Kathlynn Brown

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Peptidic tumor targeting agents: the road from phage display peptide selections to clinical applications
    Kathlynn C Brown
    Division of Translational Medicine Departments of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9185, USA
    Curr Pharm Des 16:1040-54. 2010
  2. pmc Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancer
    Michael J McGuire
    1 Departments of Internal Medicine, University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX 75390 8807, USA 2 The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX 75390 8807, USA
    Sci Rep 4:4480. 2014
  3. pmc A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density
    Bethany Powell Gray
    Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 8:e72938. 2013
  4. pmc Synthesis and characterization of a high-affinity {alpha}v{beta}6-specific ligand for in vitro and in vivo applications
    Shunzi Li
    Division of Translational Research, Department of Internal Medicine, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9185, USA
    Mol Cancer Ther 8:1239-49. 2009
  5. ncbi request reprint Patterning adhesion of mammalian cells with visible light, tris(bipyridyl)ruthenium(II) chloride, and a digital micromirror array
    Kevin J Luebke
    Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9185, USA
    J Biomed Mater Res A 68:696-703. 2004
  6. ncbi request reprint In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo
    Michael J McGuire
    Department of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas 75390 9185, USA
    J Mol Biol 342:171-82. 2004
  7. ncbi request reprint A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer
    Anissa N Elayadi
    Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 67:5889-95. 2007
  8. ncbi request reprint Novel ligands for cancer diagnosis: selection of peptide ligands for identification and isolation of B-cell lymphomas
    Michael J McGuire
    Division of Translational Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Exp Hematol 34:443-52. 2006
  9. ncbi request reprint Isolation of lung tumor specific peptides from a random peptide library: generation of diagnostic and cell-targeting reagents
    Tsuksa Oyama
    Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9185, USA
    Cancer Lett 202:219-30. 2003
  10. ncbi request reprint Peptide-mediated targeting of the islets of Langerhans
    Kausar N Samli
    Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9185, USA
    Diabetes 54:2103-8. 2005

Research Grants

  1. Chemical & Biological Approaches for Cell Targeting
    Kathlynn Brown; Fiscal Year: 2002
  2. Diagnostic & targeting reagents for lung cancer
    Kathlynn Brown; Fiscal Year: 2006
  3. A High Throughput Diagnostic Assay for Lung Cancer
    Kathlynn Brown; Fiscal Year: 2006
  4. Diagnostic & targeting reagents for lung cancer
    Kathlynn Brown; Fiscal Year: 2005
  5. Chemical & Biological Approaches for Cell Targeting
    Kathlynn Brown; Fiscal Year: 2004
  6. Chemical & Biological Approaches for Cell Targeting
    Kathlynn Brown; Fiscal Year: 2003
  7. Diagnostic & targeting reagents for lung cancer
    Kathlynn Brown; Fiscal Year: 2007
  8. Diagnostic & targeting reagents for lung cancer
    Kathlynn Brown; Fiscal Year: 2007

Collaborators

  • John Minna
  • Michael J McGuire
  • Kevin J Luebke
  • Jack Roth
  • Harold Garner
  • Jinming Gao
  • Shunzi Li
  • Kausar N Samli
  • Bethany Powell Gray
  • Jagadeesh Setti Guthi
  • Huili Guan
  • Ying Horng Liu
  • Anissa N Elayadi
  • Tsukasa Oyama
  • Christopher B Newgard
  • Jitakshi De
  • Ya Ching Chang
  • Stephen Albert Johnston
  • Xin Zhou
  • Tsuksa Oyama
  • Su Geun Yang
  • Gang Huang
  • Chalermchai Khemtong
  • Chase W Kessinger
  • Michael Peyton
  • Mai Lin
  • Xiankai Sun
  • Xian Jin Xie
  • Ignacio I Wistuba
  • Ludmila Prudkin
  • Aihua Bian
  • Jonathan C Schisler
  • Stephen A Johnston
  • Kathryn F Sykes

