Kirk Brower

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc PER3 polymorphism and insomnia severity in alcohol dependence
    Kirk J Brower
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    Sleep 35:571-7. 2012
  2. pmc A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia
    Kirk J Brower
    University of Michigan Addiction Research Center, 4250 Plymouth Road, Ann Arbor, MI 48109 5740, USA
    Alcohol Clin Exp Res 32:1429-38. 2008
  3. pmc Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances
    Kirk J Brower
    University of Michigan, Department of Psychiatry, SPC 5740, Ann Arbor, MI 48109 2700, USA
    Med Hypotheses 74:928-33. 2010
  4. doi request reprint Anabolic steroid abuse and dependence in clinical practice
    Kirk J Brower
    University of Michigan Addiction Research Center, Ann Arbor, MI 48109, USA
    Phys Sportsmed 37:131-40. 2009
  5. pmc Prevalence and correlates of withdrawal-related insomnia among adults with alcohol dependence: results from a national survey
    Kirk J Brower
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Addict 19:238-44. 2010
  6. doi request reprint Prescription sleeping pills, insomnia, and suicidality in the National Comorbidity Survey Replication
    Kirk J Brower
    University of Michigan, Department of Psychiatry, 4250 Plymouth Rd, SPC 5740, Ann Arbor, MI 48109, USA
    J Clin Psychiatry 72:515-21. 2011
  7. pmc Sleep homeostasis in alcohol-dependent, depressed and healthy control men
    Kirk J Brower
    Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5740, Ann Arbor, MI 48109 2700, USA
    Eur Arch Psychiatry Clin Neurosci 261:559-66. 2011
  8. pmc Ramelteon and improved insomnia in alcohol-dependent patients: a case series
    Kirk J Brower
    University of Michigan Department of Psychiatry and Addiction Research Center, Ann Arbor, MI 48109 2700, USA
    J Clin Sleep Med 7:274-5. 2011
  9. pmc Persistent insomnia, abstinence, and moderate drinking in alcohol-dependent individuals
    Kirk J Brower
    Department of Psychiatry and Addiction Research Center, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI 48109 2700, USA
    Am J Addict 20:435-40. 2011
  10. pmc Insomnia, self-medication, and relapse to alcoholism
    K J Brower
    Department of Psychiatry, The Alcohol Research Center, University of Michigan Medical School, Ann Arbor, MI 48108, USA
    Am J Psychiatry 158:399-404. 2001

