Affiliation: University of Missouri
Hilliard K, Brown C. Treatment of Borrelia burgdorferi-Infected Mice with Apoptotic Cells Attenuates Lyme Arthritis via PPAR-γ. J Immunol. 2019;202:1798-1806 pubmed publisher
..PPAR-γ agonists, such as rosiglitazone, may therefore be effective treatments for inducing arthritis resolution. ..
Brown C, Blaho V, Loiacono C. Treatment of mice with the neutrophil-depleting antibody RB6-8C5 results in early development of experimental lyme arthritis via the recruitment of Gr-1- polymorphonuclear leukocyte-like cells. Infect Immun. 2004;72:4956-65 pubmed
Lasky C, Olson R, Brown C. Macrophage Polarization during Murine Lyme Borreliosis. Infect Immun. 2015;83:2627-35 pubmed publisher
..These results highlight differences in the inflammatory infiltrates during Lyme arthritis and carditis and demonstrate the coexistence of multiple macrophage subsets within a single inflammatory site. ..
Lasky C, Jamison K, Sidelinger D, Pratt C, Zhang G, Brown C. Infection of Interleukin 17 Receptor A-Deficient C3H Mice with Borrelia burgdorferi Does Not Affect Their Development of Lyme Arthritis and Carditis. Infect Immun. 2015;83:2882-8 pubmed publisher
..These results demonstrate a limited role for IL-17 signaling through IL-17RA in the development of disease following infection of C3H mice with B. burgdorferi. ..
Brown C, Blaho V, Loiacono C. Susceptibility to experimental Lyme arthritis correlates with KC and monocyte chemoattractant protein-1 production in joints and requires neutrophil recruitment via CXCR2. J Immunol. 2003;171:893-901 pubmed
..These results suggest that chemokine-mediated recruitment of neutrophils into the infected joint is a key requirement for the development of experimental Lyme arthritis. ..
Brown C, Blaho V, Fritsche K, Loiacono C. Stat1 deficiency exacerbates carditis but not arthritis during experimental lyme borreliosis. J Interferon Cytokine Res. 2006;26:390-9 pubmed
Zhang Y, Olson R, Brown C. Macrophage LTB4 drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2. J Lipid Res. 2017;58:494-503 pubmed publisher
..This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BLT1. ..
Brown C, Dennis E. Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis. Biochimie. 2017;141:86-90 pubmed publisher
..These differences should be kept in mind when designing therapies and treatments for inflammatory diseases. ..