Candice M Brown

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative
    Phyllis M Wise
    Division of Biological Sciences, University of California Davis, One Shields Avenue, Davis, California 95616 8536, USA
    Endocr Rev 26:308-12. 2005
  2. ncbi Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions
    Shotaro Suzuki
    Department of Physiology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 104:6013-8. 2007
  3. ncbi Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury
    Candice M Brown
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Exp Neurol 210:782-7. 2008
  4. ncbi The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol
    Candice M Brown
    Division of Neurology, Duke University Medical Center, Durham, NC 27710, United States
    Neurobiol Aging 29:1783-94. 2008
  5. ncbi Estradiol is a potent protective, restorative, and trophic factor after brain injury
    Candice M Brown
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    Semin Reprod Med 27:240-9. 2009
  6. ncbi Androgen-mediated immune function is altered by the apolipoprotein E gene
    Candice M Brown
    Division of Neurology, Duke University Medical Center, Box 2900, Durham, North Carolina 27710, USA
    Endocrinology 148:3383-90. 2007
  7. ncbi APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress
    Carol A Colton
    Division of Neurology, Duke University Medical Center, Box 2900, Bryan Research Building, Durham, NC 27710, USA
    Neurobiol Aging 23:777-85. 2002
  8. ncbi APOE genotype-specific differences in the innate immune response
    Michael P Vitek
    Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 30:1350-60. 2009
  9. ncbi Neuroprotective effects of estrogens following ischemic stroke
    Shotaro Suzuki
    Departments of Physiology and Biophysics, and Biology, University of Washington, Seattle, WA 98195 1237, USA
    Front Neuroendocrinol 30:201-11. 2009
  10. ncbi Sex steroids, APOE genotype and the innate immune system
    Carol A Colton
    Division of Neurology, Duke University Medical Center, Box 2900, Bryan Research Bldg, Durham, NC 27710, USA
    Neurobiol Aging 26:363-72. 2005

Research Grants

  1. Anti-inflammatory properties of estradiol during stroke
    Candice Brown; Fiscal Year: 2007

Collaborators

Detail Information

Publications16

  1. ncbi Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative
    Phyllis M Wise
    Division of Biological Sciences, University of California Davis, One Shields Avenue, Davis, California 95616 8536, USA
    Endocr Rev 26:308-12. 2005
    ..Together, these results carry broad implications for the selective targeting of estrogen receptors in the treatment of neurodegenerative conditions resulting from disease or injury, particularly for aging, postmenopausal women...
  2. ncbi Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions
    Shotaro Suzuki
    Department of Physiology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 104:6013-8. 2007
    ..Our findings may help to explain the results of the Women's Health initiative that reported no beneficial effect of ET against stroke because the majority of the subjects initiated ET after an extended period of hypoestrogenicity...
  3. ncbi Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury
    Candice M Brown
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Exp Neurol 210:782-7. 2008
    ..These results show that the pro-inflammatory actions of iNOS exacerbate stroke-induced injury within the cortex and striatum, and that iNOS deletion is neuroprotective in ovariectomized and estrogen-replaced female mice...
  4. ncbi The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol
    Candice M Brown
    Division of Neurology, Duke University Medical Center, Durham, NC 27710, United States
    Neurobiol Aging 29:1783-94. 2008
    ....
  5. ncbi Estradiol is a potent protective, restorative, and trophic factor after brain injury
    Candice M Brown
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    Semin Reprod Med 27:240-9. 2009
    ....
  6. ncbi Androgen-mediated immune function is altered by the apolipoprotein E gene
    Candice M Brown
    Division of Neurology, Duke University Medical Center, Box 2900, Durham, North Carolina 27710, USA
    Endocrinology 148:3383-90. 2007
    ..Thus, our data suggest that DHT modulation of kinase activity is altered in microglia from mice expressing an APOE4 genotype and may impact androgen treatment therapies in individuals with an APOE4 genotype...
  7. ncbi APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress
    Carol A Colton
    Division of Neurology, Duke University Medical Center, Box 2900, Bryan Research Building, Durham, NC 27710, USA
    Neurobiol Aging 23:777-85. 2002
    ....
  8. ncbi APOE genotype-specific differences in the innate immune response
    Michael P Vitek
    Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 30:1350-60. 2009
    ..Overall, these data emphasize the important role of apolipoprotein E and of the APOE genotype on the immune responses that are evident in most, if not all, neurological disease...
  9. ncbi Neuroprotective effects of estrogens following ischemic stroke
    Shotaro Suzuki
    Departments of Physiology and Biophysics, and Biology, University of Washington, Seattle, WA 98195 1237, USA
    Front Neuroendocrinol 30:201-11. 2009
    ..These findings may carry far reaching implications for improving the quality of life in aging populations...
  10. ncbi Sex steroids, APOE genotype and the innate immune system
    Carol A Colton
    Division of Neurology, Duke University Medical Center, Box 2900, Bryan Research Bldg, Durham, NC 27710, USA
    Neurobiol Aging 26:363-72. 2005
    ..These data re-enforce the concept that classical activation in macrophages has multiple levels of regulation, dictated by competing or synergistic factors and genotype...
  11. ncbi Estradiol: a hormone with diverse and contradictory neuroprotective actions
    Phyllis M Wise
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195 1237, USA
    Dialogues Clin Neurosci 11:297-303. 2009
    ..Only then will we have a better understanding of the impact of hormones on the menopausal and postmenopausal period in a woman's life...
  12. ncbi Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta
    Candice M Brown
    Department of Physiology and Biophysics, University of Washington, Box 356460, Seattle, Washington 98195 4640, USA
    Endocrinology 151:4916-25. 2010
    ..Taken together, these studies identify a dramatic cytokine- and chemokine-mediated neuroinflammatory response that is regulated through ERα- and ERβ-mediated ligand-dependent and ligand-independent mechanisms...
  13. ncbi Apolipoprotein E isoform mediated regulation of nitric oxide release
    Candice M Brown
    University Program in Genetics, Department of Medicine (Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 32:1071-5. 2002
    ..These data suggest a potentially novel mechanism for gender-dependent and apoE isoform-dependent immune responses that parallel the genetic susceptibility of APOE4 carriers for the development of Alzheimer's disease...
  14. ncbi Apolipoprotein-E allele-specific regulation of nitric oxide production
    Carola A Colton
    Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 962:212-25. 2002
    ..The inappropriate levels of arginine transport and of NO in the presence of the APOE4 compared to the APOE3 gene and its products are likely to have significant impact in the CNS...
  15. ncbi Simultaneous determination of 6 L-arginine metabolites in human and mouse plasma by using hydrophilic-interaction chromatography and electrospray tandem mass spectrometry
    Candice M Brown
    Departments of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA, USA
    Clin Chem 57:701-9. 2011
    ..Methods to measure metabolites within the nitric oxide synthase/arginase pathways could provide insights into local and systemic inflammatory processes...
  16. ncbi Mechanisms of neuroprotection by estrogen
    Shotaro Suzuki
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA 95616, USA
    Endocrine 29:209-15. 2006
    ..As we uncover the important protective roles of ovarian steroid hormones in brain disease and injury, we increasingly appreciate that the mechanisms by which estrogens achieve these effects are diverse and complex...

Research Grants2

  1. Anti-inflammatory properties of estradiol during stroke
    Candice Brown; Fiscal Year: 2007
    ..Completion of these studies will enhance our understanding of the complex ways that 17beta-estradiol protects during neurological injury. ..