Holly M Brown-Borg

Summary

Affiliation: University of North Dakota
Country: USA

Publications

  1. ncbi Antioxidative mechanisms and plasma growth hormone levels: potential relationship in the aging process
    H M Brown-Borg
    Department of Physiology, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58203 9037, USA
    Endocrine 11:41-8. 1999
  2. pmc Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha)
    Beena Vallanat
    NHEERL Toxicogenomics Core, US EPA, Research Triangle Park, NC 27711, USA
    BMC Genomics 11:16. 2010
  3. ncbi Growth hormone alters components of the glutathione metabolic pathway in Ames dwarf mice
    Holly M Brown-Borg
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Ann N Y Acad Sci 1019:317-20. 2004
  4. ncbi Growth hormone administration to long-living dwarf mice alters multiple components of the antioxidative defense system
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Mech Ageing Dev 124:1013-24. 2003
  5. ncbi Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Mech Ageing Dev 126:389-98. 2005
  6. ncbi Glutathione metabolism in long-living Ames dwarf mice
    H M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Exp Gerontol 40:115-20. 2005
  7. ncbi Hormonal regulation of aging and life span
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA
    Trends Endocrinol Metab 14:151-3. 2003
  8. pmc Long-living growth hormone receptor knockout mice: potential mechanisms of altered stress resistance
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Exp Gerontol 44:10-9. 2009
  9. doi Hormonal control of aging in rodents: the somatotropic axis
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, United States
    Mol Cell Endocrinol 299:64-71. 2009
  10. pmc Hormonal regulation of longevity in mammals
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Ageing Res Rev 6:28-45. 2007

