Gregory L Brower

Summary

Affiliation: University of South Carolina
Country: USA

Publications

  1. pmc Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats
    Giselle C Melendez
    Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Hypertension 56:225-31. 2010
  2. pmc TNF-alpha inhibition attenuates adverse myocardial remodeling in a rat model of volume overload
    Lynetta J Jobe
    Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
    Am J Physiol Heart Circ Physiol 297:H1462-8. 2009
  3. pmc ETA selective receptor antagonism prevents ventricular remodeling in volume-overloaded rats
    David B Murray
    Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
    Am J Physiol Heart Circ Physiol 297:H109-16. 2009
  4. pmc Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart
    Scott P Levick
    Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Hypertension 55:270-6. 2010
  5. ncbi request reprint Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogens
    Jason D Gardner
    Department of Cell and Developmental Bioloogy and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 294:H198-204. 2008
  6. ncbi request reprint Response of cardiac mast cells to atrial natriuretic peptide
    David B Murray
    Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, 6439 Garners Ferry Rd, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 293:H1216-22. 2007
  7. doi request reprint Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats
    David B Murray
    University of South Carolina, School of Medicine, Department of Cell and Developmental Biology and Anatomy, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 294:H1251-7. 2008
  8. ncbi request reprint The relationship between myocardial extracellular matrix remodeling and ventricular function
    Gregory L Brower
    Department of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Eur J Cardiothorac Surg 30:604-10. 2006
  9. pmc Protection from adverse myocardial remodeling secondary to chronic volume overload in mast cell deficient rats
    Scott P Levick
    Department of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
    J Mol Cell Cardiol 45:56-61. 2008
  10. ncbi request reprint Cardiac mast cell regulation of matrix metalloproteinase-related ventricular remodeling in chronic pressure or volume overload
    Joseph S Janicki
    Department of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Cardiovasc Res 69:657-65. 2006