Detail Information

Publications33

  1. pmc PER3 polymorphism and insomnia severity in alcohol dependence
    Kirk J Brower
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    Sleep 35:571-7. 2012
    ..We hypothesized that the PER3 polymorphism would be an independent predictor of insomnia severity with greatest severity observed in those with the PER3(4/4)genotype...
  2. pmc A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia
    Kirk J Brower
    University of Michigan Addiction Research Center, 4250 Plymouth Road, Ann Arbor, MI 48109 5740, USA
    Alcohol Clin Exp Res 32:1429-38. 2008
    ..The purpose of this pilot study was to compare gabapentin versus placebo for the treatment of insomnia and prevention of relapse in alcohol-dependent patients...
  3. pmc Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances
    Kirk J Brower
    University of Michigan, Department of Psychiatry, SPC 5740, Ann Arbor, MI 48109 2700, USA
    Med Hypotheses 74:928-33. 2010
    ..A conceptual framework is also presented to articulate causal mechanisms. The paper concludes with implications for research and practice...
  4. doi request reprint Anabolic steroid abuse and dependence in clinical practice
    Kirk J Brower
    University of Michigan Addiction Research Center, Ann Arbor, MI 48109, USA
    Phys Sportsmed 37:131-40. 2009
    ..This article aims to aid such understanding, and guidelines are suggested for assessment and treatment of nonmedical AAS users...
  5. pmc Prevalence and correlates of withdrawal-related insomnia among adults with alcohol dependence: results from a national survey
    Kirk J Brower
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Addict 19:238-44. 2010
    ..Because of its relatively frequent prevalence and association with relapse, assessment and treatment of AWD-related insomnia should be routinely considered in clinical settings...
  6. doi request reprint Prescription sleeping pills, insomnia, and suicidality in the National Comorbidity Survey Replication
    Kirk J Brower
    University of Michigan, Department of Psychiatry, 4250 Plymouth Rd, SPC 5740, Ann Arbor, MI 48109, USA
    J Clin Psychiatry 72:515-21. 2011
    ..Moreover, the association of nonbenzodiazepine benzodiazepine receptor agonists (NBRAs) with suicidality has not been specifically studied in the US general population...
  7. pmc Sleep homeostasis in alcohol-dependent, depressed and healthy control men
    Kirk J Brower
    Department of Psychiatry, University of Michigan, 4250 Plymouth Rd, SPC 5740, Ann Arbor, MI 48109 2700, USA
    Eur Arch Psychiatry Clin Neurosci 261:559-66. 2011
    ..Finding interventions that selectively improve these different components of sleep homeostasis should be a goal of treatment for AD and MDD...
  8. pmc Ramelteon and improved insomnia in alcohol-dependent patients: a case series
    Kirk J Brower
    University of Michigan Department of Psychiatry and Addiction Research Center, Ann Arbor, MI 48109 2700, USA
    J Clin Sleep Med 7:274-5. 2011
    ..Given its lack of abuse potential and evidence of low melatonin levels in alcoholism, ramelteon deserves further study as a treatment for insomnia in this group of patients...
  9. pmc Persistent insomnia, abstinence, and moderate drinking in alcohol-dependent individuals
    Kirk J Brower
    Department of Psychiatry and Addiction Research Center, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI 48109 2700, USA
    Am J Addict 20:435-40. 2011
    ....
  10. pmc Insomnia, self-medication, and relapse to alcoholism
    K J Brower
    Department of Psychiatry, The Alcohol Research Center, University of Michigan Medical School, Ann Arbor, MI 48108, USA
    Am J Psychiatry 158:399-404. 2001
    ..This study was an investigation of the frequencies of insomnia and its self-medication with alcohol in a group of alcoholic patients, as well as the relationship of these variables to alcoholic relapse...
  11. ncbi request reprint Racially related health disparities and alcoholism treatment outcomes
    Kirk J Brower
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48108, USA
    Alcohol Clin Exp Res 27:1365-7. 2003
    ..Future studies of racial differences should include measures of social support for sobriety, motivation for treatment, and treatment alliance...
  12. pmc Effects of age and alcoholism on sleep: a controlled study
    K J Brower
    Alcohol Research Center and Department of Psychiatry, University of Michigan, Ann Arbor 48108, USA
    J Stud Alcohol 62:335-43. 2001
    ..Yet few studies have examined the combined effects of alcoholism and aging on sleep. The purpose of this study was to investigate the main and interactive effects on sleep of diagnostic group and age group...
  13. ncbi request reprint Anabolic steroid abuse and dependence
    Kirk J Brower
    Department of Psychiatry and Addiction Research Center, The University of Michigan, Ann Arbor 48108, USA
    Curr Psychiatry Rep 4:377-87. 2002
    ..When patients with AAS use disorders are compared with patients with other substance use disorders, both similarities and differences become apparent and have implications for treatment...
  14. ncbi request reprint Insomnia, alcoholism and relapse
    Kirk J Brower
    University of Michigan Addiction Research Center, Ann Arbor, MI 48108, USA
    Sleep Med Rev 7:523-39. 2003
    ....
  15. pmc Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients
    Maher Karam-Hage
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48108, USA
    Psychiatry Clin Neurosci 57:542-4. 2003
    ..Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings...
  16. pmc Sleep and body mass index in depressed children and healthy controls
    Julita Wojnar
    University of Michigan, Department of Psychiatry, Ann Arbor, MI, USA
    Sleep Med 11:295-301. 2010
    ..This study evaluated the relationship between BMI and polysomnography in children with major depressive disorder (MDD), compared to healthy controls (HCs)...
  17. ncbi request reprint Sleep problems in early childhood and early onset of alcohol and other drug use in adolescence
    Maria M Wong
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
    Alcohol Clin Exp Res 28:578-87. 2004
    ....
  18. pmc Treatment options for sleep disturbances during alcohol recovery
    J Todd Arnedt
    Sleep and Chronophysiology Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48105, USA
    J Addict Dis 26:41-54. 2007
    ....
  19. ncbi request reprint Predicting completion of outpatient opioid detoxification with clonidine
    Stephen Strobbe
    The Department of Psychiatry and Addiction Research Center, University of Michigan Medical School, Ann Arbor, USA
    Am J Addict 12:260-9. 2003
    ..The study findings may help target patients who could benefit the most from outpatient clonidine detoxification...
