Research Topics
| John O BrooksSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Neurocognitive costs and benefits of psychotropic medications in older adultsJohn O Brooks
Palo Alto Veterans Affairs Health Care System and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
J Geriatr Psychiatry Neurol 20:199-214. 2007..The neurocognitive costs and benefits of psychiatric medications should be considered in the context of disease treatment in older adults...
Corticolimbic metabolic dysregulation in euthymic older adults with bipolar disorderJohn O Brooks
UCLA Semel Institute, Los Angeles, CA 90025, USA
J Psychiatr Res 43:497-502. 2009..Persistent corticolimbic dysregulation may be related to residual affective, behavioral, and cognitive symptoms in older patients with bipolar disorder, even when not experiencing syndromal mood disturbance...
Substance use disorders as risk factors for psychiatric hospitalization in bipolar disorderJennifer C Hoblyn
Palo Alto Veterans Affairs Health Care System, Palo Alto, California, USA
Psychiatr Serv 60:50-5. 2009..This study developed risk profiles of psychiatric hospitalization for veterans diagnosed as having bipolar disorder...
Metabolic risks in older adults receiving second-generation antipsychotic medicationJohn O Brooks
UCLA Semel Institute, MC 175919, 760 Westwood Plaza, B8 233B NPI, Los Angeles, CA 90024, USA
Curr Psychiatry Rep 11:33-40. 2009..Although lifestyle modifications can help to reduce some aspects of metabolic syndrome, lifestyle modifications in conjunction with metformin therapy appear to be most effective...
Metabolic evidence of corticolimbic dysregulation in bipolar maniaJohn O Brooks
UCLA Semel Institute, 760 Westwood Plaza, B3 233 NPI, Los Angeles, CA 90024 1759, USA
Psychiatry Res 181:136-40. 2010..The findings support the hypothesis of corticolimbic dysregulation as a crucial contributor to the pathophysiology of bipolar disorder...
Resting prefrontal hypometabolism and paralimbic hypermetabolism related to verbal recall deficits in euthymic older adults with bipolar disorderJohn O Brooks
UCLA Semel Institute and Department of Psychiatry, Los Angeles, CA 90024 1759, USA
Am J Geriatr Psychiatry 17:1022-9. 2009..To evaluate deficits of delayed free recall in euthymic older patients with bipolar disorder and relate deficits to resting cerebral metabolism...
Preliminary evidence of within-subject changes in gray matter density associated with remission of bipolar depressionJohn O Brooks
Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024, USA
Psychiatry Res 193:53-5. 2011..Decreases were observed in superior and inferior frontal gyri and anterior cingulate...
Prefrontal and paralimbic metabolic dysregulation related to sustained attention in euthymic older adults with bipolar disorderJohn O Brooks
Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024, USA
Bipolar Disord 12:866-74. 2010..In the present study, we evaluated relationships between cognitive performance deficits and resting cerebral metabolism in euthymic older adults with bipolar disorder...
Safety and tolerability associated with second-generation antipsychotic polytherapy in bipolar disorder: findings from the Systematic Treatment Enhancement Program for Bipolar DisorderJohn O Brooks
UCLA Semel Institute, Los Angeles, California, USA
J Clin Psychiatry 72:240-7. 2011..Practitioners often combine 2 or more second-generation antipsychotics (SGAs) in patients with bipolar disorder, despite an absence of data to support their safety, tolerability, or efficacy...
Mood-state effects on amygdala volume in bipolar disorderLara C Foland-Ross
Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
J Affect Disord 139:298-301. 2012..The prefrontal cortex has recently been reported to have a lower volume in depressed versus euthymic bipolar patients. Here we examined whether similar mood state-dependent volumetric differences are detectable in the amygdala...