Collaborators

Detail Information

Publications19

  1. pmc Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats
    Giselle C Melendez
    Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Hypertension 56:225-31. 2010
    ..These novel observations demonstrate that IL-6 induces a myocardial phenotype almost identical to that of the hypertensive heart, identifying IL-6 as potentially important in this remodeling process...
  2. pmc TNF-alpha inhibition attenuates adverse myocardial remodeling in a rat model of volume overload
    Lynetta J Jobe
    Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
    Am J Physiol Heart Circ Physiol 297:H1462-8. 2009
    ..These observations demonstrate that TNF-alpha has a pivotal role in adverse myocardial remodeling and that treatment with etanercept can attenuate the progression to heart failure...
  3. pmc ETA selective receptor antagonism prevents ventricular remodeling in volume-overloaded rats
    David B Murray
    Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
    Am J Physiol Heart Circ Physiol 297:H109-16. 2009
    ..Furthermore, by preventing these events, ET-1 antagonism was efficacious in attenuating ventricular dilatation and limiting the development of structural and functional deficits...
  4. pmc Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart
    Scott P Levick
    Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Hypertension 55:270-6. 2010
    ....
  5. ncbi request reprint Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogens
    Jason D Gardner
    Department of Cell and Developmental Bioloogy and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 294:H198-204. 2008
    ....
  6. ncbi request reprint Response of cardiac mast cells to atrial natriuretic peptide
    David B Murray
    Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, 6439 Garners Ferry Rd, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 293:H1216-22. 2007
    ..We conclude that ANP is not a cardiac mast cell secretagogue and is not responsible for the cardiac mast cell-mediated adverse ventricular remodeling in response to volume overload...
  7. doi request reprint Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats
    David B Murray
    University of South Carolina, School of Medicine, Department of Cell and Developmental Biology and Anatomy, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 294:H1251-7. 2008
    ..Another novel finding from this study is that chronic nonspecific endothelin antagonism may inadvertently potentiate ET-1-mediated signaling...
  8. ncbi request reprint The relationship between myocardial extracellular matrix remodeling and ventricular function
    Gregory L Brower
    Department of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Eur J Cardiothorac Surg 30:604-10. 2006
    ....
  9. pmc Protection from adverse myocardial remodeling secondary to chronic volume overload in mast cell deficient rats
    Scott P Levick
    Department of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
    J Mol Cell Cardiol 45:56-61. 2008
    ..These results underscore the importance of cardiac mast cells in mediating MMP activation, collagen degradation and LV dilatation and suggest that mast cell-derived TNF-alpha plays a role in early myocardial remodeling...
  10. ncbi request reprint Cardiac mast cell regulation of matrix metalloproteinase-related ventricular remodeling in chronic pressure or volume overload
    Joseph S Janicki
    Department of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Cardiovasc Res 69:657-65. 2006
    ..The potential role of cardiac mast cells in activating MMPs, which then results in fibrillar collagen degradation and adverse myocardial remodeling secondary to chronic volume and pressure overload will be the subject of this review...
  11. pmc Cardiac mast cells: the centrepiece in adverse myocardial remodelling
    Scott P Levick
    Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Cardiovasc Res 89:12-9. 2011
    ..Moreover, there is strong evidence that premenopausal female cardioprotection may at least partly be due to gender differences in cardiac mast cells. This too will be addressed...
  12. doi request reprint Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart
    Scott P Levick
    Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Hypertension 53:1041-7. 2009
    ..Furthermore, these results identify several mechanisms, including tryptase, inflammatory cell recruitment, and cytokine regulation, by which mast cells may mediate hypertension-induced left ventricular fibrosis...
  13. pmc Estrogenic modulation of inflammation-related genes in male rats following volume overload
    Jennifer L McLarty
    Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, USA
    Physiol Genomics 44:362-73. 2012
    ..Protein levels reflected the changes observed at the gene level. These data suggest that estrogen provides its cardioprotective effects, at least in part, via genomic modulation of numerous inflammation-related genes...
  14. ncbi request reprint Nrf2 protects against maladaptive cardiac responses to hemodynamic stress
    Jinqing Li
    Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Arterioscler Thromb Vasc Biol 29:1843-50. 2009
    ....
  15. pmc Temporal evaluation of cardiac myocyte hypertrophy and hyperplasia in male rats secondary to chronic volume overload
    Yan Du
    Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Am J Pathol 177:1155-63. 2010
    ....
  16. ncbi request reprint Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure
    Gregory L Brower
    Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 292:H3057-64. 2007
    ....
  17. pmc Tryptase/Protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts
    Jennifer L McLarty
    Cell Biology and Anatomy, School of Medicine, University of South Carolina, 6349 Garners Ferry Rd, Columbia, SC 29208, USA
    Hypertension 58:264-70. 2011
    ..Specifically, tryptase causes cardiac fibroblasts to increase collagen synthesis via a mechanism involving activation of protease-activated receptor 2 and subsequent induction of extracellular signal-regulated kinase signaling...
  18. ncbi request reprint Modulation of cardiac mast cell-mediated extracellular matrix degradation by estrogen
    Amanda L Chancey
    Dept of Cell and Developmental Biology, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 289:H316-21. 2005
    ..46 +/- 0.23 vs. 0.73 +/- 0.13%, P < or = 0.05). These findings indicate that estrogen's cardioprotective role can be partially mediated by its effects on cardiac mast cells, MMPs, and the extracellular matrix...
  19. ncbi request reprint Effects of mast cells on the behavior of isolated heart fibroblasts: modulation of collagen remodeling and gene expression
    Angela de Almeida
    Department of Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
    J Cell Physiol 191:51-9. 2002
    ..These studies suggest that mast cells play an important role in the regulation of the cardiac interstitial matrix. Further studies are warranted to determine the mechanisms whereby mast cells modulate fibroblast activity...