Dorothy C Brown

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model
    Dorothy Cimino Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Anesthesiology 103:1052-9. 2005
  2. pmc Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritis
    Dorothy Cimino Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Vet Res 68:631-7. 2007
  3. pmc Use of an activity monitor to detect response to treatment in dogs with osteoarthritis
    Dorothy Cimino Brown
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 237:66-70. 2010
  4. pmc Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma
    Dorothy Cimino Brown
    Veterinary Clinical Investigations Center, Department of Clinical Studies, School of Veterinary Medicine and University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104 6010, USA
    Evid Based Complement Alternat Med 2012:384301. 2012
  5. doi request reprint Comparison of force plate gait analysis and owner assessment of pain using the Canine Brief Pain Inventory in dogs with osteoarthritis
    D C Brown
    Department of Clinical Studies Veterinary Clinical Investigation Center, School of Veterinary Medicine, Philadelphia, PA 19104 6010, USA
    J Vet Intern Med 27:22-30. 2013
  6. ncbi request reprint Outcomes based medicine in veterinary surgery: getting hard measures of subjective outcomes
    Dorothy Cimino Brown
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Vet Surg 36:289-92. 2007
  7. doi request reprint Evaluation of the effect of signalment and body conformation on activity monitoring in companion dogs
    Dorothy Cimino Brown
    Department of Clinical Studies Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Vet Res 71:322-5. 2010
  8. ncbi request reprint Effect of intrathecal and intravenous administration of oxytocin on amplitude of the reflex-evoked muscle action potential after electrical stimulation of the tooth pulp in anesthetized dogs
    Dorothy C Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    Am J Vet Res 63:1354-8. 2002
  9. doi request reprint Comparison of surgical site infection rates in clean and clean-contaminated wounds in dogs and cats after minimally invasive versus open surgery: 179 cases (2007-2008)
    Philipp D Mayhew
    Matthew J Ryan Veterinary Hospital, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 240:193-8. 2012
  10. ncbi request reprint Complications associated with use of subcutaneous vascular access ports in cats and dogs undergoing fractionated radiotherapy: 172 cases (1996-2007)
    William T N Culp
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 236:1322-7. 2010