Detail Information

Publications17

  1. pmc Peptidic tumor targeting agents: the road from phage display peptide selections to clinical applications
    Kathlynn C Brown
    Division of Translational Medicine Departments of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9185, USA
    Curr Pharm Des 16:1040-54. 2010
    ..This review discusses the recent advances in the isolation of cancer-targeting peptides by unbiased biopanning methods and highlights the use of the isolated peptides in clinical applications...
  2. pmc Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancer
    Michael J McGuire
    1 Departments of Internal Medicine, University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX 75390 8807, USA 2 The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX 75390 8807, USA
    Sci Rep 4:4480. 2014
    ..This is the first comprehensive biopanning for isolation of high affinity peptidic ligands for a single cancer type and expands the diversity of NSCLC targeting ligands...
  3. pmc A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density
    Bethany Powell Gray
    Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 8:e72938. 2013
    ..Therefore, using a high affinity and high specificity ligand targeting an over-expressed tumor biomarker does not guarantee enhanced efficacy of a liposomal drug. These results highlight the complexity of in vivo targeting. ..
  4. pmc Synthesis and characterization of a high-affinity {alpha}v{beta}6-specific ligand for in vitro and in vivo applications
    Shunzi Li
    Division of Translational Research, Department of Internal Medicine, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9185, USA
    Mol Cancer Ther 8:1239-49. 2009
    ..We anticipate that this high-affinity ligand for α(v)β(6) will find clinical use as a diagnostic and therapeutic reagent...
  5. ncbi request reprint Patterning adhesion of mammalian cells with visible light, tris(bipyridyl)ruthenium(II) chloride, and a digital micromirror array
    Kevin J Luebke
    Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9185, USA
    J Biomed Mater Res A 68:696-703. 2004
    ..Using this method, regions of cellular adhesion were patterned with single-cell resolution...
  6. ncbi request reprint In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo
    Michael J McGuire
    Department of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas 75390 9185, USA
    J Mol Biol 342:171-82. 2004
    ..1 phage was associated with cardiomyocytes isolated from mice treated with a phage in vivo. These results demonstrate the utility of biopanning on isolated cells for identifying specific binding peptides that can target a tissue in vivo...
  7. ncbi request reprint A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer
    Anissa N Elayadi
    Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 67:5889-95. 2007
    ..Thus, cell-specific peptides isolated from phage biopanning can be used for the discovery of cell surface biomarkers, emphasizing the utility of peptide libraries to probe the surface of a cell...
  8. ncbi request reprint Novel ligands for cancer diagnosis: selection of peptide ligands for identification and isolation of B-cell lymphomas
    Michael J McGuire
    Division of Translational Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Exp Hematol 34:443-52. 2006
    ..New reagents that distinguish malignant cells and enable the isolation of these cells from the normal background will enhance the molecular characterization of disease and specificity of treatment...
  9. ncbi request reprint Isolation of lung tumor specific peptides from a random peptide library: generation of diagnostic and cell-targeting reagents
    Tsuksa Oyama
    Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9185, USA
    Cancer Lett 202:219-30. 2003
    ..The isolated peptides are functional outside of the context of the phage and multimerization of the peptide increases its affinity for its given cell type, thus expanding their utility in clinical situations...
  10. ncbi request reprint Peptide-mediated targeting of the islets of Langerhans
    Kausar N Samli
    Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9185, USA
    Diabetes 54:2103-8. 2005
    ..Furthermore, this peptide does not target beta-cells in a type 2 diabetes animal model, suggesting that the peptide can discriminate between glucose-stimulated insulin secretion-functional and -dysfunctional beta-cells...
  11. pmc Biopanning of phage displayed peptide libraries for the isolation of cell-specific ligands
    Michael J McGuire
    Division of Translational Research, Department of Internal Medicine and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 504:291-321. 2009
    ..In addition, we provide methods for the synthesis of the selected peptides as both monomers and tetramers. Downstream uses for the peptides are illustrated...
  12. pmc MRI-visible micellar nanomedicine for targeted drug delivery to lung cancer cells
    Jagadeesh Setti Guthi
    Department of Pharmacology, Simmons Comprehensive Cancer Center, Department of Internal Medicine, Division of Translational Research, and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Mol Pharm 7:32-40. 2010
    ..3 +/- 6.4 nM and 73.6 +/- 6.3 nM, respectively; p < 0.005). The integrated diagnostic and therapeutic design of MFM nanomedicine potentially allows for image-guided, target-specific treatment of lung cancer...
  13. ncbi request reprint Cell-specific delivery of a chemotherapeutic to lung cancer cells
    Xin Zhou
    Center for Biomedical Inventions and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9185, USA
    J Am Chem Soc 126:15656-7. 2004
    ..As such, we have demonstrated that cell-specific targeted drugs can be synthesized, even when the cell surface target is unknown...
  14. ncbi request reprint Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library
    Jitakshi De
    Center for Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9185, USA
    Mol Biosyst 1:149-57. 2005
    ..Furthermore, a general implication of our findings is that phage display methods may be useful for identifying peptides that target a broad array of other biological pathogens in a specific fashion...
  15. pmc Peptide-targeted polyglutamic acid doxorubicin conjugates for the treatment of alpha(v)beta(6)-positive cancers
    Huili Guan
    Division of Translational Research, Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Bioconjug Chem 19:1813-21. 2008
    ..Importantly, the conjugate is more cytotoxic toward a targeted cell than a cell line that does not express the integrin...
  16. ncbi request reprint A library-selected, Langerhans cell-targeting peptide enhances an immune response
    Michael J McGuire
    Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    DNA Cell Biol 23:742-52. 2004
    ..Furthermore, we demonstrate that a low-dose injection into mice of phage bearing the LC-targeting peptide yields faster and higher immune responses against phage-associated antigens than control-phage injections...
  17. ncbi request reprint Hitting the target with bifunctional phage
    Kathlynn C Brown
    Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Chem Biol 11:1033-5. 2004
    ..In this issue of Chemistry & Biology, Pasqualini and coworkers have developed a chimeric cell-targeting phage system that can easily be modified to delivery of a variety of reagents without need for chemical conjugation...

