Research Topics
| ROBERT JOSEPH BROSNANSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Naltrexone does not affect isoflurane minimum alveolar concentration in catsRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Vet Anaesth Analg 40:225-8. 2013..To test whether naltrexone, an opioid receptor antagonist, affects the minimum alveolar concentration (MAC) of isoflurane in cats, a species that is relatively resistant to the general anesthetic sparing effects of most opioids...- Inhaled anesthetics in horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Vet Clin North Am Equine Pract 29:69-87. 2013..This article reviews the ether-type anesthetics in contemporary use, their uptake and elimination, their mechanisms of action, and their desirable and undesirable effects in horses... - Increased NMDA receptor inhibition at an increased Sevoflurane MACRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA, 95616, USA
BMC Anesthesiol 12:9. 2012..abstract:.. 
Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA
Vet Anaesth Analg 39:335-44. 2012....
Effects of body position on intracranial and cerebral perfusion pressures in isoflurane-anesthetized horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
J Appl Physiol 92:2542-6. 2002..In conclusion, ICP in isoflurane-anesthetized horses changes inversely with the brain-to-heart hydrostatic gradient. DR may also cause increases in ICP, irrespective of head position...- Carbon dioxide negatively modulates N-methyl-D-aspartate receptorsR J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Br J Anaesth 101:673-9. 2008..We hypothesized that CO2 dose-dependently decreases rat NMDA channel current via an acidifying effect at concentrations relevant to CO2 MAC... - Sedative effects of propofol in horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Vet Anaesth Analg 36:421-5. 2009..We hypothesized that propofol can produce rapidly-reversible, dose-dependent standing sedation in horses... - The relationship between digital perfusion pressure and hoof lamellar blood flow in isoflurane-anesthetized horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States
Res Vet Sci 90:138-45. 2011..The ΔLBF correlated negatively with the ΔDPP. We conclude that LBF was not solely determined by passive pressure-flow relationships and that systemic hypertension may not effectively increase dermal LBF in horses... - Effects of isoflurane anesthesia on cerebrovascular autoregulation in horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Am J Vet Res 72:18-24. 2011.... - GABA(A) receptor antagonism increases NMDA receptor inhibition by isoflurane at a minimum alveolar concentrationRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Vet Anaesth Analg 38:231-9. 2011..The objective of this study was to test whether isoflurane would function as a more potent NMDA receptor antagonist if its efficacy at GABA(A) receptors was decreased... - Anesthetic properties of carbon dioxide in the ratRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Anesth Analg 105:103-6. 2007..Carbon dioxide decreases halothane minimum alveolar concentrations (MAC) in dogs when Paco(2) exceeds 95 mm Hg. We sought to confirm these findings for several potent inhaled anesthetics in rats... - A technique to depress desflurane vapor pressureRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Vet Anaesth Analg 33:275-80. 2006.... - Anesthetic induction with guaifenesin and propofol in adult horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Am J Vet Res 72:1569-75. 2011..To evaluate whether guaifenesin can prevent adverse anesthetic induction events caused by propofol and whether a guaifenesin-propofol induction combination has brief cardiovascular effects commensurate with rapid drug washout... - Effect of administration of propofol and xylazine hydrochloride on recovery of horses after four hours of anesthesia with desfluraneEugene P Steffey
Department of Surgical and Radiological Sciences, School of Veterinary Medicine and KL Maddy Equine Analytical Chemistry Laboratory, California Animal Health and Food Safety Laboratory, University of California, Davis, CA 95616, USA
Am J Vet Res 70:956-63. 2009..Animals-8 healthy horses (mean +/- SEM age, 6.6 +/- 1.0 years; mean body weight, 551 +/- 50 kg)... - Intracranial elastance in isoflurane-anesthetized horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 65:1042-6. 2004..However, removal of small volumes of CSF may cause rapid compensatory replacement from other intracranial compartments, which suggests steady-state maintenance of an increase in intracranial volume during isoflurane anesthesia in horses... - Effects of duration of isoflurane anesthesia and mode of ventilation on intracranial and cerebral perfusion pressures in horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 64:1444-8. 2003.... - Effects of ventilation and isoflurane end-tidal concentration on intracranial and cerebral perfusion pressures in horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 64:21-5. 2003..The effect of isoflurane dose on CBF however, remains unresolved because it depends on the opposing influences of a decrease in CCP and cerebral vasodilation... - Use of propofol-xylazine and the Anderson Sling Suspension System for recovery of horses from desflurane anesthesiaEugene P Steffey
