Candice M Brown
Affiliation: University of Washington
- Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiativePhyllis M Wise
Division of Biological Sciences, University of California Davis, One Shields Avenue, Davis, California 95616 8536, USA
Endocr Rev 26:308-12. 2005..Together, these results carry broad implications for the selective targeting of estrogen receptors in the treatment of neurodegenerative conditions resulting from disease or injury, particularly for aging, postmenopausal women...
- Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actionsShotaro Suzuki
Department of Physiology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 104:6013-8. 2007..Our findings may help to explain the results of the Women's Health initiative that reported no beneficial effect of ET against stroke because the majority of the subjects initiated ET after an extended period of hypoestrogenicity...
- Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injuryCandice M Brown
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
Exp Neurol 210:782-7. 2008..These results show that the pro-inflammatory actions of iNOS exacerbate stroke-induced injury within the cortex and striatum, and that iNOS deletion is neuroprotective in ovariectomized and estrogen-replaced female mice...
- The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiolCandice M Brown
Division of Neurology, Duke University Medical Center, Durham, NC 27710, United States
Neurobiol Aging 29:1783-94. 2008....
- Estradiol is a potent protective, restorative, and trophic factor after brain injuryCandice M Brown
Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
Semin Reprod Med 27:240-9. 2009....
- Androgen-mediated immune function is altered by the apolipoprotein E geneCandice M Brown
Division of Neurology, Duke University Medical Center, Box 2900, Durham, North Carolina 27710, USA
Endocrinology 148:3383-90. 2007..Thus, our data suggest that DHT modulation of kinase activity is altered in microglia from mice expressing an APOE4 genotype and may impact androgen treatment therapies in individuals with an APOE4 genotype...
- APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stressCarol A Colton
Division of Neurology, Duke University Medical Center, Box 2900, Bryan Research Building, Durham, NC 27710, USA
Neurobiol Aging 23:777-85. 2002....
- APOE genotype-specific differences in the innate immune responseMichael P Vitek
Duke University Medical Center, Durham, NC 27710, USA
Neurobiol Aging 30:1350-60. 2009..Overall, these data emphasize the important role of apolipoprotein E and of the APOE genotype on the immune responses that are evident in most, if not all, neurological disease...
- Neuroprotective effects of estrogens following ischemic strokeShotaro Suzuki
Departments of Physiology and Biophysics, and Biology, University of Washington, Seattle, WA 98195 1237, USA
Front Neuroendocrinol 30:201-11. 2009..These findings may carry far reaching implications for improving the quality of life in aging populations...
- Sex steroids, APOE genotype and the innate immune systemCarol A Colton
Division of Neurology, Duke University Medical Center, Box 2900, Bryan Research Bldg, Durham, NC 27710, USA
Neurobiol Aging 26:363-72. 2005..These data re-enforce the concept that classical activation in macrophages has multiple levels of regulation, dictated by competing or synergistic factors and genotype...
- Estradiol: a hormone with diverse and contradictory neuroprotective actionsPhyllis M Wise
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195 1237, USA
Dialogues Clin Neurosci 11:297-303. 2009..Only then will we have a better understanding of the impact of hormones on the menopausal and postmenopausal period in a woman's life...
- Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and betaCandice M Brown
Department of Physiology and Biophysics, University of Washington, Box 356460, Seattle, Washington 98195 4640, USA
Endocrinology 151:4916-25. 2010..Taken together, these studies identify a dramatic cytokine- and chemokine-mediated neuroinflammatory response that is regulated through ERα- and ERβ-mediated ligand-dependent and ligand-independent mechanisms...
- Apolipoprotein E isoform mediated regulation of nitric oxide releaseCandice M Brown
University Program in Genetics, Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 32:1071-5. 2002..These data suggest a potentially novel mechanism for gender-dependent and apoE isoform-dependent immune responses that parallel the genetic susceptibility of APOE4 carriers for the development of Alzheimer's disease...
- Apolipoprotein-E allele-specific regulation of nitric oxide productionCarola A Colton
Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann N Y Acad Sci 962:212-25. 2002..The inappropriate levels of arginine transport and of NO in the presence of the APOE4 compared to the APOE3 gene and its products are likely to have significant impact in the CNS...
- Arginine deprivation and immune suppression in a mouse model of Alzheimer's diseaseMatthew J Kan
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710
J Neurosci 35:5969-82. 2015..Our findings strongly implicate local immune-mediated amino acid catabolism as a novel and potentially critical mechanism mediating the age-dependent and regional loss of neurons in humans with AD. ..
- Simultaneous determination of 6 L-arginine metabolites in human and mouse plasma by using hydrophilic-interaction chromatography and electrospray tandem mass spectrometryCandice M Brown
Departments of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA, USA
Clin Chem 57:701-9. 2011..Methods to measure metabolites within the nitric oxide synthase/arginase pathways could provide insights into local and systemic inflammatory processes...
- Mechanisms of neuroprotection by estrogenShotaro Suzuki
Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA 95616, USA
Endocrine 29:209-15. 2006..As we uncover the important protective roles of ovarian steroid hormones in brain disease and injury, we increasingly appreciate that the mechanisms by which estrogens achieve these effects are diverse and complex...