  20. pmc Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence
    Marcin Wojnar
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Alcohol Clin Exp Res 33:693-702. 2009
    ..The purpose of this study was to examine relationships between genetic markers of central serotonin (5-HT) and dopamine function, and risk for post-treatment relapse, in a sample of alcohol-dependent patients...
  21. pmc Impulsive and non-impulsive suicide attempts in patients treated for alcohol dependence
    Marcin Wojnar
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, United States
    J Affect Disord 115:131-9. 2009
    ..The aim of the study was to identify correlates of impulsive and non-impulsive suicide attempts among a treated population of alcohol-dependent patients...
  22. pmc Sleep problems and suicidality in the National Comorbidity Survey Replication
    Marcin Wojnar
    University of Michigan, Department of Psychiatry, 4250 Plymouth Road, Ann Arbor, MI 48109 5763, USA
    J Psychiatr Res 43:526-31. 2009
    ..Using data from a nationally representative survey, we examined the association between self-reported sleep difficulties and suicidality in the United States...
  23. pmc Perception of sleep in recovering alcohol-dependent patients with insomnia: relationship with future drinking
    Deirdre A Conroy
    University of Michigan, Ann Arbor, Michigan 48105, USA
    Alcohol Clin Exp Res 30:1992-9. 2006
    ....
  24. ncbi request reprint An open trial of cognitive-behavioral treatment for insomnia comorbid with alcohol dependence
    J Todd Arnedt
    University of Michigan Sleep and Chronophysiology Laboratory, Ann Arbor, MI, USA
    Sleep Med 8:176-80. 2007
    ..We evaluated the efficacy of cognitive-behavioral treatment for insomnia in recovering alcoholic patients in an open pilot study...
  25. ncbi request reprint Six-month changes in spirituality, religiousness, and heavy drinking in a treatment-seeking sample
    Elizabeth A R Robinson
    Addiction Research Center, University of Michigan, 4250 Plymouth Road, Ann Arbor, Michigan 48109 5740, USA
    J Stud Alcohol Drugs 68:282-90. 2007
    ..This descriptive and exploratory study investigated change in alcoholics' spirituality and/or religiousness (S/R) from treatment entry to 6 months later and whether those changes were associated with drinking outcomes...
  26. pmc Trends in non-medical use of anabolic steroids by U.S. college students: results from four national surveys
    Sean Esteban McCabe
    The University of Michigan, Substance Abuse Research Center, 2025 Traverwood Dr, Suite C, Ann Arbor, MI 48105 2194, USA
    Drug Alcohol Depend 90:243-51. 2007
    ..The characteristics associated with NMAS have important implications for future practice and research...
  27. ncbi request reprint Unaided smoking cessation among smokers in treatment for alcohol dependence
    Maher Karam-Hage
    Nicotine Research Program, Univ of Michigan Department of Psychiatry, Ann Arbor, MI, USA
    Addict Behav 30:1247-53. 2005
    ..These findings suggest that quitting smoking may be associated with low levels of nicotine dependence and favorable alcohol treatment response in alcoholic smokers...
  28. pmc Impulsive suicide attempts predict post-treatment relapse in alcohol-dependent patients
    Marcin Wojnar
    Medical University of Warsaw, Department of Psychiatry, Nowowiejska 27, 00 665 Warsaw, Poland
    Drug Alcohol Depend 97:268-75. 2008
    ..Specifically, a lifetime suicide attempt at baseline was used to predict relapse in the year after treatment. Also, the unique contribution of impulsive suicide attempts was examined...
  29. pmc Cognitive-behavioral therapy for insomnia in alcohol dependent patients: a randomized controlled pilot trial
    J Todd Arnedt
    Sleep and Chronophysiology Laboratory, Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI 48109 2700, USA
    Behav Res Ther 49:227-33. 2011
    ..The benefits of treating insomnia on drinking outcomes are less apparent...
  30. pmc The association between insomnia and suicidal thoughts in adults treated for alcohol dependence in Poland
    Anna Klimkiewicz
    University of Michigan Medical School, Department of Psychiatry, Ann Arbor, MI 48109, USA
    Drug Alcohol Depend 122:160-3. 2012
    ..For the present study, we hypothesized that self-reported sleep problems are associated with suicidal thoughts in a sample of adults seeking treatment for alcohol dependence in Poland...
  31. ncbi request reprint Sertraline treatment of co-occurring alcohol dependence and major depression
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 26:13-20. 2006
    ..This multicenter, double-blind, placebo-controlled trial of sertraline was designed to address many of the potential methodological shortcomings of studies of co-occurring disorders...
  32. ncbi request reprint [Influence of impulsivity, suicidality and serotonin genes on treatment outcomes in alcohol dependence]
    Marcin Wojnar
    Katedra i Klinika Psychiatryczna AM w Warszawie
    Psychiatr Pol 40:985-94. 2006
    ..The aim of the study was to identify risk factors of relapse by investigating relationships among suicidality, impulsivity, genetic markers of serotonin activity, and relapse in alcohol-dependent patients...
  33. ncbi request reprint Forgiveness and alcohol problems among people entering substance abuse treatment
    Jon R Webb
    East Tennessee State University, Department of Psychology, Campus Box 70649, Johnson City, TN 37614, USA
    J Addict Dis 25:55-67. 2006
    ..ForSelf may be most difficult to achieve and thus most important to recovery, thereby preventing full recovery and fostering relapses...

Research Grants8

  1. Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
    Kirk Brower; Fiscal Year: 2007
    ..Overall public health will be improved by developing science-based treatments that can augment existing, but only partially effective, treatment approaches. ..
  2. Medication Effects on Sleep in Alcoholics
    Kirk Brower; Fiscal Year: 2007
    ..He will apply these methods to alcohol dependent patients, an understudied population that may benefit clinically from a more sophisticated understanding of their sleep problems. ..
  3. Genetics, Brain Activity, and Relapse to Alcoholism
    Kirk Brower; Fiscal Year: 2007
    ....
  4. Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
    Kirk Brower; Fiscal Year: 2009
    ..Overall public health will be improved by developing science-based treatments that can augment existing, but only partially effective, treatment approaches. ..
  5. Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
    Kirk J Brower; Fiscal Year: 2010
    ..Overall public health will be improved by developing science-based treatments that can augment existing, but only partially effective, treatment approaches. ..