Collaborators

Detail Information

Publications38

  1. ncbi Antioxidative mechanisms and plasma growth hormone levels: potential relationship in the aging process
    H M Brown-Borg
    Department of Physiology, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58203 9037, USA
    Endocrine 11:41-8. 1999
    ..Animals deficient in GH (dwarf) live longer and exhibit enzyme activities and levels that may combat oxidative stress more efficiently than normal mice and those overexpressing GH...
  2. pmc Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha)
    Beena Vallanat
    NHEERL Toxicogenomics Core, US EPA, Research Triangle Park, NC 27711, USA
    BMC Genomics 11:16. 2010
    ..Many of these genes are also transcriptionally regulated by heat shock (HS) through activation by HS factor-1 (HSF1). We hypothesized that there are interactions on a genetic level between PPARalpha and the HS response mediated by HSF1...
  3. ncbi Growth hormone alters components of the glutathione metabolic pathway in Ames dwarf mice
    Holly M Brown-Borg
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Ann N Y Acad Sci 1019:317-20. 2004
    ..05). Taken together, the current results along with data from previous studies support a role for growth hormone in the regulation of antioxidative defense and, ultimately, life span in organisms with altered GH or IGF-1 signaling...
  4. ncbi Growth hormone administration to long-living dwarf mice alters multiple components of the antioxidative defense system
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Mech Ageing Dev 124:1013-24. 2003
    ..Reductions in GH and IGF-1 signaling contribute to extended life spans in a variety of species, which may be partially explained by an increased ability to neutralize deleterious byproducts of metabolism...
  5. ncbi Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Mech Ageing Dev 126:389-98. 2005
    ..Taken together, the current results along with data from previous studies support a role for growth hormone in the regulation of antioxidative defense and ultimately, life span in organisms with altered GH or IGF-1 signaling...
  6. ncbi Glutathione metabolism in long-living Ames dwarf mice
    H M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Exp Gerontol 40:115-20. 2005
    ..0001). Results of these experiments coupled with previous data provide a mechanism to partially explain the enhanced resistance to oxidative insult and conceivably, the extended longevity of dwarf mice...
  7. ncbi Hormonal regulation of aging and life span
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA
    Trends Endocrinol Metab 14:151-3. 2003
    ..This, along with other recent evidence, could provide clues towards potential therapeutic intervention to extend life span in humans...
  8. pmc Long-living growth hormone receptor knockout mice: potential mechanisms of altered stress resistance
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Exp Gerontol 44:10-9. 2009
    ..The results of these experiments suggest that these pathways may be partially responsible for differences observed in stress resistance and the capacity to respond to stressors, that in the long term, affect health and life span...
  9. doi Hormonal control of aging in rodents: the somatotropic axis
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, United States
    Mol Cell Endocrinol 299:64-71. 2009
    ..This information, along with that found in multiple other species, implicates this anabolic pathway as the major regulator of longevity in animals...
  10. pmc Hormonal regulation of longevity in mammals
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Ageing Res Rev 6:28-45. 2007
    ....
  11. ncbi Effects of growth hormone and insulin-like growth factor-1 on hepatocyte antioxidative enzymes
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    Exp Biol Med (Maywood) 227:94-104. 2002
    ....
  12. ncbi Catalase expression in delayed and premature aging mouse models
    H M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203 2817, USA
    Exp Gerontol 35:199-212. 2000
    ....
  13. ncbi Antiaging supplement holds promise to halt age-related cognitive deterioration
    H M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    Exp Biol Med (Maywood) 229:367-8. 2004
  14. ncbi Long-lived Ames dwarf mouse exhibits increased antioxidant defense in skeletal muscle
    Mark A Romanick
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Mech Ageing Dev 125:269-81. 2004
    ..These results suggest there are biological differences with regard to antioxidant defense that favor the Ames dwarf mouse in active and resting skeletal muscle when compared to wild type mice...
  15. ncbi Increases in insulin-like growth factor-1 level and peroxidative damage after gestational ethanol exposure in rats
    Jun Ren
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Pharmacol Res 47:341-7. 2003
    ..Collectively, these data suggest that gestational ethanol exposure may lead to postpartum oxidative organ damage and a possible compensatory increase in organ IGF-1 levels...
  16. doi Spatial memory is enhanced in long-living Ames dwarf mice and maintained following kainic acid induced neurodegeneration
    Sunita Sharma
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    Mech Ageing Dev 131:422-35. 2010
    ..Ames dwarf mice are long-lived animals that exhibit peripheral IGF-1 deficiency. Hippocampal-based spatial memory (a homolog of cognitive function) has not been evaluated in these long-living mice...
  17. ncbi Long-living Ames dwarf mouse hepatocytes readily undergo apoptosis
    Melissa A Kennedy
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Exp Gerontol 38:997-1008. 2003
    ....
  18. pmc GH and IGF1: roles in energy metabolism of long-living GH mutant mice
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58202 9037, USA
    J Gerontol A Biol Sci Med Sci 67:652-60. 2012
    ..Thus, several important components related to energy metabolism are altered in GH mutant mice, and these differences are likely critical in aging processes and life-span extension...
  19. pmc NMDA and kainate receptor expression, long-term potentiation, and neurogenesis in the hippocampus of long-lived Ames dwarf mice
    Sunita Sharma
    Department of Physiology, Pharmacology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA
    Age (Dordr) 34:609-20. 2012
    ....
  20. pmc Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Rd, Grand Forks, ND 58203, USA
    Age (Dordr) 34:43-57. 2012
    ..The increased OXPHOS activities, along with lower ROS production in dwarf mice, predict enhanced mitochondrial function and efficiency, two factors likely contributing to long-life in Ames mice...
  21. ncbi Altered methionine metabolism in long living Ames dwarf mice
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, P O Box 9034, Grand Forks, ND 58202, USA
    Exp Gerontol 38:491-8. 2003
    ..Taken together, the data suggest that methionine metabolism may play a role in oxidative defense in the dwarf mouse and should be studied as a potential mechanism of extended lifespan...
