Helen J Brown

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activator
    Helen J Brown
    Department of Microbiology, Division of Hematology Oncology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 285:25139-53. 2010
  2. pmc Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 RTA reactivates murine gammaherpesvirus 68 from latency
    Tammy M Rickabaugh
    Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA 90095 1735, USA
    J Virol 79:3217-22. 2005
  3. pmc Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency
    Li Peng
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    J Gen Virol 91:463-9. 2010
  4. pmc Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection
    Tammy M Rickabaugh
    Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA
    J Virol 78:9215-23. 2004
  5. ncbi request reprint Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus
    Helen J Brown
    Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA
    Antivir Ther 10:745-51. 2005
  6. pmc beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA
    Margaret Chang
    Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    J Virol 79:13538-47. 2005
  7. pmc Primary cell model for activation-inducible human immunodeficiency virus
    Bryan Burke
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1678, USA
    J Virol 81:7424-34. 2007
  8. pmc Rapid expression of human immunodeficiency virus following activation of latently infected cells
    Philip A Arlen
    David Geffen School of Medicine, University of California Los Angeles, 11 934 Factor Building, 650 Charles Young Drive South, Los Angeles, CA 90095, USA
    J Virol 80:1599-603. 2006
  9. pmc NF-kappaB inhibits gammaherpesvirus lytic replication
    Helen J Brown
    Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 77:8532-40. 2003

Collaborators

Detail Information

Publications9

  1. pmc Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activator
    Helen J Brown
    Department of Microbiology, Division of Hematology Oncology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 285:25139-53. 2010
    ..The association with CREB also highlights a novel connection and coordination between viral and cellular "immediate early" responses...
  2. pmc Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 RTA reactivates murine gammaherpesvirus 68 from latency
    Tammy M Rickabaugh
    Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA 90095 1735, USA
    J Virol 79:3217-22. 2005
    ..Our data suggest that the species specificity of MHV-68 RTA resides in the N-terminal DNA binding domain...
  3. pmc Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency
    Li Peng
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    J Gen Virol 91:463-9. 2010
    ..The data suggest that the PI3K-Akt pathway suppresses the activity of RTA and thereby contributes to the maintenance of viral latency and promotes tumorigenesis...
  4. pmc Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection
    Tammy M Rickabaugh
    Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA
    J Virol 78:9215-23. 2004
    ..The present study, by using MHV-68 as an in vivo model system, demonstrated that RTA plays a critical role in the control of viral latency and suggests that latency is a determinant of viral pathogenesis in vivo...
  5. ncbi request reprint Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus
    Helen J Brown
    Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA
    Antivir Ther 10:745-51. 2005
    ....
  6. pmc beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA
    Margaret Chang
    Department of Microbiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    J Virol 79:13538-47. 2005
    ..These findings also suggest novel therapeutic strategies for controlling the activity of this oncogenic gammaherpesvirus in vivo...
  7. pmc Primary cell model for activation-inducible human immunodeficiency virus
    Bryan Burke
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1678, USA
    J Virol 81:7424-34. 2007
    ..This model can therefore be used to study intricate molecular aspects of activation-inducible HIV infection in primary cells...
  8. pmc Rapid expression of human immunodeficiency virus following activation of latently infected cells
    Philip A Arlen
    David Geffen School of Medicine, University of California Los Angeles, 11 934 Factor Building, 650 Charles Young Drive South, Los Angeles, CA 90095, USA
    J Virol 80:1599-603. 2006
    ..This hierarchy also held true for viral protein production. These results may explain the rapid reemergence of viremia following termination of therapy...
  9. pmc NF-kappaB inhibits gammaherpesvirus lytic replication
    Helen J Brown
    Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 77:8532-40. 2003
    ..They also suggest that NF-kappaB may be a novel target for the disruption of virus latency and therefore the treatment of gammaherpesvirus-related malignancies...