ROBERT JOSEPH BROSNAN

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Naltrexone does not affect isoflurane minimum alveolar concentration in cats
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Anaesth Analg 40:225-8. 2013
  2. pmc Inhaled anesthetics in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA Electronic address
    Vet Clin North Am Equine Pract 29:69-87. 2013
  3. pmc Increased NMDA receptor inhibition at an increased Sevoflurane MAC
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA, 95616, USA
    BMC Anesthesiol 12:9. 2012
  4. doi request reprint Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA
    Vet Anaesth Analg 39:335-44. 2012
  5. ncbi request reprint Effects of body position on intracranial and cerebral perfusion pressures in isoflurane-anesthetized horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Appl Physiol 92:2542-6. 2002
  6. doi request reprint Carbon dioxide negatively modulates N-methyl-D-aspartate receptors
    R J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Br J Anaesth 101:673-9. 2008
  7. doi request reprint Sedative effects of propofol in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Anaesth Analg 36:421-5. 2009
  8. doi request reprint The relationship between digital perfusion pressure and hoof lamellar blood flow in isoflurane-anesthetized horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States
    Res Vet Sci 90:138-45. 2011
  9. doi request reprint Effects of isoflurane anesthesia on cerebrovascular autoregulation in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Vet Res 72:18-24. 2011
  10. pmc GABA(A) receptor antagonism increases NMDA receptor inhibition by isoflurane at a minimum alveolar concentration
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Anaesth Analg 38:231-9. 2011