  22. ncbi Effect of MPTP on Dopamine metabolism in Ames dwarf mice
    Dhanasekaran Muralikrishnan
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA
    Neurochem Res 27:457-64. 2002
    ..This study shows that the MAO activity and the coenzyme content of dwarf mice are similar to those of their wild-type controls and hence susceptible to MPTP-induced toxicity...
  23. ncbi Impaired cardiac excitation-contraction coupling in ventricular myocytes from Ames dwarf mice with IGF-I deficiency
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks 58203, USA
    Growth Horm IGF Res 12:99-105. 2002
    ..These results suggest that deficiency in IGF-I may be directly associated with cardiac E-C coupling dysfunction at the ventricular myocyte level...
  24. pmc Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease
    Manuchair Ebadi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Brain Res Mol Brain Res 134:67-75. 2005
    ..These data are interpreted to suggest that peroxynitrite ions are involved in the etiopathogenesis of Parkinson's disease, and metallothionein-mediated coenzyme Q10 synthesis may provide neuroprotection...
  25. ncbi Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases
    Manuchair Ebadi
    Department of Pharmacology, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Curr Drug Targets 7:1513-29. 2006
    ..Its therapeutic efficacy in Alzheimer's disease remains uncertain. In Alzheimer's disease, short term studies of selegiline suggest a beneficial effect; whereas long term studies are less convincing...
  26. ncbi Growth Hormone Alters the Glutathione S-Transferase and Mitochondrial Thioredoxin Systems in Long-Living Ames Dwarf Mice
    Lalida Rojanathammanee
    Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58203
    J Gerontol A Biol Sci Med Sci . 2013
    ..It also affects the regulation of thioredoxin and glutaredoxin, factors that regulate posttranslational modification of proteins and redox balance, thereby further influencing stress resistance...
  27. ncbi Aging and life span
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58203, USA
    Adv Exp Med Biol 567:259-83. 2005
  28. ncbi Expression of DNA Methyltransferases Is Influenced by Growth Hormone in the Long-Living Ames Dwarf Mouse In Vivo and In Vitro
    Vanessa L Armstrong
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203
    J Gerontol A Biol Sci Med Sci . 2013
    ..Growth hormone appears to modulate expression of DNMT1 and 3a in dwarf liver tissue and primary hepatocytes. Therefore, growth hormone may contribute to age-related processes, DNA methylation, and, ultimately, longevity...
  29. pmc Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202, USA
    Exp Gerontol 48:905-19. 2013
    ..These results provide further evidence that dwarf mice may be better protected against metabolic and environmental perturbations which may in turn, contribute to their extended longevity. ..
  30. pmc Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
    Shaik Shavali
    Department of Pathology, University of North Dakota, School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58202, USA
    Neurosci Lett 439:125-8. 2008
    ..This study has implications to the pathogenesis of familial PD where alpha-syn overexpression is mainly involved...
  31. ncbi Cardiac cytochrome-c oxidase deficiency occurs during late postnatal development in progeny of copper-deficient rats
    W Thomas Johnson
    USDA, ARS, GFHNRC, P O Box 9034, Grand Forks, ND 58202 9034, USA
    Exp Biol Med (Maywood) 231:172-80. 2006
    ..The resistance of CCO deficiency to repair by dietary copper supplementation may be related to the relatively slow turnover of the affected mitochondria in the terminally differentiated heart...
  32. ncbi Dopamine agonist 3-PPP fails to protect against MPTP-induced toxicity
    Dhanasekaran Muralikrishnan
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    Neurochem Res 29:379-84. 2004
    ..3-PPP had no effect on the SH-SY5Y neuronal cell growth in culture and did not block the MPP(+)-induced cytotoxicity. This study shows that the dopamine agonist 3-PPP failed to protect against MPTP-induced dopaminergic neurotoxicity...
  33. ncbi Pennington scientific symposium on mechanisms and retardation of aging
    Craig S Atwood
    Section of Geriatrics and Gerontology, University of Wisconsin Medical School, Madison, WI, USA
    Exp Gerontol 38:1217-26. 2003
  34. ncbi Ebselen effects on MPTP-induced neurotoxicity
    Muralikrishnan Dhanasekaran
    Department of Pharmacal Sciences, Division of Pharmacology and Toxicology, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
    Brain Res 1118:251-4. 2006
    ..Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum...
  35. pmc Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, ND 58202 9034, USA
    Mech Ageing Dev 127:444-50. 2006
    ....
  36. ncbi Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity
    Binu Tharakan
    Plummer Movement Disorders Center, Department of Neurology, Scott and White Clinic, Temple, TX 76508, USA
    Phytother Res 20:165-8. 2006
    ..These results show that Trichopus zeylanicus whole plant powder has anti-fatigue effects in young Sprague-Dawley rats and aged normal and mutant Ames dwarf mice providing scientific evidence for the Kani tribal practice in India...
  37. pmc Muscle disuse: adaptation of antioxidant systems is age dependent
    Chiao nan Joyce Chen
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 55455, USA
    J Gerontol A Biol Sci Med Sci 63:461-6. 2008
    ..The depletion of intracellular GSH and tGSH levels of muscles from aged animals with disuse may make aged muscles more susceptible to oxidative damage...
  38. ncbi Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity
    J Christopher Corton
    United States Environmental Protection Agency, Division of Environmental Carcinogenesis, Research Triangle Park, NC 27711, USA
    J Gerontol A Biol Sci Med Sci 60:1494-509. 2005
    ..CR reverses age-dependent decreases in PGC-1alpha, PPARalpha, and regulated genes. Strategies that target one or multiple PGC-1-regulated NR could be used to mimic the beneficial health effects found in models of longevity...

Research Grants3

  1. Role of GH deficiency on mitochondrial bioenergetics
    Holly Brown Borg; Fiscal Year: 2005
    ..Determining GH-dependent pathways and mechanisms may suggest potential therapeutic interventions to delay aging, treat aging-related disorders and extend life span in humans. ..
  2. Role of growth hormone in thiol metabolism, stress resistance and aging
    Holly Brown Borg; Fiscal Year: 2009
    ..Determining GH-dependent pathways and mechanisms may suggest potential therapeutic interventions to delay aging treat aging-related disorders and extend life span in humans. ..
  3. Role of growth hormone in thiol metabolism, stress resistance and aging
    Holly M Brown Borg; Fiscal Year: 2010
    ..Determining GH-dependent pathways and mechanisms may suggest potential therapeutic interventions to delay aging treat aging-related disorders and extend life span in humans. ..