Research Grants

Detail Information

Publications38

  1. ncbi request reprint Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model
    Dorothy Cimino Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Anesthesiology 103:1052-9. 2005
    ..Following work in laboratory animals, the authors explored the use of intrathecal resiniferatoxin to control spontaneous bone cancer pain in companion (pet) dogs...
  2. pmc Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritis
    Dorothy Cimino Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Vet Res 68:631-7. 2007
    ..To develop and psychometrically test an owner self-administered questionnaire designed to assess severity and impact of chronic pain in dogs with osteoarthritis...
  3. pmc Use of an activity monitor to detect response to treatment in dogs with osteoarthritis
    Dorothy Cimino Brown
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 237:66-70. 2010
    ..To determine whether an activity monitor (AM) could be used to detect changes in activity in dogs with osteoarthritis treated with carprofen or a placebo...
  4. pmc Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma
    Dorothy Cimino Brown
    Veterinary Clinical Investigations Center, Department of Clinical Studies, School of Veterinary Medicine and University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104 6010, USA
    Evid Based Complement Alternat Med 2012:384301. 2012
    ..These data suggest that, for those cancer patients for whom advanced treatments are not accessible, PSP as a single agent might offer significant improvements in morbidity and mortality...
  5. doi request reprint Comparison of force plate gait analysis and owner assessment of pain using the Canine Brief Pain Inventory in dogs with osteoarthritis
    D C Brown
    Department of Clinical Studies Veterinary Clinical Investigation Center, School of Veterinary Medicine, Philadelphia, PA 19104 6010, USA
    J Vet Intern Med 27:22-30. 2013
    ..There are no studies comparing these 2 outcome measures...
  6. ncbi request reprint Outcomes based medicine in veterinary surgery: getting hard measures of subjective outcomes
    Dorothy Cimino Brown
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Vet Surg 36:289-92. 2007
  7. doi request reprint Evaluation of the effect of signalment and body conformation on activity monitoring in companion dogs
    Dorothy Cimino Brown
    Department of Clinical Studies Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Vet Res 71:322-5. 2010
    ..To evaluate the effect of signalment and body conformation on activity monitoring in companion dogs...
  8. ncbi request reprint Effect of intrathecal and intravenous administration of oxytocin on amplitude of the reflex-evoked muscle action potential after electrical stimulation of the tooth pulp in anesthetized dogs
    Dorothy C Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    Am J Vet Res 63:1354-8. 2002
    ....
  9. doi request reprint Comparison of surgical site infection rates in clean and clean-contaminated wounds in dogs and cats after minimally invasive versus open surgery: 179 cases (2007-2008)
    Philipp D Mayhew
    Matthew J Ryan Veterinary Hospital, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 240:193-8. 2012
    ..To report and compare the surgical site infection (SSI) rates for clean and clean-contaminated procedures performed by either a minimally invasive surgical or open surgical approach in a large population of dogs and cats...
  10. ncbi request reprint Complications associated with use of subcutaneous vascular access ports in cats and dogs undergoing fractionated radiotherapy: 172 cases (1996-2007)
    William T N Culp
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 236:1322-7. 2010
    ..To describe complications associated with use of a subcutaneous vascular access port (SVAP) in cats and dogs treated with fractionated radiotherapy and to determine predisposing factors for developing these complications...
  11. ncbi request reprint Use of noninvasive dental dolorimetry to evaluate analgesic effects of intravenous and intrathecal administration of morphine in anesthetized dogs
    Dorothy C Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    Am J Vet Res 63:1349-53. 2002
    ....
  12. pmc Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis
    Dorothy Cimino Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 233:1278-83. 2008
    ..To determine whether the Canine Brief Pain Inventory (CBPI) can detect changes in dogs with osteoarthritis treated with an NSAID or a placebo...
  13. doi request reprint Evaluation of outcome following urethral stent placement for the treatment of obstructive carcinoma of the urethra in dogs: 42 cases (2004-2008)
    Amanda L Blackburn
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 242:59-68. 2013
    ..To evaluate the outcome following urethral stent placement for the palliative treatment of obstructive carcinoma of the urethra in dogs...
  14. doi request reprint Case-control study of Staphylococcus lugdunensis infection isolates from small companion animals
    Kathryn A Rook
    Department of Clinical Studies Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Vet Dermatol 23:476-e90. 2012
