Research Topics
Genomes and Genes | Gregory L BrowerSummaryAffiliation: University of South Carolina Country: USA Publications
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Publications
Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in ratsGiselle C Melendez
Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Hypertension 56:225-31. 2010..These novel observations demonstrate that IL-6 induces a myocardial phenotype almost identical to that of the hypertensive heart, identifying IL-6 as potentially important in this remodeling process...- TNF-alpha inhibition attenuates adverse myocardial remodeling in a rat model of volume overloadLynetta J Jobe
Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
Am J Physiol Heart Circ Physiol 297:H1462-8. 2009..These observations demonstrate that TNF-alpha has a pivotal role in adverse myocardial remodeling and that treatment with etanercept can attenuate the progression to heart failure... - ETA selective receptor antagonism prevents ventricular remodeling in volume-overloaded ratsDavid B Murray
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
Am J Physiol Heart Circ Physiol 297:H109-16. 2009..Furthermore, by preventing these events, ET-1 antagonism was efficacious in attenuating ventricular dilatation and limiting the development of structural and functional deficits... - Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heartScott P Levick
Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Hypertension 55:270-6. 2010.... 
Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogensJason D Gardner
Department of Cell and Developmental Bioloogy and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA
Am J Physiol Heart Circ Physiol 294:H198-204. 2008....- Response of cardiac mast cells to atrial natriuretic peptideDavid B Murray
Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, 6439 Garners Ferry Rd, Columbia, SC 29208, USA
Am J Physiol Heart Circ Physiol 293:H1216-22. 2007..We conclude that ANP is not a cardiac mast cell secretagogue and is not responsible for the cardiac mast cell-mediated adverse ventricular remodeling in response to volume overload... 
Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in ratsDavid B Murray
University of South Carolina, School of Medicine, Department of Cell and Developmental Biology and Anatomy, Columbia, SC 29208, USA
Am J Physiol Heart Circ Physiol 294:H1251-7. 2008..Another novel finding from this study is that chronic nonspecific endothelin antagonism may inadvertently potentiate ET-1-mediated signaling...- The relationship between myocardial extracellular matrix remodeling and ventricular functionGregory L Brower
Department of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Eur J Cardiothorac Surg 30:604-10. 2006.... - Protection from adverse myocardial remodeling secondary to chronic volume overload in mast cell deficient ratsScott P Levick
Department of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
J Mol Cell Cardiol 45:56-61. 2008..These results underscore the importance of cardiac mast cells in mediating MMP activation, collagen degradation and LV dilatation and suggest that mast cell-derived TNF-alpha plays a role in early myocardial remodeling... - Cardiac mast cell regulation of matrix metalloproteinase-related ventricular remodeling in chronic pressure or volume overloadJoseph S Janicki
Department of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Cardiovasc Res 69:657-65. 2006..The potential role of cardiac mast cells in activating MMPs, which then results in fibrillar collagen degradation and adverse myocardial remodeling secondary to chronic volume and pressure overload will be the subject of this review... - Cardiac mast cells: the centrepiece in adverse myocardial remodellingScott P Levick
Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Cardiovasc Res 89:12-9. 2011..Moreover, there is strong evidence that premenopausal female cardioprotection may at least partly be due to gender differences in cardiac mast cells. This too will be addressed... - Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heartScott P Levick
Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Hypertension 53:1041-7. 2009..Furthermore, these results identify several mechanisms, including tryptase, inflammatory cell recruitment, and cytokine regulation, by which mast cells may mediate hypertension-induced left ventricular fibrosis... - Estrogenic modulation of inflammation-related genes in male rats following volume overloadJennifer L McLarty
Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, USA
Physiol Genomics 44:362-73. 2012..Protein levels reflected the changes observed at the gene level. These data suggest that estrogen provides its cardioprotective effects, at least in part, via genomic modulation of numerous inflammation-related genes... - Nrf2 protects against maladaptive cardiac responses to hemodynamic stressJinqing Li
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA
Arterioscler Thromb Vasc Biol 29:1843-50. 2009.... - Temporal evaluation of cardiac myocyte hypertrophy and hyperplasia in male rats secondary to chronic volume overloadYan Du
Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Am J Pathol 177:1155-63. 2010.... - Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failureGregory L Brower
Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Am J Physiol Heart Circ Physiol 292:H3057-64. 2007.... - Tryptase/Protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblastsJennifer L McLarty
Cell Biology and Anatomy, School of Medicine, University of South Carolina, 6349 Garners Ferry Rd, Columbia, SC 29208, USA
Hypertension 58:264-70. 2011..Specifically, tryptase causes cardiac fibroblasts to increase collagen synthesis via a mechanism involving activation of protease-activated receptor 2 and subsequent induction of extracellular signal-regulated kinase signaling... - Modulation of cardiac mast cell-mediated extracellular matrix degradation by estrogenAmanda L Chancey
Dept. of Cell and Developmental Biology, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
Am J Physiol Heart Circ Physiol 289:H316-21. 2005..46 +/- 0.23 vs. 0.73 +/- 0.13%, P < or = 0.05). These findings indicate that estrogen's cardioprotective role can be partially mediated by its effects on cardiac mast cells, MMPs, and the extracellular matrix... - Effects of mast cells on the behavior of isolated heart fibroblasts: modulation of collagen remodeling and gene expressionAngela de Almeida
Department of Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
J Cell Physiol 191:51-9. 2002..These studies suggest that mast cells play an important role in the regulation of the cardiac interstitial matrix. Further studies are warranted to determine the mechanisms whereby mast cells modulate fibroblast activity...