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Vet Surg 38:927-33. 2009..To characterize the behavior of horses recovering in the Anderson Sling Suspension System after 4 hours of desflurane anesthesia and postdesflurane intravenous (IV) administration of propofol and xylazine... - Malignant hyperthermia in a horse anesthetized with halothaneMonica Aleman
Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, Medical Center, Davis, CA 95616, USA
J Vet Intern Med 19:363-6. 2005 - Effects of head-down positioning on regional central nervous system perfusion in isoflurane-anesthetized horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 69:737-43. 2008..To test the hypothesis that head-down positioning in anesthetized horses increases intracranial pressure (ICP) and decreases cerebral and spinal cord blood flows... - Assessment of halothane and sevoflurane anesthesia in spontaneously breathing ratsMichele A Steffey
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 64:470-4. 2003..Increases in eyelid aperture and pupil diameter are reliable signs of increasing depth of halothane and sevoflurane anesthesia. Decreasing respiratory rate is a clinical indicator of an increasing dose of halothane... - Direct measurement of intracranial pressure in adult horsesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA
Am J Vet Res 63:1252-6. 2002..The ICP values obtained in this study are within reference ranges established for other species and provide a point of reference for the diagnosis of abnormal ICP in adult horses... - Safety and efficacy of intramuscular propofol administration in ratsCarolyn M McKune
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Vet Anaesth Analg 35:495-500. 2008..To determine the safety and efficacy of intramuscularly (IM) injected 100% propofol and propofol-dimethyl sulfoxide (DMSO) mixtures... - Pharmacokinetics of inhaled anesthetics in green iguanas (Iguana iguana)Robert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 67:1670-4. 2006..CONCLUSIONS AND CLINICAL RELEVANCE: Differences in blood:gas solubility for isoflurane, sevoflurane, and desflurane did not significantly influence differences in pharmacokinetics for the inhalation agents in iguanas... - Effects of remifentanil on measures of anesthetic immobility and analgesia in catsRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 70:1065-71. 2009..To evaluate effects of various doses of remifentanil on measures of analgesia in anesthetized cats... - Pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isofluraneBruno H Pypendop
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 69:531-6. 2008..To characterize the pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane... - Rate of change of oxygen concentration for a large animal circle anesthetic systemAdrian M Solano
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Vet Res 66:1675-8. 2005.... - Median effective dose of isoflurane, sevoflurane, and desflurane in green iguanasLinda S Barter
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, 95616, USA
Am J Vet Res 67:392-7. 2006..Hence, for a constant end-tidal anesthetic concentration in an iguana, the plane of anesthesia may deepen over time, which could contribute to increased morbidity during prolonged procedures... - Ammonia has anesthetic propertiesRobert J Brosnan
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Calif 94143 0464, USA
Anesth Analg 104:1430-3, table of contents. 2007..Because in pathophysiologic concentrations, ammonia reversibly impairs memory, consciousness, and responsiveness to noxious stimuli in a manner similar to anesthetics, we investigated whether ammonia had anesthetic properties... - Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetoneLiya Yang
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
Anesth Analg 105:673-9. 2007..We tested the hypothesis that two metabolites that are elevated in ketosis (beta-hydroxybutyric acid, and acetone) modulate ion channels in a manner similar to anesthetics and produce anesthesia in animals... - The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor functionLiya Yang
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
Anesth Analg 105:393-6. 2007....
Research Grants
- Does Anesthetic Solubility Determine Receptor Specificity?ROBERT JOSEPH BROSNAN; Fiscal Year: 2010..The role of water solubility as a determinant of drug-receptor modulation would also add additional support to theories of anesthetic action at aqueous interfacial sites around cell receptor proteins. ..