    ..Little is known about the pathogenicity of S. lugdunensis in companion animals...
  15. ncbi request reprint Early nutritional support is associated with decreased length of hospitalization in dogs with septic peritonitis: A retrospective study of 45 cases (2000-2009)
    Debra T Liu
    Matthew J Ryan Veterinary Teaching Hospital, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Vet Emerg Crit Care (San Antonio) 22:453-9. 2012
    ..To determine whether the timing and route of nutritional support strategy affect length of hospitalization in dogs with naturally occurring septic peritonitis...
  16. ncbi request reprint Prognostic indicators for time to ambulation after surgical decompression in nonambulatory dogs with acute thoracolumbar disk extrusions: 112 cases
    Garrett J Davis
    Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, Philadelphia, USA
    Vet Surg 31:513-8. 2002
    ..To determine prognostic indicators for time to ambulation after surgical decompression in nonambulatory dogs with intact pain sensation and acute Hansen type-1 disk extrusions...
  17. ncbi request reprint Comparison of three techniques for ovarian pedicle hemostasis during laparoscopic-assisted ovariohysterectomy
    Philipp D Mayhew
    Department of Clinical Studies, Matthew J Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Vet Surg 36:541-7. 2007
    ..To describe the safety, surgical time, and complications associated with 3 techniques for achieving hemostasis during laparoscopic-assisted ovariohysterectomy (LAOVH)...
  18. doi request reprint Serologic prevalence of antibodies against canine influenza virus (H3N8) in dogs in a metropolitan animal shelter
    David E Holt
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 237:71-3. 2010
    ..To determine the prevalence of exposure to canine influenza virus (CIV) in dogs in a metropolitan animal shelter...
  19. doi request reprint Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases (1995-2008)
    William T N Culp
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    J Am Vet Med Assoc 242:1392-7. 2013
    ..To describe the clinical characteristics, treatments, outcomes, and factors associated with survival time in a cohort of dogs with lingual neoplasia that underwent surgical excision...
  20. pmc A novel approach to the use of animals in studies of pain: validation of the canine brief pain inventory in canine bone cancer
    Dorothy Cimino Brown
    Department of Clinical Studies, and Mari Lowe Center for Comparative Oncology Research, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6010, USA
    Pain Med 10:133-42. 2009
    ..To validate the Canine Brief Pain Inventory (CBPI), which is based on the human Brief Pain Inventory (BPI), in a canine model of spontaneous bone cancer...
  21. doi request reprint Blinding terminology used in reports of randomized controlled trials involving dogs and cats
    Michelle A Giuffrida
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 241:1221-6. 2012
    ..To review blinding terminology used in published reports of veterinary clinical randomized controlled trials (RCTs) and to determine how practicing veterinarians interpret blinding terminology...
  22. pmc Exfoliative cutaneous lupus erythematosus in German shorthaired pointer dogs: disease development, progression and evaluation of three immunomodulatory drugs (ciclosporin, hydroxychloroquine, and adalimumab) in a controlled environment
    Elizabeth A Mauldin
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3850 Spruce Street Philadelphia, PA 19104, USA
    Vet Dermatol 21:373-82. 2010
    ..The study documents the progression of ECLE and generally poor response to therapy...
  23. doi request reprint Ionized calcium concentrations in cats with septic peritonitis: 55 cases (1990-2008)
    Lindsay M Kellett-Gregory
    Section of Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Vet Emerg Crit Care (San Antonio) 20:398-405. 2010
    ..To report the prevalence of ionized hypocalcemia (iHCa) in cats with septic peritonitis, and to determine whether hypocalcemic cats had increased morbidity and mortality when compared with normocalcemic cats...
  24. ncbi request reprint Ease of oral administration and owner-perceived acceptability of triglyceride oil, dissolving thin film strip, and gelatin capsule formulations to healthy cats
    Anne M Traas
    Veterinary Clinical Investigation Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Vet Res 71:610-4. 2010
    ..To compare owner-assessed ease of administration and overall acceptability of 3 chemically inactive formulations administered PO to cats...
  25. doi request reprint Feline cholangitis: a necropsy study of 44 cats (1986-2008)
    Julie E Callahan Clark
    Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, 3800 Spruce St, PA 19104, USA
    J Feline Med Surg 13:570-6. 2011
    ..We conclude that cholangitis is not a common cause of feline mortality. Most cats that succumb to cholangitis have ANC or CNC, and concurrent disease contributes to death in many...
  26. doi request reprint The effect of laparoscopic versus open ovariectomy on postsurgical activity in small dogs