Research Grants10

  1. Chemical & Biological Approaches for Cell Targeting
    Kathlynn Brown; Fiscal Year: 2002
    ..Achieving our goals will impact vaccinology and immunomodulation therapies as well as solving many general problems in the area of cell-specific delivery in vivo. ..
  2. Diagnostic & targeting reagents for lung cancer
    Kathlynn Brown; Fiscal Year: 2006
    ..Achieving our goals will impact lung cancer diagnosis and treatment as well as solving general challenges in the field of targeted drug delivery. ..
  3. A High Throughput Diagnostic Assay for Lung Cancer
    Kathlynn Brown; Fiscal Year: 2006
    ..At the end of this pilot project we will have developed a novel diagnostic platform that can be expanded to clinical samples. Furthermore, the technologies developed here can be applied to other forms of cancer. ..
  4. Diagnostic & targeting reagents for lung cancer
    Kathlynn Brown; Fiscal Year: 2005
    ..Achieving our goals will impact lung cancer diagnosis and treatment as well as solving general challenges in the field of targeted drug delivery. ..
  5. Chemical & Biological Approaches for Cell Targeting
    Kathlynn Brown; Fiscal Year: 2004
    ..Achieving our goals will impact vaccinology and immunomodulation therapies as well as solving many general problems in the area of cell-specific delivery in vivo. ..
  6. Chemical & Biological Approaches for Cell Targeting
    Kathlynn Brown; Fiscal Year: 2003
    ..Achieving our goals will impact vaccinology and immunomodulation therapies as well as solving many general problems in the area of cell-specific delivery in vivo. ..
  7. Diagnostic & targeting reagents for lung cancer
    Kathlynn Brown; Fiscal Year: 2007
    ..Achieving our goals will impact lung cancer diagnosis and treatment as well as solving general challenges in the field of targeted drug delivery. ..
  8. Diagnostic & targeting reagents for lung cancer
    Kathlynn Brown; Fiscal Year: 2007
    ..Achieving our goals will impact lung cancer diagnosis and treatment as well as solving general challenges in the field of targeted drug delivery. ..