John O Brooks
Affiliation: University of California
- Neurocognitive costs and benefits of psychotropic medications in older adultsJohn O Brooks
Palo Alto Veterans Affairs Health Care System and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
J Geriatr Psychiatry Neurol 20:199-214. 2007..The neurocognitive costs and benefits of psychiatric medications should be considered in the context of disease treatment in older adults...
- Corticolimbic metabolic dysregulation in euthymic older adults with bipolar disorderJohn O Brooks
UCLA Semel Institute, Los Angeles, CA 90025, USA
J Psychiatr Res 43:497-502. 2009..Persistent corticolimbic dysregulation may be related to residual affective, behavioral, and cognitive symptoms in older patients with bipolar disorder, even when not experiencing syndromal mood disturbance...
- Substance use disorders as risk factors for psychiatric hospitalization in bipolar disorderJennifer C Hoblyn
Palo Alto Veterans Affairs Health Care System, Palo Alto, California, USA
Psychiatr Serv 60:50-5. 2009..This study developed risk profiles of psychiatric hospitalization for veterans diagnosed as having bipolar disorder...
- Metabolic risks in older adults receiving second-generation antipsychotic medicationJohn O Brooks
UCLA Semel Institute, MC 175919, 760 Westwood Plaza, B8 233B NPI, Los Angeles, CA 90024, USA
Curr Psychiatry Rep 11:33-40. 2009..Although lifestyle modifications can help to reduce some aspects of metabolic syndrome, lifestyle modifications in conjunction with metformin therapy appear to be most effective...
- Metabolic evidence of corticolimbic dysregulation in bipolar maniaJohn O Brooks
UCLA Semel Institute, 760 Westwood Plaza, B3 233 NPI, Los Angeles, CA 90024 1759, USA
Psychiatry Res 181:136-40. 2010..The findings support the hypothesis of corticolimbic dysregulation as a crucial contributor to the pathophysiology of bipolar disorder...
- Diagnostic and clinical implications of functional neuroimaging in bipolar disorderJohn O Brooks
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA Electronic address
J Psychiatr Res 57:12-25. 2014..Further refinement of biomarker identification, and perhaps even illness characterization are needed to find prognostic and predictive biomarkers of bipolar disorder. ..
- Preliminary evidence of within-subject changes in gray matter density associated with remission of bipolar depressionJohn O Brooks
Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024, USA
Psychiatry Res 193:53-5. 2011..Decreases were observed in superior and inferior frontal gyri and anterior cingulate...
- Prefrontal and paralimbic metabolic dysregulation related to sustained attention in euthymic older adults with bipolar disorderJohn O Brooks
Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA
Bipolar Disord 12:866-74. 2010..In the present study, we evaluated relationships between cognitive performance deficits and resting cerebral metabolism in euthymic older adults with bipolar disorder...
- Safety and tolerability associated with second-generation antipsychotic polytherapy in bipolar disorder: findings from the Systematic Treatment Enhancement Program for Bipolar DisorderJohn O Brooks
UCLA Semel Institute, Los Angeles, California, USA
J Clin Psychiatry 72:240-7. 2011..Practitioners often combine 2 or more second-generation antipsychotics (SGAs) in patients with bipolar disorder, despite an absence of data to support their safety, tolerability, or efficacy...
- Resting prefrontal hypometabolism and paralimbic hypermetabolism related to verbal recall deficits in euthymic older adults with bipolar disorderJohn O Brooks
UCLA Semel Institute and Department of Psychiatry, Los Angeles, CA 90024 1759, USA
Am J Geriatr Psychiatry 17:1022-9. 2009..To evaluate deficits of delayed free recall in euthymic older patients with bipolar disorder and relate deficits to resting cerebral metabolism...
- Effectiveness of lamotrigine in bipolar disorder in a clinical settingTerence A Ketter
Stanford University School of Medicine, 401 Quarry Road, Room 2124, Stanford, CA, USA
J Psychiatr Res 43:13-23. 2008..To assess lamotrigine effectiveness in bipolar disorder (BD) patients in a clinical setting...
- Dorsolateral and dorsomedial prefrontal gray matter density changes associated with bipolar depressionJohn O Brooks
Palo Alto Veterans Affairs Health Care System, Psychiatry Service, Palo Alto, CA, USA
Psychiatry Res 172:200-4. 2009..Moreover, our observed differences in gray matter density overlap metabolic areas of change and thus have implications for the conceptualization and treatment of affective disorders...
- Mood-state effects on amygdala volume in bipolar disorderLara C Foland-Ross
Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
J Affect Disord 139:298-301. 2012..The prefrontal cortex has recently been reported to have a lower volume in depressed versus euthymic bipolar patients. Here we examined whether similar mood state-dependent volumetric differences are detectable in the amygdala...
- Predictive socioeconomic and clinical profiles of antidepressant response and remissionFelipe A Jain
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024, USA
Depress Anxiety 30:624-30. 2013..The predictive power of any single factor, however, is limited. We aimed to develop profiles of antidepressant response and remission based upon hierarchical combinations of baseline clinical and demographic factors...
- Individual risk profiles for postoperative delirium after joint replacement surgeryFelipe A Jain
Department of Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, CA, USA
Psychosomatics 52:410-6. 2011..Delirium occurs in nearly half of older patients after joint replacement surgery. However, risk profiles for developing delirium have not been established...