrial ATP production and anaplerosis with other cellular oscillations...
  7. ncbi request reprint Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase
    Laura J Brown
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 277:32892-8. 2002
    ..We conclude that, although mGPD is not essential for thyroid thermogenesis, variations in its function affect viability and adiposity in mice...