    William T N Culp
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Vet Surg 38:811-7. 2009
    ....
  27. doi request reprint Use of indwelling, double-pigtail stents for treatment of malignant ureteral obstruction in dogs: 12 cases (2006-2009)
    Allyson C Berent
    The Matthew J Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 238:1017-25. 2011
    ..To determine the outcome of minimally invasive ureteral stent placement for dogs with malignant ureteral obstructions. DESIGN-Retrospective case series...
  28. ncbi request reprint Prospective evaluation of two intracorporeally sutured prophylactic laparoscopic gastropexy techniques compared with laparoscopic-assisted gastropexy in dogs
    Philipp D Mayhew
    Department of Clinical Studies, Matthew J Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, PA, USA
    Vet Surg 38:738-46. 2009
    ..To report technique, surgical time, complication rate, and postoperative activity in dogs undergoing 2 intracorporeally-sutured total laparoscopic gastropexy (TLG) techniques compared with a laparoscopic-assisted gastropexy (LAG) technique...
  29. doi request reprint Prevalence of regional and distant metastasis in cats with advanced oral squamous cell carcinoma: 49 cases (2005-2011)
    Maria M Soltero-Rivera
    Mari Lowe Center for Comparative Oncology, Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
    J Feline Med Surg 16:164-9. 2014
    ....
  30. doi request reprint Major abdominal evisceration injuries in dogs and cats: 12 cases (1998-2008)
    Sara B Gower
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 234:1566-72. 2009
    ..CONCLUSIONS AND CLINICAL RELEVANCE- Despite the dramatic appearance of major abdominal evisceration in cats and dogs, prompt and aggressive medical and surgical intervention can provide a favorable outcome...
  31. pmc Evaluation of optimal sampling interval for activity monitoring in companion dogs
    Caitlin Dow
    Veterinary Clinical Investigations Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Vet Res 70:444-8. 2009
    ..For dogs that have no change in routine according to the owner's report, the least variable estimates of activity can be collected by comparing activity in 7-day intervals...
  32. doi request reprint Perceptions and priorities of owners of dogs with heart disease regarding quality versus quantity of life for their pets
    Mark A Oyama
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 233:104-8. 2008
    ..To describe the relative importance of pets' quality versus quantity of life among owners of dogs with heart disease...
  33. ncbi request reprint Sources and handling of losses to follow-up in parallel-group randomized clinical trials in dogs and cats: 63 trials (2000-2005)
    Dorothy Cimino Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Am J Vet Res 68:694-8. 2007
    ..To determine the sources and handlingof losses to follow-up (LTF) in parallel-group randomized clinical trials (RCTs)...
  34. ncbi request reprint Epidemiologic evaluation of postoperative wound infection in clean-contaminated wounds: A retrospective study of 239 dogs and cats
    Matthew Nicholson
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Vet Surg 31:577-81. 2002
    ..To evaluate risk factors for development of postoperative wound infections in clean-contaminated wounds...
  35. ncbi request reprint Outcome of and prognostic indicators for dogs and cats with pneumoperitoneum and no history of penetrating trauma: 54 cases (1988-2002)
    Jennifer A Smelstoys
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    J Am Vet Med Assoc 225:251-5. 2004
    ..To determine the outcome of and prognostic indicators for dogs and cats with pneumoperitoneum and no history of penetrating trauma...
  36. ncbi request reprint Control of selection bias in parallel-group controlled clinical trials in dogs and cats: 97 trials (2000-2005)
    Dorothy Cimino Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    J Am Vet Med Assoc 229:990-3. 2006
    ..To determine how selection bias (allocation bias) was controlled in published clinical trials...
  37. doi request reprint Thoracoscopic subphrenic pericardectomy using double-lumen endobronchial intubation for alternating one-lung ventilation
    Kelli N Mayhew
    Department of Clinical Studies, Matthew J Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, PA, USA
    Vet Surg 38:961-6. 2009
    ..To report the technique, complications, and effectiveness of thoracoscopic subphrenic pericardectomy (SPP) using double-lumen endobronchial intubation for alternating 1-lung (OLV) in healthy dogs...
  38. ncbi request reprint Measurement of resiniferatoxin in serum samples by high-performance liquid chromatography
    Andrew J Mannes
    DASS NIH, Building 49, Room 1A08, 49 Convent Drive Bethesda, MD 20892, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 823:184-8. 2005
    ..Therefore, the procedure described provides a useful assay for determination of serum RTX pharmacokinetic parameters...

Research Grants2

  1. Measure Validation and RCT- Dog Bone Cancer Pain Model
    Dorothy Brown; Fiscal Year: 2007
    ....