Research Grants

  1. Does Anesthetic Solubility Determine Receptor Specificity?
    ROBERT JOSEPH BROSNAN; Fiscal Year: 2010

Collaborators

Detail Information

Publications31

  1. pmc Naltrexone does not affect isoflurane minimum alveolar concentration in cats
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Anaesth Analg 40:225-8. 2013
    ..To test whether naltrexone, an opioid receptor antagonist, affects the minimum alveolar concentration (MAC) of isoflurane in cats, a species that is relatively resistant to the general anesthetic sparing effects of most opioids...
  2. pmc Inhaled anesthetics in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA Electronic address
    Vet Clin North Am Equine Pract 29:69-87. 2013
    ..This article reviews the ether-type anesthetics in contemporary use, their uptake and elimination, their mechanisms of action, and their desirable and undesirable effects in horses...
  3. pmc Increased NMDA receptor inhibition at an increased Sevoflurane MAC
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA, 95616, USA
    BMC Anesthesiol 12:9. 2012
    ..abstract:..
  4. doi request reprint Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA
    Vet Anaesth Analg 39:335-44. 2012
    ....
  5. ncbi request reprint Effects of body position on intracranial and cerebral perfusion pressures in isoflurane-anesthetized horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Appl Physiol 92:2542-6. 2002
    ..In conclusion, ICP in isoflurane-anesthetized horses changes inversely with the brain-to-heart hydrostatic gradient. DR may also cause increases in ICP, irrespective of head position...
  6. doi request reprint Carbon dioxide negatively modulates N-methyl-D-aspartate receptors
    R J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Br J Anaesth 101:673-9. 2008
    ..We hypothesized that CO2 dose-dependently decreases rat NMDA channel current via an acidifying effect at concentrations relevant to CO2 MAC...
  7. doi request reprint Sedative effects of propofol in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Anaesth Analg 36:421-5. 2009
    ..We hypothesized that propofol can produce rapidly-reversible, dose-dependent standing sedation in horses...
  8. doi request reprint The relationship between digital perfusion pressure and hoof lamellar blood flow in isoflurane-anesthetized horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States
    Res Vet Sci 90:138-45. 2011
    ..The ΔLBF correlated negatively with the ΔDPP. We conclude that LBF was not solely determined by passive pressure-flow relationships and that systemic hypertension may not effectively increase dermal LBF in horses...
  9. doi request reprint Effects of isoflurane anesthesia on cerebrovascular autoregulation in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Vet Res 72:18-24. 2011
    ....
  10. pmc GABA(A) receptor antagonism increases NMDA receptor inhibition by isoflurane at a minimum alveolar concentration
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Anaesth Analg 38:231-9. 2011
    ..The objective of this study was to test whether isoflurane would function as a more potent NMDA receptor antagonist if its efficacy at GABA(A) receptors was decreased...
  11. ncbi request reprint Anesthetic properties of carbon dioxide in the rat
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Anesth Analg 105:103-6. 2007
    ..Carbon dioxide decreases halothane minimum alveolar concentrations (MAC) in dogs when Paco(2) exceeds 95 mm Hg. We sought to confirm these findings for several potent inhaled anesthetics in rats...
  12. ncbi request reprint A technique to depress desflurane vapor pressure
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Anaesth Analg 33:275-80. 2006
    ....
  13. doi request reprint Anesthetic induction with guaifenesin and propofol in adult horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Vet Res 72:1569-75. 2011
    ..To evaluate whether guaifenesin can prevent adverse anesthetic induction events caused by propofol and whether a guaifenesin-propofol induction combination has brief cardiovascular effects commensurate with rapid drug washout...
  14. doi request reprint Effect of administration of propofol and xylazine hydrochloride on recovery of horses after four hours of anesthesia with desflurane
    Eugene P Steffey
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine and KL Maddy Equine Analytical Chemistry Laboratory, California Animal Health and Food Safety Laboratory, University of California, Davis, CA 95616, USA
    Am J Vet Res 70:956-63. 2009
    ..Animals-8 healthy horses (mean +/- SEM age, 6.6 +/- 1.0 years; mean body weight, 551 +/- 50 kg)...
  15. ncbi request reprint Intracranial elastance in isoflurane-anesthetized horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 65:1042-6. 2004
    ..To determine whether high intracranial pressure (ICP) during spontaneous ventilation (SV) in anesthetized horses coincides with an increase in intracranial elastance (ie, change in ICP per unit change of intracranial volume)...
  16. ncbi request reprint Effects of duration of isoflurane anesthesia and mode of ventilation on intracranial and cerebral perfusion pressures in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 64:1444-8. 2003
    ....
  17. ncbi request reprint Effects of ventilation and isoflurane end-tidal concentration on intracranial and cerebral perfusion pressures in horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 64:21-5. 2003
    ..To measure the effects of isoflurane end-tidal concentration and mode of ventilation (spontaneous vs controlled) on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in horses...
  18. doi request reprint Use of propofol-xylazine and the Anderson Sling Suspension System for recovery of horses from desflurane anesthesia
    Eugene P Steffey
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Vet Surg 38:927-33. 2009
    ..To characterize the behavior of horses recovering in the Anderson Sling Suspension System after 4 hours of desflurane anesthesia and postdesflurane intravenous (IV) administration of propofol and xylazine...
  19. ncbi request reprint Malignant hyperthermia in a horse anesthetized with halothane
    Monica Aleman
    Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, Medical Center, Davis, CA 95616, USA
    J Vet Intern Med 19:363-6. 2005
  20. doi request reprint Effects of head-down positioning on regional central nervous system perfusion in isoflurane-anesthetized horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 69:737-43. 2008
    ..To test the hypothesis that head-down positioning in anesthetized horses increases intracranial pressure (ICP) and decreases cerebral and spinal cord blood flows...
  21. ncbi request reprint Assessment of halothane and sevoflurane anesthesia in spontaneously breathing rats
    Michele A Steffey
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 64:470-4. 2003
    ..To characterize halothane and sevoflurane anesthesia in spontaneously breathing rats...
  22. ncbi request reprint Direct measurement of intracranial pressure in adult horses
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Vet Res 63:1252-6. 2002
    ..To develop a method for surgical placement of a commercial microsensor intracranial pressure (ICP) transducer and to characterize normal ICP and cerebral perfusion pressures (CPP) in conscious adult horses...
  23. doi request reprint Safety and efficacy of intramuscular propofol administration in rats
    Carolyn M McKune
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Anaesth Analg 35:495-500. 2008
    ..To determine the safety and efficacy of intramuscularly (IM) injected 100% propofol and propofol-dimethyl sulfoxide (DMSO) mixtures...
  24. ncbi request reprint Pharmacokinetics of inhaled anesthetics in green iguanas (Iguana iguana)
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 67:1670-4. 2006
    ..To test the hypothesis that differences in anesthetic uptake and elimination in iguanas would counter the pharmacokinetic effects of blood:gas solubility and thus serve to minimize kinetic differences among inhaled agents...
  25. doi request reprint Effects of remifentanil on measures of anesthetic immobility and analgesia in cats
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 70:1065-71. 2009
    ..To evaluate effects of various doses of remifentanil on measures of analgesia in anesthetized cats...
  26. doi request reprint Pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane
    Bruno H Pypendop
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 69:531-6. 2008
    ..To characterize the pharmacokinetics of remifentanil in conscious cats and cats anesthetized with isoflurane...
  27. ncbi request reprint Rate of change of oxygen concentration for a large animal circle anesthetic system
    Adrian M Solano
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 66:1675-8. 2005
    ..To describe the effects of changes in circuit volume and oxygen inflow rate on inspired oxygen concentration for a large animal circle anesthetic system...
  28. ncbi request reprint Median effective dose of isoflurane, sevoflurane, and desflurane in green iguanas
    Linda S Barter
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, 95616, USA
    Am J Vet Res 67:392-7. 2006
    ..To determine the median effective dose (ED(50); equivalent to the minimum alveolar concentration [MAC]) of isoflurane, sevoflurane, and desflurane for anesthesia in iguanas...
  29. ncbi request reprint Ammonia has anesthetic properties
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Calif 94143 0464, USA
    Anesth Analg 104:1430-3, table of contents. 2007
    ..Because in pathophysiologic concentrations, ammonia reversibly impairs memory, consciousness, and responsiveness to noxious stimuli in a manner similar to anesthetics, we investigated whether ammonia had anesthetic properties...
  30. ncbi request reprint Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone
    Liya Yang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 105:673-9. 2007
    ..We tested the hypothesis that two metabolites that are elevated in ketosis (beta-hydroxybutyric acid, and acetone) modulate ion channels in a manner similar to anesthetics and produce anesthesia in animals...
  31. ncbi request reprint The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function
    Liya Yang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 105:393-6. 2007
    ....

Research Grants1

  1. Does Anesthetic Solubility Determine Receptor Specificity?
    ROBERT JOSEPH BROSNAN; Fiscal Year: 2010
    ..The role of water solubility as a determinant of drug-receptor modulation would also add additional support to theories of anesthetic action at aqueous interfacial sites around cell receptor proteins. ..