Deborah M Brown

Summary

Affiliation: University of Nebraska
Country: USA

Publications

  1. pmc Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection
    Deborah M Brown
    School of Biological Sciences, Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, Nebraska, USA
    J Virol 86:6792-803. 2012
  2. pmc Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy
    Deborah M Brown
    University of Nebraska Lincoln, School of Biological Sciences and Nebraska Center for Virology, Lincoln, NE 68583 0900, USA
    Cell Immunol 262:89-95. 2010
  3. pmc IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells
    Deborah M Brown
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Cell Immunol 257:69-79. 2009
  4. ncbi request reprint Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response
    Dawn M Jelley-Gibbs
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    J Immunol 178:7563-70. 2007
  5. ncbi request reprint CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch
    Deborah M Brown
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 177:2888-98. 2006
  6. ncbi request reprint Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation
    Javed N Agrewala
    Trudeau Institute Inc, Saranac Lake, New York 12983, USA
    J Biol Chem 282:6106-15. 2007
  7. pmc CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza
    Susan L Swain
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 211:8-22. 2006
  8. pmc Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation
    Dawn M Jelley-Gibbs
    Trudeau Institute Inc, Saranac Lake, NY 12983, USA
    J Exp Med 202:697-706. 2005
  9. ncbi request reprint Uneven distribution of MHC class II epitopes within the influenza virus
    Sherry R Crowe
    Trudeau Institute, 154 Algoquin Ave, Saranac Lake, NY 12983, USA
    Vaccine 24:457-67. 2006
  10. pmc Control of early Theiler's murine encephalomyelitis virus replication in macrophages by interleukin-6 occurs in conjunction with STAT1 activation and nitric oxide production
    Tyler C Moore
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA
    J Virol 86:10841-51. 2012

Collaborators

Detail Information

Publications16

  1. pmc Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection
    Deborah M Brown
    School of Biological Sciences, Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, Nebraska, USA
    J Virol 86:6792-803. 2012
    ..Taken together, these data strengthen the concept that CD4 T cell effectors are broadly multifunctional with direct roles in promoting protection against lethal influenza virus infection...
  2. pmc Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy
    Deborah M Brown
    University of Nebraska Lincoln, School of Biological Sciences and Nebraska Center for Virology, Lincoln, NE 68583 0900, USA
    Cell Immunol 262:89-95. 2010
    ..Therefore, vaccine strategies aimed at targeting CD4 CTL should be developed in conjunction with vaccines incorporating B cell and CD8 CTL epitopes...
  3. pmc IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells
    Deborah M Brown
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Cell Immunol 257:69-79. 2009
    ..These data have implications for the design of vaccines that may induce cytolytic CD4 cells in vivo and improve cell-mediated immunity to viral and bacterial infections...
  4. ncbi request reprint Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response
    Dawn M Jelley-Gibbs
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    J Immunol 178:7563-70. 2007
    ....
  5. ncbi request reprint CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch
    Deborah M Brown
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 177:2888-98. 2006
    ....
  6. ncbi request reprint Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation
    Javed N Agrewala
    Trudeau Institute Inc, Saranac Lake, New York 12983, USA
    J Biol Chem 282:6106-15. 2007
    ..These data also argue that memory cells in lymphoid sites are longer lived and not in equilibrium with those in non-lymphoid sites...
  7. pmc CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza
    Susan L Swain
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 211:8-22. 2006
    ....
  8. pmc Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation
    Dawn M Jelley-Gibbs
    Trudeau Institute Inc, Saranac Lake, NY 12983, USA
    J Exp Med 202:697-706. 2005
    ..Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained...
  9. ncbi request reprint Uneven distribution of MHC class II epitopes within the influenza virus
    Sherry R Crowe
    Trudeau Institute, 154 Algoquin Ave, Saranac Lake, NY 12983, USA
    Vaccine 24:457-67. 2006
    ....
  10. pmc Control of early Theiler's murine encephalomyelitis virus replication in macrophages by interleukin-6 occurs in conjunction with STAT1 activation and nitric oxide production
    Tyler C Moore
    School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, USA
    J Virol 86:10841-51. 2012
    ..These results indicate that immediate-early production of IL-6 could protect macrophages from TMEV infection...
  11. ncbi request reprint CD4 T cell responses to influenza infection
    Deborah M Brown
    Trudeau Institute, Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Semin Immunol 16:171-7. 2004
    ..We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets...
  12. doi request reprint Interferon response factor 3 is crucial to poly-I:C induced NK cell activity and control of B16 melanoma growth
    Tyler C Moore
    School of Biological Sciences, University of Nebraska Lincoln, United States
    Cancer Lett 346:122-8. 2014
    ..Thus, IRF3 is a key factor controlling melanoma growth through NK-cell activities, especially during poly-I:C therapy. ..
  13. pmc IRF3 helps control acute TMEV infection through IL-6 expression but contributes to acute hippocampus damage following TMEV infection
    Tyler C Moore
    School of Biological Sciences, University of Nebraska Lincoln, United States
    Virus Res 178:226-33. 2013
    ..Altogether, IRF3 contributes to early control of TMEV replication through induction of IL-6 and IFN-β and support of IL-6 antiviral effects, but contributes to TMEV-induced hippocampal injury. ..
  14. ncbi request reprint CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency
    Timothy J Powell
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Clin Immunol 113:89-100. 2004
    ..These studies demonstrate how CD8(+) and CD4(+) T cells respond to influenza at early time points postinfection and the differential kinetics of antigen-specific CD4(+) and CD8(+) T cells...
  15. ncbi request reprint Regulation of memory CD4 T cells: generation, localization and persistence
    Susan L Swain
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Adv Exp Med Biol 512:113-20. 2002
  16. pmc IRF3 polymorphisms induce different innate anti-Theiler's virus immune responses in RAW264.7 macrophages
    Tyler C Moore
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, NE 68583 0740, USA
    Virology 418:40-8. 2011
    ..Therefore IRF3 polymorphisms contribute to viral persistence and altered cytokine expression...